基本介紹
- 中文名：陳世楨
- 外文名：Shizhen Chen
- 畢業院校：華中師範大學
- 學位：博士學位
- 研究領域：磁共振分子影像及腫瘤的多模態影像研究
- 職稱：研究員
簡歷,研究領域,代表論著,
簡歷
陳世楨，女，博士，研究員，博導。從事磁共振分子影像及腫瘤的多模態影像研究，主要影像手段包括MRI、 CT、 PET、超聲、光聲和光學成像等。承擔多項國家自然科學基金項目及中科院前沿科學重點研究計畫和中科院科研儀器研製項目各一項。在Nano. Lett，ACS Nano，Angew. Chemie等國際知名期刊上發表SCI 論文30餘篇，總引超過1200次。申請15項發明專利，授權8項。2017年獲中國分析測試協會科技獎（第一完成人），2018年入選中國科學院青年創新促進會。2020年榮獲“湖北省百名優秀女性科技創新人才”稱號。2021年榮獲武漢"新時代巾幗英雄"。
研究領域
主要從事磁共振分子影像及腫瘤的多模態影像研究，主要影像手段包括MRI、CT、PET、超聲、光聲和光學成像等
代表論著
1.Ruifang Wang, Maosong Qiu, Lei Zhang, Meiju Sui, Long Xiao, Qiao Yu, Chaohui Ye, Shizhen Chen*, Xin Zhou*. Augmenting Immunotherapy via Bioinspired MOF-based Ros Homeostasis Disruptor with Nanozyme-Cascade Reaction. Advanced Materials. (2023).
2.Yu Li, Jing Zhang, Lijun Zhu, Mou Jiang, Changsheng Ke, Hanxiong Long, Ruoyun Lin, Chaohui Ye, Xin Zhou, Zhongxing Jiang*, Shizhen Chen*. All-in-One Heptamethine Cyanine Amphiphiles for Dual Imaging-Guided Chemo-Photodynamic-Photothermal Therapy of Breast Cancer. Advanced Healthcare Materials. (2023).
3.Haiwei Shan, Lei Shi, Shuang Liu, Yaping Yuan, Hongchuang Li, Shizhen Chen, Xin Zhou*. A Local-Saturation-and-Delay MRI Method for Evaluation of Red Blood Cells Aggregation in Vivo for Tumor-Bearing or Drug-Used Rats. Frontiers in Bioengineering and Biotechnology, Vol 11, 1111840. (2023).
4.Lijun Zhu, Yu Li, Mou Jiang, Changsheng Ke, Hanxiong Long, Maosong Qiu, Lei Zhang, Chaohui Ye, Xin Zhou, Zhongxing Jiang*, Shizhen Chen*. Self-Assembly of Precisely Fluorinated Albumin for Dual Imaging-Guided Synergistic Chemo–Photothermal–Photodynamic Cancer Therapy. ACS Applied Materials & Interfaces, Vol 15(2), 2665-2678. (2023).
5.Wen Qin, Jinzhao Huang, Chunsheng Yang, Quer Yue, Shizhen Chen, Mengdie Wang, Shangbang Gao, Xin Zhou, Xiangliang Yang, Yan Zhang*. Protease-Activatable Nanozyme with Photoacoustic and Tumor-Enhanced Magnetic Resonance Imaging for Photothermal Ferroptosis Cancer Therapy. Advanced Functional Materials, Vol 33(4), 2209748. (2023).
6.Shizhen Chen, Mou Jiang, Yaping Yuan, Baolong Wang, Yu Li, Lei Zhang, Zhongxing Jiang, Chaohui Ye, Xin Zhou*. Using Endogenous Glycogen as Relaxation Agent for Imaging Liver Metabolism by MRI. Fundamental Research, Vol 3(4), 481-487. (2023)
7.Ting Tang, Qiang Zhu, Shuang Liu, Hailong Dai, Yu Li, Caihong Tang, Kexin Chen, Mou Jiang, Lijun Zhu, Xin Zhou, Shizhen Chen*, Zitong Zheng*, Zhongxing Jiang*. 19F MRI-Fluorescence Imaging Dual-Modal Cell Tracking with Partially Fluorinated Nanoemulsions. Frontiers in Bioengineering and Biotechnology, Vol 10, 1049750. (2022).
