基本介紹
- 中文名：閆亞平
- 畢業院校：陝西師範大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：神經免疫和神經炎症性疾病
- 職務：陝西師範大生命科學學院博士生導師
- 任職院校：陝西師範大生命科學學院
個人經歷,研究方向,學術成果,榮譽獎勵,
個人經歷
2002、2005、2008年分別在陝西師範大學獲得生物學本科、碩士和博士學位。後於2008年9月至2012年8月在美國托馬斯傑弗遜大學神經內科系進行博士後科研訓練。2012年9月至2017年1月任天津醫科大學總醫院、天津市神經病學研究所研究員，2013年被遴選為博士研究生導師。2017年1月加入陝西師範大學生命科學學院，西北瀕危藥材資源開發國家工程實驗室。
兼任教育部藥學類教學指導委員會委員，藥用資源與天然藥物化學教育部重點實驗室主任，藥用資源與天然藥物化學教育部重點實驗室學術委員會委員，陝西省科技特派員。
研究方向
主要從事神經免疫和神經炎症性疾病領域的研究。
學術成果
先後主持國家自然科學基金項目4項，主持國家重點研發計畫中醫藥現代化研究課題1項，參與國家重大基礎研究計畫（973）項目1項。在國際一流刊物上發表52篇學術論文，論文被引1670餘次。
在研課題：
1.國家自然科學基金面上項目，81571596，膜錨定補體調節蛋白CD59在視神經脊髓炎中樞神經系統特異性病灶形成中的作用研究，2016/01-2019/12，支持，54萬。
2.國家重點研發計畫中醫藥現代化研究重點專項，2017YFC1701300，山茱萸、黃芩、白及高品質道地中藥材規範化種植及精準扶貧示範研究，2018/01-2021/12,課題負責人，180萬。
已發表論文：
2019:
1. Zhu W, Tian L, Yue X, Liu J, Fu Y,Yan Y*. Lnc RNA exoression profiling of ischemic stroke during the transition from the acute to subcute stage.Frontiers in Neurology, 2019, 10: 36.
2. Tian L, Zhu W, Liu Y, Gong Y, Lv A, Wang Z, Ding X, Li S, Fu Y, Lin Y*,YanY*. LIF-transfected NSCs Promote Neuroprotection in a Rat Model of Cerebral Ischemia.Neuroscience Bulletin, 2019, in press.
3. Zhu W, Wang Z, Hu S, Gong Y, Liu Y, Song H, Ding X, Fu Y,Yan Y*. A human C5-specific single-chain variable fragment ameliorates brain injury in a model of NMOSD.Neurology:Neuroimmunology & Neuroinflammation, 2019, in press.
4. Yang C, Yang Y, Ma L, Zhang GX, Shi FD,Yan Y, Chang G. Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica.Int J Mol Med, 2019, 43 (3): 1395-1405.
2018:
5. Yu X, Chen B, Tang H, Li W, Fu Y, Zhang Z,Yan Y*. A novel mutation of GARS in a Chinese Family with distal hereditary motor neuropathy type V.Fron Neurol, 2018 9: 571.
6. Chen C, Zhou Y, Wang J,Yan Y, Peng L, Qiu W. Dysregulated microRNA involvement in multiple sclerosis by induction of T helper 1 cell differentiation.Front Immunol, 2018, 9:1256.
7. Fu Y,Yan Y*. Emerging role of immunity in cerebral small vessel disease.Front Immunol,2018, 9:67.
2017:
8. Wang Z,Yan Y*. Immunopathogenesis in myasthenia gravis and neuromyelitis optica.Front Immunol, 2017, 8:1785.
9. Wen L, Cao X, Han L, Zhao H, Qiu S,Yan Y, Wang X, Chen X, Zheng W, Xu X, Gao Y, Chen Y, Li J, Yang Y, Xu Y. Association of increased Treg and Th17 with pathogenesis of moyamoya disease.Sci Rep, 2017, 7(1): 3071.
10. Wang Z, Guo W, Liu Y, Gong Y, Ding X, Shi K, Thome R, Zhang GX, Shi FD,Yan Y. Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes.Brain Behav Immun, 2017, 65: 173-182.
11.Li YH, Yu JW, Xi JY, Yu WB, Liu JC, Wang Q, Song LJ, Feng L,Yan YP, Zhang GX, Xiao BG, Ma CG. Fasudil enhances therapeutic efficacy of neural stem cells in the mouse model of MPTP-induced Parkinson’s disease.Molecular Neurobiology, 2017, 54 (7): 5400-5413.
12. Li X, Zhang Y,Yan Y, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, Zhang GX. LINGO-1-fc-transduced neural stem cells are effective therapy for chronic stage experimental autoimmune encephalomyelitis.Mol Neurobiol, 2017, 54 (6): 4365-4378.
