北京大學心血管研究所副所長，北京大學基礎醫學院黨委委員，北大博雅特聘教授，全國重點實驗室主任助理，基礎醫學院心腦血管和代謝學科群副主任。國家“萬人計畫”科技創新領軍人才（萬人2023）；國家“萬人計畫”青年拔尖人才（青拔2015）；國家“優秀青年基金”獲得者（優青2014）；教育部“新世紀人才”人才基金。作為第一完成人獲得2022年北京醫學科技獎一等獎和2022年度北京市科學技術獎二等獎。主持國自然血管重大等7項國自然基金等，作為項目負責人（2023）參加科技部重大專項等5項，主持北京市重點基金（2023）等3項與京津冀聯合基金（2023）。心血管代謝與蛋白質組學研究室主任（PI），教授，博士生導師，專業為心血管病理生理學。
基本介紹
- 中文名：鄭樂民
- 國籍：中國
- 畢業院校：美國克利夫蘭州立大學
- 學位/學歷：博士
- 職業：教師、醫生
- 專業方向：病理生理學
- 發表論文數目：126篇（截至2024年4月）
研究方向,個人經歷,代表SCI論文,培養研究生獲獎,
研究方向
研究方向：
1. 代謝以及腸道菌群代謝對心腦血管疾病影響研究。代謝與心腦血管疾病研究密切相關，心腦血管疾病（包括心梗與中風）的發生髮展與預後都有代謝的參與，代謝調控是基因與蛋白調控之後一個重要的研究領域。該團隊也先後發現了一些代謝分子以及相關蛋白對心腦血管疾病的新的病理生理機制與臨床相關研究，其中包括琥珀酸代謝、能量代謝、脂代謝與脂蛋白等信號通路對於心腦血管系統的影響。腸道菌群是人體代謝的另一個重要來源，它存在著穩態與非穩態的平衡，這些平衡的打破能夠帶來不同的代謝物，由於這些代謝物的存在，從而影響到了腸道之外的其他器官，比如心腦血管系統等，從而產生了腸心軸、腸腦軸、腸肝軸等新的理論體系。該團隊發現了一系列新的腸道菌群代謝物例如TMAVA(三甲基-5-氨基戊酸)對心臟以及肝臟的病理生理作用，也發現了已經被大家熟知的TMAO（氧化三甲胺）新的病理生理功能比如在卒中與肺動脈高壓中的新機制。
2. 代謝對其他相關疾病影響研究。代謝除了對心腦血管疾病產生巨大作用外，代謝性疾病也會影響到心腦血管疾病之外的疾病例如糖尿病。同時代謝方面的機制不但能影響到糖尿病腎病、脂肪肝等代謝性疾病，還能通過代謝通路影響到腫瘤中的血管新生以及腫瘤。通過代謝的干預以及代謝相關調控，該們能夠對疾病的治療提供新的思路與見解。
3. 結合新材料新技術開展心腦血管相關轉化醫學研究。心腦血管功能方面的套用，包括治療與體外診斷技術的套用與研究。結合納米技術與探針材料開展對心腦血管的診斷與治療研究，對特定細胞例如炎症細胞等進行標記，對特定細胞進行藥物運輸，使得心腦血管的診斷與治療能夠在新賽道上繼續發展。開展包括生物質譜技術在內的診斷學研究，將新的監測與診斷技術套用在心腦血管疾病的預防與預後上。
個人經歷
2023年入選國家“萬人計畫”科技創新領軍人才。
2022年作為第一完成人獲得北京醫學科技獎一等獎和2022年度北京市科學技術獎二等獎。
2018年擔任北京大學心血管研究所副所長，教育部重點實驗室主任助理。
2014年擔任博士生導師；2015年擔任北京大學基礎醫學院研究員，博士生導師，研究室主任。
2005.3-2007.10，PrognostiX Inc.（現為克利夫蘭醫院所屬Cleveland Heart Lab），研究科學家。
2001.5-2005.3，克利夫蘭醫院細胞生物系，蛋白質組學中心，心血管診斷和防治中心，研究助理。
2000.8-2001.5，克利夫蘭州立大學化學系，教學助理。
1998.7-2000.7，中國科學院感光化學所，科研管理。
2000.8-2005.5 在美國第四大醫院克利夫蘭醫院（Cleveland Clinic）/美國克利夫蘭州立大學留學，2005.5獲得臨床生物分析化學博士。
1998.7畢業於北京師範大學化學系獲學士學位。
代表SCI論文
40篇代表SCI論文（*作為責任作者）中科院一區top5%為23篇
1. Rui Zhan,Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, YangkaiXu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang,Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen,Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li,Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, DehuaChui, Y Eugene Chen, Zheng Sun, *Erdan Dong, *Yongjun Wang, *Lemin Zheng.NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Aug29:S0896-6273(23)00622-0. (IF=16.2，JCR：Q1)