8.Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhongxing Jiang, Maili Liu, Xin Zhou*. In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19F NMR. Angewandte Chemie International Edition, Vol 61(50), e202213495.(2022).
9.Shizhen Chen, Maosong Qiu, Ruifang Wang, Lei Zhang, Conggang Li, Chaohui Ye, Xin Zhou*. Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy. Bioconjugate Chemistry, Vol 33(9), 1729-1740. (2022)
10.Jing Ma, Yaping Yuan, Li Zhang, Shizhen Chen, Haiyan Cao, Liu Hong, Juanjuan Liu, Xiaoyan Song, Jiawei Shi, Yi Zhang, Li Cui, Xin Zhou*, Mingxing Xie*. Evaluation of Right Ventricular Function and Myocardial Microstructure in Fetal Hypoplastic Left Heart Syndrome. Journal of Clinical Medicine, Vol 11(15), 4456. (2022)
11.Kexin Chen, Tingjuan Wu, Mou Jiang, Anfeng Li, Xingxing Peng, Shizhen Chen, Zhigang Yang, Xin Zhou, Xing Zheng*, Zhongxing Jiang*. Partially Fluorinated Nanoemulsions for 19F MRI-fluorescence Dual Imaging Cell Tracking. Colloids and Surfaces B: Biointerfaces, Vol 215, 112493. (2022).
12.Anfeng Li, Xingxing Peng, Mou Jiang, Tingjuan Wu, Kexin Chen, Zhigang Yang, Shizhen Chen, Xin Zhou, Xing Zheng*, Zhongxing Jiang*. Synthesis of Trifluoromethylated Aza-BODIPYs as Fluorescence-19F MRI Dual Imaging and Photodynamic Agents. Organic & Biomolecular Chemistry, Vol 20(16), 3335-3341. (2022).
13.Shizhen Chen , Yina Lan, Haidong Li, Liming Xia, Chaohui Ye, Xin Lou*, Xin Zhou*. Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized 129Xe-MRI-based 8-Month Follow-Up. Biomedicines, Vol 10(4), 781-789. (2022).
14.Tingjuan Wu, Kexin Chen, Mou Jiang, Anfeng Li, Xingxing Peng, Shizhen Chen, Zhigang Yang, Xin Zhou, Xing Zheng*, Zhongxing Jiang*. Hydrofluorocarbon Nanoparticles for 19F MRI-Fluorescence Dual Imaging and Chemo-Photodynamic Therapy. Organic & Biomolecular Chemistry, Vol 20(6), 1299-1305. (2022)
15.Tingjuan Wu, Anfeng Li, Kexin Chen, Xingxing Peng, Jing Zhang, Mou Jiang, Shizhen Chen, Xing Zheng*, Xin Zhou*, Zhongxing Jiang*. Perfluoro-tert-butanol: A Cornerstone for High Performance Fluorine-19 Magnetic Resonance Imaging. Chemical Communications, Vol 57(63), 7743-7757. (2021)
16.Yuqi Yang, Yingfeng Zhang, Baolong Wang, Qianni Guo, Yaping Yuan, Weiping Jiang, Lei Shi, Minghui Yang, Shizhen Chen, Xin Lou, Xin Zhou*. Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks. Chemical Science, Vol 12(12), 4300-4308. (2021).
17.Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129Xe MRI. Science Advances, Vol 7(1), eabc8180. (2021).
18.Sha Li, WeipingJiang, Yaping Yuan, Meiju Sui, Yuqi Yang, Liqun Huang, Ling Jiang, Maili Liu,Shizhen Chen*, Xin Zhou*. DelicatelyDesigned Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19FMR/PA/FL Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, Vol 12(51),57290-57301. (2020).
19.Lili Ren, Shizhen Chen*, Weiping Jiang, Qingbin Zeng, Xu Zhang,Long Xiao, Michael T. McMahon, Xin Lou, Xin Zhou*. Efficient Temperature-feedback Liposome for 19F MRI SignalEnhancement. Chemical Communication,Vol 56(92), 14427-14430. (2020).
