陳興珍，湖北工業大學教授/博導，湖北省“百人計畫”、武漢光谷“3551”創新人才獲得者。加拿大阿爾伯塔(Alberta)大學醫學院終身教授/博導。國際膜蛋白疾病及分子醫學研究領域權威專家，國際膜蛋白與健康和疾病（CSMB）委員會副主席。國際上報導 TRPP3 蛋白具有離子通道功能的第一人。1978 考入浙江大學計算機系，1991-1997 加拿大蒙特婁(Montréal)大學物理學博士，1997-2000 美國哈佛大學醫學院博士後, 研究助理教授。加拿大國立衛生研究院(CIHR) 、阿爾伯塔醫學研究基金會(AHFMR)、加拿大腎臟病基金會(KFC) 、美國國立衛生院(NIH)、美國國防部醫學研究計畫(CDMRP)基金評審專家。以第一作者或通訊作者在 Nature, Nature Protocols, J Clin Inv, PNAS, Hum Mol Genet, FASEB J, JBC等著名雜誌發表論文70餘篇。總引用次數超過4,200 次，單篇引用超過500次（另一篇Nature 1999 文章）。近年來獲得科研項目30餘項，科研經費累計超過500萬加元。擔任Nature, PNAS, Hum Mol Genet, BBA, JASN, Biophys J, JBC等著名雜誌審稿人。
科研成果：
（1）科研項目：
1. 武漢光谷3551人才計畫：急性腎臟損傷早期診斷系列免疫檢測試劑的研發，主持，100萬，2014099，2014-2016。
2. 湖北工業大學科研啟動經費：FUBP1對PKD2蛋白表達的調控機制及ADPKD治療性抑制短肽的篩選研究，主持，100萬，337296，2015-2019。
（2）代表性論文（“*”為通訊作者）：
1. Chen, X.-Z., Vassilev, P.M., Basora, N., Peng, J.-B., Nomura, H., Segal, Y., Brown, E.M., Reeders, S.T., Hediger, M.A., and Zhou, J. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401, 383-386, 1999.
2. Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U.V., Chen, X.-Z., Wang, Y.-X., Brubaker, R.F., and Hediger, M.A. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature399, 70‑75, 1999.
3. Wu, Y., Li, Q., and Chen, X.-Z.* Detecting protein-protein interactions by Far Western blotting. Nature Protocols. 2, 3278-3284, 2008.
4. Wu, Y., Dai, X.-Q., Li, Q., Chen, C.X., Mai, W., Hussain, Z., Long, W., Montalbetti, N., Li, G., Glynne, R., Wang, S., Cantiello, H.F., Wu, G., and Chen, X.-Z.* Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. Hum. Mol. Genet. 15, 3280-3292, 2006.
5. Liang, G., Yang, J., Wang, Z., Li, Q., Tang, Y., and Chen, X.-Z.* Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α. Hum. Mol. Genet. 17, 3254-3262, 2009.
6. Liang, G., Li, Q., Tang, Y., Kokame, K., Kikuchi, T., Wu, G., and Chen, X.-Z.* Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17, 1109-1119, 2009.
（3）近年論文（“*”為通訊作者）：
1. Zheng, W., Hussein, S., Yang, J., Huang, J., Zhang, F., Hernandez-Anzaldo, S., Fernandez-Patron, C., Cao, Y., Zeng, H., Tang, J., andChen, X.-Z.* A novel PKD2L1 C-terminal domain critical for trimerization and channel function. Scientific Rep. 5, 9460, 2015. DOI: 10.1038/srep09460.
2. Wang, Q., Cantero, M.R., Zheng, W., Wang, Z., Yang, J., Hussein, S., Cantiello, H.F., Tang, J., and Chen, X.-Z.* Filamin-A increases the stability and plasma membrane expression of polycystin-2. PLOS One. 10, e0123018, 2015. DOI: 10.1371/journal.pone.0123018.
3. Long, W., Panwar, P., Witkowska, K., Wong, K., O'Neill, D., Chen, X.-Z., Lemieux, M.J.,and Cheeseman, C.I. Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport. J. Biol. Chem. In press, 2015.
4. Hu, Q., Wu, Y., Tang, J., Zheng, W., Wang, Q., Jing, X., Li, Q., Duszyk, M., Wang, S., Tu. J.-C. , and Chen, X.-Z.* Expression of polycystins and fibrocystin on primary cilia of lung cells. Biochem. Cell Biol. 92, 547-54, 2014.
