金京波，男，博士，研究員，博士生導師。 1974年3月出生於吉林省圖們市，1996年在中國農業大學獲學士學位，1999年和2002年在韓國慶尚國立大學獲碩士和博士學位。2002年3月至 2008年11月分別在韓國浦項工業大學和美國普渡大學進行博士後工作。現任中國科學院植物研究所研究員及課題組組長。2008年入選“百人計畫”。迄今發表SCI收錄刊物論文34篇。其中，通訊（或共同通訊）作者兩篇，第一（或共同第一）作者論文5篇。正在指導博士生3名和碩士生3名。
基本介紹
- 中文名：金京波
- 出生日期：1974年3月
- 職業：植物研究所植物分子生理學重點實驗室 研究組長，研究員
- 主要成就：中科院“百人計畫”入選者
工作經歷,研究方向,主要研究領域及內容,部分發表文章,
工作經歷
1992.07-1996.06 中國農業大學 學士 農業套用化學；
1997.03-1999.02 韓國慶尚國立大學 碩士 分子生物學；
1999.03-2002.02 韓國慶尚國立大學 博士 分子生物學；
2002.03-2004.05 韓國浦項工業大學 博士後；
2004.06-2008.11 美國普渡大學 博士後；
2008.11-至今 中科院植物所 研究員。
研究方向
融合遺傳、生化、分子和細胞生物學的方法,研究sumoylation和組蛋白去甲基化在環境脅迫感應和植物發育過程的調控機制。
主要研究領域及內容
融合遺傳、生化、分子和細胞生物學的方法,研究sumoylation和組蛋白去甲基化在環境脅迫感應和植物發育過程的調控機制。
1. 在動物，蛋白質加SUMO化調控免疫系統，細胞分裂和分化，DNA修飾，epigenetic基因表達，細胞核與細胞質物質移動，信號傳導等。我要闡明sumoylation調控植物抗逆反應和發育程式機制，包括但不限於：(1)篩選及研究SIZ1和SUMO相互作用分子；(2)發現及研究SIZ1的下游基因；(3)篩選及研究siz1suppressor 突變體；(4) 研究SIZ1自身調控的機制。
2. 組蛋白甲基化(Histone methylation) 影響基因表達和染色質狀況，調節多細胞生物的激素和脅迫反應及發育程式。最近的科學研究結果發現組蛋白去甲基化酶(histone demethylase)對植物的開花時期和發育起重要的調控作用。除此之外，好多抗逆相關基因的表達與組蛋白甲基化有密切聯繫，但對其調節機制並不清楚。我的遠程目標是闡明植物組蛋白去甲基化酶的功能及作用機制。(1)研究SUMO modification調節FLD (一個組蛋白去甲基化酶) 蛋白質活性的機制；(2)建立完善抗逆基因表達和組蛋白去甲基化的相關性。(3) 發現新的組蛋白去甲基化酶並研究它們的功能和作用機制。
3. 利用所得到的研究結果，結合已有的技術基礎，開發抗逆及符合不同生長環境的高產量農作物或能源作物。
部分發表文章
1. Jin, J.B., and Hasegawa, P.M. 2008. Flowering time regulation by the SUMO E3 ligase SIZ1. Plant Signaling & Behavior In press.
2. Jin, J.B., Jin, Y.H., Lee, J., Miura, K., Yoo, C.Y., Kim, W.Y., Oosten, M.V., Hyun, Y., Somers, D.E., Lee, I., Yun, D.J., Bressan, R.A., and Hasegawa, P.M. 2008. The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure. Plant J. 53:530-540.
3. Kim, J.I., Sharkhuu, A., Jin, J.B., Li, P., Jeong, J.C., Baek, D., Lee, S.Y., Blakeslee, J.J., Murphy, A.S., Bohnert, H.J., Hasegawa, P.M., Yun, D.J., Bressan, R.A. 2007. yucca6, a Dominant Mutation in Arabidopsis, Affects Auxin Accumulation and Auxin-related Phenotypes. Plant Physiol. 145:722-35.
4. Miura, K., Jin, J.B., Hasegawa, P.M. 2007. Sumoylation, a post-translational regulatory process in plants. Curr. Opin. Plant Biol. 10:495-502.
5. Inan, G., Goto, F., Jin, J.B., Rosado, A., Koiwa, H., Shi, H., Hasegawa, P.M., Bressan, R.A., Maggio, A., Li, X. 2007. Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant Mol. Biol.65:295-309.
6. Miura, K., Jin, J.B., Lee, J., Yoo, C.Y., Stirm, V., Miura, T., Yun, D.-J., Bressan, R.A., and Hasegawa, P.M. 2007. Low temperature induces SIZ1-mediated sumoylation of ICE1 that controls CBF3/DREB1A expression and freezing tolerance. Plant Cell 19: 1403-14.
7. Lee, J., Nam, J., Park, H.C., Na, G., Miura, K., Jin, J.B., Yoo, C.Y., Baek, D., Kim, D.H., Jeong, J.C., Kim, D., Lee, S.Y., Salt, D.E., Mengiste, T., Gong, Q., Ma, S., Bohnert, H.J., Kwak, S.-S., Bressan, R.A., Hasegawa, P.M. and Yun, D.-J. 2007. Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Plant J. 49: 79-90.
8. Lee, M.H., Lee, S.H., Kim, H., Jin, J.B., Kim, D.H., Hwang, I. 2006. A WD40 repeat protein, Arabidopsis Sec13 homolog 1, may play a role in vacuolar trafficking by controlling the membrane association of AtDRP2A. Mol. Cells 22:.210-9.
