博士生導師。2012年獲得中國科學院生物信息學博士學位,2015年從美國加州大學河濱分校訪學回國,受聘為福建農林大學林學中心全職教授。第十四屆林業青年科技獎獲得者。2016年入選福建省C類引進高層次人才,2017年獲福建農林大學“金山學者”榮譽稱號。以福建農林大學為依託單位主持2015年國家自然科學基金面上項目“自毒脅迫下杉木可變剪接與microRNA相互調控網路研究”,承擔2016年國家重點專項“林木次生生長的分子調控和環境脅迫機制”子課題。承擔2018年“十三五”國家重點研發計畫專項“竹資源高效培育關鍵技術研究”項目“筍-竹生長發育機制與生長性狀評價”研究的子課題。在PNAS、Cell Research、Nature genetics等權威期刊上發表相關文章39篇。目前主要從事生物信息學和林木遺傳改良相關研究。
基本介紹
- 中文名:顧連峰
- 畢業院校:中國科學院
- 學位/學歷:博士
- 專業方向:生物信息學
- 職務:教授
- 主要成就:福建省C類引進高層次人才
- 學術代表作:plant journal
- 獲獎:第十四屆林業青年科技獎獲得者
人物研究,發表論文,人物獲獎,
人物研究
開發生物信息學軟體解析來自高通量技術所產生的大批量數據,從基因組、轉錄組和蛋白質組等組學數據中挖掘林木次生生長的規律。結合二代和三代高通量測序及蛋白組學數據開展重要速生樹種(毛竹、杉木和楊樹)的基因表達調控網路研究。並深入開展轉錄後調控網路和表觀遺傳學研究,為林木遺傳改良提供理論依據。
發表論文
Papers 2019 (*first-author #corresponding author)
Wang HY*, Wang HH*, Zhang H*, Liu S, Wang Y, Gao Y, Xi F, Zhao L, Liu B, Reddy A, Lin C, Gu L#. (2019). The interplay between microRNA and alternative splicing of linear and circular RNAs in eleven plant species. Bioinformatics, btz038
Wang Y*, Gao Y*, Zhang H*, Wang H, Liu X, Xu X, Zhang Z, Kohnen M, Hu K, Wang H, Xi F, Zhao L, Lin C, Gu L#. (2019). Genome-wide profiling of circular RNAs in the rapidly growing shoots of moso bamboo (Phyllostachys edulis). Plant and Cell Physiology. DOI: 10.1093/pcp/pcz043
Zhao L, Zhang H, Kohnen M, Prasad K, Gu L#, Reddy A#. (2019), Analysis of transcriptome and epitranscriptome in plants using PacBio Iso-Seq and Nanopore-based direct RNA sequencing. Front. Genet. doi: 10.3389/fgene.2019.00253
Wu B, Zhang H, Lin L, Wang H, Gao Y, Zhao L, Chen YP #, Chen R #, Gu L# (2019), A similarity searching system for biological phenotype images using deep convolutional encoder-decoder architecture. Current Bioinformatics, DOI : 10.2174/1574893614666190204150109
Gao Y, Xi F, Zhang H, Liu X, Wang H, Zhao L, Reddy A, Gu L # (2019), Single-molecule real-time (SMRT) isoform sequencing (Iso-Seq) in plants: The status of the bioinformatics tools to unravel the transcriptome complexity, Current Bioinformatics, DOI : 10.2174/1574893614666190204151746
Clark S, Yu F, Gu L, Min X# (2019) Expanding alternative splicing identification by integrating multiple sources of transcription data in tomato , Front. Plant Sci. | doi: 10.3389/fpls.2019.00689
Liu Xu, Gao Y, Zhao L, Cai Y, Wang H, Miao M, Gu L#, Zhang H# (2019) Biogenesis, research methods, and functions of circular RNAs Hereditas. Vol. 41 Issue (6): 469-485
Papers 2018 (*first-author #corresponding author)
Ye G*, Zhang H*, Chen B, Nie S, Liu H, Gao W, Wang H, Gao Y, Gu L#.De novo genome assembly of the stress tolerant forest species Casuarina equisetifolia provides insight into secondary growth, (2018), Plant Journal. https://doi.org/10.1111/tpj.14159.
Zhang H*, Wang H*, Zhu Q*, Gao Y, Wang H, Zhao L, Wang Y, Xi F, Wang W, Yang Y, Lin C, Gu L# (2018),Transcriptome characterization of moso bamboo (Phyllostachys edulis) seedlings in response to exogenous gibberellin applications, BMC plant biology,2018,18:125
Wang Q, Zuo Z, Wang X, Liu Q, Gu L, Oka Y, Lin C (2018),Beyond the photocycle – how cryptochromes regulate photoresponses in plants?, Current Option in Plant Biology, 45, 120-126.
