隋廣超教授，博士生導師。北京大學本科及博士學位，瑞典Karolinska 醫學院醫學博士學位，美國哈佛大學醫學院博士後。在美國Wake Forest 大學醫學院做9年的獨立PI，至副教授，於2014年全職引進東北林業大學生命科學學院。在Cell, PNAS, Oncogene, Nucleic Acids Res, Mol Cancer (第一或通訊作者) 等刊物共發表80餘篇SCI文章，英文專著一部。在美國主持過NIH R01, 美國癌症協會和美國國防部等多項癌症研究基金。自2014年回國後，主持了三項國家自然科學基金面上項目和一項黑龍江省國自然基金重點項目。指導學生獲得國際基因工程大賽（iGEM）金獎5次，銀獎3次，單項獎3次；全國生命科學聯賽一等獎兩次，二等獎一次。在美國和中國多次參加基金評審。發明shRNA抑制基因表達方法，該方法已被世界範圍實驗室廣泛使用。獲兩項發明專利（美國和中國各一項）。研究領域為癌症發病的分子機制，抑癌藥物開發和天然活性物質的抑癌機理研究。
基本介紹
- 中文名：隋廣超
- 職業：教師
教育經歷 ,工作經歷 ,專業特長,研究領域,教學情況 ,評審經歷 ,承擔課題,發表文章,發明專利 ,代表性著作 ,
教育經歷
1983/09－1987/07，北京大學，生物系，生物化學專業學士
1990/10－1995/07，北京大學，生命科學學院，生物化學及分子生物學博士
1995/10－1998/11，瑞典Karolinska醫學院，臨床化學系，醫學博士
1998/11－1999/07，瑞典Karolinska醫學院，臨床化學系，博士後
1999/07－2004/08，美國哈佛大學哈佛醫學院，病理系，博士後
工作經歷
2004/09－2005/08，美國哈佛大學哈佛醫學院，講師
2005/09－2012/09，美國Wake Forest大學醫學院癌症生物學系，美國NIH綜合癌症研究中心，助教授
2012/10－2014/06，美國Wake Forest大學醫學院癌症生物學系，美國NIH綜合癌症研究中心，副教授
2014－至今，東北林業大學生命科學學院，教授（全職）
專業特長
分子生物學，生物化學，細胞生物學，遺傳學及表觀遺傳學，非編碼RNA (noncoding RNA)，基因表達及調控，癌症生物學
研究領域
1.藥用植物抑癌活性成分的藥效機理研究：藥用植物中的很多成分具有抑癌活性，但其藥效機理不明，限制其臨床套用。為突破該瓶頸，我們將探究植物藥用成分在肝癌細胞內的分子靶點、所影響的重要基因及細胞生物途徑，創立科學的聯合給藥方式以有效抑制肝癌發展並降低對機體副作用。首次在細胞水平驗證了鞣花酸聯合阿黴素或聯合順鉑的抗肝癌活性，並在小鼠模型中鑑定了鞣花酸聯合阿黴素使用，可以顯著加強阿黴素抗肝癌活性，減弱由高濃度下阿黴素引發的心肌毒性。此外，我們還研究了百里香琨，地榆皂苷II的植物天然活性物質的抑癌活性。
2.發明了以DNA載體為基礎的RNA干擾（RNAi）技術（即shRNA方法）。這一技術的發明為許多生物學科的研究提供了全新的方法，尤其是對基因和蛋白質功能的研究具有重大的創新性，也進了RNAi技術在醫療上的套用。這一方法已經成為世界範圍實驗室用於研究基因功能的常規實驗技術。該方法的DNA載體成為Ambion/Life Technologies公司的第一代產品（商品名pSilencer）。做為第一作者的相關PNAS文章已被引用上千次。
3.利用對Yin Yang 1（YY1）蛋白在腫瘤發生中功能的研究來探索幾種常見癌症（乳腺癌，前列腺癌，肺癌）的致病機制。我的多年的研究成果確立了YY1的癌基因地位。作為一個多功能蛋白，YY1在癌症發生中的終極作用一直有爭議。我在2004年發表的Cell文章中發現了YY1對p53的負調控，奠定了YY1的癌基因的地位。這些研究進一步確定YY1的癌基因地位，並揭示了YY1在癌症治療中作為靶基因的可能性。通過干擾YY1與癌蛋白之間相互作用以抑制腫瘤生長的多肽已被授權專利。