9. Yoo, C.Y., Miura, K., Jin, J.B., Lee, J., Park, H.C., Salt, D.E., Yun, D.J., Bressan, R.A., Hasegawa, P.M. 2006. SIZ1 SUMO E3 Ligase Facilitates Basal Thermotolerance in Arabidopsis Independent of Salicylic Acid. Plant Physiol. 142: 1548-58.
10.Kang, C.H., Jung, W.Y., Kang, Y.H., Kim, J.Y., Kim, D.G., Jeong, J.C., Baek, D.W., Jin, J.B., Chung, W.S., Mengiste, T., Koiwa, H., Bahk, J.D., Lee, S.Y., Nam, J.S., Yun, D.J. and Cho, M.J. 2005. AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants. Cell Death Differ. 13: 84-95 .
11.Miura, K., Rus, A., Sharkhuu, A., Yokoi, S., Karthikeyan, A.S., Raghothama, K.G., Baek, D., Koo, Y.D., Jin,
J.B., Bressan, R.A., Yun, D.J., and Hasegawa, P.M. 2005. The Arabidopsis SUMO E3 ligase SIZ1 controls
phosphate deficiency responses. Proc. Natl. Acad. Sci. 102:7760-7765.
12.Narasimhan, M.L.*, Coca, A.*, Jin, J.B., Yamauchi, T., Ito, Y., Kadowaki, T., Kim, K.K., Pardo, J.M., Damsz,
B., Hasegawa, P.M., Yun, D.J. and Bressan, R.A. 2005. Osmotin is a homolog of mammalian adiponectin and
controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Molecular Cell 17: 171-180.
(*These authors contributed equally to this work.) .
13.Jin. J.B., Bae, H.-J., Kim, D.H., Lee, Y.J., Tse, Y.C., Kim, S.J., Jiang, L., Goh, C.-H., Jin, Y.H. and Hwang, I.
2003. New Arabidopsis dynamin-like proteins, ADL1E and ADL1C, play a critical role in mitochondrial
morphogenesis. Plant Cell 15: 2357-2369.
14.Kim, C.Y.*, Koo, Y.D.*, Jin, J.B.*, Moon, B.C., Kang, C.H., Kim, S.T., Park, B.O., Lee, S.Y., Kim, M.L.,
Hwang, I., Kang, K.Y., Bahk, J.D., Lee, S.Y. and Cho, M.J. 2003. Rice C2-domain proteins are induced and
translocated to the plasma membrane in response to fungal elicitor. Biochemistry 42: 11625-11633. (*These
authors contributed equally to this work.) .
15.Lee, K.H., Kim, S.J., Lee, Y.J., Jin, J.B. and Hwang, I. 2003. The M domain of atToc159 plays an essential role in the import of proteins into chloroplasts and chloroplast biogenesis. J. Biol. Chem. 278: 36794-36805.
16.Lee, M.H., Min, M.K., Lee, Y.J., Jin, J.B., Shin, D.H., Kim, D.H., Lee, K.H. and Hwang, I. 2002. ADP-
ribosylation factor 1 of Arabidopsis plays a critical role in intracellular trafficking and maintenance of endoplasmic
reticulum morphology in Arabidopsis. Plant Physiol. 129: 1507-1520.
17.Lee, S.H., Jin, J.B., Song, J., Min, M.K., Park, D.S., Kim, Y.W. and Hwang, I. 2002. The intermolecular
interaction between the PH domain and the C-terminal domain of Arabidopsis dynamin-like 6 determines lipid
binding specificity. J. Biol. Chem. 277: 31842-31849.
18.Jin, J.B., Kim, Y.A., Kim, S.J., Lee, S.H., Kim, D.H., Cheong, G.W. and Hwang, I. 2001. A new dynamin-like
protein, ADL6, is involved in trafficking from the trans-Golgi network to the central vacuole in Arabidopsis. Plant
Cell 13: 1511-1526.
19.Kim, D.H., Eu, Y.J., Yoo, C.M., Kim, Y.W., Pih, K.T., Jin, J.B., Kim, S.J., Stenmark, H. and Hwang, I. 2001.
Trafficking of phosphatidylinositol 3-phosphate from the trans-Golgi network to the lumen of the central vacuole
in plant cells. Plant Cell 13: 287-301.
20.Piao, H.L., Pih, K.T., Lim, J.H., Kang, S.G., Jin, J.B., Kim, S.H. and Hwang, I. 1999. An Arabidopsis
GSK3/shaggy-like gene that complements yeast salt stress-sensitive mutants is induced by NaCl and abscisic
acid. Plant Physiol. 119: 1527-34.
21.Pih, K.T., Kabilan, V., Lim, J.H., Kang, S.G., Piao, H.L., Jin, J.B. and Hwang, I. 1999. Characterization of two
new channel protein genes in Arabidopsis. Mol. Cells 9: 84-90.
22.Kang, S.G., Jin, J.B., Piao, H.L., Pih, K.T., Jang, H.J., Lim, J.H. and Hwang, I. 1998. Molecular cloning of an
Arabidopsis cDNA encoding a dynamin-like protein that is localized to plastids. Plant Mol. Biol. 38: 437-47.
23.Jang, H.J., Pih, K.T., Kang, S.G., Lim, J.H., Jin, J.B., Piao, H.L. and Hwang, I. 1998. Molecular cloning of a
novel Ca2+-binding protein that is induced by NaCl stress. Plant Mol. Biol. 37: 839-47.