Wang, G., Sun, P., Gong, Z., Gu, L., Lou, Y., Fang, W., Zhang, L., Su, L., Yang, T., Wang, B. and Zhou, J., 2018.Srk1 kinase, a SR protein‐specific kinase, is important for sexual reproduction, plant infection and pre‐mRNA processing in Fusarium graminearum.Environmental microbiology.
Liu B., Zhang J., Yang Z., Matsui A., Li S., Yan X., Kohnena M., Gu L., Prasad K., Tuskan G., Lu M.,# Oka Y.# (2018).PtWOX11 acts as master regulator conducting the expression of key transcription factors to induce de novo shoot organogenesis in poplar.Plant Molecular Biology. (2018): 1-18.
Papers 2017 (*first-author #corresponding author)
Wang T*, Wang H*, Cai D*, Gao Y, Zhang H, Wang Y, Lin C, Ma L#, Gu L#, (2017), Comprehensive profiling of rhizome-associated alternative splicing and alternative polyadenylation in moso bamboo (Phyllostachys edulis). The Plant Journal.
Wang W*, Gu L*, Ye S, Zhang H, Cai C, Xiang M, Gao Y, Wang Q, Lin C, Zhu Q#, (2017), Genome-wide analysis and transcriptomic profiling of the auxin biosynthesis, transport and signaling family genes in moso bamboo (Phyllostachys heterocycla). BMC Genomics. 2017 Nov 13;18(1):870. doi: 10.1186/s12864-017-4250-0.
Wang K*, Jiao Z*, Xu M*, Wang Y, Li R, Cui X, Gu L#, Zhang S#. (2017), Landscape and Fruit Developmental Regulation of Alternative Splicing in Tomato by Genome-wide Analysis Horticultural Plant Journal. supplemental website
Wang, X., Wang, Q., Han, Y.J., Liu, Q., Gu, L., Yang, Z., Su, J., Liu, B., Zuo, Z., and He, W., Wang,J., Liu, B., Matsui, M., Kim,J., Oka, Y., Lin,C (2017). A CRY-BIC negative feedback circuitry regulating blue light sensitivity of Arabidopsis. The Plant Journal.
Hansheng Zhao*, Shancen Zhao*, International Network for Bamboo and Rattan, Benhua Fei, Huan Liu, Huanming Yang, Honghai Dai, Dan Wang, Wei Jin, Feng Tang, Qiang Gao, Hang Xun, Yuwei Wang, Lianghua Qi, Xianghua Yue, Shuyan Lin, Lianfeng Gu, Lubin Li, Tiansheng Zhu, Qiang Wei, Zhen Su, Tarmeze Bin Wan Ariffin Wan, Daniel A. Ofori, George Mbeva Muthike, Yigardu Mulatu Mengesha, Roberto Magno de Castro e Silva, Antonio Ludovico Beraldo, Zhimin Gao#, Xin Liu#, Zehui Jiang#; Announcing the Genome Atlas of Bamboo and Rattan (GABR) project: promoting research in evolution and in economically and ecologically beneficial plants. Gigascience 2017 gix046. doi: 10.1093/gigascience/gix046
Papers 2016(*first-author †corresponding author)
Zhang, H., Lin, C. and Gu, L†. (2016), Light Regulation of Alternative Pre-mRNA Splicing in Plants. Photochem Photobiol. Photochem Photobiol. doi:10.1111/php.12680(†corresponding).
Wang Q*, Zuo Z*, Wang X*, Gu L, Yoshizumi T,Yang,Z H,Liu Q,Liu W,Han Y,Liu B, Wohlschlegel J A, Matsui M, Oka Y and Lin C.(2016) Photoactivation and inactivation mechanisms of Arabidopsis cryptochrome2. Science.Vol. 354, Issue 6310, pp. 343-347.DOI: 10.1126/science.aaf9030
Yan H, Zhang H, Wang Q, Jian H, Qiu X, Baudino S, Just J, Raymond O, Gu L, Jihua W, Bendahmane M and Tang K (2016). The Rosa chinensis cv. Viridiflora phyllody phenotype is associated with misexpression of flower organ identity genes. Front. Plant Sci. 7:996. doi: 10.3389/fpls.2016.00996
Li S, Zhang G, Zhang X, Yuan J, Deng C, Gu L†, Gao W†. DPTEdb, an integrative database of transposable elements in dioecious plants. Database 2016: baw078 doi:10.1093/database/baw078 (†co-corresponding).