4.對其它抑癌基因、原癌基因及非編碼RNA的研究：（1）利用基因晶片等方法對抑癌基因SOX7的研究，發現其上、下游調控因子及可能的調節機制；（2）對DMTF1研究，發現了這一基因產生mRNA的不同選擇性剪接（alternative splicing）形態對乳腺癌發生和發展具有完全相反的作用，以及調節該可變剪接的分子機制；（3）研究了幾種microRNA對原癌基因EZH2、YY1和FASN的調節作用；（4）利用多個乳腺癌及它們對應的癌旁組織樣品中的長非編碼RNA（lncRNA）的分析，發現了多種在乳腺癌中差異性表達的lncRNA，目前正在對它們的生物學意義和對乳腺癌的調節功能進行鑑定。
教學情況
1.曾經在Wake Forest大學醫學院授課：Oncogenes, Tumor suppressors, Cancer Epigenetics, Non-coding RNAs.
2.表觀遺傳學與套用（本科生必修課）
3.留學生課程（全英語）：
（1）Epigenetics
（2）Developmental Biology (Animal)
（3）Theories and Applications of Molecular Biology and Biochemistry
4.負責iGEM指導和培訓工作，曾獲2014-2016年iGEM銀獎；2018年最佳單項獎；2017-2020年iGEM金獎。
評審經歷
美國國防部 (DOD) 癌症研究基金評審 (2007-2017; 12次)
美國癌症協會 (ACS) 研究基金評審 (2013)
義大利健康部 (2010, 2013, 2015, 2017)
英國研究基金 (2012)
美國佛羅里達健康部門基金評審 (2015, 2016)
中國國家自然科學基金 (2019-2021)
中國國家科技部重點研發及國際合作項目 （2021）
承擔課題
國家自然科學基金 (項目主持人): 2015年01月至2018年12月
題目: SOX7在乳腺癌中調控機制的研究
黑龍江省自然科學基金重點項目 (項目主持人): 2015年07月至2018年06月
題目:利用YY1的OPB肽段抑制腫瘤細胞生長
國家自然科學基金 (項目主持人): 2017年01月至2020年12月
題目:乳腺癌中YY1調節促癌蛋白活性的機制及其套用價值的研究
國家自然科學基金 (項目主持人): 2019年01月至2022年12月
題目：乳腺癌細胞基因組內G-四鏈體的形成特徵及調節因素研究
美國National Institute of Health (NIH): R01, 2009 - 2014
項目主持人(PI): Guangchao Sui
題目: Dmp1-p53/YY1 interplays and their roles in lung cancer development
美國American Cancer Society (ACS)：Research Scholar Grant, 2009 - 2013
項目主持人(PI): Guangchao Sui
2009 – 2013：The role of YY1 in prostate cancer
其它：
美國Department of Defense (DOD)前列腺癌研究項目
Golfers Against Cancer (GAC)
Kulynych Interdisciplinary Cancer Research Fund
Cell Growth and Survival Program Push Grant
發表文章
1. Guang-Chao Sui, Hong Sun, Man Zhang and Mei-Hao Hu. High level expression of recombinant plasminogen activator inhibitor-1 in Escherichia coli and generation of its mutants involving Asp125, Glu128 and Glu130. Biochem. Mol. Biol. Int., (1997) 42(3):621-629.
2. Guang-Chao Sui and Björn Wiman. Stability of plasminogen activator-1: role of Tyrosine221. FEBS Letters, (1998) 423(3):319-323.
