從1993 年~1998年,曾先後在奧地利(Johannes-Kepler University Linz),美國(University of Nevada Reno), 加拿大(The University of British Columbia) 等大學留學和工作,主要從事新藥研發、天然產物全合成、藥物化學等方面的研究。1998 年起進入生物製藥和生物技術工業界發展,曾先後在美國數家生物醫藥高科技公司從事抗癌新藥研究和開發,曾擔任各種關鍵職位, 歷任高級科學家, 研究課題負責人, 研究室主任和副總裁和總裁,在新藥研發, 藥物篩選, 藥品配方, 藥物化學合成和生產工藝,新藥臨床前研究等方面有比較豐富的經驗。 此外陳清奇曾在2002年 ~ 2005年與朋友起在美國加州舊金山市創辦一家生物醫藥公司,成功地向美國市場推出了2種具有療效功能的保健產品。
6 Qingqi Chen, Jessica Blomberg. 題目待公開, (PCT and US provisional patent application, filed in August, 2008)
5. Qingqi Chen, Bing Li, Rong Li, Manufacturing of fabric sheet contained grass seeds, super-aborsbent, control released fertilizer, and protective agents, Chinese Patent, CN1994038 (2006).
4. Chen, Qingqi; Lopez, Rocio A.; Heller, Jonathan D.; Morris, Amanda Jean. Preparation of nordialkoxyguaiaretic acid derivatives for use as therapeutic agents. PCT Int. Appl. WO 2008042896 (2008).
3. Chen, Qingqi; Lopez, Rocio A.; Heller, Jonathan D.; Morris, Amanda Jean. Tetra-o-substituted butane-bridge modified nordihydroguairetic derivatives, their synthesis and pharmaceutical use. PCT Int. Appl. WO 2008042921 (2008).
2. Qingqi Chen, Damian Sowa, Reinhard Gabathuler, The Use Of Isocyanate Linkers for the Synthesis Of Hydrolyzable Active Agent Biopolymer Conjugates PCT Patent, WO-2004008101 (2004); US Patent application: 20060029586 (Feb 9, 2006); 20040176270 (Sept 9, 2004).
1. Reinhard Gabathuler, Gerrassimos Kolaitis, Robert Charles Brooks, Qingqi Chen, Delara M. Karkan, Gavin D. Arthur, Jean Paul St. Pierre, Wilfred Jeffries, Chemotherapeutic Agents conjugated to P97 and Their Methods of Use in Treating Neurological tumors, PCT Patent, WO-0213843 (2002), US Patent application: 20020119095 (Aug. 22, 2002).
陳清奇已發表的科學研究論文(按最新發表排序:
2008
89 Karkan D, Pfeifer C, Vitalis TZ, Arthur G, Ujiie M, Chen Q, Tsai S, Koliatis G, Gabathuler R, Jefferies WA. A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier. PLoS ONE. 2008 Jun 25;3(6):e2469.
2007
88 Zhang G, Yang G, Wang S, Chen Q, Ma JS, A highly fluorescent anthracene-containing hybrid material exhibiting tunable blue-green emission based on the formation of an unusual "T-shaped" excimer. Chemistry. 2007;13(13):3630-5.
87 Guoqi Zhang, Guoqiang Yang*, Shuangqing Wang, Qingqi Chen, Jin Shi Ma*, A Highly Fluorescent Anthracene-Containing Hybrid Material Exhibiting Tunable Blue-Green Emission Based on the Formation of an Unusual "T-Shaped" Excimer, Chemistry - A European Journal, 2007, 13(13), 3630
86 Zhong Li, Dingqiao Yang, Reinhard Gabathuler, Qingqi Chen,* Synthesis of novel heterobifunctional isocyanato cross-linkers and their applications for the preparation of 10-hydroxycamptothecin and SN-38 conjugates with melanotransferrin p97, Synthetic Communications, 2007, 37, 1899 – 1915.
2006
85 Guo-Qi Zhang, Guo-Qiang Yang*, Lin-Na Zhu, Qing-Qi Chen, Jin-Shi Ma*, A potential fluorescent sensor for Zn2+ based on a selective bis-9-anthryldiamine ligand operating in buffer, Sensors and Actuat. B-Chem. 2006, 114, 995-1000.