2. Pengxiang Qu,Oren Rom, Ke Li, Linying Jia, Xiaojing Gao, ZhipengLiu, Shusi Ding, Mingming Zhao, Huiqing Wang, Shuangshuang Chen, Xuelian Xiong,Ying Zhao, Chao Xue, Yang Zhao, Chengshuang Chu, Bo Wen, Alexandra C. Finney,Zuowen Zheng, Wenbin Cao, Jinpeng Zhao, Liang Bai, Sihai Zhao, Duxin Sun, RongZeng, Jiandie Lin, Wanqing Liu, *Lemin Zheng, *Jifeng Zhang, *Enqi Liu,Y. *Eugene Chen. DT-109 ameliorates nonalcoholic steatohepatitis in nonhumanprimates. Cell Metabolism.2023, April 10, ISSN 1550-4131. (IF=29，JCR：Q1)
3. Qingyuan Liu,Ke Li, Hongwei He, Zengli Miao, Hongtu Cui, Jun Wu, Shusi Ding,Zheng Wen, Jiyuan Chen, *Xiaojie Lu, *Jiangan Li, *Lemin Zheng, *ShuoWang. The markers and risk stratification model of intracranial aneurysminstability in a large Chinese cohort. Science bulletin.2023 May 10:S2095-9273(23)00308-0.(IF=18.9，JCR：Q1)
4. Jianing Gao,Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S Lu, *LeminZheng. The mechanism and therapy of aortic aneurysms. Signal transduction and targeted therapy.2023 Feb 3;8(1):55. (IF=39.3，JCR：Q1)
5. Jianing Gao,Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie,Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S Lu, Ying H Shen, YongLiu, Jifeng Zhang, Y Eugene Chen, Alan Daugherty, *Dao Wen Wang, *LeminZheng. Gasdermin D Deficiency in Vascular Smooth Muscle Cells AmelioratesAbdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Advanced Science (Weinh).2022 Dec25:e2204038. (IF=15.1，JCR：Q1)
6. Huanhuan Cao,Yujie Zhu, Gaofei Hu, Qi Zhang, *Lemin Zheng. Gut microbiome andmetabolites, the future direction of diagnosis and treatment ofatherosclerosis? PharmacologicalResearch. 2023 Jan;187:106586. (IF=9.3，JCR：Q1)
7. Mingming Zhao,Haoran Wei, Chenze Li, Rui Zhan, Changjie Liu, Jianing Gao, YaodongYi, Xiao Cui, Wenxin Shan, Liang Ji, Bing Pan, Si Cheng, Moshi Song, HaipengSun, Huidi Jiang, Jun Cai, Minerva Garcia-Barrio, Y. Eugene Chen, XiangbaoMeng, Erdan Dong, *Dao Wen Wang, *Lemin Zheng. Gut microbiota productionof trimethyl-5-aminovaleric acid reduces fatty acid oxidation and acceleratescardiac hypertrophy. NatureCommunications. 2022 Apr 1;13(1):1757. (IF=16.6，JCR：Q1)
8. Yang Y,Zeng Q, Gao J, Yang B, Zhou J, Li K, Li L, Wang A, LiX, Liu Z, Luo Q, Zhao Z, Liu B, Xue J, Jiang X, Konerman MC, *Zheng Lemin,*Xiong C. High-circulating gut microbiota-dependent metabolite trimethylamineN-oxide is associated with poor prognosis in pulmonary arterial hypertension. EuropeanHeart Journal Open. 2022 Mar29;2(5):oeac021.
