陳思鋒，男，教授，博士生導師 ，1963年12月16日生。曾任第二軍醫大學病理生理系代主任、美國University of Alabama at Birmingham 醫學院腎臟系assistant professor of medicine, 主要從事急性和慢性非感染性血管炎症特別是移植性血管內膜病變的發生機制和基因治療研究。主持（4 項）和承擔國家自然科學基金7 項。在美國主持（PI ）和承擔（Co-PI ）美國NIH 項目4 項、國際I 型糖尿病協會重大項目1 項。在JEM 、PNAS 、JASN 、AJT 等雜誌發表論著45 篇。曾獲德國洪堡獎學金、國際癌症聯盟技術轉移獎、波蘭科技進步獎（國際合作研究）各1項，軍隊科技進步二、三等獎7 項。曾參加《病理生理學》英文版教材、《病理生理學進展》、《急救醫學》、《Laboratory Techniques in Biochemistry and Molecular Biology 》等專著的編寫， 現為American Journal of Physiology-Cell Physiology 、Inflammation Research 等國際性雜誌審稿人、 中國病理生理協會微循環專業委員會副主任委員。
Biosketch
Dr. Chen graduated with honors from Second Military Medical University in Shanghai , China . He then joined the Department of Pathophysiology at the same university as an assistant professor and was promoted to associated professor. He also served as the active chairman of the department before being awarded with Humboldt Fellowship by Alexander von Humboldt Foundation, Germany to work in Department of Surgery at University of Magdeburg , Germany . He received post-doctoral training in Divisions of Pulmonary, Oncology, and Nephrology, Hypertension and Transplantation at the University of Florida in Gainesville . In September 2001, he became a research assistant professor. In January 2004, he accepted a position of assistant professor in the Division of Nephrology at the University of Alabama at Birmingham . In January 2006 ，he assumed current position at Fudan University as a professor of physiology and pathophysiology. He was awarded by multiple national and in ternational academic awards. His research was supported by 7 National Natural Science Foundation grants, 4 NIH grants, 1 center grant of Juvenile Diabetes Research Foundation International. His current support includes startup funding and grant awarded by National Natural Science Foundation.
Research Description：
Cytokine-modified cell therapy in chronic vascular rejection
The focus of Dr. Chen's research is to provide anti-rejection protection to renal transplants by providing gene-modified cells to the transplant kidney. These cells will be derived from the recipient's mesenchymal stem cells (MSC) or endothelial cells (EC) which are modified ex vivo with interleukin-10 (IL-10) and/or a reporter gene using adeno-associated viral vectors and seeded into the kidney at the time of transplantation. The studies will include: (i) examine the feasibility of delivering modified MSC or EC into the rat kidney in a model of renal transplantation; (ii) examine infiltration and differentiation of the cells in rat models of aortic and renal transplantation (iii) examine the effects of pre-existing IL -10 in MSC and EC on ischemia-reperfusion injury, immune rejection, the number of functional renal cells, and graft survival.
Selected Publications:
· Deshane J, Chen S , Was H, Grochot-Przeczek A, Lach R, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Agarwal A. Stromal cell-derived factor-1 promotes angiogenesis via a heme oxygenase-1 dependent mechanism. J Exp Med. 2007 Mar 19;204(3):605-18.
· Chen B, Kapturczak MH , George G, Wasserfall C , Campbell-Thompson M, Tisher CC, Flotte TR, Atkinson MA , Agarwal A , Chen S . rAAV-mediated Interleukin-10 Prolongs Graft Survival in Rat Kidney Transplantation, Am J Transplant. 2007 May;7(5):1112-20.
· Chen S , Wasserfall C , Kapturczak MH , Atkinson MA , Agarwal A . Freeze-thaw increases adeno-associated virus transduction of cells. Am J Physiol Cell Physiol. 2006; 291(2):C386-92.
· Chen S , Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin-10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proceedings of the National Academy of Sciences USA . 102 (20):7251-7256, 2005.
· Chen S , Agarwal A, Glushakova OY, Jorgensen MS, Salgar S, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. J Am Soc Nephrol. 14:947-958, 2003.
陳思鋒 教授