鄭高偉

鄭高偉，男，博士，華東理工大學教授，博士生導師。

基本介紹

• 中文名：鄭高偉
• 畢業院校：華東理工大學
• 學位/學歷：博士
• 職業：教師
• 專業方向：新酶催化機制與構效關係解析、多酶分子機器的構建與調控
• 任職院校：華東理工大學

個人經歷

教育經歷

2005.09-2010.08華東理工大學生物化工碩博連讀許建和教授博士

2001.09-2005.07四川大學生物工程專業學士

工作經歷

2019.09-present華東理工大學生物反應器工程國家重點實驗室教授

2013.09-2019.08華東理工大學生物反應器工程國家重點實驗室副研究員

2011.03-2013.08華東理工大學生物反應器工程國家重點實驗室助理研究員

留學經歷

2015.09-2016.09英國曼徹斯特大學Manchester Institute of BiotechnologyNicholas J Turner教授

研究方向

(1)新酶催化機制與構效關係解析

(2)多酶分子機器的構建與調控

(3)酶促反應過程的強化與放大

學術成果

科研項目

1.亞胺還原酶立體選擇性的分子調控機制及其理性設計，國家自然科學基金面上項目/ 21878085

2.新型胺脫氫酶催化酮不對稱還原胺化的分子機制探索，國家自然科學基金面上項目/ 21472045

3.新型微生物亞胺還原酶的催化性能及催化機制研究，國家自然科學基金青年項目/31200050

4.手性環氧丙酸(酯)的化學-酶法合成技術，863計畫子課題/2011AA02A210

論文

[1] Xu-Min Gong, Zhen Qin, Fu-Long Li, Bu-Bing Zeng, Gao-Wei Zheng*, Jian-He Xu*. Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor. ACS Catal., 2019, 9, 147–153. (IF: 12.2)

[2] Fei-Fei Chen,† Gao-Wei Zheng,† Lei Liu, Hao Li, Qi Chen, Fu-Long Li, Chun-Xiu Li, and Jian-He Xu*. Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines. ACS Catal. 2018, 8, 2622−2628. (IF: 12.2)

[3] Gao-Wei Zheng*,#, Yan-Yan Liu#, Qi Chen#, Lei Huang, Hui-Lei Yu, Wen-Yong Lou, Chun-Xiu Li, Yun-Peng Bai, Ai-Tao Li, Jian-He Xu*. Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1. ACS Catal. 2017, 7, 7174–7181. (IF: 12.2)

[4] Gao-Wei Zheng and Jian-He Xu*. New Opportunities for Biocatalysis: Driving the Synthesis of Chiral Chemicals. Curr. Opin. Biotechnol. 2011, 22, 784–792. (IF: 8.38)

[5] Hao-Yu Jia,Min-Hua Zong, Gao-Wei Zheng*,Ning Li*. One-pot Enzyme Cascade for Controlled Synthesis of Furan Carboxylic Acids from 5-Hydroxymethylfurfural via H2O2 Internal Recycling. ChemSusChem, 2019, doi.org/10.1002/cssc.201902199. (IF: 7.82)

[6] Hao Li, Ping Tian, Jian-He Xu*, Gao-Wei Zheng*. Identification of an Imine Reductase for Asymmetric Reduction of Bulky Dihydroisoquinolines. Org. Lett. 2017, 19(12): 3151–3154. (IF: 6.50)

[7] Hieu-Huy Nguyen-Tran, Gao-Wei Zheng,* Xu-Hong Qian and Jian-He Xu*. Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1. Chem Commun 2014, 50, 2861–2864. (IF: 6.20)

[8] Jin-Gang Yin, Yi Gong, Xiao-Yan Zhang, Gao-Wei Zheng*, and Jian-He Xu*. Green access to chiral Vince lactam in a buffer-free aqueous system using a newly identified substrate-tolerant (−)-γ-lactamase. Catal. Sci. Technol. 2016, 6, 6305-6310. (IF: 5.73)

[9] Hao Li, Zheng-Jiao Luan, Gao-Wei Zheng,* and Jian-He Xu*. Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis. Adv. Synth. Catal. 2015, 357, 1692-1696. (IF: 5.50)

[10] Yu-Jun Zhang, Wen-Xia Zhang, Gao-Wei Zheng,* and Jian-He Xu*. Identification of an ε-Ketoester Reductase for Efficient Synthesis of (R)-α-Lipoic Acid Precursor. Adv. Synth. Catal. 2015, 357, 1697-1702. (IF: 5.50)