陳纘光

陳纘光，男，1961年生，博士。中山大學藥學院教授，藥物分析專業和生物醫學工程專業博士生導師，分析儀器研究所所長。廣東省政協常委。兼任廣東省科技諮詢專家、廣東省重大行政決策諮詢論證專家、新藥評審專家，《分析測試學報》編委等。

科學研究領域包括分析儀器與醫學儀器、藥物分析、藥物篩選、生物感測器、臨床化學、日用化工等。帶領團隊主要從事儀器研製、藥物與體內代謝物分析，基於微流控晶片技術在斑馬魚、線蟲、細胞和酶水平的藥物篩選與評價，保健品、消毒藥械等研究。

基本介紹

• 中文名：陳纘光
• 國籍：中國
• 民族：漢族
• 職業：教師
• 畢業院校：中山大學
• 學位/學歷：博士
• 職務：中山大學分析儀器研究所所長
• 職稱：教授

研究方向

分析儀器與醫學儀器、藥物分析、藥物篩選、生物感測器、臨床化學、消毒藥械和保健品等。

人物經歷

教育經歷

1978.3～1982.1 中山大學化學系分析化學專業，理學學士
1996.9～1998.6 中山大學法律系經濟法專業，在職碩士班
1997.9～2000.6 中山大學化學院分析化學專業，理學博士

工作經歷

1982.2～1986.1 北京農業大學，助教
1986.1～1987.1 廣東進出口商品檢驗局，助理工程師
1987.1～2004.6 中山醫科大學(中山大學)基礎醫學院，助教、講師、副教授
（期間，1992.2～2000 中山醫科大學三環專利事務所代理人[兼職]）
2004.6～現在 中山大學藥學院，副教授、教授、博士生導師
（期間，2003.9～2006.1 中山大學法醫鑑定中心鑑定人[兼職]，
2004.7～2004.12 廣東省陽春市人民政府市長助理[掛職])

教授課程

講授藥學本科生“分析化學”(課程負責人)和“藥物分析學”，醫學本科生“基礎化學”，研究生“毛細管電泳和微流控晶片”和“藥物分析新進展”等課程。發表教學論文多篇，參編《基礎分析化學》(副主編)、《基礎儀器分析》(副主編)等高校教材3本，主持學校教學改革項目2項。

社會兼職

(1) 廣東省政協常委

(2) 《分析測試學報》編委

學術成果

科研項目

作為負責人主持國家級項目6項(重點項目1項)、省部級項目3項(重點1項)，主要涉及微流控晶片和生物感測器等領域。承擔企業委託項目多項，主要涉及消毒藥械和保健品等。作為主要成員參與各種項目多項。

代表性論文

(1) Xiangyan Wang, Duanping Sun, Yanli Tong*, Yongsheng Zhong, Zuanguang Chen*, A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support, Microchim Acta, DOI 10.1007/s00604-017-2160-0 (2017)

(2) Zhixian Liang, Haiyun Zhai∗, Zuanguang Chen, Shiqiao Wang, Haihang Wang, Shumei Wang, A sensitive electrochemical sensor for flavonoids based on a multi-walled carbon paste electrode modified by cetyltrimethylammonium bromide-carboxylic multi-walled carbon nanotubes, Sensors and Actuators B, 244, 897–906 (2017)

(3) Wensi Jian, Chunping Wang, Zuanguang Chen*, Yanyan Yu, Duanping Sun, Liping Han and Lijuan Shi, Nonenzymatic Electrochemical Immunosensor Using Ferroferric Oxide–Manganese Dioxide–Reduced Graphene Oxide Nanocomposite as Label for α-Fetoprotein Detection, NANO, 11(10) 1650116 (12 pages) (2016)

(4) HE Qi-Di, HUANG Dan-Ping, HUANG Guan, CHEN Zuan-Guang*, Advance in Research of Microfluidic Polymerase Chain Reaction Chip, Chinese Journal of Analytical Chemistry, 44(4): 542–550 (2016)

(5) Fan Yang*, Chuan Gao, Ping Wang, Guo-Jun Zhang* and Zuanguang Chen, Fish-on-a-chip: microfluidics for zebrafish research, Lab on a Chip, 16, 1106–1125 (2016)