5. Wu, S.Y., Yu, M.X., Li, X.G., Xu, S.F., Shen, J., Sun, Z., Zhou, X., Chen, X.-Z., and Tu, J.C. Identification of Homer1 as a potential prognostic marker for intrahepatic cholangiocarcinoma. Asian Pac J Cancer Prev. 15, 3299-304, 2014.
6. Yang, J., Zheng, W., Wang, Q., Lara, C., Hussein, S., and Chen, X.-Z.* Translational up-regulation of polycystic kidney disease protein PKD2 by endoplasmic reticulum stress. FASEB J. 27, 4998-5009, 2013.
7. Wang, Q., Dai, X.-Q., Li, Q., Tuli, J., Liang, G., Li, S., and Chen, X.-Z.* Filamin interacts with ENaC and inhibits its channel function. J. Biol. Chem. 288, 264-273, 2013.
8. Wang, Q., Dai, X.-Q., Wang, Z., Li, Q., Cantero, M.R., Li, S., Shen, J., Tu, J.-C., Cantiello, H.F. and Chen, X.-Z.* Structural interaction and functional regulation of polycystin-2 by filamin. PLoS ONE. 7, e40448, 2012.
9. Yang, J., Wang, Q., Zheng, W., Tuli, J., Li, Q., Wu, Y., Hussein, S., Dai, X.-Q., Shafiei, S., Li, X.-G., Shen, P.Y., Tu, J.-C., and Chen, X.-Z.* Receptor for activated C kinase 1 (RACK1) inhibits the function of TRP-type channel Pkd2L1 through physical interaction. J. Biol. Chem. 287, 6551-6561, 2012.
10. Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., and Yang, J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc. Natl. Acad. Sci.106, 11558-11563, 2009.
11. Raychowdhury, M., Ramos, A., Zhang, P., McLaughin, M., Dai, X.-Q., Chen, X.-Z., Montalbetti, N., Cantero, M.D.R., Ausiello, D., and Cantiello, H.F. Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. Am. J. Physiol. Renal Physiol. 296, F87-F97, 2009.
12. Liang, G., Yang, J., Wang, Z., Li, Q., Tang, Y., and Chen, X.-Z.* Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2α. Hum. Mol. Genet. 17, 3254-3262, 2008.
13. Liang, G., Li, Q., Tang, Y., Kokame, K., Kikuchi, T., Wu, G., andChen, X.-Z.* Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum. Mol. Genet. 17, 1109-1119, 2008.
14. Chen, X.-Z.*, Li, Q., Wu, Y., Liang, G., Lara, C.J., and Cantiello, H.F. Interaction of TRPP2 with the cell
cytoskeleton. FEBS J. 275, 4675-4683, 2008.
15. Kim, I., Li, C., Liang, D., Chen, X.-Z., Coffy, R.J., Ma, J., Zhao, P., and Wu, G. Polycystin-2 expression is
regulated by a PC2-binding domain in the intracellular portion of fibrocystin. J. Biol. Chem. 283, 31559-31566, 2008.
專利：
1. Li, Q. and Chen, X.-Z. Mammalian cell expression vectors and utilization. Publication no.
US-2011-0097798-A1. Publication date: April 28, 2011.
論著：
1. Cantiello, H.F., Montalbetti, N., Li, Q., andChen, X.-Z.(2007) The cytoskeletal connection to ion channels as a potential mechanosensory mechanism: lessons from polycystin-2 (TRPP2). In Current Topics in Membranes. Vol 59, Chapter 10, 233-296. Elsevier Inc.
2. Chen, X.-Z. and Li, Q. (2006) Improved tandem affinity purification of polycystin channels from MDCK cells. Biochemistry and Cell Biology, special edition on "Membrane proteins in health and disease".
3. Liu, Y., Li, Q., Zhang, Y.-Y., and Chen, X.-Z. (2002) Roles of the N-terminus of polycystin-L in the basal channel activity and calcium-induced channel activation. Biochemistry and Cell Biology, special edition on "Membrane proteins in health and disease".
4. Smith, K.M., Loewen, S.K., Slugoski, M.D., Ng, A.M.L., Yao, S.Y.M., Chen, X.-Z., Cass, C.E., Baldwin, S., Karpinski, E., and Young, J.D. (2002) Electrophysiological and chimeric studies of the human Na-dependent nucleoside transporters hCNT1 and hCNT3. Biochemistry and Cell Biology, special edition on "Membrane proteins in health and disease".
