醫學博士、博士生導師；是新世紀百千萬人才工程國家級人選、上海市（第三期）重點學科帶頭人和上海市優秀學科帶頭人。現任上海市口腔醫學研究所所長、附屬第九人民醫院口腔頜面外科系和口腔頜面-頭頸腫瘤科行政副主任。美國德克薩斯大學 M.D安德森癌症中心胸/頭頸腫瘤科客座教授。兼任中華醫學會口腔生物醫學專業委員會副主任委員，上海市口腔醫學會口腔基礎專業委員會主任委員；是《口腔生物醫學》雜誌副主編。
主攻研究方向為口腔頜面部-頭頸腫瘤分子診斷和靶向治療基礎和臨床研究和口腔顱頜面部遺傳性疾病研究。主持包括國家自然科學基金重點項目、重大研究計畫（培育）項目的國家級課題8項，主持國際合作和上海市重點項目8項。近年發表專業SCI論文40多篇；申請國家和國際專利7項，主編專著和教材4部；獲省、部和市局級科技成果獎8項，其中第1完成人4項。先後榮獲政府特殊津貼、上海市銀蛇獎、明治乳業生命科學優秀獎，上海市醫務職工科技創新“新人獎”和科技創新標兵，上海交通大學醫學院特殊貢獻獎等榮譽稱號。
基本介紹
- 中文名稱：陳萬濤
- 民族：漢
- 畢業院校：上海交通大學（上海第二醫科大學）
- 臨床職稱：研究員
- 專業：口腔頜面外科
- 學歷：研究生
- 教學職稱：教授
- 執業地點：上海交通大學醫學院附屬第九人民醫院
- 科室：口腔頜面-頭頸腫瘤
研究方向,出診信息,教育經歷,工作經歷,科研成果,學術兼職,獲獎情況,主要論文,著作譯作,
研究方向
口腔頜面部-頭頸腫瘤分子診斷和靶向治療基礎和臨床研究，口腔顱頜面部遺傳性疾病診治研究。
出診信息
每周二(全天)
教育經歷
1981.9-1986.7 青島大學醫學院（原青島醫學院）大學本科；
1993.9-1998.6 上海交通大學醫學院（原上海第二醫科大學）碩博連讀；
2007.5-2008.11 美國德州大學MD安德森腫瘤中心 高級訪問學者
工作經歷
1986.8-1993.8山東泰山醫學院附屬醫院口腔科醫師
1998.7-1999.8上海交通大學醫學院附屬第九人民醫院口腔頜面外科主治醫師
1999.8-2003.6上海交通大學醫學院附屬第九人民醫院口腔頜面外科副主任醫師、副教授
1999.10-至今 附屬第九人民醫院口腔頜面外科腫瘤生物學實驗室主任
2001.1-至今 上海交通大學口腔醫學院口腔臨床免疫教研室主任
2004.12-至今 上海市口腔醫學重點實驗室常務副主任、博士生導師
2005.11-至今 上海交通大學醫學院附屬第九人民醫院口腔頜面外科 研究員
2008.8-至今 上海交通大學醫學院附屬第九人民醫院口腔頜面外科系行政副主任
2008.9-至今 上海交通大學醫學院口腔醫學院口腔基礎教研室副主任
2009.11-至今 上海市（第三期）重點學科帶頭人（口腔基礎醫學）上海交通大學醫學院教授
2012.3-至今 上海交通大學醫學院附屬第九人民醫院口腔頜面-頭頸腫瘤科行政副主任
2012.12-至今 上海口腔醫學研究所所長
科研成果
主持包括1項國家自然科學基金重點項目、1項國家自然科學基金重大研究計畫（培育）項目、6項國家自然科學基金面上項目，主持3項國際合作研究項目、2項上海市納米專項、3項上海市重點基礎項目；獲省、部級科技成果獎6項，其中第1完成人3項。專業雜誌發表SCI論文40多篇。主編專著和教材4、副主編1部、參編6部。
學術兼職
中華口腔醫學會口腔生物醫學專業委員會副主任委員，上海市口腔醫學會口腔基礎醫學專業委員會主任委員；還兼任國際口腔頜面外科醫師協會、國際分析細胞學協會、美國腫瘤研究學會(AACR)、美國醫學遺傳學會(ASHG)會員。是《口腔生物醫學》雜誌副主編，Head and Neck Oncology, Chinese Journal Dental Research、《中華口腔醫學雜誌》、《中國口腔頜面外科雜誌》等10本專業雜誌的編委。
獲獎情況
1. 口腔癌基因表達譜和診治靶點基因的基礎和臨床，2012年度(第十一屆)上海醫學科技獎二等獎，陳萬濤（第1完成人）
2.口腔黏膜上皮細胞體外癌變模型的建立及基因組學、蛋白質組學研究，2014教育部高等學校優秀成果自然科學獎二等獎，陳萬濤（第7完成人）
3. 口腔頜面部鱗癌診斷和治療靶點的基礎與臨床套用, 2014教育部高等學校優秀成果自然科學獎二等獎, 陳萬濤(第1完成人)