2005
84 Guo-qi Zhang, Guo-qiang Yang*, Lan-ying Yang, Qing-qi Chen, Jin-Shi Ma*, Synthesis, Characterization and Photophysical Properties of Novel Dinuclear Silver(I) and Mononuclear Palladium(II) Complexes with 1,2-Bis[(anthracen- 9-ylmethyl)amino]ethane, Eur. J. Inorg. Chem. 2005, 1919–1926
83 Guoxi Zhang; Guoqiang Yang; Qingqi Chen; Jinshi Ma*; Novel Network Polymers Formed by Self-Assembly of Silver Nitrate and Pyrrol-2-yl-methyleneamine Ligands with Flexible Spacers Cryst. Growth Des. 2005; 5(2); 661-666
2004
82. .Lanying Yang, Xufeng Shan, Qingqi Chen, Jin Shi Ma*, Self-assembly of 1,4-bis(pyrrol-2-ylmethyleneamine)butane mediated by Ni(II) and weak intermolecular interactions, J. Chem. Res. 2004, 636-637
81. Xufeng Shan, Lanying Yang, Wei Li, Qingqi Chen, Zhengping Wang, Jiming Hu, Jinshi Ma, Synthesis, Fourier-transform Raman and Infrared Spectroscopic Analysis, and Crystal Structure of (NiL)2, (L = Bis(2,4-dimethyldipyrrin-3-yl)methane, J. Chem. Crystal. 2004, 34(7), 433 – 439.
80. Qingqi Chen*, Reinhard Gabathuler, Synthesis of Camptothecin Melantotransferrin (P97) Conjugate Through A Carbamate Bond, Synth. Commun. 2004, 34(13), 2415 - 2424.
79. Qingqi Chen*, Reinhard Gabathuler, Efficient Synthesis of Polyethylene Glycol Mono-Carboxylate Via Michael Conjugate Addition, Synth. Commun. 2004, 3 (13), 2425 - 2432.
77. Zhikun Wu, Qingqi Chen, Guoqiang Yang, Chengbin Xiao, Jingang Liu, Shiyong Yang, Jin Shi Ma, Novel fluorescent sensor for Zn(II) based on bis(pyrrol-2-yl-methyleneamine) ligands, Sensors and Actuat. B-Chem. 2004, 99,511–515.
76. Lanying Yang, Yi Zhang, Guoqiang Yang, Qingqi Chen, Jin Shi Ma*. Zn(II) and Co(II) Mediated self-assembly of bis(dipyrrin) ligands with a methylene spacer bridged at 3,3’-poistions and their optical properties. Dyes and Pigments. 2004, 62(1), 27-33.
75 Lanying Yang, Xufeng Shan, Qingqi Chen, Zhengping Wang, Jin Shi Ma*. The first silver(I) side-on η2 coordination network formed by self-assembly of bis(pyrrol-2-yl-methyleneamine). Eur. J. Inorg. Chem. 2004, 1474- 1477
74. Lanying Yang, Qingqi Chen, Yan Li, Shaoxiang Xiong, Genpei Li, Jin Shi Ma*. Self-assembly of bis(pyrrol-2-yl-methyleneamine) ligands with CuII controlled by bridging spacers (-(CH2)n-) and weak intermolecular hydrogen bonding C–H…Cu. Eur. J. Inorg. Chem. 2004, 1478-1487.
73. Zhikun Wu, Guoqiang Yang, Qingqi Chen, Jingang Liu, Shiyong Yang, Jinshi Ma, One-pot synthesis and self-assembly of double stranded helical metal complexes, Inorg. Chem. Comm. 2004, 7, 249-252.
72. Lanying Yang, Yi Zhang, Qingqi Chen, Jin Shi Ma*. Molecular Rectangle Formed by Head-to-tail Self-Assembly of 1-(Dipyrrin-2-yl)-1’-(dipyrrin-3-yl)methane. Monatsh. Chem. 2004, 135, 223-229
2003
71. Lanying Yang, Qingqi Chen, Guoqiang Yang, Jinshi Ma. Self-assembly of bis(pyrrol-2-yl-methyleneamine)s bridged by flexible linear carbon chains. Tetrahedron, 2003, 59(50), 100037-100041.