2016:
13. Chen C, Zhang Y, Qiakefu K, Zhang X, Han L, Hu W,Yan Y, Wang Z. Overexpression of tomato prosystemin (LePS) enhances pest resistance and the production of tanshinones inSalvia miltiorrhizaBunge.Journal of Agricuture and Food Chemistry, 2016, 64 (41): 7760-7769.
14. Shi K, Wang Z, Liu Y, Gong Y, Fu Y, Hao JW, Shi F-D,Yan Y. CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders.Journal of Immunology, 2016, 197(9):3471-3480.
15. Zhang CJ, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S, Wood K, Ladha S, Shi FD, Liu Q,Yan Y. Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in Myashenia Gravis.Journal of Immunology, 2016, 197: 2610-2617.
16. Yu JW, Li YH, Song GB, Yu JZ, Liu CY, Liu JC, Zhang HF, Yang WF, Wang Q,Yan YP, Xiao BG, Ma CG. Synergistic and superimposed effect of bone marrow-derived mesenchymal stem cells combined with fasudil in experimental autoimmune encephalomyelitis.J Mol Neurosci, 2016. 60 (4):486-497.
17. Li S, Yan Y, Jiao Y, Gao Z, Xia Y, Kong L, Yao Y, Tao Z, Song J,Yan Y, Zhang G, Yang J. Neuroprotective effect of Osthole on neuron synapses in an Alzheimer’s disease cell model via upregulation of microRNA-9.J Mol Neurosci, 2016, 60 (1):71-81.
18. Fu Y,Yan Y, Qi Y, Yang L, Li T, Zhang N, Yu C, Su L, Zhang R, Shen Y, Lin S, Liu Q, Shao Z, Han Z, Shi FD. Impact of autologous mesenchymal stem cell infusion on neuromyelitis optica spectrum disorder: a pilot, 2-year observation study.CNS Neurosci Ther, 2016, 22 (8): 677-685.
19. Li X, Zhang Y,Yan Y, Ciric B, Ma C-G Gran B, Curtis M, Rostami A, Zhang G-X. Neural stem cells engineered to express three therapeutic factors mediate recovery from chronic stage CNS autoimmunity.Molecular Therapy, 2016. 24(8): 1456-1469.
20.Yan Y, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD.Sci China Life Sci. 2016, 59 (12): 1270-1281.
2015:
21. Liu Y, Fu Y, Schoonheim MM, Zhang N, Fan M, Su L, Shen Y,Yan Y, Yang L, Wang Q, Zhang N, Yu C, Barkhof F, Shi FD. Structural MRI substrates of cognitive impairment in neuromyelitis optica.Neurology, 2015, 85: 1491-1499.
22. Li M,Yan Y. Experimental models of neuromyelitis optica: current status, challenges and future directions.Neurosci Bull,2015, 31:735-744.
23. Li YJ, Chang GQ, Liu Y, Gong Y, Yang C, Wood K, Shi FD, Fu Y, Yan Y. Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage.Neurosci Bull,2015, 31:755-762.
24. Ding X,Yan Y, Li X, Li K, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, Lovett-Racke AE, Zhang GX, Rostami A. Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity.J Immunol,2015, 194: 4251-4264.
25. Li YJ, Zhang F, Qi Y, Chang GQ, Fu Y, Su L, Shen Y, Sun N, Borazanci A, Yang C, Shi FD,Yan Y. Association of circulating follicular helper T cells with disease course of NMO spectrum disorders.J Neuroimmunol,2015, 278: 239-46.
2014:
26. Fu Y, Zhang N, Ren L,Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD. Impact of an immune modulator fingolimod on acute ischemic stroke.Proc Natl Acad Sci U S A.2014, 111(51): 18315-20.
27. Kong XD, Bai S, Chen X, Wei HJ, Jin WN, Li MS,Yan Y, Shi FD. Alterations of natural killer cells in traumatic brain injury.Neurosci Bull.2014,30 (6): 903-12.
28. Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ,Yan Y, Huang D, Yu C, Shi FD. Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study.JAMA Neurol.2014,71(9):1092-101.
29. Kalantari T, Karimi MH, Ciric B,Yan Y, Rostami A and Kamali-Sarvestani E. Tolerogenic dendritic cells produced by lentiviral-mediated CD40- and IL-23p19- specific shRNA can ameliorate experimental autoimmune encephalomyelitis by suppressing Th17 cells.Clin Exp Immunol,2014, 176(2): 180-189.
30. Zhang CJ, Zhai H,Yan Y, Hao J, Li MS, Jin WN, Su N, Vollmer TL, Shi FD.Glatiramer acetate ameliorates experimental autoimmune neuritis.Immunol Cell Biol.2014,92(2):164-9.
31. Yang J,Yan Y, Xia Y, Kang T, Li X, Ciric B, Xu H, Rostami A, Zhang GX. Neurotrophin 3 Transduction Augments Remyelinating and Immunomodulatory Capacity of Neural Stem Cells.Mol Ther.2014, 22 (2): 440-50.
