金建平，漢族，江蘇崑山人，畢業於南京農業大學，現任浙江大學生命科學研究院 教授、資深研究員、博士生導師。
基本介紹
- 中文名：金建平
- 國籍：中國
- 民族：漢
- 出生地：江蘇崑山
- 畢業院校：南京農業大學
- 職稱：教授
教育背景,工作經歷 ,研究方向,發表論文,所獲榮譽,社會任職,
教育背景
1985, 南京農業大學,獲學士學位
1988, 江蘇省中國科學院植物研究所,獲碩士學位
2000, 美國德克薩斯農工大學, 獲生物化學博士學位
工作經歷
1988-1994, 江蘇省中國科學院植物研究所,實習研究員及助理研究員
2000-2001,冷泉港實驗室,博士後, 導師Scott Lowe教授
2001-2007,貝勒醫學院及哈佛醫學院,博士後, 導師J Wade Harper教授
2007-2018, 美國德克薩斯大學休斯敦健康科學中心,助理教授、副教授
2018 - 浙江大學生命科學研究院, 教授, 資深研究員,博士生導師
研究方向
泛素信號轉導通路: 從基本機制到人類疾病
泛素是一個小信號蛋白, 能連線到其他蛋白質底物, 從而改變蛋白質底物的命運與功能.泛素化是由泛素激活酶 (E1), 泛素耦聯酶 (E2), 及泛素連線酶 (E3) 按順序地催化而成. 泛素化的一個主要結果是通過26S蛋白酶體來降解蛋白質底物. 這是真核細胞內特異性降解蛋白質的主要途徑. 許多和泛素化有關的基因在人類疾病中存在遺傳變異. 大量的證據表明,泛素信號的異常調控和人類疾病的發生密切相關。
發表論文
1. Jin J, Dong W, Guarino LA. 1998. The LEF-4 subunit of baculovirus RNA polymerase has RNA 5’-triphosphatase and ATPase activities. J. Virol. 72:10011-10019.
2. Jin J, Guarino LA. 2000. 3’-End formation of baculovirus late RNAs. J. Virol. 74:8930-8937.
3. Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. 2003. SCF links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes & Development. 17:3062-3074.
4. Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE. 2004. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. USA 101:9085-9090.
5. Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. 2004. The Keap1-BTB protein Is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase. Mol. Cell. Biol. 24:8477-8486.
6. Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW. 2004. Systematic analysis and nomenclature of mammalian F-box proteins. Genes & Development. 18:2573-2580.
7. Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J. 2005. Phosphorylation-dependent ubiquitylation and degradation of SREBP1 by the SCF-FBW7 complex. Cell Metabolism. 1:379-391.
8. Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. 2005. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 8:25-33.
9. Jin J, Arias EE, Chen J, Harper JW, Walter JC. 2006. A family of diverse Cul4-Ddb1 interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Molecular Cell. 23:709-721. (Featured Article).
10. Jin J, Li X, Gygi SP, Harper JW. 2007. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature. 447:1135-1138. (Editor's choice, Science, Vol. 2007, Issue 393, p. tw238; Research Highlights, Nature Reviews Molecular Cell Biology, 2007, Vol 8, p599).
11. Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. 2010. CRL4-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase. Molecular Cell. 40(1):22-33.
12. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. 2011. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nature Structural & Molecular Biology. 18(12):1400-1407. (The first two authors contribute this work equally)
13. Ding C, Chan DW, Liu W, Liu M, Li D, Song L, Li C, Jin J, Malovannaya A, Jung SY, Zhen B, Wang Y, Qin J. 2013. Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements. Proc Natl Acad Sci U S A. 110(17):6771-6776.
14. Li C, Peart N, Xuan Z, Lewis DE, Xia Y, Jin J. 2014. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 26(7):1369-1378.
15. Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. 2014. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Molecular Cell. 53(2):235-246.
16. Li JM, Wu H, Zhang W, Blackburn MR, Jin J. 2014. The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis. Mol Cell Biol. 34(3):335-347.
17. Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P. 2017. The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun. 8:15751.
18. Wu H, Bogdanov M, Zhang Y, Sun K, Zhao S, Song A, Luo R, Parchim NF, Liu H, Huang A, Adebiyi MG, Jin J, Alexander DC, Milburn MV, Idowu M, Juneja HS, Kellems RE, Dowhan W, Xia Y. 2016. Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease. Sci Rep. 6:29637.
19. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. 2017. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 8:14108.
20. Liu N, Zhang J, Yang X, Jiao T, Zhao X, Li W, Zhu J, Yang P, Jin J, Peng J, Li Z, Ye X. 2017. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. J Virol. 91(16). pii: e00340-17.
所獲榮譽
2008美國皮尤生物醫學學者獎
2008美國德克薩斯大學休斯敦健康科學中心青年研究員獎
2002美國國防部乳腺癌研究博士後獎學金
1999美國德克薩斯農工大學農業與生命科學學院, 生物化學與生物物理學優秀研究生獎學金
1995 美國德克薩斯農工大學董事會獎學金
社會任職
美洲華人生物科學學會（SCBA）終身會員
2014-, Editorial Board Member, Journal of Biological Chemistry
2014-,member of The American Society for Biochemistry and Molecular Biology
