鄭媛婷，復旦大學生命科學學院副教授，從事藥物基因組學與臨床個性化用藥的基礎與轉化研究。
基本介紹
- 中文名：鄭媛婷
- 國籍：中國
- 畢業院校：中國藥科大學
- 學位/學歷：理學博士
人物簡介,研究方向,主要成果,
人物簡介
研究方向
從事藥物基因組學與臨床個性化用藥的基礎與轉化研究。採用高通量組學、生物信息學和分子生物學等手段，研究腫瘤、2型糖尿病等疾病個性化用藥標誌物與治療新靶點。
主要成果
1.Qing T, Zhu SB, Suo C, Zhang L,Zheng YT*, Shi LM*. Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients.Scientific Reports. 2017; 7(1): 4951.
2.Zhu JH, Chen G, Zhu SB, Li SQ, Wen Z, Li B,Zheng YT*, Shi LM*. Identification of tissue-specific protein-coding and noncoding transcripts across 14 human tissues using RNA-seq.Scientific Reports. 2016; 6: 28400.
3. Wen Z, Chen G, Zhu SB, Zhu JH, Li B, Song YJ, Li SQ, Shi LM,Zheng YT*, Li ML*. Expression profiling and functional annotation of noncoding genes across 11 distinct organs in rat development.Scientific Reports. 2016; 6: 38575.
4. Zhou N#,Zheng YT#, Xing JF, Yang HY, Chen HM, Xiang XQ, Liu J, Tong SS, Zhu B, Cai WM. Application of a new dynamic model to predict the in vitro intrinsic clearance of tolbutamide using rat microsomes encapsulated in a Fab hydrogel.Drug Metabolism and Disposition. 2016; 44 (1): 40-9.
5.Zheng YT, Qing T, Song YJ, Zhu JH, Yu Y, Shi WW, Pusztai L, Shi LM. Standardization efforts enabling next-generation sequencing and microarray based biomarkers for precision medicine.Biomarkers in Medicine. 2015; 9(11): 1265-72.
6.Zheng YT, Yang HY, Li T, Zhao B, Shao TF, Xiang XQ, Cai WM. Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway.Acta Pharmacologica Sinica. 2015; 36(5): 614-26.
7. Shao TF,Zheng YT*, Zhao B, Li T, Cheng KG, Cai WM. Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity.Science China Life Sciences. 2014; 57(10): 1011-7.
8. Yang HY#,Zheng YT#, Zhao B, Shao TF, Shi QL, Zhou N, Cai WM. Encapsulation of liver microsomes into a thermosensitive hydrogel for characterization of drug metabolism and toxicity.Biomaterials. 2013; 34(38): 9770-8.
9. Wang J, Yu Y, Shen H, Qing T,Zheng Y, Li Q, Mo X, Wang S, Li N, Chai R, Xu B, Liu M, Brindley PJ, McManus DP, Feng Z, Shi L, Hu W. Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum.Nature Communications. 2017; 8: 14693.22.
10. Su Z#, Łabaj PP#, Li S#, Thierry-Mieg J#, Thierry-Mieg D#, Shi W#, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD, Xiao W, Xu W, ,…,Zheng YT, …, Kreil DP*, Mason CE*, Shi L*. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology, 32(9):903-14 (2014).
