鄒鈞(上海海洋大學水產及生命學院教授)

鄒鈞, 上海海洋大學水產及生命學院特聘教授，博士生導師，水產及生命學院水生動物醫學系主任，魚類免疫學與病害防控學科方向帶頭人。

基本介紹

• 中文名：鄒鈞
• 出生地：湖南
• 職業：教授
• 畢業院校：阿伯丁大學

教育經歷

1987年畢業於北京大學生物系，獲學士學位，1990年獲中國科學院水生生物研究所碩士學位(導師：朱作言院士)，1992年留學英國阿伯丁大學(University of Aberdeen)並於1998年獲得博士學位（導師：朱作言院士和Dominic F Houlihan教授）。曾任阿伯丁大學生命與環境科學研究所研究員、高級研究員和蘇格蘭魚類研究中心科研主任。

主要成就

2004年獲得國家自然科學基金委海外傑出青年基金（B類，海外）資助、2012年獲福建省“閩江學者”。現為Developmental and Comparative Immunology、Fish and Shellfish Immunology、Biology和Aquaculture and Fisheries編委，多次擔任國家自然科學基金委生命科學部會審評審和科技部海外函評專家，以及英國醫學研究基金會（Medical Research Council）、英國生物技術與生命科學研究基金會（Biotechnology and Biological Sciences Research Council）、德國研究基金會(German Research Council)、瑞士國家科學基金會（Swiss National Science Foundation）研究項目函評人。

長期從事魚類遺傳學、免疫學和魚類病害防控研究，分別於1999、2004、2007和2009年首次報導了魚類白細胞介素1、伽馬乾擾素、防禦素和模式識別受體類RIG_I家族；對魚類細胞因子的功能與進化，尤其是魚類干擾素的抗病毒功能與起源等進行了深入探討和研究，開創性地提出了脊椎動物I型干擾素的分子進化理論。在PLOS Pathogens、J Immunology、J Virology、Immunological Reviews等學術刊物上發表研究論文和綜述120餘篇，論文總引用率達5600餘次，H因子為47。

主要研究方向

研究領域：魚類免疫學、比較免疫學。主要研究方向包括：1）魚類細胞因子與T/B細胞功能；2）宿主與病原互作機制；3）養殖魚類疫苗與免疫製劑的作用機理；4）魚類抗病的分子遺傳機制；5）免疫系統起源與分子進化。

主持和參與的科教項目

[1]國家自然科學基金委員會與葡萄牙科技基金會合作研究項目（課題編號：41761134050），魚類免疫在極端環境下的進化，2017/01-2019/12，251萬元，在研，參與

[2]國家自然科學基金委員會重大國際合作項目（課題編號：31320103913），魚類伽馬乾擾素的分泌調控，信號傳導及其免疫功能研究，2014/01-2018/12，270萬元，在研，境外合作人

[3]國家自然科學基金傑出青年科學基金（亞類，海外青年學者合作研究基金，課題編號：3042B24），RNAi transgenic fish，2005/01-2007/12，40萬元，已結題，主持

　　

　　

發表的主要論文情況

[1] Milne DJ, Campoverde C,Andree KB, Chen X,Zou J, Secombes CJ. The discovery and comparative expression analysis of three distinct type Iinterferons in the perciform fish, meagre (Argyrosomus regius). Dev Comp Immunol. 2018;84:123-32.

[2] Secombes, CJ,Zou J. Evolution of interferons and interferon receptors. Front Immunol. 2017;8:209. doi: 10.3389/fimmu.2017.00209.

[3] Milne DJ, Campoverde C,Andree KB,Zou J, Secombes CJ. Two types of TNFα in meagre (Argyrosomusregius):Discovery, distribution and expression modulation. Mol Immunol. 2017;92:136-45.

[4] Lee PT, Bird S,Zou J, Martin SAM. Phylogeny and expression analysis of C-reactive protein (CRP) and serum amyloid-P (SAP) like genes reveal two distinct groups in fish. Fish Shellfish Immunol. 2017;65:42-51.

[5] Wang J, Wang T, Benedicenti O, Collins C, Wang K,Secombes CJ,Zou J. Characterisation of ZBTB46 and DC-SCRIPT/ZNF366 in rainbow trout, transcription factors potentially involved in dendritic cell maturation and activation in fish. Dev Comp Immunol.2016;doi: 10.1016/j.dci.2016.11.007.