3. Guang-Chao Sui and Björn Wiman. Functional effects of single amino acid substitutions in the region Phe113 to Asp138 in the PAI-1 molecule. Biochem. J., (1998) 331(2):409-415.
4. Gunnar Falk, Guang-Chao Sui, Sam Schulman and Björn Wiman. Detection of a new polymorphism in the propeptide region of the PAI-1 gene in two individuals with bleeding tendencies. Fibrinolysis and Proteolysis, (1999) 13(1):26-30.
5. Guang-Chao Sui, Helena Mångs and Björn Wiman. The role of His143 to PAI-1 function. Biochim. Biophys. Acta., (1999) 1434(1):58-63.
6. Helena Mångs, Guang-Chao Sui and Björn Wiman. PAI-1 stability: role of histidine residues. FEBS Letters, (2000) 475(3):192-196.
7. Guang-Chao Sui and Björn Wiman. The B beta-sheet in the PAI-1 molecule plays an important role in regulating its stability. Thrombosis and Haemostasis, (2000) 83(6):896-901.
8. Dominica Calvo, Martin Vector, Frederique Gay, Guangchao Sui, Margaret P Luck, Pascle Dufourcq, Gengyun Wen, M Maduro, J Rothman and Yang Shi. A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. EMBO. J., (2001) 20(24):7197-7208.
9. Guangchao Sui, Christina Soohoo, El Bachir Affar, Frederique Gay, Yujiang Shi, William C. Forrester, and Yang Shi. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA, (2002) 99:5515-5520.
10. Yujiang Shi, Junichi Sawada, Guangchao Sui, El Bachir Affar, Johnathan R. Whetstine, Fei Lan, Hidesato Ogawa, Margaret Po-Shan Luke, Yoshihiro Nakatani and Yang Shi. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature, (2003) 422:735-738.
11. Guangchao Sui, El Bachir Affar, Yujiang Shi, Chrystelle Brignone, Nathan R. Wall, Peng Yin, Mary Donohoe, Margaret P. Luke, Dominica Calvo, Steven R. Grossman and Yang Shi. Yin Yang 1 is a negative regulator of p53. Cell, (2004) 117:859-872.
12. Peter Baumeister, Shengzhan Luo, William C. Skarnes, Guangchao Sui, Edward Seto, Yang Shi and Amy S. Lee. Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol. Cell. Biol., (2005) 25:4529-4540.
13. Guangchao Sui and Yang Shi. Gene silencing by a DNA vector-based RNAi technology. Methods Mol. Biol., (2005) 309:205-218.
14. El Bachir Affar, Margaret Po-shan Luke, Frederique Gay, Dominica, Calvo, Guangchao Sui, Robert S. Weiss, En Li, and Yang Shi. Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents. Cancer Research. (2006) 66:3456-3462.
15. Margaret P. Luke, Guangchao Sui, Huifei Liu and Yang Shi. Yin Yang 1 physically interacts with HoxA11 and represses HoxA11-depedent transcription. J. Biol. Chem., (2006) 281:33226-33232.
16. Zhiyong Deng, Meimei Wan and Guangchao Sui*. PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger. Mol. Cell. Biol., (2007) 27(10):3780-3792.
17. Dohoon Kim, Minh Nguyen, Matthew Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph Rodgers, Ivana Delalle, Joseph Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David Sinclair and Li-Huei Tsai. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. (2007) 26(13):3169–3179.
18. Zhiyong Deng, Meimei Wan, Paul Cao, Anuradha Rao, Scott D. Cramer and Guangchao Sui*. Yin Yang 1 Regulates the Transcriptional Activity of Androgen Receptor. Oncogene; (2009) 28:3746-3757.
19. Guangchao Sui*. The regulation of YY1 in tumorigenesis and its targeting potential in cancer therapy. Mol. Cell. Pharmacol. (2009) 1(3):157-176 (Invited review)
20. Zhiyong Deng, Paul Cao, Meimei Wan and Guangchao Sui*. Yin Yang 1: a multifaceted protein beyond a transcription factor. Transcription. (2010) 1(2):81-84. (Invited review)
21. Paul Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D Cramer, Jianfeng Xu, Ming Lei and Guangchao Sui*. MicroRNA-101 Negatively Regulates Ezh2 and Its Expression is Modulated by Androgen Receptor and HIF-1alpha/HIF-1beta. Mol. Cancer, (2010) 9(1):108.
