陳聯國，男，研究員，博士生導師，環境污染與生態風險學科組組長。
基本介紹
- 中文名：陳聯國
- 畢業院校：香港科技大學
- 職稱：研究員
人物經歷,簡歷介紹,研究方向,社會任職,獲獎及榮譽,代表論著,
人物經歷
2008年，獲中國海洋大學水產養殖專業學士學位；
2012年，獲中國科學院水生生物研究所環境毒理專業碩士學位；
2016年，獲香港科技大學海洋環境科學專業哲學博士學位；
2016年9月至2018年8月，在香港城市大學海洋污染國家重點實驗室從事博士後階段研究；
2018年9月，通過中國科學院人才計畫引進水生所工作。
簡歷介紹
主要研究方向為水生態毒理學，闡明典型或新型持久性有機污染物的環境行為、毒性效應、作用機理及控制技術。以第一作者或通訊作者在環境科學或毒理學領域的國際主流刊物發表SCI論文47篇（影響因子＞3），其中Environmental Science & Technology發表10篇（影響因子：7.864），Environmental Science & Technology Letters發表1篇（影響因子：7.678）。研究成果受到美國 “Environmental Health News”、新華社、中科院之聲等科學媒體的關注和報導，並被挪威環保局採用、作為污染物風險評估的主要依據。現主持國家自然科學基金面上項目、青年基金、香港國際合作項目、中科院知識創新工程青年人才專項等研究任務。
研究方向
（1）揭示污染物對內分泌系統、繁殖功能、神經系統、微生物群落、及營養代謝等方面的毒性效應；
（2）開發新型毒理學研究技術，確定污染物的結合靶點和分子起始事件，構建有害結局通路；
（3）基於益生菌與益生元，開發污染物毒性危害控制措施。
社會任職
中國毒理學會分析毒理專業委員會青年委員；
Toxics期刊Guest Editor；
國家自然科學基金函評專家
獲獎及榮譽
2020年，國家青年海外人才計畫（中組部）
2020年，武漢市黃鶴英才
2020年，武漢市青年科技朝陽計畫
2019年，湖北省海外人才引進計畫
2019年，湖北省青年科技晨光計畫
2019年，教育部自然科學二等獎
2018年，中科院海外人才引進計畫（擇優支持）
2013年，香港科技大學理學院Research Excellence Award
代表論著
#共同第一作者；*通訊作者
Environmental Science & Technology (IF: 7.864):
1. Hu, C., Liu, M., Wan, T., Tang, L., Sun, B., Zhou, B., Lam, J.C.W., Lam, P.K.S., Chen, L.* Disturbances in microbial and metabolic communication across the gut-liver axis induced by a dioxin-like pollutant: An integrated metagenomics and metabolomics analysis. Environmental Science & Technology 2020, 55, 529？537.
2. Chen, L.,* Lam, J.C.W., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B.* Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental Science & Technology 2020, 54, 7494？7503.
3. Chen, L.,* Tsui, M.M.P., Hu, C., Wan, T., Au, D.W.T., Lam, J.C.W., Lam, P.K.S., Zhou, B. Parental exposure to perfluorobutanesulfonate impairs offspring development through inheritance of paternal methylome. Environmental Science & Technology 2019, 53, 12018？12025.
4. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Lam, P.K.S., Zhou, B. Perfluorobutanesulfonate exposure skews sex ratio in fish and transgenerationally impairs reproduction. Environmental Science & Technology 2019, 53, 8389？8397.
5. Chen, L., Hu, C., Tsui, M.M.P., Wan, T., Peterson, D.R., Shi, Q., Lam, P.K.S., Au, D.W.T., Lam, J.C.W.,* Zhou, B.* Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology 2018, 52, 4432–4439.
6. Chen, L., Zhang, W.,# Hua, J., Hu, C., Lai, N.L.S., Qian, P.Y., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysregulation of intestinal health by environmental pollutants: Involvement of the estrogen receptor and aryl hydrocarbon receptor. Environmental Science & Technology 2018, 52, 2323–2330.
7. Chen, L., Au, D.W.T., Hu, C., Peterson, D.R., Zhou, B.,* Qian, P.Y.* Identification of molecular targets for 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in teleosts: New insight into mechanism of toxicity. Environmental Science & Technology 2017, 51, 1840–1847.