4. 口腔頜面部癌靶向生物治療和化療的基礎及臨床研究，2006年上海市科學技術進步三等獎,陳萬濤（第1完成人）.
5. 高危型人乳頭狀瘤病毒與口腔黏膜癌變的相關性研究, 2005年教育部提名國家科學技術獎(自然科學)二等獎,陳萬濤(第7完成人).
6. 口腔鱗癌順鉑耐藥相關基因表達譜鑑定及靶向CCND1/cLAP1/XIAP的增敏效果, 2014中華口腔醫學會科技三等獎, 陳萬濤(第2完成人)
主要論文
1. Xiao M, Wang X, Chen W*. The clinical translational potential of p53-relatedalterations as cancer biomarkers. Histol Histopathol. 2015, 12:11637.
2. Zhang J,Qin X,Sun Q,Guo H, Wu X, Xie F,Xu Q, Yan M,Liu J,Han Z and Chen W*. Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. Oncogene. 2015, 34(25):3283- 3295.
3. Cui Z, Song L, Hou Z, Han Y, Hu Y, Wu Y, Chen W, Mao L*. PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma. Oncol Rep. 2015, 33(5):2454-2460.
4. Lv Z, Wu X, Cao W, Shen Z, Wang L, Xie F, Zhang J, Ji T, Yan M, Chen W*. Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2014,18:33:100. doi: 10.1186/s13046-014-0100-y
5.Pan J, Wang T, Wang L, Chen W*, Song M*. Cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells via the Rho signaling pathway. PLOS ONE. 2014, 11;9(3):e91580. doi: 10.1371/journal.pone.0091580
6. Yu J, Deng H, Xie F, Chen W, Zhu B*, Xu Q*. The potential of pH-responsive PEG-hyperbranched polyacylhydrazone micelles for cancer therapy. Biomaterials. 2014,35(9):3132-3144
7. Yu J, Xie F, Bao X, Chen W*, Xu Q*. miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer. Mol Cancer. 2014,24;13:121
8. Wang L, Pan J, Wang T, Song M*, Chen W*. Pathological cyclic strain-induced apoptosis in human pathological cyclic strain-induced apoptosis in human caspase-3/PARP pathway. PLOS ONE. 2013, 8(10): e75973. doi:10.1371/journal.pone.0075973.
9. Deng R, Wang X, Lv Y, Yan M, Hanada S, Xu Q, Zhang J, Han Z, Chen W*, Zhang P*. A new gamboge derivative Compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma. J Cell Mol Med. 2013, 17(11):1422-1433.