22. Linara S. Axanova, Yong Q. Chen, Thomas McCoy, Guangchao Sui and Scott D. Cramer. 1,25-dihydroxyvitamin D3 and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells. Prostate. (2010) 70(15):1658-1671.
23. Rui Fang, Andrew J. Barbera, Yufei Xu, Michael Rutenberg, Thiago Leonor, Qing Bi, Fei Lan, Pinchao Mei, Guo-Cheng Yuan, Christine Lian, Junmin Peng, Dongmei Cheng, Guangchao Sui, Ursula B. Kaiser, Yang Shi and Yujiang Geno Shi. Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation. Mol. Cell, (2010) 39(2):222-233.
24. Zandra K. Pinnix, Lance D. Miller, Wei Wang, Ralph D’Agostino Jr., Tim Kute, Mark C. Willingham, Heather Hatcher, Lia Tesfay, Guangchao Sui, Xiumin Di, Suzy V. Torti, Frank M. Torti. Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis. Sci Transl Med. (2012) 22, 43ra56.
25. Helen Yu, Nazar Mashtalir, Salima Daou, Ian Hammond-Martel, Julie Ross, Guangchao Sui, Gerald W. Hart, Frank J. Rauscher III, Elliot Drobetsky, Eric Milot, Yang Shi and El Bachir Affar. The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and is a Critical Regulator of Gene Expression. Mol. Cell. Biol., (2010) 30(21):5071-5085.
26. Salima Daou, Nazar Mashtalir, Ian H Martel, Helen Pak, Helen Yu, Guangchao Sui, Jodi Vogel, Thomas Kristie, El Bachir Affar. Crosstalk Between O-GlcNAcylation And Proteolytic Cleavage Regulates The Host Cell Factor-1 Maturation Pathway. Proc. Natl. Acad. Sci. USA, (2011) 108(7):2747-2752.
27. Sophia L Maund, Wendy W Barclay, Laura D Hover, Linara S Axanova, Guangchao Sui, Jason D Hipp, James C. Fleet, Andrew Thorburn, and Scott D Cramer. Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells. (2011) Cancer Research, 71(15):5276-5286.
28. Qiang Zhang, Daniel Stovall, Kazushi Inoue and Guangchao Sui*. The oncogenic role of Yin Yang 1. Critical Reviews in Oncogenesis, (2011) 16(3-4):163-197. (Invited review)
29. Weiwei Huang, Philip J. Smaldino, Qiang Zhang, Lance D. Miller, Paul Cao, Kristin Stadelman, Meimei Wan, Banabihari Giri, Ming Lei, Yoshikuni Nagamine, James P. Vaughn, Steven A. Akman and Guangchao Sui*. Yin Yang 1 contains G-quadruplex structures in its promoter and 5’-UTR and its expression is modulated by G4 Resolvase 1. Nucleic Acids Research, (2012) 40(3):1033-1049.
30. Shihua Wang, Jiansheng Wu, Janel Suburu, Zhennan Gu, Jiaozhong Cai, Linara S. Axanova, Scott D. Cramer, Michael J. Thomas, Donna L. Perry, Iris Edwards, Lorelei Mucci, Jennifer Sinnott, Massimo Loda, Guangchao Sui, Isabelle M. Berquin and Yong Q. Chen. Effect of Dietary Polyunsaturated Fatty Acids on Castration-resistant Pten-null Prostate Cancer. Carcinogenesis, (2012) 33(2):404-412.