20.Huaibin Zhang,Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou*, ShizhenChen*, Zhongxing Jiang*. FluorinatedPorphyrin-Based Theranostics for Dual Imaging and Chemo-Photodynamic Therapy. Journal of Materials Chemistry B, Vol 8(20), 4469-4474.(2020).
21.Huaibin Zhang, QiaoYu, Yu Li, Zhigang Yang, Xin Zhou, Shizhen Chen*, ZhongxingJiang*. Fluorinated Cryptophane-A andPorphyrin-based Theranostics for Multimodal Imaging-guided Photodynamic Therapy. Chemical Communication, Vol 56(25), 3617-3620. (2020).
22.Lianhua Liu, YapingYuan, Yuqi Yang, Michael McMahon, Shizhen Chen*, Xin Zhou*. A Fluorinated Aza-BODIPY Derivative for NIR fluorescence/PA/19FMR Tri-modality In Vivo Imaging. ChemicalCommunications, Vol 55(42), 5851-5854. (2019).
23.Huaibin Zhang, Shizhen Chen, Yaping Yuan,Yu Li, Zhongxing Jiang*, Xin Zhou*. Xe Hyper-CEST/F MRI MultimodalImaging System for Sensitive and Selective Tumor Cells Detection. ACS Applied Bio Materials, Vol 2(1), 27-32. (2019).
24.Yuqi Yang, Shizhen Chen, Haidong Li, Yaping Yuan, Zhiying Zhang,Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. EngineeredParamagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. NanoLetters, Vol 19(1), 441-448. (2019).
25.Sha Li, Yaping Yuan, Yuqi Yang, ConggangLi, Michael T. McMahon, Maili Liu, Shizhen Chen*, Xin Zhou*. Potential Detectionof Cancer with Fluorinated Silicon Nanoparticles in 19F MR andFluorescence Imaging. Journal of Materials Chemistry B,Vol 6, 4293-4300. (2018).
26.Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, ShizhenChen*, Xin Zhou*. pH-responsive Theranostic Nanocomposites as Synergistically EnhancingPositive and Negative Magnetic Resonance Imaging Contrast Agents. Journalof Nanobiotechnology, Vol 16(30). (2018)
27.Xin Liu, YapingYuan, Shaowei Bo, Zhigang Yang, Xin Zhou, Shizhen Chen*, ZhongxingJiang*. Monitoring Fluorinated Dendrimer-BasedSelf-Assemble Drug-Delivery Systems with 19F Magnetic Resonance. European Journal of Organic Chemistry, Vol 2017(30),4461-4468. (2017).
28.Yuqi Yang, Shizhen Chen, Lianhua Liu,Sha Li, Qingbin Zeng, Xiuchao Zhao, Haidong Li, Zhiying Zhang, Louis-S.Bouchard, Maili Liu, Xin Zhou*. IncreasingCancer Therapy Efficiency through Targeting and Localized Light Activation. ACS Applied Materials & Interfaces, Vol 9(28),23400-23408. (2017)
29.Lili Ren, Shizhen Chen, Haidong Li, Zhiying Zhang, Jianping Zhong,Maili Liu, Xin Zhou*. MRI-Guided Liposomes for Targeted TandemChemotherapy and Therapeutic Response Prediction. ActaBiomaterialia, Vol 35, 260-268. (2016).
30.Shizhen Chen, Yuqi Yang, Haidong Li, Xin Zhou*, Maili Liu. pH-Triggered Au-fluorescent Mesoporous Silica Nanoparticles for 19F MR/FluorescentMultimodal Cancer Cellular Imaging. ChemicalCommunications, Vol 50(3), 283-285. (2014).
31.Yuqi Yang, YingfengZhang, Baolong Wang, Qianni Guo, Yaping Yuan, Weiping Jiang, Lei Shi, MinghuiYang, Shizhen Chen, Xin Lou, Xin Zhou*. Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks. Chemical Science. (2021).