(6) Duanping Sun, Jing Lu, Yuwen Zhong*, Yanyan Yu, Yu Wang, Beibei Zhang, Zuanguang Chen*, Sensitive electrochemical aptamer cytosensor for highly specific detection of cancer cells based on the hybrid nanoelectrocatalysts and enzyme for signal amplification, Biosensors and Bioelectronics, 75, 301–307 (2016)

(7) Min Liao, Xiao Chen, Jiefeng Chen, Mengping Liu, Junyi Wang, Zuanguang Chen, Zhiyong Xie, Meicun Yao∗, Determination of pseudoprotodioscin in rat plasma by UPLC–MS/MS: Assay development and application to pharmacokinetic study, Journal of Chromatography B, 1026, 97–104 (2016)

(8) Min Liao, Cong Dai, Mengping Liu, Jiefeng Chen, Zuanguang Chen, Zhiyong Xie, Meicun Yao∗, Simultaneous determination of four furostanol glycosides in rat plasma by UPLC–MS/MS and its application to PK study after oral administration of Dioscorea nipponica extracts, Journal of Pharmaceutical and Biomedical Analysis, 117, 372–379 (2016)

(9) Meng-ping Liu, Min Liao, Cong Dai, Jie-feng Chen, Chun-juan Yang, Ming Liu, Zuan-guang Chen, Mei-cun Yao*, Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen speciesmediated mitochondria-caspase dependent apoptotic pathway, Scientific Reports, 6:34245, DOI: 10.1038/srep 34245 (2016)

(10) Zhixian Liang, Haiyun Zhai*, Zuanguang Chen*, Haihang Wang, Shumei Wang, Qing Zhou, Xiaoting Huang，A simple, ultrasensitive sensor for gallic acid and uric acid based on gold microclusters/sulfonate functionalized graphene modified glassy carbon electrode, Sensors and Actuators B: Chemical, 224,915–925 (2016)

(11) Haihang Wang, Haiyun Zhai*, Zuanguang Chen, Zhixian Liang, Shumei Wang, Qing Zhou and Yufang Pan, The electrochemical behaviors of tetrahydropalmatine at a nickel nanoparticles/sulfonated graphene sheets modified glassy carbon electrode, RSC Adv., 6, 71351-71359 (2016)

(12) Duanping Sun, Jing Lu, Zuanguang Chen*, Microfluidic contactless conductivity cytometer for the electrical cell sensing and counting, RSC Adv., 5, 59306–59313 (2015)

(13) Duanping Sun, Jing Lu, Zuanguang Chen*, Yanyan Yu, Manni Mo, A repeatable assembling and disassembling electrochemical aptamer cytosensor for ultrasensitive and highly selective detection of human liver cancer cells, Analytica Chimica Acta, 885, 166–173 (2015)

(14) Lijuan Shi, Yanyan Yu, Zuanguang Chen*, Lin Zhang, Sijing He, Qiujia Shi and Hongzhi Yang*, A label-free hemin/G-quadruplex DNAzyme biosensor developed on electrochemically modified electrodes for detection of a HBV DNA segment, RSC Adv., 5, 11541–11548 (2015)

(15) Yinbao Li, Xiujuan Yang, Zuanguang Chen*, Beibei Zhang, Jianbin Pan, Xinchun Li, Fan Yang, and Duanping Sun, Comparative toxicity of lead (Pb2+), copper (Cu2+), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip, Biomicrofluidics, 9, 024105 (2015)

(16) Sijing He, Qiyou Wang*, Yanyan Yu, Qiujia Shi, Lin Zhang, Zuanguang Chen*, One-step synthesis of potassium ferricyanide-doped polyaniline nanoparticles for label-free immunosensor, Biosensors and Bioelectronics, 68, 462–467 (2015)

(17) Xiujuan Yang, Cui Liu, Zuanguang Chen*, Rapid Determination of Uric Acid in Human Urine by CE with an Improved Electromagnetic Induction Detector, Chromatographia, 78,119-123 ( 2015)

(18) Yanyan Yu, Zuanguang Chen*, Wensi Jian, Duanping Sun, Beibei Zhang, Xinchun Li, Meicun Yao*, Ultrasensitive electrochemical detection of avianinfluenza A(H7N9) virus DNA based on isothermal exponential amplification coupled with hybridization chain reaction of DNAzyme nanowires, Biosensors and Bioelectronics, 64, 566–571 (2015)