8. Chen, L., Zhang, W., Ye, R., Hu, C., Wang, Q., Seemann, F., Au, D.W.T., Zhou, B., Giesy, J.P., Qian, P.Y.* Chronic exposure of marine medaka (Oryzias melastigma) to 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) reveals its mechanism of action in endocrine disruption via the hypothalamus-pituitary-gonadal-liver (HPGL) axis. Environmental Science & Technology 2016, 50, 4492–4501.
9. Chen, L., Sun, J.,# Zhang, H., Au, D.W.T., Lam, P.K.S., Zhang, W., Bajic, V.B., Qiu, J.W., Qian, P.Y.* Hepatic proteomic responses in marine medaka (Oryzias melastigma) chronically exposed to antifouling compound butenolide [5-octylfuran-2(5H)-one] or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Environmental Science & Technology 2015, 49, 1851–1859.
10. Chen, L., Yu, K.,# Huang, C., Yu, L., Zhu, B., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 2012, 46, 9727–9734.
Environmental Science & Technology Letters (IF: 7.678):
11. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Wang, Q., Giesy, J.P., Lam, P.K.S. Perfluorobutanesulfonate exposure causes durable and transgenerational dysbiosis of gut microbiota in marine medaka. Environmental Science & Technology Letters 2018, 5, 731–738.
Environmental Pollution (IF: 6.792):
12. Tang, L., Liu, M., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos. Environmental Pollution 2020, 266, 115284.
13. Liu, M., Song, S., Hu, C., Tang, L., Lam, J.C.W., Lam, P.K.S., Chen, L.* Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish. Environmental Pollution 2020, 265, 114832.
14. Sun, Y.,# Tang, L.,# Liu, Y., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish. Environmental Pollution 2019, 255, 113357.
15. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Wang, Q., Hu, C., Wai, O.W.H., Zhou, B., Lam, P.K.S. Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments. Environmental Pollution 2019, 245, 218–225.
16. Chen, L., Hu, C., Lai, N.L.S., Zhang, W., Hua, J., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 2018, 240, 17–26.
17. Chen, L., Guo, Y., Hu, C., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution 2018, 234, 307–317.
18. Chen, L., Wang, X., Zhang, X., Lam, P.K.S., Guo, Y., Lam, J.C.W.,* Zhou, B.* Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 2017, 230, 96–106.
19. Chen, L., Zhu, B., Guo, Y., Xu, T., Lee, J.-S., Qian, P.Y., Zhou, B.* High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental Pollution 2016, 214, 324–333.
Science of the Total Environment (IF: 6.551):
20. Hu, C., Liu, M.,# Tang, L., Sun, B., Huang, Z., Chen, L.* Probiotic Lactobacillus rhamnosus modulates the impacts of perfluorobutanesulfonate on oocyte developmental rhythm of zebrafish. Science of the Total Environment 2021, 776, 145975.
21. Guo, Y., Chen, L.,# Wu, J., Hua, J., Yang, L., Wang, Q., Zhang, W., Lee, J.S., Zhou, B.* Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring. Science of the Total Environment 2019, 650, 557–565.
22. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S. Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors. Science of the Total Environment 2019, 660, 136–144.
Chemosphere (IF: 5.778):
23. Hu, C., Tang, L., Liu, M., Lam, P.K.S., Lam, J.C.W.,* Chen, L.* Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology. Chemosphere 2020, 258, 127409.
24. Tang, L., Song, S., Hu, C., Liu, M., Lam, P.K.S., Zhou, B., Lam, J.C.W., Chen, L.* Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish. Chemosphere 2020, 256, 127169.
25. Zhu, B.,* He, W., Yang, F., Chen, L.* High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo. Chemosphere 2020, 244, 125468.
26. Chen, L.,* Hu, C., Guo, Y., Shi, Q., Zhou, B. TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure. Chemosphere 2019, 217, 732–741.
27. Chen, L., Xu, Y., Wang, W., Qian, P.Y.* Degradation kinetics of a potent antifouling agent, butenolide, under various environmental conditions. Chemosphere 2015, 119, 1075–1083.
Ecotoxicology and Environmental Safety (IF: 4.872):
28. Liu, M., Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish. Ecotoxicology and Environmental Safety 2021, 214, 112107.