32.Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie,Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung GasExchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129XeMRI. ScienceAdvances, Vol 7(1), eabc8180. (2021).
33.Weitao Yang, Chenyang Xiang, Yan Xu, ShizhenChen, Weiwei Zeng, Kai Liu, Xiao Jin, Xin Zhou*, Bingbo Zhang*. Albumin-constrained Large-scale Synthesis of Renal Clearable FerrousSulfide Quantum Dots for T-Weighted MR Imaging andPhototheranostics of Tumors. Biomaterials,Vol 255, 120186. (2020).
34.Jing Zhang, YuanYuan, Yu Li, Hao Yang, Huaibin Zhang, Shizhen Chen, Xin Zhou, Zhigang Yang*,Zhongxing Jiang*. Synthesis ofBranched Monodisperse Oligoethylene Glycols and 19FMRI-Traceable Biomaterials through Reductive Dimerization of Azides. The Journal of Organic Chemistry, Vol 85(10), 6778-6787.(2020).
35.Xuemeng Wang, Yu Li, Tingjuan Wu, Zhigang Yang,Xing Zheng, Shizhen Chen, Xin Zhou*, Zhongxing Jiang*. QuantitativelyFine-Tuning the Physicochemical and Biological Properties of Peptidic Polymersthrough Monodisperse PEGylation. Biomacromolecules, Vol 21(2),725-731. (2020)
36.Junfei Zhu, HuaibinZhang, Kexin Chen, Yu Li, Zhigang Yang, Shizhen Chen, Xing Zheng, Xin Zhou,Zhongxing Jiang*. PeptidicMonodisperse PEG "Comb" as Multifunctional "Add‐On" Module for Imaging‐Traceable andThermo‐Responsive Theranostics. AdvancedHealthcare Materials, Vol 9(3), 1901331. (2020).
37.Haonan He, Kelu Zhao, Long Xiao, Yi Zhang, Yi Cheng, Sikang Wan,Shizhen Chen, Lei Zhang*, Xin Zhou*, Kai Liu*, Hongjie Zhang. Detection and ChiralRecognition of α-hydroxyl Acid through 1H and CESTNMR Spectroscopy Using a Ytterbium Macrocyclic Complex. AngewandteChemie - International Edition, Vol 58(50), 18286-18289. (2019).
38.Junfei Zhu, Yan Xiao, Huaibin Zhang, Yu Li,Yaping Yuan, Zhigang Yang, Shizhen Chen, Xing Zheng, Xin Zhou, ZhongxingJiang*. PeptidicMonodisperse PEG "combs" with Fine-Tunable LCST and MultipleImaging Modalities. Biomacromolecules, 20(3),1281-1287. (2019).
39.Weitao Yang,Xiudong Shi, Yuxin Shi, Defan Yao, Shizhen Chen, Xin Zhou, BingboZhang*. Beyond the Roles in BiomimeticChemistry: An Insight into the Intrinsic Catalytic Activity of an Enzyme forTumor-Selective Phototheranostics. ACS Nano,Vol 12(12), 12169-12180. (2018).
40.Qiaoli Peng, Yu Li,Shaowei Bo, Yaping Yuan, Zhigang Yang, Shizhen Chen, Xin Zhou, ZhongxingJiang*. Paramagnetic Nanoemulsions with UnifiedSignals for Sensitive 19F MRI Cell Tracking. Chemical Communications, Vol 54(47), 6000-6003. (2018).
41.Shaowei Bo, Yaping Yuan, Yongping Chen, ZhigangYang, Shizhen Chen, Xin Zhou, Zhongxing Jiang*. In Vivo Drug Trackingwith 19F MRI at Therapeutic Dose. ChemicalCommunications, Vol 54(31), 3875-3878. (2018)
42.Shengjun Yang, Qingbin Zeng, Qianni Guo, ShizhenChen, Hongbin Liu, Maili Liu, Michael T. McMahon, Xin Zhou*. Detection andDifferentiation of Cys, Hcy and GSH Mixtures by 19F NMR Probe. Talanta,Vol 184, 513-519. (2018)
43.Yu Li, Qiuyan Shi, Jiajia Shao, Yaping Yuan, Zhigang Yang,Shizhen Chen, Xin Zhou, Shijun Wen, Zhongxing Jiang*. Synthesis andBiological Evaluation of 20-Epi-Amino-20-Deoxysalinomycin Derivatives. EuropeanJournal of Medicinal Chemistry, Vol 148(25), 279-290. (2018).