70. Zhikun Wu, Qingqi Chen, Shaoxiang Xiong, Bin Xin, Zhenwen Zhao, Lijin Jiang, JinShi Ma, Novel Double Stranded Hexlicates, Triangle and Square Formed By Self Assembly of Pyrrol-2-yl-methyleneamines with Zinc (II), Angew. Chem. Int. Ed, 2003, 42(28), 3271-3274.
69 Qingqi Chen, David Dolphin, “3,3’-Dipyrrolylsulfides, Useful Building Blocks for the Syntheses of Macrocycles Containing Dipyrromethene Units”, Can. J. Chem. 2003, 81(9), 988-991.
68 Qingqi Chen, Damian A. Sowa, Jianlin Cai, Reinhard Gabathuler, Efficient One-Pot Synthesis Of Doxorubicin Conjugates Through Its Amino Group To Melanotransferrin P97, Synth. Commun. 2003, 33(14), 2399-2419.
67 Qingqi Chen, Damian A. Sowa, Jainlin Cai, Reinhard Gabathuler, Synthesis Of Doxorubicin Conjugates Through Hydrazone Bonds To Melanotransferrin P97, Synth. Commun. 2003, 33(14), 2375-2388.
66 Qingqi Chen*, Damian A. Sowa, Reinhard Gabathuler, Synthesis Of Doxorubicin Conjugates Through 14-Hydroxy Group To Melanotransferrin P97, Synth. Commun. 2003, 33(14), 2389-2398.
65 Qiuan Wang, Yanlin Li, Qingqi Chen, A Conventient, Large Scale Synthesis of Trans-(+)-Sobrerol, Synth. Commun. 2003, 33(12), 2125 – 2134.
63 Qingqi Chen, David Dolphin, Fast, Efficient Synthesis of Linear Polydipyrromethene, Can. J. Chem, 2002, 80(12), 1668-1675
62 Qingqi Chen, Yongjun Zhang, David Dolphin*, Synthesis and Self-assembly of Novel Tetra- and Hexapyrroles Containing Dipyrrins Linked by A Sulfur Bridge at the -Position, Tetrahedron Lett. 2002, 43(46), 8413-8416.
61. Yi Zhang, Qingqi Chen, Zheming Wang, Chuhua Yan, Genpei Li, Jinshi Ma*, Tetra-N-Confused Cyclohexapyrrole: The Unusual Product Formed by Condensation of 3,3’-Dipyrromethane with Tripyrrin-aldehyde, J. Org. Chem. 2002, 67(14), 4997-5000.
60. Peng Wang, Qingqi Chen, Yi Zhang, Jin-shi Ma, An Efficient One-Step Conversion of Biliverdins to 14-formyl-Tripyrrinones, Org. Prec. Prep. Int. 2002, 34(2), 182-187.
59 Qingqi Chen*, Tianyu Wang, Yi Zhang, Qiuan Wang, Jinshi Ma, A Facile, Highly Efficient Synthesis of Fully N-confused Calix[5]pyrroles, Synth. Comm. 2002, 32(7), 1041-1049.
57 Qingqi Chen*, Tianyu Wang, Yi Zhang, Qiuan Wang, Jinshi Ma, Large Scale, Efficient Synthesis of 9-Unsubstituted dipyrrinone, Synth. Comm. 2002, 32(7), 1031-1040.
2001
56 Jiming Hu, Tianyu Wang, Damien Moigno, Minawer Wumaier, Wolfgang Kiefer, Jungang Mao, Qiaofeng Wu, Fei Niu, Yinghong Gu, Qingqi Chen, Jinshi Ma, Haitao Feng, Fournier-transform Raman and infrared spectroscopic analysis of dipyrrinones and mesobilirubins, Spectrochimica Acta Part A, 2001, 57, 2737–2743
55 Bin Tu, Qingqi Chen, Fang Yan, Jinshi Ma*, Karl, Grubmayr, Heinz Falk, Efficient Routes to -Chloroalkyl Bilirubins and C12-N22 Bridged Biliverdins, Monatshefte fur Chemie 2001, 132, 693-705.
