鄧聯東

鄧聯東，中國籍，漢族，天津大學化工學院高分子科學與工程系副教授。

基本介紹

• 中文名：鄧聯東
• 國籍：中國
• 民族：漢族
• 職業：副教授

人物簡介

鄧聯東，天津大學化工學院高分子科學與工程系副教授。

研究方向

主要從事功能高分子材料與藥用輔料的相關研究工作，主要涉及的領域包括溫敏原位水凝膠材料、聚合物納米材料、納米藥物遞送和siRNA 納米遞送系統。

講授課程

聚合物合成工藝學

功能高分子材料

功能材料

高分子反應工程

科研項目

(1) 國家自然科學基金面上項目，項目名稱：“自凝膠和自釋放功能性納米載體腫瘤定位持續釋放siRNA與化療藥物”，項目編號：81371667，經費：70萬，期限：2014.01.01-2017.12.31

(2) 天津大學自主創新基金，項目名稱：“基於多元持續定位遞送系統提高納米藥物抗腫瘤功效的基礎科學問題”，項目編號：2013XJ-0011，經費：15萬，期限：2013.01-2015.12

(3) 863項目，項目名稱：“小核酸技術的前言研究-核酸新型遞送系統的製備和表征”，項目編號：2012AA022501，經費：39.33，期限：2012.11-2015.12

(4) 天津市自然科學基金項目，項目名稱：“注射用新型可生物降解原位凝膠材料的研究”，項目編號：08JCYBJC01800，經費10萬，期限：2008.4～2011.3。

(5) 負責多吉美的聚合物納米粒的製備及初步評價，合作方：上海中醫藥大學附屬普陀醫院，經費2萬，期限：2011.6.22-2011.8.30

(6) 載藥聚乳酸/聚乙二醇嵌段共聚物納米粒的製備，合作方：上海中醫藥大學附屬普陀醫院，經費2.5萬，期限：2011.9.15-2011.11.30

代表性論文

(第一作者或通訊作者)：

(1) Xiang Yuzhang, Xiao Miao, Han Shangcong, Xu Shuxin, Cao Yan, Lv Zesheng, Liu Jianfeng, Liu Jinjian, Deng Liandong, Dong Anjie. Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. 2014, 25(11): 1144-1158. DOI: 10.1080/09205063.2014.923365

(2) Shuxin Xu, Weiwei Wang, Xijing Li, Jianping Liu, Anjie Dong, Liandong Deng. Sustained release of PTX-incorporated nanoparticles synergized by burst release of DOX·HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency. European Journal of Pharmaceutical Sciences, 2014, 62: 267–273

(3) Zesheng Lv, Longlong Chang, Xingwen Long, Jianping Liu, Yuzhang Xiang, Jinjian Liu, Jianfeng Liu, Hongzhang Deng, Liandong Deng,∗, Anjie Dong. Thermosensitive in situ hydrogel based on the hybrid of hyaluronicacid and modified PCL/PEG triblock copolymer. Carbohydrate Polymers, 2014, 108: 26-33

(4) LL Chang, WW Wang, PS Huang, ZS Lv, FQ Hu, JH Zhang, DL Kong, LD Deng, AJ Dong. Photo-crosslinked poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles for controllable paclitaxel release. J Biomat Sci-Polym E, 2013, 24(16): 1900-1921, DOI: 10.1080/09205063.2013.808152

(5) Chaoyu Wang, Jing Zhang, Jingjing Li, Liandong Deng, Anjie Dong, Xianggao Li. Preparation and characterization of TiO₂/SiO₂-cationic hybrid nanoparticles for electrophoretic displays. J Nanopart Res, 2013, 15(9):1921

(6) Jiao Li, Pingsheng Huang, Longlong Chang, Xingwen Long, Anjie Dong, Jinjian Liu, Liping Chu, Fuqiang Hu, Jianfeng Liu, Liandong Deng. Tumor targeting and pH-responsive polyelectrolyte complex nanoparticles based on hyaluronic acid-paclitaxel conjugates and Chitosan for oral delivery of paclitaxel. Macromolecular Research, 2013, 21(12): 1331-1337. DOI: 10.1007/s13233-013-1171-x