9. Xu J,Hao X, Zhan R, Jiang X, Jin A, Xue J, Cheng A, Liu J,Lin J, Meng X, Li H, *Zheng L, *Wang Y. Effect of Lipoprotein(a) onStroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) andInflammation Levels. Stroke.2022 Apr 12:101161STROKEAHA121034924. (JCR：Q1)
10. Xiao-Xiao Chen,Yufei Wu, Xiaoxiao Ge, Liandi Lei, *Li-Ya Niu, *Qing-Zheng Yang, *LeminZheng. In vivo imaging of heart failure with preserved ejection fraction bysimultaneous monitoring of cardiac nitric oxide and glutathione using athree-channel fluorescent probe. Biosensorsand Bioelectronics. Volume 214, 2022, 114510, ISSN 0956-5663.（IF=12.6，JCR：Q1）
11. Cui H,Chen Y, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, LeiI, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, *WangD, *LeminZheng. Untargetedmetabolomics identifies succinate as a biomarker and therapeutic target inaortic aneurysm and dissection. EuropeanHeart Journal. 2021 Nov 7;42(42):4373-4385. (IF=39.3，JCR：Q1)
12. Jiang X, Xu J,Hao X, Xue J, Li K, Jin A, Lin J, Meng X, *Zheng L, *Wang Y. Elevatedlipoprotein(a) and lipoprotein-associated phospholipase A2 are associated withunfavorable functional outcomes in patients with ischemic stroke. Journal of Neuroinflammation. 2021Dec 28;18(1):307. (IF=9.3，JCR：Q1)
13. Xu J,Zhao M, Wang A, Xue J, Cheng S, Cheng A, Gao J, Zhang Q, Zhan R,Meng X, Xu M, Li H, Zheng L*, Wang Y*. Association Between PlasmaTrimethyllysine and Prognosis of Patients With Ischemic Stroke. Journal of the American Heart Association. 2021Dec 7;10(23):e020979.
14. Xu J,Cheng A, Song B, Zhao M, Xue J, Wang A, Dai L, Jing J, Meng X, LiH, *Zheng L, *Wang Y. Trimethylamine N-Oxide and Stroke RecurrenceDepends on Ischemic Stroke Subtypes. Stroke.2021 Nov 19:STROKEAHA120031443.(JCR：Q1)
15. Li C,Zhao M, Xiao L, Wei H, Wen Z, Hu D, Yu B, Sun Y, Gao J, Shen X,Zhang Q, Cao H, Huang J, Huang W, Li K, Huang M, Ni L, Yu T, Ji L, Xu Y, Liu G,Konerman MC, *Lemin Zheng, *WangD. Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid inPatients With Heart Failure. Circulation:Heart Failure. 2021 Nov;14(11):e008459 （IF=9.7，JCR：Q1）
16. Wu L,Liu C, Chang D Y, Zhan R, Zhao M, Lam S M, Shui G, Zhao M H, *Lemin Zheng, *Chen M. The attenuation of diabetic nephropathyby annexin A1 via regulation of lipid metabolism through AMPK/PPARα/CPT1bpathway. Diabetes. 2021 Oct;70(10):2192-2203.(JCR：Q1)
17. Wei H,Zhao M, Huang M, Li C, Gao J, Yu T, Zhang Q, Shen X, Ji L, Ni L,Zhao C, Wang Z, Dong E, Zheng L*, Wang DW*. FMO3-TMAO axis modulates theclinical outcome in chronic heart-failure patients with reduced ejectionfraction: evidence from an Asian population. Frontiers of Medicine. 2021 Jun 22. （JCR：Q1）
18.Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X,Ma D, Ji L, Li W, Xu S, *Pan B, *LeminZheng. Anxa1 insmooth muscle cells protects against acute aortic dissection. CardiovascularResearch. 2021 Mar 23:cvab109. (IF=10.8，JCR：Q1)
19.JingxuanLi, Yingyu Chen, Jianing Gao, Yue Chen, Changping Zhou,Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang,*Bing Pan, *Lemin Zheng. Eva1aameliorates atherosclerosis by promoting re-endothelialization of injuredarteries via Rac1/Cdc42/Arpc1b. CardiovascularResearch. 2021 Jan 21;117(2):450-461. (IF=10.8，JCR：Q1)
20. Man Z, Cui H, LvZ, Xu Z*, Wu Z, Wu Y, Liao Q, Liu M, Xi P*, Zheng L*, Fu H*. OrganicNanoparticles-Assisted Low-Power STED Nanoscopy. Nano Letters. 2021 Apr 28;21(8):3487-3494. (IF=10.8，JCR：Q1)
21. Wu L, Liu C, Chang DY, Zhan R, Sun J, Cui SH, Eddy S, NairV, Tanner E, Brosius FC, Looker HC, Nelson RG, Kretzler M, Wang JC, Xu M, Ju W,Zhao MH, *Chen M, *LeminZheng. AnnexinA1 alleviates kidney injury by promoting the resolution of inflammation indiabetic nephropathy. Kidney International.2021 Jul;100(1):107-121. (IF=19.6，JCR：Q1)