[6] Yoon S, Alnabulsi A, Wang TY, Lee PT, Chen TY,Bird S,Zou J, Secombes CJ. Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Fish Shellfish Immunol. 2016;57:79-86.

[7]Zou J,Secombes CJ. The Function of Fish Cytokines. Biology (Basel). 2016;5(2).pii:E23.Doi: 10.3390/biology5020023.

[8] Maisey K, Montero R, Corripio-Miyar Y,Toro-Ascuy D, Valenzuela B, Reyes-Cerpa S, Sandino AM,Zou J, Wang T, Secombes CJ, Imarai M. Isolation and Characterization of Salmonid CD4+ T Cells. J Immunol. 2016;196:4150-63.

[9] Yousaf MN, Koppang EO,Zou J, Secombes CJ, Powell MD. Immunolocalization of immune cells and cell cycle proteins in the bulbus arteriosus of Atlantic salmon (Salmo salarL.). Fish Shellfish Immunol. 2016;51:64-9.

[10] Gorgoglione B, Zahran E, Taylor NG, Feist SW,Zou J, Secombes CJ. Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen. Mol Immunol. 2016;71:64-77.

[11] Xu Q, Jiang Y, Wangkahart E,Zou J, Chang M, Yang D, Secombes CJ,Nie P, Wang T. Sequence and Expression Analysis of Interferon Regulatory Factor10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense.PLoS One. 2016;11:e0147181.

[12] Zou J, Redmond AK, Qi Z, Dooley H,Secombes CJ.The CXC chemokine receptors of fish: Insights into CXCR evolution in the vertebrates. Gen Comp Endocrinol. 2015;215:117-31.

[13] Johansson P, Wang T,Collet B, Corripio-Miyar Y, Monte MM, Secombes CJ,Zou J. Identification and expression modulation of a C-type lectin domain family 4 homologue that is highly expressed in monocytes/macrophages in rainbow trout (Oncorhynchus mykiss).Dev Comp Immunol. 2016;54:55-65.

[14] Yoon S, Mitra S, Wyse C,Alnabulsi A,Zou J, Weerdenburg EM,M van der Sar A, Wang D, Secombes CJ, Bird S. First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One.2015;10:e0126378.

[15] Bela-Ong DB, Schyth BD,Zou J, Secombes CJ, Lorenzen N. Involvement of two microRNAs in the early immune response to DNA vaccination against a fish rhabdovirus. Vaccine. 2015;33:3215-22.

[16] Lee PT,Zou J, Holland JW, Martin SA, Scott CJ,Kanellos T, Secombes CJ. Functional characterisation of a TLR accessory protein, UNC93B1, in Atlantic salmon (Salmo salar). Dev Comp Immunol. 2015;50:38-48.

[17] Monte MM, Wang T, Collet B,Zou J, Secombes CJ. Molecular characterisation of four class 2 cytokine receptor family members in rainbowtrout,Oncorhynchus mykiss. Dev Comp Immunol. 2015;48:43-54.

[18] Heidari Z, Bickerdike R,Tinsley J,Zou J, Wang TY, Chen TY,Martin SA. Regulatory factors controlling muscle mass: Competition between innate immune function and anabolic signals in regulation of atrogin-1 in Atlantic salmon. Mol Immunol. 2015;67:341-9.

[19] Heidari Z, Tinsley J,Bickerdike R, McLoughlin MF,Zou J,Martin SA. Antiviral and metabolic gene expression responses to viral infectionin Atlantic salmon (Salmo salar).Fish Shellfish Immunol. 2015;42:297-305.

[20]Zou J, Gorgoglione B, Taylor NGH, Summathed T, Lee PT, Panigrahi A, Genet C, Chen YM, Chen TY, Hassan M, Mughal SM, Boudinot P, Secombes CJ.Salmonids have an extraordinary complex type I interferon system: Characterisation of the IFN locus in rainbow troutOncorhynchus mykissreveals two novel IFN subgroups. J Immunol.2014;193:2273-86.