(19) Sijing He, Yanyan Yu, Zuanguang Chen*, Qiujia Shi, Lin Zhang, Synergistic Effect of Graphene and Multiwalled Carbon Nanotubes on a Glassy Carbon Electrode for Simultaneous Determination of Uric Acid and Dopamine in the Presence of Ascorbic Acid, Analytical Letters, 48, 248–258 (2015)

(20) Haiyun Zhai*, Zihao Su, Zuanguang Chen*, Zhenping Liu, Kaisong Yuan, Lu Huang, Molecularly imprinted coated graphene oxide solid-phase extraction monolithic capillary column for selective extraction and sensitive determination of phloxine B in coffee bean, Analytica Chimica Acta, 865, 16–21 (2015)

(21) Haiyun Zhai*, Zhenping Liu, Zuanguang Chen*, Zhixian Liang, Zihao Su, Shumei Wang, A sensitive electrochemical sensor with sulfonated graphenesheets/oxygen-functionalized multi-walled carbon nanotubesmodified electrode for the detection of clenbuterol, Sensors and Actuators B, 210, 483–490 (2015)

(22) Haiyun Zhai*, Zhixian Liang, Zuanguang Chen*, Haihang Wang, Zhenping Liu, Zihao Su, Qing Zhou, Simultaneous detection of metronidazole and chloramphenicol by differential pulse stripping voltammetry using a silver nanoparticles/ sulfonate functionalized graphene modified glassy carbon electrode, Electrochimica Acta, 171, 105–113 (2015)

(23) Haiyun Zhai*, Kaisong Yuan, Xiao Yu*, Zuanguang Chen, Zhenping Liu, Zihao Su, A simple and compact fluorescence detection system for capillary electrophoresis and its application to food analysis, Electrophoresis, 36, 2509–2515, 2015

(24) Kaisong Yuan, Jianzhuang Wang, Haiyun Zhai*, Zuanguang Chen*, Lu Huang, and Zihao Su, Sensitive determination of rose bengal in brown sugar by a molecularly imprinted solid-phase extraction monolithic capillary column coupled with capillary electrophoresis, Analytical Methods, 7, 8297–8303, 2015

(25) Yanyan Yu, Zuanguang Chen*, Lijuan Shi, Fan Yang, Jianbin Pan, Beibei Zhang, and Duanping Sun, Ultrasensitive Electrochemical Detection of MicroRNA Based on an Arched Probe Mediated Isothermal Exponential Amplification, Analytical Chemistry, 86(16), 8200−8205 (2014)

(26) Beibei Zhang, Yinbao Li, Qidi He, Jun Qin, Yanyan Yu, Xinchun Li, Lin Zhang, Meicun Yao, Junshan Liu, and Zuanguang Chen*, Microfluidic platform integrated with worm-counting setup for assessing manganese toxicity, Biomicrofluidics, 8, 054110 (2014)

(27) Sijing He, Zuanguang Chen*, Yanyan Yu and Lijuan Shi, A novel non-enzymatic hydrogen peroxide sensor based on poly-melamine film modified with platinum nanoparticles, RSC Advances, 4, 45185-45190, (2014)

(28) Duanping Sun, Jing Lu, Zuanguang Chen*, Yanyan Yu, Yinbao Li, A novel three-dimensional microfluidic platform for on chip multicellular tumor spheroid formation and culture, Microfluid and Nanofluid, 17,831–842 (2014)

(29) Yinbao Li, Fan Yang, Zuanguang Chen*, Lijuan Shi, Beibei Zhang, Jianbin Pan, Xinchun Li, Duanping Sun, Hongzhi Yang*, Zebrafish on a Chip: A Novel Platform for Real-Time Monitoring of Drug-Induced Developmental Toxicity, PLos ONE, 9(4): e94792. (2014)

(30) Yanyan Yu, Zuanguang Chen*, Sijing He, Beibei Zhang, Meicun Yao*, Direct electron transfer of glucose oxidase and biosensing for glucose based on PDDA-capped gold nanoparticle modified graphene/multiwall carbon nanotubes electrode, Biosensors and Bioelectronics, 52, 147–152 (2014)

(31) Jianbin Pan, Zuanguang Chen*, Meicun Yao, Xinchun Li, Yinbao Li, Duanping Sun and Yanyan Yu, A two-electrode system-based electrochemiluminescence detection for microfluidic capillary electrophoresis and its application in pharmaceutical analysis, Luminescence, 29, 427–432 (2014)