(7) LL Chang, JJ Liu, JH Zhang, LD Deng, AJ Dong. pH-sensitive nanoparticles prepared from amphiphilic and biodegradable methoxy poly(ethylene glycol)-block-(polycaprolactone-graft- poly(methacrylic acid)) for oral drug delivery. Polym Chem, 2013, 4, 1430

(8) C Chen, L Wang, LD Deng, RJ Hu, AJ Dong. Performance optimization of injectable chitosan hydrogel by combining physical and chemical triple crosslinking structure. J Biomed Mater Res Part A: 101A: 684-693, 2013

(9) Zhang Biao, Deng Liandong, Xing Jinfeng, Yang Jun, Dong Anjie. Ternary Complexes of Poly(Vinyl Pyrrolidone)-Graft-Poly(2-Dimethylaminoethyl Methacrylate), DNA and Bovine Serum Albumin for Gene Delivery. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2013, 24(1): 45-60

(10)Yanqin Liang, Li Xiao, Yinglei Zhai, Chaopeng Xie, Liandong Deng, Anjie Dong. Preparation and Characterization of Biodegradable Poly(sebacic anhydride) Chain Extended by Glycol as Drug Carrier. J Appl Polym Sci, 2013, 127: 3948-3953

(11)Longlong Chang, Liandong Deng, Weiwei Wang, Zesheng Lv, Fuqiang Hu, Anjie Dong, and Jianhua Zhang. Poly(ethyleneglycol)‑b‑Poly(ε-caprolactone-co-γ-hydroxyl-ε-caprolactone) Bearing Pendant Hydroxyl Groups as Nanocarriers for Doxorubicin Delivery. Biomacromolecules, 2012, 13: 3301-3310

(12)B Liu, LD Deng, CG Guo, RW Guo, AJ Dong, JH Zhang. Facile Prepared Bis(carbazyl thiocarbonyl) Disulfide as Chain Transfer Agent for RAFT Polymerization of Methyl Methacrylate. J Appl Polym Sci, 2012,126: 740-748

(13)B Zhang, LD Deng, JF Xing, J Yang, AJ Dong. Improved biocompatibility of poly(vinylpyrrolidone)-graft-poly(2-dimethylaminoethyl methacrylate)/DNA complexes by coating with bovine serum albumin. Chinese Chemical Letters, 2012, 23: 627-630

(14)J Zhang, YQ Liang, N Li, X Li, RJ Hu, JF Xing, LD Deng, FQ Hu, AJ Dong. Thermosensitive hydrogel based on poly(ether-ester anhydride) nanoparticle as drug delivery system: Preparation, characterization and biocompatibility. Colloids and Surfaces B-Biointerfaces, 2012, 96: 56-61

(15) J Zhang, YQ Liang, N Li, XM Zhao, RJ Hu, FQ Hu, JF Xing, LD Deng, AJ Dong. Poly(ether-ester anhydride)-based amphiphilic block copolymer nanoparticle as delivery devices for paclitaxel. Micro & Nano Letters, 2012, 7(2): 183-187

(16) XN Lin, LD Deng, AJ Dong. Synthesis of Fluorescent Methoxy Poly(ethylene glycol)-b-Poly(ethyl cyanoacrylate)-2-(N-carbazolyl) Ethyl Methacrylate Copolymer via Living Oxyanion-Initiated Polymerization. J Appl Polym Sci, 2012, 123: 3575-3579

(17) C Chen, AJ Dong, J Yang, LD Deng. Preparation and properties of an injectable thermo-sensitive double crosslinking hydrogel based on thiolated chitosan/beta-glycerophosphate. J Mater Sci, 2012, 47: 2509-2517

(18) JJ Li, LD Deng, JF Xing, AJ Dong, XG Li. Preparation and characterization of TiO2-cationic hybrid nanoparticles as electrophoretic particles. Appl Surf Sci, 2012, 258: 3152-3157

(19) WW Wang, LL Chang, X Li, YL Wu, JF Xing, LD Deng, AJ Dong. Controlled thermal gelation of poly(epsilon-caprolactone)/poly(ethylene glycol) block copolymers by modifying cyclic ether pendant groups on poly(epsilon-caprolactone). Soft Matter, 2012, 8(5): 1575-1583

