人物經歷
2014.01-2018.02,美國Emory University,兒科系血液/腫瘤科,主要從事造血幹細胞調控與白血病發病機理研究;神經幹細胞發育調控研究。
2008.6-2013.12,美國 Case Western Reserve University,病理系血液/腫瘤科,獲NIH高級人才資助計畫,主要從事造血幹細胞調控與白血病發病機理研究;神經幹細胞發育調控研究。
2005.9-2009.12,安徽醫科大學,基礎醫學院,病理生理學教研室副主任及支部書記,機能中心副主任,安徽省病理生理學會副理事長,副教授。
2000.7-2006.8,安徽醫科大學,基礎醫學院,病理生理學教研室,講師。
研究方向
1. 造血調控及白血病發生機理;腫瘤免疫與調控
2. 神經幹細胞發育及功能調控機制。
主要成就
科研項目
1. 國家自然科學基金面上項目,No. 81670097,(Shp2)調控小鼠造血幹細胞骨髓微環境促進骨髓增殖性腫瘤發生及其機制,2017.1-2020.12,60萬元,主持;
2. 國家自然科學基金面上項目,No.81870085, 谷氨醯胺載體ASCT2在激活突變Ptpn11(Shp2)致骨髓增殖性腫瘤和白血病中的作用及機制, 2019.1-2022.12,57萬元,主持;
3. 2018 年安徽省高層次人才平台獎補資助(個人);
4. 入選2019年安徽省高校學科(專業)拔尖人才。
學術論文
(1) Wu M, Ma M, Tan Z, Zheng H (通訊作者), Liu X. Neutrophil: A New Player in Metastatic Cancers. Front. Immunol., 24 September 2020 | https://doi.org/10.3389/fimmu.2020.565165
(2)Liu J, Fang Q, Lin H, Yu X, Zheng H(通訊作者), Wan Y.Alginate-poloxamer/silk fibroin hydrogels with covalently and physically cross-linked networks for cartilage tissue engineering. Carbohydr Polym. 2020 Nov 1;247:116593.
(3)Zheng H , Yu WM, Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK. Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellum development. Sci Adv. 2018 Oct 10;4(10):eaat2681. (IF=11.51)
(4)Zheng H, Yu WM, Waclaw RR, Kontaridis MI, Neel BG, Qu CK. Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. Sci Signal. 2018 Mar 20;11(522). (IF=6.83)
(5)Dong L*, Yu WM*, Zheng H * (共同第一), Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK. Leukemogenic effects of Ptpn11 (Shp2) activating mutations in the stem cell microenvironment. Nature. 2016 Nov 10;539(7628):304-308. (IF=40.137)
(6)Dong L, Zheng H , Qu CK. CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment. Blood. 2017 Sep 21;130(12):1471-1474. (IF=13.164)
(7) Liu X, Zheng H (共同第一), Li XB, Wang SY, Meyerson HJ, Yang WT, Neel BG, Qu CK. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):984-9. (IF=9.661)
(8)Liu X, Zheng H (共同第一), Yu WM, Cooper TM, Bunting KD, Qu CK. Maintenance of hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood. 2015 125(10):1562-5. (IF=13.164)
(9) Zheng H (通訊作者), Wang SY, Zhou PK, Liu W, Ni F. Effects of Ligustrazine on DNA damage and apoptosis induced by irradiation. Environmental Toxicology and Pharmacology. 2013, 36: 1197–1206. (IF=1.862)
(10) Zheng H , Li SH, Hsu P, Qu CK. Acute induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) leads to cellular senescence and apoptosis. J Biol Chem. 2013, 288(36): 25727-38. (IF=4.651)
(11)Xu D, Zheng H (共同第一), Yu WM, Qu CK. Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder. PLoS ONE. 2013, 8(5): e63152. (IF=4.092)
(12) Liu X, Zheng H, Qu CK. An essential role of protein tyrosine phosphatase Shp2 (Ptpn11) in the maintenance of chromosome stability. Cancer Res. 2012, 72 (20):5296-306. (IF=9.188)
(13)Zheng H .et al,SHP-2 tyrosine phosphatase in human diseases. Int J Clin Exp Med. 2009, 2(1): 17-25. (IF=1.422)
(14) Zheng H, Zhou PK, Chen ZW, et al. Protective effect of Vanillin derivative dimethoxyvanillin on radiation-induced DNA damage. Eur J Pharm Sci. 2008 Jan, 33(1):52-9. (IF=3.65)
(15)Zheng H, Chen XL, Chen ZW, et al. Effect of Ligustrazine on liver injury after burn trauma. Burns. 2006, 32:328-34. (IF=1.139)
(16)Gao S, Chen ZW, Zheng H, et al. Ligustrazine attenuates acute myocardium injury after thermal trauma. Burns. 2007, 33(3):321-7. (IF=1.1)
(17)Zheng H, Chen XL, Han ZX, et al, Ligustrazine attenuates acute lung injury after burn trauma. Burns. 2005, 31(4):453-458. (IF=1.1)