31. Wennuan Liu, Johan Lindberg, Guangchao Sui, Jun Luo, Tao Li, Carol Xie, Meimei Wan, Seong-Tae Kim, Aubrey Turner, Jishan Sun, Yi Zhu, Zheng Zhang, Scott D Cramer, Robert L. Vessella, S. Lilly Zheng, Henrik Grönberg, William B. Isaacs and Jianfeng Xu. Genome-wide analysis of somatic DNA copy number reveals novel CHD1-associated collaborative alterations of genomic structure in prostate cancer. Oncogene, (2012) 31(35):3939-48.
32. Caroline I. Schnegg, Mitra Kooshki, Fang-Chi Hsu, Guangchao Sui and Mike E. Robbins. PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-кB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway. Free Radical Biology and Medicine, (2012) 52:1734-1743.
33. Donna P. Frazier, Robert D. Kendig, Fumitake Kai, Dejan Maglic, Takayuki, Sugiyama, Rachel L. Morgan, Sarah J. Lagedrost, Guangchao Sui and Kazushi Inoue. Dmp1 physically interacts with p53 and positively regulates p53’s stability, nuclear localization and transcriptional activity. Cancer Research, (2012) 72:1740-1750.
34. Meimei Wan, Weiwei Huang, Timothy E. Kute, Lance Miller, Qiang Zhang, Heather Hatcher, Jingxuan Wang, Daniel Stovall, Gregory B. Russell, Paul Cao, Zhiyong Deng, Wei Wang, Qingyuan Zhang, Ming Lei, Suzy Torti, Steven A. Akman and Guangchao Sui*. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. American Journal of Pathology, (2012) 180(5):2120-2133.
35. Min Wu, Lihong Shi, Adela Cimic, Lina Romero, Guangchao Sui, Cynthia J. Lees, J. Mark Cline, Darren F. Seals, Joseph S. Sirintrapun, Thomas P. McCoy, Jielin Sun, Seong-Tae Kim, Wennuan Liu, Donna M. Peehl, Jianfeng Xu, Scott D. Cramer. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Research, (2012) 72(11):2833-2843.
36. Shuai Tang, Meenu Mishra, Donna P. Frazier, Miranda L. Moore, Kazushi Inoue, Rajendar Deora, Guangchao Sui and Purnima Dubey. Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines. PLoS One, (2012) 7(4): e35570.
37. Daniel Stovall and Guangchao Sui*. The Function of YY1 and its Oncogenic Role in Prostate Cancer. In: Gerhard Hamilton, eds. Advances in Prostate Cancer. InTech. 2012:563-587.
38. Daniel Stovall, Meimei Wan, Qiang Zhang, Purnima Dubey and Guangchao Sui*. DNA Vector-based RNA Interference to Study Gene Function in Cancer. Journal of Visualized Experiments, (2012) (64), pii: 4129.
39. Zhiyong Deng, Guangchao Sui, Paulo Mottin Rosa and Weiling Zhao. Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells. PLoS One, (2012) 7(5):e36739.
40. Wei Wang, David Grier, Jennifer Woo, Martha Ward, Guangchao Sui, Suzy V. Torti, Frank M. Torti, and Michael W. Beaty. Ferritin H is a novel marker of early erythroid precursors and macrophages. Histopathology. (2013) 62(6):931-40.
41. Sinan Zhu, Ryan T. Mott, Elizabeth A. Fry, Pankaj Taneja, George Kulik, Guangchao Sui*, and Kazushi Inoue*. Cooperation between Dmp1-loss and cyclin D1 overexpression in breast cancer. American Journal of Pathology. (2013) 183(4):1339-1350.
42. Daniel B. Stovall, Meimei Wan, Lance D. Miller, Paul Cao, Dejan Maglic, Qiang Zhang, Martha R. Stampfer, Wennuan Liu, Jianfeng Xu and Guangchao Sui*. The Regulation of SOX7 and its Tumor Suppressive Role in Breast Cancer. American Journal of Pathology. (2013) 183(5):1645-1653.