2013:
32. Wu S, Li K,Yan Y, Gran B, Han Y, Zhou F, Guan YT, Rostami A, Zhang GX. Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis.J Clin Cell Immunol.2013; 4(3). doi: 10.4172/2155-9899.1000142.
33. Zhang N, Wen Q, Ren L, Liang W, Xia Y, Zhang X, Zhao D, Sun D, Hu Y, Hao H,Yan Y, Zhang G, Yang J, Kang T. Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells.Int J Mol Sci.2013;14(9):18657-69.
34.Yan Y, Li Z, Zhang GX, Williams MS, Carey GB, Zhang J, Rostami A, Xu H. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis.Apoptosis.2013;18(9):1106-19.
35. Li Y, Wang Y, Yu L, Sun C, Cheng D, Yu S, Wang Q,Yan Y, Kang C, Jin S, An T, Shi C, Xu J, Wei C, Liu J, Sun J, Wen Y, Zhao S, Kong Y. miR-146b-5p inhibits glioma migration and invasion by targeting MMP16.Cancer Lett.2013; 339(2):260-9.
36.Zhang Y,Yan YP, Wu YC, Hua WP, Chen C, Ge Q, Wang ZZ.Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation.Metab Eng.2013; 21C:71-80.
37. Wang Y, Li Y, Sun J, Wang Q, Sun C,Yan Y, Yu L, Cheng D, An T, Shi C, Xu J, Wei C, Liu J, Wen Y, Zhao S, Li H, Zhang H, Xu H, Yu S. Tumor-suppressive effects of miR-29c on gliomas.Neuroreport.2013; 24(12):637-45.
38.Li Z, Li K, Zhu L, Kan Q,Yan Y, Kumar P, Xu H, Rostami A, Zhang GX.Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation.BMC Immunol.2013; 14:20.
2012:
39. Zhang N, Kang T, Xia Y, Wen Q, Zhang X, Li H, Hu Y, Hao H, Zhao D, Sun D,Yan Y, Zhang GX, Yang J. Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells.Eur J Pharmacol,2012,697 (1-3): 32-39.
40. Zhou F, Ciric B, Li H,Yan Y, Cullimore M., Safavi F., Zhang G.X., and Rostami AM. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells.Eur. J. Immunol.2012,42 (6): 1449-1458.
41.Yan Y, Zhang G-X, Williams MS, Carey GB, Rostami AM, and Xu H. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation.Molecular Immunology,2012,52(2):71-8.
42.Yang J,Yan Y, Ciric B, Yu S, Ciric B, Guan Y, Xu H, RostamiAM, Zhang GX. Acceleraated and enhanced effect of CCR5-transducedbone marrow neural stem cells on autoimmune encephalomyelitis.Acta Neuropathologica,2012,124(4):491-503.
43. Yu D, Corbett B,Yan Y, Zhang GX, Reinhart P, Cho SJ, Chin J. Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease.Neurobiol Aging,2012,33(12):2942-2947.
44.Wang ZJ, Cui LJ, Chen C, Liu XJ,Yan Y, and Wang Z.Downregulation of Cinnamoyl CoA Reductase affects Lignin and Phenolic Acids Biosynthesis in Salvia miltiorrhiza Bunge.Plant Molecular Biology Reporter，2012,30 (5): 1229-1236.
45.Yan Y, Ding X, Li K, Ciric B., Xu H., Gran B., Rostami A., Zhang G. X. CNS- specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes.Molecular Therapy,2012,20(7):1338-48.
2011:
46.El-Behi M, Ciric B, Dai H,Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A.The encephalitogenicity of Th17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.Nat Immunol.2011,12 (6): 568-575.
2010 and before:
47.Yang J,Yan Y, Ciric B, Yu S, Guan Y, Xu H, Rostami AM, ZhangGX.Evaluation of bone marrow- and brain-derived neural stem cells in therapy of central nervous system autoimmunity.Am. J. Pathol.2010,177:1989-2001.
48.Yan Y, Zhang G X, Cric B, Rostami AM, Xu H. IDO upregulates Treg cells via tryptophan catabolite and suppresses encephalitogenic T cell responces in EAE.J. Immunol.2010, 185:5953-61.
49. Xu H,Yan Y, Fitzgerald DC, Zhang GX, Rostami AM. MS4a4B, a CD20 homologue in T cell, inhibits T cell propagation by modulation of cell cycle.PloS One,2010, Nov 1; 5(11):e13780.
50. Zhang Y,Yan Y, Wang Z. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza.J Agr Food Chem,2010, 58, 12168-12175.
51.Yan Y, Wang Z, Tian W, Dong Z, Spencer SF. Generation and analysis of expressed sequence tags from the medicinal plantSalvia miltiorrhiza.Sci China Life Sci,2010, 53 (2): 273-285.
52.Yan Y, Wang Z. Genetic transformation of the medicinal plant Salvia miltiorrhiza by Agrobacterium tumefaciens-mediated method.Plant Cell, Tissue and Organ Culture,2007, 88: 175-184.