22.ZhangM, Gao J, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B,Yan X, Wu J, Meng X, Yin H, *Lemin Zheng.p38α in macrophages aggravates arterial endothelium injury by releasing IL-6through phosphorylating megakaryocytic leukemia 1. Redox Biology. 2021 Jan;38:101775. (IF=11.4，JCR：Q1)
23.JianKong, Changyu Yao, Shuying Dong, Shilun Wu,Yangkai Xu, Ke Li, Liang Ji, Qiang Shen, Qi Zhang, Rui Zhan, Hongtu Cui,Changping Zhou, Haigang Niu, Guoming Li, *Wenbing Sun, *Lemin Zheng.ICAM-1 Activates Platelets and Promotes Endothelial Permeability throughVE-cadherin after Insufficient Radiofrequency Ablation. AdvancedScience (Weinh).2021 Jan 4;8(4):2002228. (IF=15.1，JCR：Q1)
24.MingmingZhao, Lin Zhao, Xuelian Xiong, Yuan He, Wei Huang,Zihao Liu, Liang Ji, Bing Pan, Xuefeng Guo, Leibo Wang, Si Cheng, Ming Xu,Hongyuan Yang, Yuxin Yin, Minerva T. Garcia-Barrio, Y. Eugene Chen, XiangbaoMeng, *Lemin Zheng. TMAVA, aMetabolite of Intestinal Microbes, Is Increased in Plasma From Patients WithLiver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates FattyLiver in Mice. Gastroenterology.2020 Jun;158(8):2266-2281. (IF=29.4，JCR：Q1)
25.XiaoxiaoGe, Hongtu Cui, Jian Kong, Shi-Yu Lu, Rui Zhan, JianingGao, Yangkai Xu, Shuangyan Lin, Kaixin Meng, Lingyun Zu, Shaojun Guo, *Lemin Zheng. A Non-InvasiveNanoprobe for In Vivo Photoacoustic Imaging of Vulnerable AtheroscleroticPlaque. Advanced Materials. 2020 Sep;32(38):e2000037. (IF=29.4，JCR：Q1)
26.ZhengLv, Zhongwei Man, Hongtu Cui, Zhenzhen Xu*, HuanhuanCao, Shuai Li, Qing Liao, Qihua He, Lemin Zheng*, and Hongbing Fu*. RedAIE Luminogens with Tunable Organelle Specific Anchoring for Live Cell DynamicSuper Resolution Imaging. Advanced Functional Materials. 2020,31(10), 2009329. (IF=19.0，JCR：Q1)
27. Zheng Lv , Li Li, Zhongwei Man, Zhenzhen Xu*, Hongtu Cui, Rui Zhan,Qihua He, *Lemin Zheng, Hongbing Fu*. Polarity-activatedsuper-resolution imaging probe for the formation and morphology of amyloidfibrils. Nano Research. 2020, 13(9):2556-2563. (IF=9.9，JCR：Q1)
28. Jianping Li, Changping Zhou, Hongbing Xu, Robert Brook,Shengcong Liu, Tieci Yi, Yang Wang, Baihuan Feng, Mingming Zhao, Xu Wang, QianZhao, Jie Chen, Xiaoming Song, Tong Wang, Shuo Liu, Yi Zhang, Rongshan Wu,Jianing Gao, Bing Pan, Subramaniam Pennathur, Sanjay Rajagopalan, Yong Huo, *Lemin Zheng, *Wei Huang. Ambient Air Pollution isAssociated with High-Density Lipoprotein Dysfunction in Healthy Adults. Arteriosclerosis, Thrombosis, and VascularBiology. 2019 Mar;39(3):513-522. （JCR：Q1）
29. Man Z, Lv Z, *XuZ, Cui H, Liao Q, Zheng Lemin*, JinX, He Q, Fu H*. Organic nanoparticles with ultrahigh stimulated emissiondepletion efficiency for low-power STED nanoscopy. Nanoscale. 2019;11(27):12990-12996. (JCR：Q1)
30.He D, Zhao M, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L,Willard B, Mathew A, Chen Y, Pennathur S, Yin H, He Y, *Pan B, *Lemin Zheng.Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing andcompromises reendothelialization impaired by oxidized HDL through SR-B1. RedoxBiology.2018May;15:228-242. (IF=11.4，JCR：Q1)
31.Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, ZhangT, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, ChenY, *Chui D, *Lemin Zheng. Dapsone protectsbrain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death & Disease. 2018 Jun7;9(6):683. （IF=9.0，JCR：Q1）
32.Li D, Ke Y, Zhan R, Liu C,Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, *Lemin Zheng, *Hong H.Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice. Aging Cell. 2018 Aug;17(4):e12768. (JCR：Q1)
33. Liu D,Ji L, Zhao M, Wang Y, Guo Y, Li L, Zhang D, Xu L, Pan B, Su J,Xiang S, Pennathur S, Li J, Gao J, Liu P, *Willard B, *Lemin Zheng.Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory functionin type 2 diabetes mellitus. Journalof Molecular and Cellular Cardiology. 2018 Sep;122:47-57.