43. Dana Yancey, Kyle C. Nelson, Daniele Baiz, Sazzad Hassan, Anabel Flores, Ashok Pullikuth, Yelena Karpova, Victoria Moore1, Guangchao Sui and George Kulik. BAD Dephosphorylation and Decreased Expression of MCL-1 Induce Rapid Apoptosis in Prostate Cancer Cells. PLoS One. (2013) 8(9):e74561.
44. Daniele Baiz, Sazzad Hassan, Young A Choi, Anabel Flores, Yelena Karpova, Dana Yancey, Ashok Pullikuth, Guangchao Sui, Michel Sadelain, Waldemar Debinski and George Kulik. Combination of the PI3K Inhibitor ZSTK474 with a PSMA-Targeted Immunotoxin Accelerates Apoptosis and Regression of Prostate Cancer. Neoplasia. (2013) 15(10):1720-1183.
45. Elizabeth A. Fry, Pankaj Taneja, Dejan Maglic, Sinan Zhu, Guangchao Sui*, and Kazushi Inoue*. Dmp1α Inhibits HER2/neu-induced Mammary Tumorigenesis. PLoS One. (2013) 8(10):e77870.
46. Guorui Deng and Guangchao Sui*. Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players. Int. J. Mol. Sci. (2013) 14:18319-18349. (Invited review)
47. Wei Wang, Zhiyong Deng, Heather Hatcher, Lance D. Miller, Xiumin Di, Lia Tesfay, Guangchao Sui, Ralph B. D'Agostino Jr., Frank M. Torti, and Suzy V. Torti. IRP2 regulates breast tumor growth. Cancer Research. (2014) 74(2):497-507.
48. Nicholas R. Galloway, Carlos J. Diaz Osterman, Karl Reiber, Jessica M.S. Jutzy, Fengzhi Li, Guangchao Sui, Ubaldo Soto, Nathan R. Wall. Yin Yang 1 regulates the transcriptional repression of surviving. Biochem Biophys Res Commun. (2014) 445(1):208-213.
49. Daniel B. Stovall, Paul Cao and Guangchao Sui*. SOX7: From a developmental regulator to an emerging tumor suppressor. Histol Histopathol. (2014) 29(4):439-445.
50. Dejan Maglic, Daniel B. Stovall, Mark Cline, Elizabeth A. Fry, Ali Mallakin, Pankaj Taneja, David L. Caudell, Mark C. Willingham, Guangchao Sui*, and Kazushi Inoue*. DMP1β, a splice isoform of the tumor suppressor DMP1 locus, induces proliferation and progression of breast cancer. J. Pathol. (2015) 236(1):90-102.
51. Jinming Shi, Aixin Hao, Qiang Zhang, and Guangchao Sui*. The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies. Current Cancer Drug Targets. (2015) 15(2):145-157.
52. Qiang Zhang, Meimei Wan, Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik, and Guangchao Sui*. Yin Yang 1 Promotes mTORC2-mediated AKT Phosphorylation. J. Mol. Cell. Biol. (2016) 8(3):232-243.
53. Jingxuan Wang, Xiao Zhang, Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang and Guangchao Sui*. Fatty Acid Synthase is a Primary Target of MiR-15a and MiR-16-1 in Breast Cancer. Oncotarget. (2016) 7(48):78566-78576.
54. Na Tian, Jialiang Li, Jinming Shi and Guangchao Sui*. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. (2017) Int. J. Mol. Sci. 18(191):1-20.
55. Wenmeng Wang, Dangdang Li and Guangchao Sui*. YY1 Is an Inducer of Cancer Metastasis. Crit. Rev. Oncog. (2017) 22(1-2):1-11.
56. Li Yao*, Heming Wang, Yuanyuan Song and Guangchao Sui*. BioQueue: a novel pipeline framework to accelerate bioinformatics analysis. Bioinformatics. (2017) 33(20):3286-3288.
57. Chen Zhong, Nathan R. Wall, Yuangang Zu and Guangchao Sui*. Therapeutic Application of Natural Medicine Monomers in Cancer Treatment. Curr. Med. Chem. (2017) 24(34):3681-3691.