[21] Boudinot P,Zou J, Ota T, Buonocore F, Scapigliati G, Canapa A, Cannon J, Litman G, Hansen JD. A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths. J Exp Zool B Mol DevEvol.2014;322:415-37.

[22] Lee PT,Zou J,Holland JW, Martin SA, Collet B, Kanellos T, Secombes CJ. Identification and characterisation of TLR18-21 genes in Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2014;41:549-59.

[23] Powell MD, Yousaf MN,Rasmussen KJ, Köllner B,Zou J,Secombes C, Speare DJ. Immunohistochemical localization of inflammatory cellsand cell cycle proteins in the gills of Loma salmonae infected rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2014;40:91-8.

[24] Chen YM, Kuo CE, ChenGR, Kao YT,Zou J, Secombes CJ, Chen TY. Functional analysis of an orange-spotted grouper (Epinepheluscoioides) interferon gene and characterisation of its expression in response to nodavirus infection. Dev Comp Immunol.2014;46:117-28.

[25] Chang MX#,Zou J#, Nie P, Huang B, Yu Z, Collet B,Secombes CJ.Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013;9:e1003736. (# Joint first author).

[26] Chen J, Xu Q, Wang T,Collet B, Corripio-Miyar Y, Bird S, Xie P, Nie P, Secombes CJ,Zou J. Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. Dev Comp Immunol. 2013;41:137-52.

[27] Lee PT,Zou J, Holland JW, Martin SA, Kanellos T, Secombes CJ. Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar). Dev Comp Immunol.2013;41:295-305.

[28] Monte MM, Wang T,Holland JW,Zou J, Secombes CJ. Cloning and characterisation of rainbow trout Interleukin (IL)-17A/F2 and IL-17RA: Expression during infection and bioactivity of the recombinant IL-17A/F2. Infect and Immun. 2013;81:340-53.

[29] Yousaf MN, Koppang EO,Skjødt K, Hordvik I,Zou J, Secombes C, Powell MD. Comparative cardiac pathological changes of Atlantic salmon (Salmo salarL.) affected with heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD). Vet ImmunolImmunopathol. 2013;151:49-62.

[30] Li R, Wang T, Bird S,Zou J, Dooley H, Secombes CJ. B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias). Fish Shellfish Immunol. 2013;34:1404-15.

[31] Yousaf MN, Koppang EO,Skjødt K, Köllner B, Hordvik I,Zou J,Secombes C, Powell MD. Cardiac pathological changes of Atlantic salmon (Salmo salarL.) affected with heart and skeletal muscle inflammation (HSMI). Fish Shellfish Immunol. 2012;33:305-15.

[32] Johansson P,Corripio-Miyar Y, Wang T, Collet B, Secombes CJ,Zou J. Characterisation and expression analysis of the rainbow trout (Oncorhynchus mykiss) homologue of the human dendritic cell marker CD208/lysosomal associated membrane protein3. Dev Comp Immunol. 2012;37:402-13.

[33] Corripio-Miyar Y,Secombes CJ,Zou J. Long-term stimulation of trout head kidney cells with the cytokines MCSF, IL-2 and IL-6:Gene expression dynamics. Fish Shellfish Immunol. 2012;32:35-44.

[34]Zou J, Secombes CJ. Teleost fish interferons and their role inimmunity. Dev Comp Immunol. 2011;35:1376-87.

[35] Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes CJ,Zou J. Expression and functional characterization of the RIG-I like receptors MDA5 and LGP2 in rainbow troutOncorhynchus mykiss. J Virol. 2011;85:8403-12.

[36] Sun B, Skjæveland I,Svingerud T,Zou J, Jørgensen J, Robertsen B. Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type Iinterferon. J Virol. 2011;85:9188-98.

[37]Zou J, Bird S, Secombes CJ. Antiviral sensing in teleost fish.Current Pharmaceutical Design 2011;16:4185-93.

[38] Monte MM,Zou J, Wang T, Carrington A, Secombes CJ. Cloning, expression analysis and bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-22. Cytokine.2011;55:62-73.

[39] Shewring DM,Zou J, Corripio-Miyar Y,Secombes CJ.Analysis of the cathelicidin 1 gene locus in Atlantic cod (Gadusmorhua). Mol Immunol.2011;48:782-7.

