鄒國漳於1994年和1997年在南開大學化學系獲得理學學士學位和理學碩士學位。2003年在美國紐約州立大學環境與林業學院獲理學博士學位，之後繼續從事博士後研究工作，在此期間研究設計建立了用ELISA快速準確檢測藻毒素的方法。2005年到美國馬里蘭大學人類病毒所從事研究治療性多肽和蛋白的結構與功能，以及糖基化修飾對蛋白和單克隆抗體的結構與功能的影響。2010年被國家納米科學中心聘為副研究員。
基本介紹
- 中文名：鄒國
- 國籍：中國
- 職業：副研究員
- 畢業院校：南開大學
個人信息,研究領域,代表論著,
個人信息
鄒國漳，副研究員。
研究領域
1. 糖基化修飾對多肽與蛋白的結構功能的影響
利用固相多肽合成，生物物理， 及納米技術解析糖基化修飾對蛋白錯誤摺疊和自組裝的抑制機理。
結合分子生物方法和生物化學方法解析糖基化修飾對抗體結構及功能的影響，在分子水平上調控改善抗體的生物活性。
2.藻毒素anatoxin-a的快速特異性檢測
代表論著
1. Chong Li, Marzena Pazgier, Jing Li, Changqing Li, Min Liu, Guozhang Zou, Zhenyu Li, Jiandong Chen, Sergey G. Tarasov, Wei-Yue Lu, and Wuyuan Lu*. Limitations of peptide retro-inverso isomerization in molecular mimicry, and why. J Biol. Chem (in press)
2. Gang Wei, Marzena Pazgier, Erik de Leeuw, Mohsen Rajabi, Jing Li, Guozhang Zou, Grace Jung, Weirong Yuan, Wei-Yue Lu, Robert I. Lehrer*, and Wuyuan Lu*. Trp-26 Imparts Functional Versatility to Human α-Defensin HNP1. J Biol. Chem. (in press)
3. Gang Wei, Erik de Leeuw, Marzena Pazgier, Weirong Yuan, Guozhang Zou, Jianfeng Wang, Bryan Ericksen, Wei-Yue Lu, Robert I. Lehrer, and Wuyuan Lu*. Through the looking glass: Mechanistic insights from enantiomeric human defensins. J Biol. Chem
4. Erik de Leeuw*, Mohsen Rajabi, Guozhang Zou, Marzena Pazgier and Wuyuan Lu. Selective arginines are important for the antibacterial activity and host cell interaction of human -defensin 5 FEBS Lett
5. Marzena Pazgier, Min Liu, Guozhang Zou, Weirong Yuan, Changqing Li, Cong Li, Jing Li, Juahdi Monbo, Davide Zella, Sergey Tarasov, and Wuyuan Lu*. Structural basis for high-affinity peptide inhibition of P53 interactions with MDM2 and MDMX Proc. Natl. Acad. Sci. USA
6. Guozhang Zou*. Structural and functional elements of human alpha defensins Curr Top Pept Protein Res
7. Cong Li, Min Liu, Juandi Monbo, Guozhang Zou, Changqing Li, Weirong Yuan, Davide Zella, Wei-Yue Lu, and Wuyuan Lu*. Turning a scorpion toxin into an antitumor miniprotein J. Am. Chem. Soc
8. Guozhang Zou, Erik de Leeuw, Jacek Lubkowski, and Wuyuan Lu*. Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its pro peptide J. Mol. Biol
9. Guozhang Zou, Erik de Leeuw, Chong Li, Changqing Li, Pengyun Zeng, Jacek Lubkowski, Wei-Yue Lu, and Wuyuan Lu* Toward understanding the cationicity of defensins: Arg and Lys versus their noncoded analogs J. Biol. Chem
10. Jingsong Wang, Hengguang Li, Guozhang Zou, and Lai-Xi Wang*. Novel template-assembled obligosaccharide clusters as HIV-1 candidate vaccine: design, synthesis, and binding to human antibody 2G12 Org. Biomol. Chem
11. Xianqun Li, Guozhang Zou, Weirong Yuan, and Wuyuan Lu*. Defining the native disulfide topology in the somatomedin B domain of human vitronectin. J. Biol. Chem
12. Zhibin Wu, Xiangqun Li, Bryan Ericksen, Erik de Leeuw, Guozhang Zou, Pengyun Zeng, Cao Xie, Cong Li, Jacek Lubkowski, Wei-Yue Lu, and Wuyuan Lu*. Impact of pro segments on the folding and function of human neutrophil α-defensins J. Mol. Biol.
13. Guozhang Zou and Gregory L. Boyer*. Synthesis and Properties of Different Metal Complexes of the Siderophore Desferriferricrocin. BioMetals
14. Yuqing Qi, Guozhang Zou, Daizheng Liao, Zonghui Jiang*, and Genglin Wang Synthesis and properties of the complexes of gadolinium with nitronyl nitroxides. Pol. J
15. Xiangjun Meng, Huizhong Kou, Guozhang Zou, Daizheng Liao*, Zonghui Jiang*, and Genglin Wang Synthesis and magnetism of dinuclear Cu(II) complexes bridged through iodanilic acid anion. Yingyong Huaxue
