2005--2008 Harvard Medical School, Postdoctoral Fellow；
2008-- Nankai University, Professor。陳凌懿教授
研究方向
小鼠胚胎早期發育中轉錄編程的調控機制；胚胎幹細胞的發育多能性的分子機制；建立誘導。
Selected Publications
1.Chen, L. and Liu, L. (2009) Current progress and prospects of induced pluripotent stem cells. Sci. China C Life Sci. 52:622-636。
2.Chen, L., Yabuuchi, A., Eminli, S., Takeuchi, A., Lu, C.W., Hochedlinger, K., Daley, G.Q. (2009) Cross-regulation of the Nanog and Cdx2 promoters. Cell Res. 19:1052-1061。
3.Chen, L. and Daley, G.Q. (2008) Molecular basis of pluripotency. Hum. Mol. Genet. 17(R1): R23-R27。
4.Segal E., Fondufe-Mittendorf Y., Chen L., Th?str?m A., Field Y., Moore I.K., Wang J.P., and Widom J. (2006) A Genomic Code for Nucleosome Positioning. Nature 442: 772-778。
5. Chen, L. and Widom, J. (2005) Mechanism of transcriptional silencing in yeast. Cell 120: 37-48。
6. Chen, L. and Widom, J. (2004) Molecular Basis of Transcriptional Silencing in Budding Yeast. Biochem. Cell Biol. 82: 413-418。
主要學術論文:
陳凌懿,劉林. Current progress and prospects of induced pluripotent stem cells. Science in China 52-7-622-636. 2009-7-1；
Lingyi Chen, Dekun Wang, Zhaoting Wu, Liping Ma, George Q Daley. Molecular basis of the first cell fate determination in mouse embryogenesis. Cell Research 20-9-982-993. 2010-9-13；
Liu, Z., Hu, Z., Pan, X., Li, M., Togun, T.A., Tuck, D., Pelizzola, M., Huang, J., Ye, X., Yin, Y., Liu, M., Li, C., Chen, Z., Wang, F., Zhou, L., Chen, L., Keefe, D.L., and Liu, L. . Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ova. Hum Mol Genet 20-7-1339-1352. 2011-4-1；
Mou, C., and Chen, L.. Battle for Pluripotency: Derivation of Induced Pluripotent Stem Cells. . Recent Patents on Regenerative Medicine 1--123-130. 2011-1-20；
Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L.. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res. 22-4-757-768. 2012-4-1；
Lingyi Chen And Li-Feng Zhang. A balanced network: transcriptional regulation in pluripotent stem cells. stem cell research & therapy S10--004. 2012-8-9；
Zhaoting Wu, Meng Yang, Hongjie Liu, Hongchao Guo, Yuan Wang, Hong Cheng, and Lingyi Chen. Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance. Journal of Biological Chemistry 287-45-38295-38304. 2012-11-21版），科學出版社,2009.1。
陳凌懿教授