34. Ke Y,Li D, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, *LeminZheng, *Hong H. Gut flora-dependent metabolite Trimethylamine-N-oxideaccelerates endothelial cell senescence and vascular aging through oxidativestress. Free Radical Biology andMedicine. 2018 Jan 8;116:88-100. (JCR：Q1)
35. Lu J, Chen B, Chen T, Guo S,Xue X, Chen Q, Zhao M, Xia L, Zhu Z, *Lemin Zheng, *Yin H. Comprehensive metabolomics identified lipidperoxidation as a prominent feature in human plasma of patients with coronaryheart diseases. Redox Biology. 2017 Aug;12:899-907. (IF=11.4，JCR：Q1)
36. Feng C, *Xu Z, Wang X, Yang H, *Lemin Zheng, *Fu H.Organic-nanowire-SiO2 core-shell microlasers with highly polarized and narrowemissions for biological imaging. ACS Applied Materials &Interfaces. 2017.Mar 1;9(8):7385-7391. (IF=9.5，JCR：Q1)
37. Zhang H, Wang X, Liao Q, Xu Z, Li H, *Lemin Zheng, *Fu H. EmbeddingPerovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probesin Cell Imaging. Advanced Functional Materials.2017Feb;27(7):1604382. (IF=19.0，JCR：Q1)
38.KongJ, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, *Lemin Zheng, Sun W*, YC-1 enhances theanti-tumor activity of sorafenib through inhibition of signal transducer andactivator of transcription 3 (STAT3) in hepatocellular carcinoma. MolecularCancer. 2014 Jan 13;13:7.(IF=37.3，JCR：Q1)
39. Pan B, Ren H, He Y, Lv X, Ma Y,Li J, Huang L, Yu B, Kong J, Niu C, Zhang Y, Sun WB, *LeminZheng. HDLof Patients with Type 2 Diabetes Mellitus Elevates the Capability of PromotingBreast Cancer Metastasis. ClinicalCancer Research. 2012 Mar 1;18(5):1246-56.(IF=11.5，JCR：Q1)
40. Lemin Zheng, Nukuna B, Brennan M, Sun M, GoormasticM, Settle M, Schmitt D, Fu X, Thomson L, Fox P, Ischiropoulos H, Smith J,Kinter M, and Hazen S. Apolipoprotein A-I is a selective target formyeloperoxidase-catalyzed oxidation and functional impairment in subjects withcardiovascular disease. Journal of Clinical Investigation.2004 Aug;114(4):529-41. (IF=15.9，JCR：Q1)
培養研究生獲獎
高佳寧（博士生, 2023，鄭樂民為導師）：北京大學“優博”。
吳靚 （博士生, 2022，鄭樂民為共同導師）：北京市“優博”；北京大學“優博”。
崔宏圖（博士生, 2021，鄭樂民為導師）：北京市優秀畢業生；北大優秀畢業生；國家“博新計畫博士後” 獲得者。
趙明明（博士生, 2020，鄭樂民為導師）：北京市優秀畢業生；北京大學“優博”；北大優秀畢業生；國家“博新計畫博士後”獲得者。現為北大第三醫院副研究員。