Li C, Gu L, Gao L, Chen C, Wei C, Qiu Q, Chien C, Wang S, Jiang L, Chen C, Yang S, Nguyen V, Snyder M, Burlingame A, Kohalmi S, Huang S, Cao X, Wang Z, Wu K, Chen X, Cui Y. Concerted genomic targeting of histone H3 lysine 27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis. Nature genetics. (2016). doi:10.1038/ng.3555
Cui X*, Lu F*, Qiu Q*, Zhou B*, Gu L, Zhang S, Kang Y, Cui X, Ma X, Yao Q, Ma J, Zhang X, Cao X. REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. Nature genetics. (2016). doi:10.1038/ng.3556
Deng X*, Lu T*, Wang L*, Gu L, Sun J, Kong X, Liu C, Cao X. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5.PNAS 2016, doi:10.1073/pnas.1522458113
Zhang S, Xu M, Qiu Z, Wang K, Du Y, Gu L†, Cui X†. Spatiotemporal transcriptome provides insights into early fruit development of Solanum lycopersicum, Sci. Rep. 6, 23173; doi: 10.1038/srep23173 (2016). (†co-corresponding).
Wu, Z*, Zhu D*, Lin X*, Miao L*, Gu L, Deng X, Yang Q, Sun K, Zhu D, Cao X, TSUGE T, Dean C, Aoyama T, Gu H, Qu L. RNA-binding proteins At RZ-1B and At RZ-1C play a critical role in regulation of pre-mRNA splicing and gene expression during Arabidopsis development. The Plant Cell (2016): TPC2015-00949.
Papers before 2016
Zhang Y.,* Gu, L.,* Hou, Y.*, Wang L., Deng, X., Hang, R.,Chen,D., Zhang,X., Zhang, Y., Liu, C., and Cao, X. 2015 Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeted alternative polyadenylation .Cell Research. 2015 Jun 23. doi: 10.1038/cr.2015.77 PMID: 26099751
Wei L,* Gu L,* Song X*, Cui X, Lu Z, Zhou M, Wang L, Hu F, Zhai J, Meyer B, Cao X. (2014) Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice. Proc Natl Acad Sci U S A 111: 3877-3882.
Deng, X.,* Gu, L.,* Liu, C.*, Lu, T*., Lu, F., Lu, Z., Cui, P., Pei, Y., Wang, B., Hu, S., and Cao, X. (2010). Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proc Natl Acad Sci U S A 107, 19114-19119.
Zhou, M.*, Gu, L.*, Li, P., Song, X., Wei, L., Chen, Z. and Cao, X. (2010) Degradome sequencing reveals endogenous small RNA targets in rice (Oryza sativa L. ssp. indica). Front. Biol., 5, 67-90.
Wu, B., Suo, F., Lei, W., and Gu, L †. (2014). Comprehensive Analysis of Alternative Splicing in Digitalis purpurea by Strand-Specific RNA-Seq. PLoS One 9, e106001.
Gu, L., and Guo, R. (2007). Genome-wide detection and analysis of alternative splicing for nucleotide binding site-leucine -rich repeats sequences in rice. J Genet Genomics 34, 247-257.
Wang, L., Song, X., Gu, L., Li, X., Cao, S., Chu, C., Cui, X., Chen, X., and Cao, X. (2013). NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis. Plant Cell 25, 715-727.
Cui X., Jin P., Cui X., Gu, L., Lu Z., Xue Y., Wei L., Qi J., Song X., Luo M., Gynheung An, Cao X. (2013) Control of Transposon Activity by a Histone H3K4 Demethylase in Rice. Proc Natl Acad Sci U S A. 110(5):1953-1958.
Zhang L., Cheng Z., Qin R., Qiu Y., Wang J., Cui X., Gu, L., Zhang X., Guo X., Wang D., Jiang L., Wu C., Wang H., Cao X., Wan J. (2012). Identification and Characterization of an Epi-1 allele of OsFIE1 Reveals a Regulatory Linkage between two Epigenetic Marks in Rice. Plant Cell 24, 4407-4421.
Zhou H., Zhou M., Yang Y., Li J., Zhu L., Jiang D., Dong J., Liu Q., Gu L., Zhou L., … Cao X., Zhuang C. (2014). RNAase Zs1 processes UBL40 mRNA and controls thermo-sensitive genic male sterility in rice. NATURE COMMUNICATIONS. doi:10.1038/ncomms5884
人物獲獎
2017年11月,獲得第十四屆林業青年科技獎。