54 Hao Cheng, Dehe Zhang and Jinshi Ma*, Qingqi Chen, Synthesis of 5-p-[N-(2-Prrolidinonephenyl-10,15,20-Triphenylporphyrin), Synth. Comm. 2001, 31, 1941-1945.
53 Qingqi Chen*, David Dolphin, A Highly Efficient Preparation of N-Confused Cyclodecapyrroles Tetrahedron Lett. 2001, 42, 3263-3265.
52 Qingqi Chen, David Dolphin*, A highly Efficient Preparation of 3,3'-dipyrrolylsuflide, Synthesis, 2001, 40-42.
2000
51 Qiuan Wang*; Zhaoxu Sun; Qingqi Chen, A Facile Total Synthesis of 1,4-Benzodioxane Type Neolignans Eusiderin G, Chinese J. Org. Chem.( = Youji Huaxue), 2000, 20(6), 910-914.
50 Jiming Hu*, Damien Moigno, Wolfgang Kiefer, Jinshi Ma, Qingqi Chen, Changqi Wang , Haitao Feng, Jingkai Shen, Fei Niu, Yinghong Gu, Fourier-transform Raman and infrared spectroscopic analysis of novel biliverdin compounds, Spectrochimica Acta Part A 2000, 56, 2365–2372.
49 Micheal T. Huggins, Adrianne K. Tipton, Qingqi Chen, David A. Lightner*, Hydrogen-Bonded Double Strands. Crystal Structure and Spectroscopic Properities of a 2,2-Dipyrryl Ketone, Monatshefte fur Chemie 2000, 131, 825-838.
48 Qingqi Chen*, Xiaoli Li, and Bingzi Chen, An Efficient Preparation of 1,2-Bisdipyrrin-9-ylene)-ethane, the First Fully Conjugated b-Homobilin. Synthetic Communications 2000, 30(3), 383-396.
1999
47 Qingqi Chen, Micheal T. Huggins, David Lightner*; Wilma Norona, and Antony F. McDonagh, Synthesis of the First 10-Oxo-Bilirubin. Effects of the Oxo Group on Conformation, Transhepatic Transport and Glucuronidation, J. Am. Chem. Soc. 1999, 121, 9253-9263.
1998
46 Qingqi Chen, David. A. Lightner*; Hemirubin: An Intramolecularly Hydrogen Bonded Analog for One-Half Bilirubin, J. Org. Chem. 1998; 63(8); 2665-2675. CA 128:243858.
45 Liaoli Li, Qingqi Chen, Synthesis of Tetrahydrofuran Analogs, Huaxue Shiji, 1998, 20(5), 317. CA 130:38258(1999).
44. Bingzi Chen, Xiulin Ye, Qingqi Chen*, An Efficient and Highly Practical Synthesis of Tetrahydrofurofurane Lignans, Synthetic Communications 1998, 28(15), 2831-2841. CA 129:216455.
43. Qingqi Chen*, Xiaoli Li, and Bingzi Chen, An Efficient Route to 1,2-Bis(9’-bromodipyrrin)ethane, Synthetic Communications 1998, 28(18), 3359-3369. CA 129:275761.
1997
42. Xiaoli Li, Qingqi Chen*, An Improved Preparation of Tetrahydro-2,5-dimethoxyfuran, Chem. Res. Chin. Uni. 1997, 13(1), 89-90. CA 126:238263.
1996
41. Heinz Falk*, Qingqi Chen, Ronald Micura, On the Chemistry of Pyrrole Pigments, XCVII: Synthesis, Sterochemistry and Solvatoromic effect of 1-(dipyrr-1-one-9-ylene)-3-(dipyrrinone-9-yl)-propene-1: Monatshefte für Chemie (Chemical Monthly), 1996, 127(1), 77-83. CA: 124:342939c.
40. Heinz Falk*, Qingqi Chen, On the Chemistry of Pyrrole Pigments, XCVI: An Efficient Synthesis of Corrphycenes, Monatshefte für Chemie (Chemical Monthly), 1996, 127(1), 69-75. CA: 125:10444m
1995
39. Qingqi Chen, Heinz Falk, Ronald Micura, On the Chemistry of Pyrrole Pigments, XCII: Syntheses of 1,2-Bisdipyrrolylethanes, Monatshefte für Chemie (Chemical Monthly), 1995, 126, 473-479. CA 123:111721p.