[40] Castro R,Zou J, Secombes CJ, Martin SA.Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line. Fish Shellfish Immunol.2011;30:215-23.

[41] Chang M, Wang T, Nie P,Zou J, Secombes CJ.Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol.2010;30:118-27.

[42] Qi Z, Nie P, Secombes C,Zou J.Intron-containing type I and III interferons (IFN) co-exist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs. J Immunol.2010;184:5038-46.

[43] Chaves-Pozo1E,Zou J,Secombes C, Cuesta1A,Tafalla C.The rainbow trout (Oncorhynchus mykiss) interferon response in the ovary. Mol Immunol.2010;47:1757-64.

[44] Chen WQ, Xu QQ, Chang MX,Zou J, Secombes CJ, Peng KM, Nie P.Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gammarel) in grass carpCtenopharyngodonidella. Vet Immunol Immunopathol.2010;134:199-207.

[45] Castro R, Martin SA,Zou J, Secombes CJ.Establishment of an IFN-gamma specific reporter cell line in fish.Fish Shellfish Immunol.2010;28:312-9.

[46]Zou J, Chang M, Nie P, Secombes CJ. Origin and evolution of the RIG-I like RNA helicase gene family. BMC Evol Biol. 2009;9:85.

[47] Chang M, Nie P, Collet B, Secombes CJ,Zou J. Identification of an additional two-cysteine containing type I interferon in rainbowtroutOncorhynchus mykissprovidesevidence of a major gene duplication eventwithin this gene family in teleosts. Immunogenetics. 2009;61:315-25.

[48] Gao Q, Nie P, Thompson KD, Adams A, Wang T, Secombes CJ,Zou J. The search for the IFN-γ receptor in fish: functional and expression analysis of putative binding and signallingchains in rainbowtroutOncorhynchusmykiss. Dev Comp Immunol.2009;33:920-31.

[49] Corripio-Miyar Y,Zou J, Richmond H, Secombes CJ. Identification of interleukin-22 in gadoids and examination of its expression level in vaccinatedfish. Mol Immunol. 2009;46:2098-106.

[50] Wang T, Bird S, Koussounadis A, Holland JW, Carrington A,Zou J, Secombes CJ. Identification of a novel IL-1 cytokine family memberin teleostfish. J Immunol. 2009;183:962-74.

[51] Díaz-Rosales P, Bird S, Wang TH, Fujiki K, Davidson WS,ZouJ,Secombes CJ. Rainbow trout interleukin-2: Cloning, expression and bioactivityanalysis. Fish Shellfish Immunol. 2009;27:414-42.

[52] Casadei E, Wang T,Zou J, González Vecino JL, Wadsworth S, Secombes CJ. Characterization of three novel beta-defensin antimicrobial peptides in rainbow trout (Oncorhynchus mykiss).Mol Immunol. 2009;46:3358-66.

[53] Casani D, Randelli E, Costantini S, Facchiano AM,Zou J, Martin S, Secombes CJ, Scapigliati G, Buonocore F.Molecular characterisation and structural analysis of an interferon homologue in seabass(Dicentrarchuslabrax L.). Mol Immunol.2008;46:943-52.

[54] Harun NO,Zou J, Zhang YA, Nie P, Secombes CJ. The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8. Dev Comp Immunol. 2008;32:673-81.

[55] Holland JW, Bird S, Williamson B, Woudstra C, Mustafa A, Wang T,Zou J, Blaney SC, Collet B, Secombes CJ. Molecular characterization of IRF3 and IRF7 in rainbowtrout,Oncorhynchusmykiss:functional analysis and transcriptional modulation. Mol Immunol.2008;46:269-85.

[56] Buonocore F, Randelli E, Casani D, Guerra L, Picchietti S, Costantini S, Facchiano AM,Zou J, Secombes CJ,Scapigliati G. A CD4 homologue in seabass (Dicentrarchuslabrax):molecular characterization and structural analysis. Mol Immunol.2008;45:3168-77.

[57] Skjaveland I, Iliev DB,Zou J, Jorgensen T,Jorgensen JB. A TLR9 homologthatis up-regulated by IFN-gin Atlantic salmon (Salmosalar). Dev CompImmunol. 2008;32:603-7.