58. Yumeng Zhang, Daniel B. Stovall, Meimei Wan, Qiang Zhang, Jeff W. Chou, Dangdang Li and Guangchao Sui*. SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function. Int. J. Mol. Sci. (2018) 19(5):pii: E1451.
59. Yingzhou Li, Xiao Zhang, Yang Gao, Jiming Shi and Guangchao Sui*. G-quadruplexes in the BAP1 promoter positively regulate its expression. Exp. Cell. Res. (2018) 369(1):147-15.
60. Jeffrey P Chmielewski, Sarah Bowlby, Frances Wheeler, Lihong Shi, Guangchao Sui, Amanda L. Davis, Timothy Howard, Ralph B. D'Agostino, Lance Miller, S. Joseph Sirintrapun, Scott Cramer and Steven J. Kridel. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol. Cancer. Res. (2018) 16(11):1687-1700.
61. Xiao Zhang, Bo Zhao, Ting Yan, Aixin Hao, Yang Gao, Dangdang Li and Guangchao Sui*. G-Quadruplex Structures at the Promoter of HOXC10 Regulate its Expression. BBA-Gene Regul. Mech., (2018) 1861(11):1018-1028.
62. Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*. Characterization of YY1 OPB Peptide for Its Anticancer Activity, Current Cancer Drug Targets, (2019) 19(6):504-511.
63. Chen Zhong, Shuang Qiu, Jialiang Li, Jingling Shen, Yuangang Zu, Jinming Shi* and Guangchao Sui*. Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma. Phytomedicine, (2019) 59:152921.
64. Kuida Chen, Yao Lu, Ke Shi, Daniel B. Stovall, Dangdang Li and Guangchao Sui*. Functional analysis of YY1 zinc fingers through cysteine mutagenesis. FEBS Letters, (2019) 593(12):1392-1402.
65. Shuting Lu, Liping Liu, Henan Wang, Wancheng Zhao, Zeyu Li, Zheng Qu, Jialu Li, Tiedong Sun, Ting Wang and Guangchao Sui. Synthesis of dual functional gallic-acid-based carbon dots for bioimaging and antitumor therapy. Biomaterials Science, (2019) 7(8):3258-3265.
66. Ting Yan, Bo Zhao, Qiong Wu, Wenmeng Wang, Jinming Shi, Dangdang Li, Daniel B. Stovall and Guangchao Sui*. Characterization of G-quadruplex formation in the ARID1A promoter. Int J Biol Macromol. (2020) 147:750-761.
67. Dangdang Li, Daniel B. Stovall B, Wenmeng Wang and Guangchao Sui*. Advances of Zinc Signaling Studies in Prostate Cancer. Int J Mol Sci. (2020) 21(2):667.
68. Tianyan Liu, Yu Zhang, Yukai Cao, Shan Jiang, Rui Sun, Jiechao Yin, Zhenqiu Gao, Guiping Ren, Zhenzhong Wang, Qingzhong Yu, Guangchao Sui, Xu Sun, Wenying Sun, Wei Xiao and Deshan Li. Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses. Gene Therapy. (2020) (online)
69. Yunxuan Wang, Ting Yan, Jialiang Li, Wenmeng Wang, Qiong Wu, Jinming Shi, Dangdang Li, Daniel B. Stovall, Qingyuan Zhang* and Guangchao Sui*. The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication. Exp Cell Res. (2020) 394(2):112158.
70. Wenmeng Wang, Shuangli Hu, Yaru Gu, Yunxiao Yan, Daniel B. Stovall, Dangdang Li* and Guangchao Sui*. Human MYC G-quadruplex: From discovery to a cancer therapeutic target. Biochim Biophys Acta - Rev Cancer. (2020) 1874(2):188410.
71. Shah Jehan, Chen Zhong, Guangyue Li, Syed Zulqarnain Bakhtiar, Dangdang Li* and Guangchao Sui*. Thymoquinone selectively induces hepatocellular carcinoma cell apoptosis in synergism with clinical therapeutics and dependence of p53 status. Front Pharmacol., (2020) 11:555283.