(20) YQ Liang, Y Qiao, ST Guo, L Wang, YL Zhai, CP Xie, RJ Hu,LD Deng, AJ Dong. Investigation on Injectable, Thermally and Physically Gelable Poly(Ethylene Glycol)/Poly(Octadecanedioic Anhydride) Amphiphilic Triblock Co-polymer Nanoparticles. J Biomat Sci-Polym E, 2012, 23: 465-482

(21) JF Xing,LD Deng, CP Xie, L Xia, YL Zhai, FM Jin, YM Li, AJ Dong. Methoxy poly(ethylene glycol)-b-poly(octadecanoic anhydride)-b-methoxy poly(ethylene glycol) amphiphilic triblock copolymer nanoparticles as delivery vehicles for paclitaxel. Polym. Adv. Technol. 2011, 22 669-674

(22) YQ Liang, L Xiao, YM Li, YL Zhai, CP Xie,LD Deng, AJ Dong. Poly(ester anhydride)/mPEG Amphiphilic Block Co-polymer Nanoparticles as Delivery Devices for Paclitaxel. J Biomat Sci-Polym E, 2011, 22: 701-715

(23) XY Yue, Y Qiao, N Qiao, ST Guo, JF Xing, LD Deng, JQ Xu, AJ Dong. Amphiphilic Methoxy Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) Cationic Copolymer Nanoparticles as a Vector for Gene and Drug Delivery. Biomacromolecules, 2010, 11: 2306-2312

(24) ST Guo, WW Wang, LD Deng, JF Xing, AJ Dong. Poly(epsilon-caprolactone)-graft-poly(2- (dimethylamino)ethyl methacrylate) Amphiphilic Copolymers Prepared via a Combination of ROP and ATRP: Synthesis, Characterization, and Self-Assembly Behavior. Macromol Chem Phys, 2010, 211(14): 1572-1578

(25) YQ Liang, Y Qiao, ST Guo, L Wang, CP Xie, YL Zhai,LD Deng, AJ Dong. Thermoreversible gelation of poly(ethylene glycol)/poly(ester anhydride) triblock copolymer nanoparticles for injectable drug delivery systems. Soft Matter, 2010, 6: 1915-1922

(26) LD Deng, YL Zhai, ST Guo, FM Jin, CP Xie, XH He, AJ Dong. Investigation on properties of P((MAA-co-DMAEMA)-g-EG) polyampholyte nanogels. J Nanopart Res, 2009, 11: 365-374

(27) YL Zhai, Y Qiao, CP Xie, XN Lin, YZ Ma, AJ Dong, LD Deng. Preparation and In Vitro Release of D,L-tetrahydropalmatine-Loaded Graft Copolymer Nanoparticles. J Appl Polym Sci, 2008, 110: 3525-3531

(28) XN Lin, RM Zhou, Y Qiao, FM Jin, YL Zhai, JF Xing, LD Deng, AJ Dong. Poly(ethylene glycol)/Poly(ethyl cyanoacrylate) Amphiphilic Triblock Copolymer Nanoparticles as Delivery Vehicles for Dexamethasone. J Polym Sci: Part A: Polym Chem, 2008, 46: 7809-7815

已獲專利

(1) 鄧聯東，董岸傑，癸二酸酐與十八烷二元酸酐共聚物及其製備方法和套用，ZL 200710056732.2

(2) 鄧聯東，董岸傑等，兩親性三嵌段共聚物及製備方法和套用，ZL200810053015.9

(3) 董岸傑，鄧聯東，溫敏性可生物降解聚酸酐共聚物及其水凝膠體系和套用，ZL200610129256.8

(4)鄧聯東，郭術濤，劉莎莎，董岸傑，含環醚側基的可生物降解兩親性嵌段共聚物及其製備方法和套用，ZL 201010200249.9

(5)鄧聯東，董岸傑等，ABC型兩親性生物降解聚酯三嵌段共聚物及製備方法和套用，ZL 200910070599.5

(6)鄧聯東，董岸傑，李晶晶，二氧化鈦/陽離子聚合物核殼結構的電泳粒子及其製備方法， ZL 201110268650.0