[58] Su J, Zhu Z, Wang Y,Zou J, Hu W. Toll-likereceptor 3 regulates Mx expression in rare minnowGobiocyprisrarusafter viral infection. Immunogenetics. 2008;60:195-205.

[59] Su J, Zhu Z, Wang Y, Xiong F,Zou J.The cytomegalovirus promoter-driven short hairpin RNA constructs mediate effective RNA interference in zebrafishin vivo. Mar Biotechnol (NY). 2008;10:262-9.

[60]Zou J, Taffala C, Truckle J,Secombes C.Identification of a second group of type I interferons in fish sheds light on interferon evolutionin vertebrates.JImmunol.2007;179:3859-71.

[61]Zou J,Mercier C, Koussounadis A, Secombes CJ.Discovery of multiple beta-defensin like homologues in teleost fish.Mol Immunol. 2007;44:638-47.

[62] Wang T, Holland JW, Carrington A,Zou J,Secombes CJ. Molecular and functional characterization of IL-15 in rainbow troutOncorhynchusmykiss: a potent inducer of IFN-gamma expression in spleen leukocytes.J Immunol. 2007;179:1475-88.

[63]Martin SA,Zou J, Houlihan DH, Secombes, CJ. Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling.BMC Genomics.2007;8:150.

[64] Martin SA., Taggart JB, Seear PJ, Bron JE, Talbot R, Teale AJ, Sweeney GE, Hoyheim B,Houlihan DF, Tocher DR,Zou J,Secombes CJ. Interferon type I and type II responses in an Atlantic salmon (Salmosalar) SHK-1 cell line using the salmon TRAITS/SGP microarray. PhysiolGenomics. 2007;32:33-44.

[65]Morrison RN,Zou J, Secombes CJ, Scapigliati G, Adams MB,Nowak BF.Molecular cloning and expression analysis of tumour necrosis factor-alpha in amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.).Fish Shellfish Immunol.2007;23:1015-31.

[66] Nascimento DS, Pereira PJ, Reis MI, de Vale A,Zou J, Silva MT,Secombes CJ, Dos Santos NM.Molecular cloning and expression analysis of sea bass (Dicentrarchuslabrax L.) tumor necrosis factor-alpha (TNF-alpha).Fish Shellfish Immunol.2007;23:701-10.

[67] Jørgensen JB, Johansen A, Hegseth MN,Zou J,Robertsen B, Collet B, Secombes CJ. A recombinant CHSE-214 cell line expressing an Mx1 promoter-reporter system responds to bothinterferon type I and type II fromsalmonids and represents a versatile tool to study the IFN-system in teleostfish. Fish ShellfishImmunol. 2007;23:1294-303.

[68] Nascimento DS, de Vale A,Thomas AM,Zou J, Silva MT,Secombes CJ, Dos Santos NM.Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchuslabrax L.) interleukin-12 p40 and p35 subunits.Mol Immunol.2007;44:2277-91.

[69] Collet B, Munro ES, Gahlawat S, Acosta F, Garcia J, Roemelt C,Zou J, Secombes CJ, Ellis AE. Infectiouspancreaticnecrosis virus suppresses type I interferonsignalling in rainbowtroutgonadcell line but not in Atlantic salmon macrophages.Fish ShellfishImmunol.2007;22:44-56.

[70] Laing KJ,Zou JJ,Purcell MK, Phillips R, Secombes CJ, Hansen JD. Evolution of the CD4 family: teleost fish possess two divergent forms of CD4 in addition to lymphocyte activation gene-3.J Immunol.2006;177:3939-51.

[71] Robertsen B,Zou J, Secombes C,Leong J-A. Molecular and expression analysis of an interferon-gamma-inducibleguanylate-binding proteinfromrainbowtrout (Oncorhynchusmykiss).Dev CompImmunol. 2006;30:1023-33.

[72] Kono T,Zou J,Bird S, SavanR, Sakai M, Secombes CJ.Identification and expression analysis of lymphotoxin-beta like homologues in rainbow troutOncorhynchus mykiss.MolImmunol.2006;43:1390-401.

[73] ChangC-I, Zhang, Y-A,Zou J, Nie P, Secombes CJ.Fish cathelicidins: two cathelicidin genes are present in both rainbow troutOncorhynchus mykissand Atlantic salmonSalmo salar.Antimicrobial Agents and Chemotherapy.2006;50:185-95.

