基本介紹
- 中文名：顧月清
- 國籍：中國
- 民族：漢族
- 性別：女
主要研究經歷,目前研究方向,近年來發表的論文,
主要研究經歷
顧月清教授1997年於南京航空航天大學測試計量技術及儀器專業獲工學博士學位，主要研究光纖感測器實現體內藥物的微創實時監測。1999底赴美國賓夕法尼亞大學（University of Pennsylvania）醫學院從事博士後研究，主要從事近紅外分子探針在活體動物內的分布研究。2002年轉至美國德州大學（University of Texas）進行近紅外光譜及成像以監測各種臨床治療的研究。期間作為課題負責人分別獲得美國國防部博士後基金及新研究者基金的資助，於2003年被聘為該校生物醫學工程系的研究助理教授。2004年底於中國藥科大學建立生物醫學工程學研究室，主要是將各種光譜及成像技術套用於藥物研發的各環節中，已獲得多項國家自然科學基金的資助。
目前研究方向
1） 設計螢光探針及光學檢測系統，實現大分子藥物體內動力學過程的無損在位實時監測；
2） 設計併合成各種腫瘤特異性標誌物的靶向分子探針，以實現腫瘤的早期分子診斷；
3） 設計併合成各種高分子納米藥物載體，以實現腫瘤的主動/被動靶向治療；
4） 從基因水平設計特異性DNA序列探針，以研究腫瘤的生長、轉移機制；
5） 利用病毒載體實現疾病的早期診斷及治療。
近年來發表的論文
Submitted manuscript:
Fei Liu, Xinyang Chen, Dawei Deng, Yueqing Gu*, “Folate conjugated near infrared fluorescence probe for in vivo optical molecular imaging of cancer”, submitted to International Journal of Cancer.
Xinyang Chen, Fei Liu, Yueqing Gu*, “In vivo tumor imaging in mice with near-infrared - low density lipoprotein conjugates” submitted to Investigative Radiology
Hanyan Chen，Yueqing Gu*. “Characterization of CdHgTe/CdS quantum dots for noninvasive imaging of spinal cord in mouse model” submitted to Nanotechnology.
Jian zhang, Yueqing Gu*, “In vivo anti-tumor efficacy of docetaxel-loaded thermally responsive nanohydrogel”, submitted to Nanotechnology
Publications:
Da-Wei Deng, Peng Li, Yueqing Gu. “The simple synthesis and structural analysis of angled nanocrystals”, Crystal Research and Technology, 2009, in press.
Yueqing Gu, Jian Zhang, Haiyan Chen, “Dynamic properties of different kind of nanoparticles in mouse model after intravenous administration”, Proc. SPIE, 2009, 71900F1-F9
Da-Wei Deng, Yueqing Gu. “Spontaneous transition and concomitant self-assembly of CdTe nanoparticles into CdS nanosheets induced by L-cysteine”, Proc. SPIE, 2009, 719017-1–12.
Jian Zhang, Haiyan Chen, Lin Xu, Yueqing Gu*. The targeted behavior of thermally responsive nanohydrogel evaluated by NIR system in mouse model. Journal of Controlled Release, 2008, 131, 34-40.
Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Real time in vivo non-invasive optical imaging of temperature sensitive co-polymeric nanohydrogel, Nanotechnology, 2008, 19, 185707
Huimin Qian Yueqing Gu*, Minwang, Samuel Achilefu, “Optimization of the near-infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model” J Fluorescence, 2008
Yueqing Gu, Zhiyu Qian, Yunli Song, In Vivo Near Infrared Techniques for Protein Drug Development, Encyclopaedia of Heathcare Information System, IGI Global , 2008
Haiyan Chen, Yuanqing Wang, Jing Xu, Jian Zhang, Yuzhu Hu, Yueqing Gu*, Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model. J Fluoresc. 2008, 18, 801-811.
Haiyan Chen, Yueqing Gu*, Yuzhu Hu, “Comparison of two polymeric carrier formulations for controlled release of hydrophilic and hydrophobic drugs”, Journal of Materials Science: Materials in Medicine, 2008 Feb;19(2):651-8.
Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Zhiyu Qian, “Characterization of pH and temperature sensitive hydrogen nanoparticle for controlled drug release, PDA Journal of Pharmaceutical Science and Technology, 2007, Jul-Aug;61(4):303-13
Hao Gao, Yueqing Gu*, Qingneng Ping, “The implantable 5-fluororacil-loaded poly (L-lactic acid) fibers prepared by wet-spinning from suspension”, Journal of Controlled Release, 2007 Apr ;118(3):325-32.
Haiyan Chen, Jian zhang, Yueqing Gu*, “Characterization of Target effect of Nano- hydrogel by Real Time Optical Imaging using Near-infrared Fluorescent Quantum Dots”, Proceeding of International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore,2006 (EI index)
Huimin Qian, Yueqing Gu, “Near-infrared fluorescent labeling of L-asparaginase”, Proceeding of International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore, 2006 (EI index)
Qiong Wu, Zhiyu Qian, Yueqing Gu, “An Optimization Algorithm to Inverse Problem in 2-D Optical Computed Tomography by BP Neural Network，” International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore,2006 (EI index)
Yueqing Gu, Yunlin, Song, Anca Constantinescu “tumor vascular contents assessed non-invasively by near infrared spectroscopy and 19F NMR spectroscopy of perfulubron” Chinese Optics Letters, Vol.3 (suppl),2005
Zhiyu Qian Yueqing Gu, “In vivo measurement of absorption coefficient in rat brain and statistic analysis”, Chinese Optics Letters. Vol.3(suppl),2005
Yueqing Gu, R. P. Mason, Hanli Liu, “Estimated fraction of tumor vascular blood contents sampled by near infrared spectroscopy and 19F magnetic resonance spectroscopy” Optics Express, vol.13, No.5, 1724-1733(2005)
Yueqing Gu, Wei Chen, Mengna Xia, Hanli Liu, “Effect of photothermal therapy on breast tumor vascular contents: noninvasive monitoring by NIR Spectroscopy”, Photochemistry and Photobiology, Vol 81(3) (2005)
Yueqing Gu, Vikram Kodibagkar, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu, “Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance”, Optics in Health Care and Biomedical Optics, Proceedings of SPIE, vol 5630, Beijing, 2005