38. Qingqi Chen, Jinshi Ma, Chongqi Wang, Yongyong Liu, Fan Yan, Lingjiang Cheng, Sheng Jin, and Heinz Falk, 1,2-Bis-dipyrrinone-ethene: a Novel b-Homo-verdin Chromophore: the Reaction of 9-Methyl-10H-dipyrrin-1-ones with Bromine, Monatshefte für Chemie (Chemical Monthly), 1995, 126, 983-991. CA 124:29494d.
37. Qingqi Chen, Heinz Falk, On the Chemistry of Pyrrole Pigments, XCIII: 1,2-bis(dipyrrinon-9-ylene)-ethane, A Novel b-Homo-biliverdins, Monatshefte für Chemie (Chemical Monthly), 1995, 126, 1097-1107. CA 124:29496f.
36. Qingqi Chen, Heinz Falk, On the Chemistry of Pyrrole Pigments, XCIV: 1-(Dipyrrinon-9-yl)-3-(dipyrrinone-9-ylene)-propene-1, A Novel b-Vinylogous Verdin Chromophore, Monatshefte für Chemie (Chemical Monthly), 1995, 126, 1233-1244. CA 124:86667m.
35. Qingqi Chen, Heinz Falk, On the Chemistry of Pyrrole Pigments, XCV: 1,4-Bis(dipyrrinone-9-ylene)-butene-2, A Novel b-Homoverdin Chromophore, Monatshefte für Chemie (Chemical Monthly), 1995, 126, 1323-1329.
34 Qingqi Chen, Fan Yan; Jinshi Ma, Sheng Jin, Syntheses of 1,2-Bis-[5-(2'-benzoxazolyl)-pyrrole-2-yl]-ethene, Dyes and Pigments 1995, 28(4), 291-295.
33. Qingqi Chen, Chongqi Wang, Lingjiang Cheng, Jinshi Ma, Sheng Jin, Synthesis and Intramolecular Hydrogen Bonding of Symmetric dipyrrylmethanes, Gaodeng Xuexiao Huaxue Xuebao = Chemical Journal of Chinese Universities, 1995, 16(5), 725-729. CA 123-256459u.
32. Jinshi Ma, Qingqi Chen, Chongqi Wang, Yongyong Liu, Fan Yan, Lingjiang Cheng, Sheng Jin, Heinz Falk, A Novel 16,24-Dehydrobiladiene-ab System: the Reaction of Xanthorubic Acid Methyl Ester with Bromine, Monatshefte für Chemie (Chemical Monthly), 1995, 126(2), 201. CA 122:290551g
31. Jinshi Ma, Qingqi Chen; Chongqi Wang, Lingjiang Cheng, Sheng Jin, Intramolecular Hydrogen Bonding in Symmetric Pyrro-methanes, Spectroscopy Letter 1995, 28(2), 223-230. CA 123:256459u
1994
30. Jinshi Ma; Qingqi Chen; Chongqi Wang; Sheng Jin; The Formation of 1,2-Bisdipyrrinone-Ethene, Chinese Chem. Lett. 1994, 5(12), 1017-20. CA 122-160338(1995).
29. Wang Qiu-An, Chen Qing-qi. Analytical Technology of Daily Chemical Flavor And Essence [J]. China Surfactant Detergent & Cosmetics, 1994, (2):36-41(Chinese).
28. Wang Qiu-An, Chen Qing-qi. Analytical Technology of Daily Chemical Flavor And Essence, Shanghai Light Industry 1994, 24(4), 22-26 (Chinese).
1993
27 Wang Qiu-An, Chen Qing-qi. Monitoring international new development, and suggestion to improve China’s Essence and Perfume Industry, Beijing Chemical Industry for Daily Necessitates, 1993, (2), 2-4 (Chinese).
26. Jinshi Ma, Chongqi Wang, Qingqi Chen, Yongyong Liu, Jingzhong Wang, Sheng Jin, Formation of 16,24-Dehydrobiladiene-ab From Pyrromethenone, Chinese Chem. Lett. 1993, 4(12), 1039-40. CA 121:35125 (1994)
25. Lingjiang Chen, Qingqi Chen, Hancheng Yuan, Jinshi Ma, Baozhen Yan, Guangzhi Xu, The Kinetic Studies on the Photoismerization of 1,2-Disubstituted Ethylenes, Chinese Chem. Lett. 1993, 4(4), 335. CA 120:76750m.