[74] Bird S,Zou J,Secombes CJ.Advances in fish cytokine biology give clues to the evolution of a complex network.Curr Phar Des.2006;12:3051-69.

[75] Benedetti S, Randelli E, Bounocore F,Zou J, Secombes CJ, Scapigliati G. Evolution of cytokine responses: IL-1beta directly affects intracellular Ca2+ concentration of teleost fish leukocytes through a receptor-mediated mechanism.Cytokine.2006;34:9-16.

[76]Zou J,Carrington A, Collet B, Dijkstra JM, Bols N, Secombes CJ.Identification and bioactivities of interferon gamma in rainbow troutOncorhynchus mykiss:the first Th1 type cytokine characterised functionally in fish. JImmunol.2005;175:2484-94.

[77] Chang C-I, Pleguezuelos O, Zhang Y-A,Zou J, Secombes CJ.Identification of a novel cathelicidin gene in the rainbow trout,Oncorhynchus mykiss.Infect Immun.2005;73:5053-64.

[78] Bird S,Zou J, Savan R, Kono T, Sakai M, Secombes CJ. Characterisation and expresssion analysis of an interleukin 6 homologue in the Japanese pufferfish,Fugu rubripes. Dev Comp Immunol.2005;29:775-89.

[79] Bird S,ZouJ,Kono T, Sakai M, Dijkstra JM, Secombes C.Characterisation and expression analysis ofinterleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish,Fugu rubripes, following their discovery by synteny. Immunogenetics.2005;56:909-23.

[80] Secombes CJ, Bird S,Zou J. Adaptive immunity in teleosts: cellular immunity.Dev. Biol. (Basel).2005;121:25-32.

[81]Zou J,Yoshiur, Y, Dijkstra JM, Sakai M, Ototake M, Secombes CJ. Identification of an interferon gamma homologue in Fugu,Takifugurubripes. Fish Shellfish Immunol. 2004;17:403-9.

[82]Zou J,Bird S, Truckle J, Bols N, Horne M, Secombes C. Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss).Eur J Biochem.2004;271:1913-23.

[83] Hong S,Zou J, Collet B, Bols NC, Secombes CJ. Analysis and characterisation of IL-1beta processing in rainbow trout,Oncorhynchus mykiss.Fish Shellfish Immunol.2004;16:453-9.

[84] Zhang YA,Zou J, Chang CI,Secombes CJ. Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout. Vet ImmunolImmunopathol.2004;101:259-69.

[85] Wang T, Johnson N,Zou J, Bols N, Secombes CJ.Sequencing and expression of the second allele of the interleukin-1beta1 gene in rainbowtrout (Oncorhynchus mykiss):identification of a novel SINE in the third intron.Fish ShellfishImmunol.2004;16:335-58.

[86] Buonocore F, Mazzini M, Forlenza M, Randelli E, Secombes CJ,Zou J, Scapigliati G. Expression inEscherchia coliand purification of sea bass (Dicentrarchuslabrax) interleukin 1beta,a possible immunoadjuvant in aquaculture.Mar.Biotechnol.(NY).2004;6:53-9.

[87]Zou J,Secombes CJ, Long L, Miller N, Clem LW, Chinchar VJ. Molecular identification and expression analysis of tumor necrosis factor in channel catfish (Ictalurus punctatus). Dev Comp Immunol.2003;27:845-58.

[88]Zou J, Clark MS, Secombes CJ.Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish,Fugu rubripes. Immunogenetics.2003;55:325-35.

[89]Zou J,Peddie S, Scapigliati G, Zhang Y, Bols NC, Ellis AE, Secombes CJ. Functional characterisation of the recombinant tumor necrosis factors in rainbow trout,Oncorhynchus mykiss. Dev Comp Immunol.2003;27:813-22.

[90] Peddie S, McLauchlan PE,Zou J, Ellis AE, Secombes C.The effect of intraperitoneally administrered IL-1derived peptides on immune parameters and resistance to viral haemorrhagic septicaemia (VHS) in the rainbow trout (Oncorhynchus mykiss). Dis of Aquat Organ.2003;56:195-200.