(32) Jianping Yang, Zuanguang Chen*, Poying Ching, Qiujia Shi and Xinchun Li, An integrated microfluidic platform for evaluating in-vivo antimicrobial activity of natural compounds using a whole-animal infection model, Lab on a Chip, 13 (17), 3373 - 3382, (2013)

(33) Sifeng Wang, Zuanguang Chen*, Xiuwen Tang, Lijuan Shi, Lin Zhang, Meicun Yao*, Rapid determination of partition coefficients of pharmaceuticals by microchip capillary electrophoresis with contactless conductivity detection, Journal of Separation Science, 36, 3615–3622 (2013)

(34) Beibei Zhang, Zuanguang Chen*, Yanyan Yu, Jianping Yang, Jianbin Pan, Determination of sulfonamides in pharmaceuticals and rabbit plasma by microchip electrophoresis with LED-IF detection, Chromatographia, 76:821–829 (2013)

(35) Jianbin Pan, Xinchun Li, Zuanguang Chen*, Fan Yang, Xiaohang Wu, Yinbao Li, Duanping Sun, Yanyan Yu, A beveled working electrode coupled to a sandglass shape detection cell: A strategy to improve the sensitivity of electrochemiluminescence detection in microchip electrophoresis, Electrochimica Acta, 90, 101–107 (2013)

(36) Zhirui Song, Yue Xu*, Zuanguang Chen*, Jianping Yang, Xinchun Li, Zhiguang Zhang, Quantification of lactate in synovia by microchip with contactless conductivity detection, Analytical Biochemistry, 434, 73–77 (2013)

(37) Xinchun Li, Zuanguang Chen*, Jianbin Pan; Fan Yang; Yinbao Li; Meicun Yao*, Differential pulsed amperometry coupled to microchip capillary electrophoresis, Journal of Chromatography A, 1291, 174-178 (2013)

(38) Xinchun Li, Zuanguang Chen*, Fan Yang, Jianbin Pan, Yinbao Li, Development of a microchip-pulsed electrochemical method for rapid determination of L-DOPA and tyrosine in Mucuna pruriens, Journal of Separation Science, 36, 1590–1596 (2013)

(39) YanyanYu, Zuanguang Chen*, Beibei Zhang, XinchunLi, Jianbin Pan, Selective and sensitive determination of uric acid in the presence of ascorbic acid and dopamine by PDDA functionalized grapheme/graphite composite electrode, Talanta, 112，31– 36 (2013)

(40) Jianping Yang, Zuanguang Chen*, Fan Yang, Shuping Wang, Fenghua Hou, A microfluidic device for rapid screening of chemotaxis-defective Caenorhabditis elegans mutants, Biomedical Microdevices,15,211–220 (2013)

(41) Xinchun Li, Zuanguang Chen∗, Yuwen Zhong*, Fan Yang, Jianbin Pan, Yajing Liang, Cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode as electrochemical sensor on microfluidic chip, Analytica Chimica Acta, 710, 118– 124 (2012)

(42) Xiu-juan Yang, Jun-Feng, Zuan-guang Chen*, Rifang Liao, Xinchun Li, Determination of six analgesics by capillary electrophoresis with an improved electromagnetic induction Detector, Chromatographia, 75, 71–76 (2012)

(43) Shuping Wang, Xinchun Li, Jianping Yang, Xiujuan Yang, Fenghua Hou, Zuanguang Chen*, Rapid determination of creatinine in human urine by microchip electrophoresis with LED induced fluorescence detection, Chromatographia, 75, 1287–1293 (2012)

(44) Junshan Liu∗, Fei Xu, Sifeng Wang, Zuanguang Chen*, Jianbin Pan, Xinran Ma, Xiaokai Jia, Zheng Xu, Chong Liu, Liding Wang, A polydimethylsiloxane electrophoresis microchip with a thickness controllable insulating layer for capacitatively coupled contactless conductivity detection, Electrochemistry Communications, 25, 147–150 (2012)

(45) Jin Xiong Qian, Zuan Guang Chen*, A novel electromagnetic induction detector with a coaxial coil for capillary electrophoresis, Chinese Chemical Letters, 23(02), 201-204 (2012)

(46) Zi-You Cai, Yong-Chong Li, Li-Hua Li, Zuan-Guang Chen*, Analysis of arecoline in Semen Arecae decoction pieces by microchip capillary electrophoresis with contactless conductivity detection, Journal of Pharmaceutical Analysis, 2(5), 356–360 (2012)