24. Qingqi Chen; Fan Yan, Jinshi Ma, Sheng Jin, A Facile Synthesis of 1,2-Bispyrroleethylenes, Chinese Chem Lett. 1993, 4(7), 567-568. CA 120-298398s.
1992
23. Qiu-An Wang, Qingqi Chen, Application of membrane separation technologies in food industry, Mechanics of Light Industry, 1992, (4), 4-8.
1991
22. Qingqi Chen, Absorbent Film Used as Preservative for Foodstuff, Food Science , 1991, 6, 54-57.
1990
21. Qingqi Chen, Natural Organic Products Used as Food Antioxidative, Food Science, 1990, 121(1), 16-18. CA 113-38970f.
20. Qingqi Chen, Guiji, Jiang, Yongjun Gao, Application Research on Super Absorbent, Scienes & Technology of Food Industry, 1990, 57(1), 45-50.
19. Qingqi Chen, Deodorization of Fresh Garlic, J. Chinese Condiment, 1990, 24, 21-22. CA 115-181600.
18. Qingqi Chen, Yajun Hu, Manufacturing of Packing-Films Using Starch-based Plastic, Cereal and Oil, 1990, 1, 32-34.
17. Qingqi Chen, Zhuwan Li; Aimin Wang, Synthesis and application of Stable Chlorine Dioxide, Food Research and Development, 1990, 2, 11-17.
16. Qingqi Chen, Research on Starch-base Super Absorbent---Answer to Reader, Scienes & Technology of Food Industry, 1990, 1, 45-50.
15. Qingqi Chen, Zhenjun Wang, Syntheses of Starch-base Super Absorbent, Cereal and Oil, 1990, 4, 16-19.
1989
14. Qingqi Chen, Zhuwen Li; Aimin Wang, Natural Additives From Edible Materials to Improve Tobacco Quality, Part I, Food and Feed Additive Information, 1989, 3, 3-6.
13. Qingqi Chen, Zhuwen Li; Aimin Wang, Natural Additives From Edible Materials to Improve Tobacco Quality, Part II, Food and Feed Additive Information, 1989, 4, 8-12.
12. Qingqi Chen; Zhuwen Li; Wang, Aimin Wang; Natural Additives From Edible Materials to Improve Tobacco Quality, Part III, Food and Feed Additive Information, , 1989, 5, 36-37.
1988
11. Qingqi Chen, Nature Products Used in Food Preservation, Science & Technology of Food Industry, 1988, 46(1), 34-36.
10. Qingqi Chen; Li, Xiaoli; Recent Development on Research of Food Deodorants, Food Research and Development,1988, 4, 13-14.
9. Qingqi Chen; Yuxiang Zhang, Storing and Preservative Methods of Strawberry, Scienes & Technology of Food Industry, 1988, 5, 32-35.
8. Qingqi Chen; Xiaoli Li, New Trend on Research and Development of Starch Products, Food Research and Development, 1988, 4, 13-14.
6. Qingqi Chen, Natural Products Used for Antioxidation of Edible Oil, Food and Feed Additive Information, 1988, 1, 1-3.
1987
5 Qingqi Chen, Xiaoli Li, Bulletin of Changchun Normal College (Natural Science Version), 1987, 8(2), 44-52.
1986
4 Qingqi Chen, Bulletin of Chenzhou Normal College (Natural Science Version), 1986, 6(1), 55-66.
3 Qingqi Chen; Xiaoli Li; New Method to Predict Chemical Shifts of Substituted Aromatic Compounds, Bulletin of Changchun Normal College (Natural Science Version), 1986, 7(2), 54-67.
1984
2 Qingqi Chen; Bulletin of Chenzhou Normal College (Natural Science Version), 1984, 4(3), 25-36.
1 Qingqi Chen, Study on Mechanism of Ozonlysis of Olefins, Bulletin of Chenzhou Normal College (Natural Science Version), 1984, 4(2), 59-64