[91] Hong S, Peddie S,Campos-Perez JJ,Zou J, Secombes CJ.The effect of intraperitoneally administered recombinant IL-1beta on immune parameters and resistance toAeromonassalmonicidain the rainbow trout (Oncorhynchus mykiss). Dev Comp Immunol.2003;27:801-12.

[92]Zou J,Wang T, Hirono I, Aoki T, Inagawa H, Honda T, Soma GI, Ototake M, Nakanishi T,Ellis AE, Secombes CJ. Differential expression of two tumor necrosis factor genes in rainbow trout,Oncorhynchus mykiss. Dev Comp Immunol. 2002;26:161-72.

[93] Bird S,Zou J, Wang T, Munday B, Cunningham C, Secombes CJ. Evolution of interleukin-1beta. Cytokine Growth Factor Rev. 2002;13:483-502.

[94] Bird S, Wang T,Zou J, Cunningham C, Secombes CJ. The first cytokine sequence within cartilaginous fish: IL-1 beta in the small spotted catshark (Scyliorhinuscanicula). JImmunol.2002;168:3329-40.

[95] Wang T,Zou, J, Cunningham C, Secombes CJ. Cloning and functional characterisation of the interleukin-1 beta 1 promoter of rainbow trout (Oncorhynchus mykiss). BiochimBiophysActa.2002;1575:108-16.

[96] Laing KJ,Zou JJ, Wang T, Bols N, Hirono I, Aoki T, Secombes CJ. Identification and analysis of an interleukin 8-like molecule in rainbow troutOncorhynchus mykiss. Dev Comp Immunol.2002;26:433-44.

[97] Peddie S,Zou J,Secombes C.A biologicall active IL-1 derived peptide stimulates phagocytosis and bactericidal activity in rainbow trout,Oncorhynchuscykiss(Walbaum), head kidney leucocytes in vitro. J Fish Diseases.2002;25:351-260.

[98] Peddie S,Zou J, Secombes CJ.Immunostimulation in the rainbow trout (Oncorhynchus mykiss) following intraperitoneal administration of Ergosan. Vet ImmunolImmunopathol.2002;86:101-13.

[99] Subramaniam S, Stansberg C, Olsen L,ZouJ,Secombes CJ,Cunningham C.Cloning of aSalmo salarinterleukin-1 receptor-like cDNA. Dev Comp Immunol.2002;26:415-31.

[100] Hong S,ZouJ, Crampe M, Peddie S, Scapigliati G, Bols N, Cunningham C, Secombes, CJ.The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta. Vet ImmunolImmunopathol. 2001;81:1-14.

[101] Jorgensen JB,Zou J,Johansen A, Secombes CJ.Immunostimulatory CpG oligodeoxynucleotides stimulate expression of IL-1beta and interferon-like cytokines in rainbow trout macrophages via a chloroquine-sensitive mechanism. Fish Shellfish Immunol.2001;11:673-82.

[102] Laing KJ, Wang T,Zou J, Holland J, Hong S, Bols, N, Hirono I, Aoki T, Secombes CJ.Cloning and expression analysis of rainbow troutOncorhynchus mykisstumour necrosis factor-alpha. Eur JBiochem.2001;268:1315-22.

[103] Peddie S,Zou J, Cunningham C, Secombes CJ. Rainbow trout (Oncorhynchus mykiss) recombinant IL-1beta and derived peptides induce migration of head-kidney leucocytes in vitro. Fish Shellfish Immunol. 2001;11:697-709.

[104] Secombes CJ, Wang T, Hong S, Peddie S, CrampeM, Laing KJ, Cunningham C,Zou J. Cytokines and innate immunity of fish. Dev Comp Immunol. 2001;25:713-23.

[105] Secombes CJ, Bird S, Hong S, Laing KJ,Zou J. Phylogeny of vertebrate cytokines. Adv Exp Med Biol. 2001;484:89-94.

[106] Scapigliati G, Buonocore F, Bird S,ZouJ, Pelegrin P, Falasca C, Prugnoli D,Secombes CJ. Phylogeny of cytokines: molecular cloning and expression analysis of sea bassDicentrarchuslabraxinterleukin-1beta. Fish Shellfish Immunol. 2001;11:711-26.