(47) Junshan Liu*, Junyao Wang, Zuanguang Chen, Yong Yu, Xiujuan Yang, Xianbin Zhang, Zheng Xu, Chong Liu, A three-layer PMMA electrophoresis microchip with Pt microelectrodes insulated by a thin film for contactless conductivity detection, Lab on a Chip, 11, 969–973 (2011)

(48) Fan Yang, Xin-chun Li, Wen Zhang, Jian-bin Pan, Zuan-guang Chen*. A facile light-emitting-diode induced fluorescence detector coupled to an integrated microfluidic device for microchip electrophoresis, Talanta, 84, 1099–1106 (2011)

(49) Fan Yang, Zuanguang Chen*, Jianbin Pan, Xinchun Li, Jun Feng, Hui Yang, An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics, Biomicrofluidics, 5, 024115 (2011)

(50) Xinchun Li, Jianbin Pan, Fan Yang, Jun Feng, Jinyuan Mo, Zuanguang Chen*, Simple amperometric detector for microchip capillary electrophoresis, and its application to the analysis of dopamine and catechol, Microchim Acta, 174, 123–130 (2011)

(51) Hui Yang, Xin-chun Li, Fan Yang, Jun Feng, Miao-yin Lin, Zuan-guang Chen*, Electro- chemiluminescence detection system for microchip capillary electrophoresis and its application to pharmaceutical analysis, Microchim Acta, 175, 193–199 (2011)

(52) Jing Zhao, Zuanguang Chen*, Xinchun Li, Jianbin Pan, A novel microchip based on indium tin oxide coated glass for contactless conductivity detection, Talanta, 85, 2614– 2619 (2011)

(53) Jun Feng, Xiu-juan Yang, Xin-chun Li, Hui Yang, and Zuan-guang Chen*, An automated fluid-transportation device for microfluidic system, Analytical Sciences, 27, 1057-1060 (2011)

(54) 張雯, 陳纘光*, 馮軍, 劉翠, 微孔板發光二極體誘導螢光-表面活性劑增敏法測定鹽酸小檗鹼, 分析化學, 39（8）1218-22 (2011)

(55) Xiu-juan Yang, Zuan-guang Chen*, Cui Liu, Ou-lian Li，Electromagnetic induction detector for capillary electrophoresis and its application in pharmaceutical analysis, Talanta, 82, 1935–1942 (2010)

(56) Li Xiang, Tong Yan-li, Liu Cui, Li Ou-lian, Yang Xiu-juan, Chen Zuan-guang*，Dual detection methods for microchip and conventional capillary electrophoreses，Chin J Anal Chem, 37(10), 1547–1554 (2009)

(57) Zuan-guang Chen*, Ou-lian Li, Cui Liu, Xiu-juan Yang, Electromagnetic induction detector with a vertical coil for capillary electrophoresis and microfluidic chip, Sensors and Actuators B: Chemical, 141, 130-133 (2009)

(58) 童艷麗，李偶連，劉翠，李想，楊秀娟，陳纘光*，微流控晶片電解質介導連線在柱式電導檢測，分析化學，37(7), 1088-1092 (2009)

(59) Cui Liu, Yun-yan Mo, Zuan-guang Chen*, Xiang Li, Ou-lian Li, Xie Zhou, Dual fluorescence/contactless conductivity detection for microfluidic chip, Anal Chim Acta, 621, 171 (2008)

(60) Ou-lian Li, Yan-li Tong, Zuan-guang Chen*, Cui Liu, Shen Zhao, Jin-yuan Mo, A glass/PDMS hybrid microfluidic chip embedded with integrated electrodes for contactless conductivity detection, Chromatographia, 68, 1039–1044 (2008)

(61) 楊秀娟，李偶連，陳纘光*，劉翠，藍悠，趙慎，微流控晶片非接觸電導法測定感冒藥中的鹽酸偽麻黃鹼和氫溴酸右美沙芬，分析化學，36(5)，673～677 (2008)

(62) Zuanguang Chen*, Quanwen Li, Oulian Li, Xie Zhou, You Lan, Yuanfang Wei, Jinyuan Mo, A thin glass chip for contactless conductivity detection in microchip capillary electrophoresis, Talanta, 71(3), 1944-1950 (2007)

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