72. Jialiang Li, Ke Shi, Tianqi Xu, Jingru Hu, Tianxin Li, Guangyue Li, Kuida Chen, Dangdang Li, Kazushi Inoue and Guangchao Sui*. Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α. Int J Oncol., (2020) 58(1):20-32.
73. Aixin Hao, Yu Wang, Xiao Zhang, Jialiang Li, Yingzhou Li, Dangdang Li, George Kulik and Guangchao Sui*. Long Non-coding Antisense RNA HYOU1-AS is Essential to Human Breast Cancer Development Through Competitive Binding hnRNPA1 to Promote HYOU1 Expression. Biochim Biophys Acta - Molecular Cell Research. (2021) 1868(4):118951.
74. Qiong Wu, Bo Zhao, Guangchao Sui* and Jinming Shi*. Phytochemicals block glucose utilization and lipid synthesis to counteract metabolic reprogramming in cancer cells. Applied Sciences. (2021) 11:1259.
75. Albert Gyapong Aduhene, Hongliang Cui, Hongyi Yang, Chengwei Liu, Guangchao Sui* and Changli Liu*. Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties. Front Bioeng Biotech. (2021) 9:646995.
76. Shuang Qiu, Chen Zhong, Bo Zhao, Guangyue Li, Jinhua Wang, Shah Jehan, Jialiang Li, Xudong Zhao, Dangdang Li and Guangchao Sui*. Transcriptome Analysis of Signaling Pathways Targeted by Ellagic Acid in Hepatocellular Carcinoma Cells. Biochim Biophys Acta – General Subjects. (2021) 1865(7):129911.
77. Lanlan Zhang, Ting Yan, Wenmeng Wang, Qiong Wu, Guangyue Li, Dangdang Li, Daniel B Stovall, Yunxuan Wang, Yuhua Li* and Guangchao Sui*. AKT1 is positively regulated by G-quadruplexes in its promoter and 3'-UTR. Biochem Biophys Res Commun. (2021) 561:93-100.
78. Cheng Yi, Guangyue Li, Wenmeng Wang, Yixuan Sun, Yueling Zhang, Chen Zhong, Daniel B. Stovall, Dangdang Li, Jinming Shi* and Guangchao Sui*. Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development. Cancers. (2021) 13(10):2402.
79. Jialiang Li, Guangyue Li, Yige Qi, Yao Lu, Hao Wang, Ke Shi, Dangdang Li, Jinming Shi, Daniel B. Stovall and Guangchao Sui*. SRSF5 Regulates Alternative Splicing of DMTF1 pre-mRNA through Modulating SF1 Binding. RNA Biology. (2021) accepted.
80. Aixin Hao, Yunxuan Wang, Daniel B. Stovall, Yu Wang* and Guangchao Sui*. Emerging Roles of LncRNAs in the EZH2-regulated Oncogenic Network. Int J Biol Sci. (2021) 17(13):3268-3280.
81. Bo Zhao, Jinyan Zhao, Mingshuai Lv, Xiaoyan Li, Jinhua Wang, Zhengrong Yue, Jinming Shi, Guocai Zhang* and Guangchao Sui*. Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches. Int J Biol Macromol. (2021) 188:215-225.
發明專利
- 發明人：Yang Shi and Guangchao Sui. Compositions and Methods of Suppressing Eukaryotic Gene Expression. Publication of US20030180756A1
https://patents.google.com/patent/US20030180756A1/en
2. 發明人：隋廣超
發明專利：一種具有抗癌活性的OPB寡肽及其表達載體和套用
專利號：ZL 2016 1 0018929.6
授權公告號：CN 105601724 B
代表性著作
Yin Yang 1 in Metastasis,Critical Reviews™ in Oncogenesis, 22(1-2), 2017.Begell House Inc. Invited editor:Guangchao Sui.http://dx.doi.org/doi:10.1615/CritRevOncog.v22.i1-2