[107]Zou J, Holland J, Pleguezuelos O, Cunningham C, Secombes CJ.Factors influencing the expression of interleukin-1 beta in cultured rainbow trout (Oncorhynchus mykiss) leucocytes. Dev Comp Immunol.2000;24:575-82.

[108]Zou J,Bird S, Minter R, Horton J, Cunningham C, Secombes CJ. Molecular cloning of the gene for interleukin-1betafrom Xenopus laevisand analysis of expression in vivo and in vitro. Immunogenetics. 2000;51:332-8.

[109] Pleguezuelos O,Zou J, Cunningham C, Secombes CJ.Cloning, sequencing, and analysis of expression of a second IL-1beta gene in rainbow trout (Oncorhynchus mykiss). Immunogenetics.2000;51:1002-11.

[110] Brubacher JL, Secombes CJ,Zou J, Bols NC.Constitutive and LPS-induced gene expression in a macrophage-like cell line from the rainbow trout (Oncorhynchus mykiss). Dev Comp Immunol.2000;24:565-74.

[111]Zou J, Grabowski PS, Cunningham C, Secombes CJ.Molecular cloning of interleukin 1beta from rainbow troutOncorhynchus mykissreveals no evidence of an ice cut site. Cytokine.1999;11:552-60.

[112]Zou J,Neumann NF, Holland JW, Belosevic M, Cunningham C, Secombes CJ, Rowley AF. Fish macrophages express a cyclo-oxygenase-2 homologue after activation. Biochem J.1999;340:153-9.

[113]Zou J, Cunningham C, Secombes CJ.The rainbow troutOncorhynchus mykissinterleukin-1 beta gene has a differ organization to mammals and undergoes incomplete splicing. Eur J Biochem.1999;259:901-8.

[114] Daniels GD,Zou J, Charlemagne J, Partula S, Cunningham C, Secombes CJ. Cloning of two chemokine receptor homologs (CXC-R4 and CC-R7) in rainbow troutOncorhynchus mykiss. J LeukocBiol.1999;65:684-90.

[115] Secombes CJ, Bird S, Cunningham C,Zou J. Interleukin-1 in fish. Fish Shellfish Immunol. 1999;9:335~43.

[116] Secombes C,ZouJ,Laing KJ, Daniels G. Cytokine genesin fish. Aquaculture. 1999;172:93-102.

[117] Secombes C,Bird S,Cunningham C, Zou J. Interleukin-1 in fish. Fish Shellfish Immunol. 1999;9:335-343

[118] Secombes C,Zou J, Daniels G, Cunningham C, Koussounadis A, Kemp G. Rainbowtrout cytokine and cytokine receptor genes. Immunol Rev.1998;166:333-40.

[119]Zou J,Trudeau VL, Cui Z, Brechin J, Machenzie K, Zhu Z, Houlihan DF, Peter RE.Estradiol stimulates growth hormone production in female goldfish. Gen Comp Endocrinol. 1997;106:102-12.

申請和授權專利情況

Secombes CJ,Cunningham C,Zou J,Rainbow trout IL-1beta: encoding nucleic acid: materials and methods, application patent number. WO98/17802, 1998/04/30-2003/02/29.

專著和教材情況

[1]參編，《水產動物免疫學》（主編：蘇建國），中國農業出版社，出版中.

[2]參編，Zou J, Castro R, Tafalla C. Antiviral Immunity: Origin and Evolution in Vertebrates. In《The evolution of the Immune System: Conservation and Diversification》(Edited by Davide Malagoli). Academic Press. 2016.pp. 173-204.

[3]參編，Secombes CJ,Zou J, Bird S. Cytokines of Cartilaginous Fish in Immunobiology of the Shark (Edited by Sylvia L. Smith, Robert B. Sim and Martin F. Flajnik). CRC Press Taylors & Francis Group. 2015. pp. 123-142.

[4]參編，Secombes CJ,ZouJ, Bird S. Fish cytokines: Discovery, activities and potential applications. In Fish Defenses, Vol 1. Immunology (Edited by G. Zaccone, J.Meseguer, A. Garcia-Ayala and B.G.Kapoor). Science Publishers. 2009. pp. 1-36。