陶韋新:男,武漢大學藥學院講師
學習簡歷:
2008.9-2011.7 東亞大學生命資源科學學院(韓國),博士
2003.9-2006.6 華中農業大學農業微生物國家重點實驗室,碩士
1999.9-2003.6 華中農業大學生命科學技術學院,學士
工作簡歷:
2013.12-至今 武漢大學藥學院,講師
2011.11-2013.11 武漢大學基礎醫學博士後流動站,博後
2006.11-2008.5 廣東中大南海海洋生物技術國家工程中心
業績概要:
在活性天然產物生物合成及功能宏基因組學方向有著多年的研究和積累,在國外學術期刊,如“Angew Chem Int Edit”、“Appl Environ Microbiol”等發表多篇科研論文。
研究興趣與方向:
微生物來源活性天然產物的生物合成研究:利用比較基因組學、宏基因組學等研究手段發掘新的天然產物生物合成基因簇;基於分子水平解答天然產物生物合成中一些關鍵問題,進而改進並最佳化相關代謝路徑以實現產物的高產或修飾。
承擔課題與經費:
2014:國家自然科學基金青年基金,23萬,在研
2012:中國博士後科學基金面上資助,5萬,結題
科研成果(至少應有近五年的代表性成果):
1. Tao, W., Zhu, M., Deng, Z., and Sun Y. (2013) Biosynthesis of Tetronate Antibiotics: A Growing Family of Natural Products with Broad Biological Activities. Sci China Chem. 56:1364–1371
2. Kanchanabanca, C*., Tao, W*., Hong, H., Liu, Y., Hahn, F., Samborskyy, M., Deng, Z., Sun, Y., and Leadlay, P. F. (2013) Unusual acetylation-elimination in the formation of tetronate antibiotics. Angew Chem Int Edit. 52:5785-8(*co-first author)
3. Tao, W., Lee, M. H., Wu, J., Kim, N. H., Kim, J. C., Chung, E. S., Hwang, E. C., and Lee, S. W. (2012) Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase. Appl Environ Microbiol. 78:6295-6301
4. Tao, W., Lee, M. H., Yoon, M. Y., Kim, J. C., Malhotra, S., Wu, J., Hwang, E. C., and Lee, S. W. (2011) Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase. J Microbiol Biotechnol. 21:1203–1210
5. Tao, W., Lee, M. H., Wu, J., Kim, N. H., and Lee, S. W. (2011) Isolation and characterization of a family VII esterase derived from alluvial soil metagenomic library. J Microbiol. 49:178-185
6. Lee, M. H., Hong, K. S., Malhotra, S., Park, J. H., Hwang, E. C., Choi, H. K., Kim, Y. S., Tao, W., and Lee, S. W. (2010) A new esterase EstD2 isolated from plant rhizosphere soil metagenome. Appl Microbiol Biotechnol. 88:1125-1134
7. Li, W*., Wu, J*., Tao, W., Zhao, C., Wang, Y., He, X., Chandra, G., Zhou, X., Deng, Z., Chater, K. F., and Tao, M. (2007) A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett. 266:20-28