44.Qiaoli Peng, YapingYuan, Huaibin Zhang, Shaowei Bo, Yu Li, Shizhen Chen, Zhigang Yang, XinZhou, Zhongxing Jiang*. 19F CEST Imaging Probes for Metal Ion Detection. Organic & Biomolecular Chemistry, Vol 15(30), 6441-6446.(2017).
45.Yu Li, Guiquan Xia,Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, ZhongYin Zhang, XinZhou, ZhongXing Jiang*. Design, Synthesisand Evaluation of Novel 19F Magnetic Resonance SensitiveProtein Tyrosine Phosphatase Inhibitors. Medicinal Chemistry Communication, Vol 7(8),1672-1680. (2016).
46.Qiuyan Shi, Yu Li, Shaowei Bo, Xiaofei Li, PengZhao, Qi Liu, Zhigang Yang, Hengjiang Cong, Hexiang Deng, Mingnan Chen, ShizhenChen, Xin Zhou, Hong Ding, Zhongxing Jiang*. Discovery of a 19FMRI Sensitive Salinomycin Derivative with High Cytotoxicity Towards CancerCells. ChemicalCommunications, Vol 52(29), 5136-5139. (2016).
47.Bo Li, Xudong Wang, Yali Guo, Anam Iqbal, YapingDong, Wu Li, Weisheng Liu, Wenwu Qin*, Shizhen Chen, Xin Zhou, YunhuangYang*. One-PotSynthesis Polyamines Improved Magnetism and Fluorescence FeO-CarbonDots Hybrid NPs for Dual Modal Imaging. Dalton Transactions, Vol 45,5484-5491. (2016).
48.Shaowei Bo, Cong Song, Yu Li, Weijiang Yu,Shizhen Chen, Xin Zhou, Zhigang Yang, Xing Zheng*, Zhongxing Jiang*. Design andSynthesis of Fluorinated Amphiphile as 19F MRI/FluorescenceDual-Imaging Agent by Tuning the Self-Assembly. The Journalof Organic Chemistry, Vol 80(12), 6360-6366. (2015)
49.LiliRen, Shizhen Chen, Haidong Li, Zhiying Zhang, Chaohui Ye, Maili Liu, XinZhou*. MRI-Visible LiposomeNanovehicles for Potential Tumor-Targeted Delivery of Multimodal Therapies. Nanoscale, Vol 7, 12843-12850. (2015).
50.Weijiang Yu, Yuqi Yang, Shaowei Bo, Yu Li,Shizhen Chen, Zhigang Yang, Xing Zheng, Zhongxing Jiang*, XinZhou. Designand Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI. The Journalof Organic Chemistry, Vol 80(9), 4443-4449. (2015).
51.Xiaolei Zhu, Shizhen Chen, Qing Luo, ChaohuiYe, Maili Liu, Xin Zhou*. Body TemperatureSensitive Micelles for MRI Enhancement. ChemicalCommunications, Vol 51(44), 9085-9088. (2015).
52.Qi Wang, ShizhenChen, Qing Luo, Maili Liu, Xin Zhou*. A Europium-Lipoprotein Nanocomposite for High-Sensitive MR-FluorescenceMultimodal Imaging. RSC Advances, Vol 5(3),1808-1811. (2015)
53.袁晨露，郭茜旎，陳世楨，周欣*. 新型葫蘆[6]脲納米顆粒超極化129Xe"分子籠"研究. 波譜學雜誌, Vol 36(4), 472-480. (2019).
54.張繼，羅晴，郭茜旎，陳世楨，周欣*. 超極化129Xe磁共振分子影像學. 波譜學雜誌, Vol 30(2), 280-292.(2013).