29. Shi, Q., Tsui, M.M.P., Hu, C., Lam, J.C.W., Zhou, B., Chen, L.* Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae. Ecotoxicology and Environmental Safety 2019, 179, 119–126.
30. Tsui, M.M.P., Chen, L.,# He, T., Wang, Q., Hu, C., Lam, J.C.W., Lam, P.K.S.* Organic ultraviolet (UV) filters in the South China sea coastal region: Environmental occurrence, toxicological effects and risk assessment. Ecotoxicology and Environmental Safety 2019, 181, 26–33.
Aquatic Toxicology (IF: 4.344):
31. Chen, L.* Visual system: an understudied target of aquatic toxicology. Aquatic Toxicology 2020, 225, 105542.
32. Tang, L., Liu, M., Song, S., Hu, C., Lam, P.K.S., Lam, J.C.W., Chen, L.* Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos. Aquatic Toxicology 2020, 222, 105466.
33. Chen, L., Tsui, M.M.P., Shi, Q., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S.,* Lam, J.C.W.* Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure. Aquatic Toxicology 2018, 201, 1–10.
34. Chen, L., Au, D.W.T., Hu, C., Zhang, W., Zhou, B., Cai, L., Giesy, J.P., Qian, P.Y.* Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3′-diindolylmethane (DIM). Aquatic Toxicology 2017, 183, 135–143.
35. Chen, L., Ye, R., Xu, Y., Gao, Z., Au, D.W.T., Qian, P.Y.* Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquatic Toxicology 2014, 149, 116–125.
36. Chen, L., Zhang, H.,# Sun, J., Wong, Y.H., Han, Z., Au, D.W.T., Bajic, V.B., Qian, P.Y.* Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Aquatic Toxicology 2014, 157, 47–56.
37. Chen, L., Hu, C., Huang, C., Wang, Q., Wang, X., Yang, L., Zhou, B.* Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 2012, 120–121, 11–18.
Journal of Environmental Sciences (IF: 4.302):
38. Liu, M., Sun, Y.,# Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Fingerprinting fecal DNA and mRNA as a non-invasive strategy to assess the impact of polychlorinated biphenyl 126 exposure on zebrafish. Journal of Environmental Sciences 2021, 106, 15–25.
39. Chen, L.,* Lam, J.C.W. SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern. Journal of Environmental Sciences 2017, 61, 68–79.
Chemical Research in Toxicology (IF: 3.184):
40. Tang, L., Song, S., Hu, C., Lam, J.C.W., Liu, M., Zhou, B., Lam, P.K.S., Chen, L.* Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish. Chemical Research in Toxicology 2020, 33, 1605–1608.
41. Chen, L., Ye, R., Zhang, W., Hu, C., Zhou, B., Peterson, D.R., Au, D.W.T., Lam, P.K.S., Qian, P.Y.* Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (HPGL) axis in marine medaka (Oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3'-diindolylmethane (DIM). Chemical Research in Toxicology 2016, 29, 1020–1028.
Marine Pollution Bulletin (IF: 4.049):
42. Chen, L., Lam, J.C.W., Zhang, X., Pan, K., Guo, C., Lam, P.K.S, Wang, W., Liu, H., Qian, P.Y.* Relationship between metal and polybrominated diphenyl ether (PBDE) body burden and health risks in the barnacle Balanus amphitrite. Marine Pollution Bulletin 2015, 100, 383–392.
Environmental Toxicology and Chemistry (IF: 3.152):
43. Chen, L., Huang, C., Hu, C., Yu, K., Yang, L., Zhou, B.* Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology and Chemistry 2012, 31, 2338–2344.
44. Chen, L., Huang, Y., Huang, C., Hu, B., Hu, C., Zhou, B.* Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environmental Toxicology and Chemistry 2013, 32, 1370–1375.
Progress in Organic Coatings (IF: 4.469):
45. Chen, L., Xia, C., Qian, P.Y.* Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests. Progress in Organic Coatings 2017, 109, 22–29.
Marine Drugs (IF: 4.073):
46. Chen, L., Qian, P.Y.* Review on molecular mechanisms of antifouling compounds: An update since 2012. Marine Drugs 2017, 15, 264.
Environmental Toxicology and Pharmacology (IF: 3.292):
47. Xu, T., Chen, L.,* Hu, C., Zhou, B. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environmental Toxicology and Pharmacology 2013, 35, 13–20.