10. Wu X, Cao W, Wang X, Zhang J, Lv J, Qin X, Wu Y, Chen W*. TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer. Mol Cancer. 2013, 12(1):151. doi: 10.1186/1476-4598-12-151
11. Song X, Xia R, Li J, Long Z, Ren H, Chen W, Mao L*. Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res, 2013, 1;20(3):701-10. doi: 10.1158/1078-0432.CCR-13-1050
12. Liu J, Wang X, Liu P, Deng R, Lei M, Chen W*, Hu L*. 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Bioorg Med Chem. 2013,15;21(14):4279-4287.
13. Yan M, Yang X, Wang L, David C, Ye D, Chen W*, Zhang P*. Plasma membrane proteomics of tumor spheres identify CD166 as a novel marker for cancer stem-like cells in head and neck squamous cell carcinoma. Mol Cell Proteomics. 2013,12(11):3271-3284.
14. Cui Z, Cao W, Li J, Song X, Mao L*, Chen W*. TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes. PLOS ONE. 2013,8(5):e63887.
15. Zuo J, Huang X, Zhong X, Zhu B, Sun Q, Jin C, Quan H, Tang Z *, Chen W *. A comparative study of the influence of three pure titanium plates with different micro- and nanotopographic surfaces on preosteoblast behaviors. J Biomed Mater Res A. 2013 ,101(11):3278-3284
16. Xu Q, Sun Q, Zhang J, Yu J, Chen W*, Zhang Z*. Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis. 2013,34(3):539–549.
17. Sun Q, Zhang J, Cao W, Wang X, Xu Q, Yang M, Wu X, Chen W*. Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin. Int J Biochem Cell Biol. 2013,45:513-520.
18. Wang X, Deng R, Lv Y, Xu Q, Yang M, Ye D, Chen W*. Gambogic acid as a non-competitive inhibitor of ATP-Binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-Binding cassette transporter B1 protein degradation. Basic Clin Pharmacol Toxicol. 2013,112(1):25-33
19. Wang X, Chen W*. Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation. angiogenesis and metastasis. Anticancer Agents Med Chem. 2012,12(8):994-1000
20. Feng Z, Xu Q, Chen W*. Epigenetic and genetic alterations-based molecular classification of head and neck cancer. Expert Rev Mol Diagn. 2012,12(3):279–290.
21. Zhang J, Sun Q, Zhang J, Ge SF Han Z, Chen W*. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene. 2013,32(1):61-69.
22. Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Li M, Chen W*. Up-regulation of enhancer of zeste homolog 2 ss associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma. Cancer. 2012,118(11):2858-2871.
23. Feng Z, Guo W, Zhang C, Xu Q, Zhang P, Sun J, Zhu H, Wang Z, Li J, Wang L, Wang B, Ren G, Ji T, Tu W, Yang X, Qiu W, Mao L, Zhang Z*, Chen W*. CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma. PLOS ONE. 2011,6(10):e26399.
24. Wang X, Lv Y, Shen G, Chen W*. One germline mutation of PTCH gene in a Chinese family with non-syndromic keratocystic odontogenic tumours. Int J Oral Maxillofac Surg. 2011 ,40(8):829-833.
25. Cao W, Younis R, Li J, Chen H, Xia R, Li M, Chen W*, Ren H*. EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia. Cancer Prev Res. 2011,4(11):1816-1824.
26. Song M, Xiao C, Wang T, Pei Q, Wang S, Xu L, Chen W*. Study of the differentially expressed genes in pleomorphic adenoma using cDNA microarrays. Pathol Oncol Res. 2011,17(3):765-769.
27. Zhang T, Chen M, Lu Y, Xing Q*, Chen W*. A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese family with nevoid basal cell carcinoma syndrome. Biochem Biophys Res Commun. 2011,409(2):166-170
28. Zhang J, Cao W, Xu Q, Chen W*. The expression of EMP1 is downregulated in oral squamous cell carcinoma and possibly associated with tumour metastasis. J Clin Pathol. 2011,64(1):25-29.
