阮進學，男，1985年出生，湖北紅安人，博士，現為華中農業大學動物遺傳育種繁殖系副研究員，碩士生導師。
基本介紹
- 中文名：阮進學
- 學位/學歷：博士
- 職業：教師
- 專業方向：動物基因編輯
- 任職院校：華中農業大學動物科學技術學院動物醫學院
個人經歷,研究方向,學術成果,榮譽獎項,
個人經歷
教育經歷
2005.09-2009.07，華中農業大學，動物科學專業畢業，農學學士
2009.09-2012.07，華中農業大學，動物遺傳育種與繁殖專業畢業，農學碩士
2012.09-2015.07，吉林大學，生物化學與分子生物學專業畢業，理學博士
工作經歷
2016.02-2017.12，美國密西根大學安娜堡分校，博士後
2018.04-至今，華中農業大學動物遺傳育種與繁殖系，副研究員，碩士生導師
研究方向
基因編輯技術的改進、基因編輯動物的製備
學術成果
A著作類 1. 《動物基因組編輯》，2016年，科學出版社，李奎主編，阮進學參編
B論文類 1. Jinxue Ruan, Hiroyuki Hirai, Dongshan Yang, Linyuan Ma, Xia Hou, Hong Jiang, Hongguang Wei, Carthic Rajagopalan, Hongmei Mou, Guoshun Wang, Jifeng Zhang, Kui Li, Yuqing E Chen, Fei Sun, Jie Xu. (2019) Efficient gene editing at major CFTR mutation loci. Molecular therapy-nucleic acids.
2. Jinxue Ruan, Hegang Li, Kui Xu, Tianwen Wu, Jingliang Wei, Rong Zhou, Zhiguo Liu, Yulian Mu, Shuling Yang, Hongsheng Ouyang, Ruby Yanru Chen-Tsai, Kui Li. (2015) Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs. Scientific reports. 5.
3. Ruan Jinxue, Zhang Yuanyuan, Yuan Jing, Xin Leilei, Xia Jihan, Liu Nan, Mu Yulian, Chen Yaoxing, Yang Shulin, Li Kui. (2016) A long-term high-fat, high-sucrose diet in Bama minipigs promotes lipid deposition and amyotrophy by up-regulating the myostatin pathway. Molecular and Cellular Endocrinology. 425, 123-132.
4. Jinxue Ruan, Jie Xu, Ruby Yanru Chen-Tsai, Kui Li. (2017) Genome editing in livestock: are we ready for a revolution in animal breeding industry? Transgenic Research. 1-12.
5. Jinxue Ruan, Nan Liu, Hongsheng Ouyang, Shulin Yang, Kui Li. (2014). Spatiotemporal control of porcine p65RHD expression by advanced Tet-On system in PIEC cells helps regulate NFкB activity. Mol Biol Rep. 41(3), 1753-1761.
6. Kong S, Ruan J (Co-first), Zhang K, Hu B, Cheng Y, Zhang Y, Yang S, Li K. (2018) Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis. PeerJ.
7. Xiaodan Liu, Jinxue Ruan, Jihan Xia, Shulin Yang, Junhua Fan, Kui Li. The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide. Mol Cell Biochem. 394(1-2), 59-66.
8. Siyuan Kong, Jinxue Ruan, Leilei Xin, Junhua Fan, Jihan Xia, Zhiguo Liu, Yulian Mu, Shulin Yang, Kui Li. (2016) Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis. Mol Med Rep. 13(1), 669-680
9. Jun Song, Dongshan Yang, Jinxue Ruan, Jifeng Zhang, Y. Eugene Chen, and Jie Xu. Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting. Scientific reports. 7(1), 12202
10. Hegang Li, Guojian Ma, Duan Gui, Shuanpin Zhao, Pan Wang, Kongwang He, Xuemin Wang, Jinxue Ruan, Jiyue Cao, Shulin Yang, Kui Li. (2011), Characterization of the porcine p65 subunit of NF-κB and its association with virus antibody levels. Mol Immunol. 48(6), 914-923.
科研項目
1. 端粒酶Tert基因編輯豬細胞模型構建及豬早衰機制研究；國家自然科學基金青年科學基金2018.01
2. 新的家畜安全、高效的轉基因定向整合位點的克隆、鑑定及外源基因低（無）嵌合的高效定點整合；國家科技重大專項項目（子課題） 2018.01
3. 新型插入型打靶載體介導的高效基因敲入系統的創製研究；華中農業大學自主科技創新基金 2018.01
榮譽獎項
1. 2015年獲中國農業部中華農業科技獎優秀創新團隊獎（相當於部級一等獎），排名第19