29. Yan M, Wang L, Zuo H, Zhang Z, Chen W, Mao L and Zhang P*. HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. Oral Oncol. 2011, 4(6)7:504-509.
30. Xu Q, Liu X, Chen W, Zhang Z*. Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference. J Transl Med. 2010,8:136. doi: 10.1186/1479-5876-8-136
31. Cao W, Zhang Z, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han Z, Chen W*. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelial cell carcinoma. Mol Cancer, 2010, 9:296 doi:10.1186/1476-4598-9-296.
32. Zhang J, Guo H*, Qian G, Ge S, Ji H, Hu X, Chen W. MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network. Mol Cancer, 2010, 9:211.
33. Yan M, Xu Q, Zhang P, Zhou X, Zhang Z, Chen W*. Correlation of NF-kappaB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma. BMC Cancer, 2010, 10:437.
34. Xu Q, Liu X, Cai Y, Yu Y*, Chen W*. RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumour Biol. 2010,31(3):217-224
35. Lu Y，Zhou H, Chen W, Zhang Y，Hamburger A*. The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. Breast Cancer Res Treat. 2011,126(1):27-36
36. He D, Xu Q, Zhang P, Yan M, Zhou X, Zhang Z，Chen W*. The NF-kappa B inhibitor celastrol could enhance the anti-cancer effect of Gambogic acid on oral squamous cell carcinoma. BMC Cancer. 2009, 9:343doi:10.1186/1471-2407-9-343.
37. Xu Q, Chen W, Wang Z, Zheng J, Zhang Z*. Mice transgenic with SV40-late-promoter-driven polyomavirus middle T oncogene exclusively develop hemangiomas. Transgenic Res. 2009, 18(3):399-406.
38. Zhang P, Zhang Y, Mao L, Zhang Z, Chen W*. Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes. Cancer Lett. 2009, 277(2):227-234.
39. Zhou X, Zhang Z, Yang X, Chen W*, Zhang P*. Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity. Int J Cancer. 2009;124(2):483-489.
40. Xu Q, Zhang Z, Zhang P, Chen W*. Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma. BMC Cancer. 2008,8;159.doi:10.1186/14712407-8-159.
41. Lv Y, Zhu H,Ye W, Zhang M, He D, Chen W*. A new germline mutation of PTCH gene in a Chinese family with nevoid basal cell carcinoma syndrome. Chin Med J. 2008,121(2):118-121.
42. Yu Y, Chen W, Zhang Y, Hamburger A, Pan H, Zhang Z*. Suppression of salivary adenoid cystic carcinoma growth and metastasis by ErbB3 Binding protein Ebp1 transfer. Int J Cancer. 2007,120(9):1909-1913.
43. Jiang C, Ye D, Qiu W, Zhang X, Zhang Z, He D, Zhang Z, Chen W*. Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO. BMC Cancer. 2007,7:40.
44. Zhang B*, Guan C, Chen W*, Zhang P, Yan M, Shi J, Qin C, Yang Q. A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-κB activation. Chin Med J. 2007,120(20):1830-1835.（*通訊作者）
著作譯作
1.主編：陳萬濤. 《口腔臨床免疫學實驗技術》;上海交通大學出版社，2009年，29萬字
2.主編：陳萬濤. 《口腔臨床免疫學》；上海交通大學出版社，2010年，56萬字
10.Chief in Editor: Shree Ram Singh. Stem Cell, Regenerative Medicine and Cancer;Nova Science Publishers, Inc.2010,(參編6萬字：陳萬濤)
3.主編：王松靈.《口腔分子生物學與口腔實驗動物模型》;人民衛生出版社，2011年，（參編11萬字：陳萬濤）
4.Chief in Editor： Wantao Chen. Fundamentals of Oral Biomedicine; SCIENCE PRESS, 2014
5.主編：陳萬濤. 《口腔頜面頭頸部腫瘤生物學》;上海交通大學出版社，2015年
