郭興啟，男，1963年10月生，山東嘉祥人。博士，教授，博士生導師。現任山東農業大學生命科學學院副院長，山東省生物化學與分子生物學學會常務理事。近年來主持承擔了國家自然科學基金、國家轉基因植物研究專項、中國博士後科學基金、山東省中青年科學家科研獎勵基金等多項課題。在棉花和蜜蜂重要抗病抗逆基因的分離與功能分析、植物抗病基因工程等方面，均獲得了許多擁有我國自主智慧財產權的研究成果，獲得國家發明專利6項。曾獲山東省科技進步二等獎、三等獎各1項；獲山東農業大學教學成果一等獎3項、山東省教學成果二等獎、三等獎各1項。在《植物病理學報》、《中國科學》、《Journal of Experimental Botany》、《Plant Molecular Biology》、《FEBS Journal》、《BMC Plant Biology》等國內外著名學術刊物上發表論文60餘篇。曾為《Gene》、《Plant Biology》、《Journal of Insect Physiology》、《New Phytologist》等國際學術刊物審稿多篇。
基本介紹
- 中文名：郭興啟
- 國籍：中國
- 出生日期：1963
- 職業：教授
- 性別：男
個人簡介,教學工作,研究方向,科研項目,發表論文,
個人簡介
郭興啟，男，1963年10月生，山東嘉祥人。博士，教授，博士生導師。現任山東農業大學生命科學學院副院長，山東省生物化學與分子生物學學會副理事長，生物技術國家級特色專業建設項目負責人，生物技術與工程省級實驗教學示範中心主任。獲山東省教學成果二等獎1項（首位）、三等獎1項（首位），山東省教學名師，山東省優秀研究生指導教師。近年來主持承擔過國家自然科學基金、國家轉基因植物研究專項、農業部現代農業產業技術體系建設專項等多項課題。多年來以重要經濟作物棉花和特種經濟動物蜜蜂為研究對象，從生物化學與分子生物學角度深入開展了棉花和蜜蜂抗病抗逆功能的研究，分離獲得了多個擁有我國自主智慧財產權的重要抗病抗逆功能基因，闡明了部分基因的表達調控模式及信號轉導通路，並對這些基因的生物學功能及套用潛質進行了深入廣泛的研究。近年來，已獲得國家發明專利6項，在《病毒學報》、《Journal of Experimental Botany》、《Free Radical Biology and Medicine》、《Insect Biochemistry and Molecular Biology》、《Plant Molecular Biology》等國內外著名學術刊物上發表論文80餘篇。
教學工作
承擔本科生《分子生物學》、《基礎生物化學實驗》；碩士研究生《分子生物學》、《高級生物化學實驗技術》；博士研究生《植物逆境信號轉導與基因工程》等課程的教學工作。
研究方向
1. 棉花抗病抗逆分子生物學
2. 中華蜜蜂抗病抗逆分子生物學
科研項目
1. 國家自然科學基金《棉花激酶GhMKK6基因的功能分析及其級聯信號途經的鑑定》（No. 31471424）
2. 國家自然科學基金《棉花GhMPK7基因廣譜抗病功能的分子機理研究》（No. 31171837）
3. 國家自然科學基金《溫度對RNA沉默的抑制及其分子機理研究》（No. 30370928）
4. 國家自然科學基金《RNA介導抗性轉基因植物的抗病機制及遺傳規律》（No. 30571215）
5. 中國博士後科學基金《轉基因植物中RNA介導抗性的遺傳學》（No. 2002031167）
6. 山東省中青年科學家科研獎勵基金《抗病毒轉基因植物釋放的環境風險性研究》（No. 02BS025）
7. 國家轉基因植物研究重大專項《棉花高產性狀激素調控基因的克隆和克隆新方法的研究》子課題（No. 2009ZX08009-113B）
8. 農業部現代農業產業技術體系建設專項《現代農業蜂產業技術體系建設》子課題（No. NYCYTX-43）
發表論文
1. Yan Yan, Haihong Jia, Fang Wang, Chen Wang, Shuchang Liu, Xingqi Guo*. Overexpression of GhWRKY27a reduces tolerance to drought stress and resistance to Rhizoctonia solani infection in transgenic Nicotiana benthamiana. Frontiers in Physiology, 2015, 6: 265.
2. Xiaoqian Chu, Chen Wang, Xiaobo Chen, Wenjing Lu, Han Li, Xiuling Wang, Lili Hao, Xingqi Guo*. The cotton WRKY gene GhWRKY41 positively regulates salt and drought stress tolerance in transgenic Nicotiana benthamiana. PLoS ONE, 2015, 10(11): e0143022.
3. Xiaobo Chen, Ji Wang, Ming Zhu, Hailong An, Dongdong Liu, Lili Hao, Xingqi Guo*. A cotton Raf-like MAP3K gene, GhMAP3K40, mediates reduced tolerance to biotic and abiotic stress in Nicotiana benthamiana by negatively regulating growth and development. Plant Science, 2015, 240: 10-24.
4. Haihong Jia, Chen Wang, Fang Wang, Shuchang Liu, Guilin Li, Xingqi Guo*. GhWRKY68 reduces resistance to salt and drought in transgenic Nicotiana benthamiana. PLoS ONE, 2015, 10(3): e0120646.
5. Yifeng Huaxia, Fang Wang, Yan Yan, Feng Liu, Hongfang Wang, Xingqi Guo*, Baohua Xu. A novel 1-Cys thioredoxin peroxidase gene in Apis cerana cerana: characterization of AccTpx4 and its role in oxidative stresses. Cell Stress and Chaperones, 2015, 20(4): 663-672.
6. Xiaobo Chen, Pengbo Yao, Xiaoqian Chu, Lili Hao, Xingqi Guo*, Baohua Xu. Isolation of arginine kinase from Apis cerana cerana and its possible involvement in response to adverse stress. Cell Stress and Chaperones, 2015, 20(1): 169-183.
7. Huiru Yan, Haihong Jia, Xiaobo Chen, Lili Hao, Hailong An, Xingqi Guo*. The cotton WRKY transcription factor GhWRKY17 functions in drought and salt stress in transgenic Nicotiana benthamiana through ABA signaling and the modulation of reactive oxygen species production. Plant & Cell Physiology, 2014, 55(12),2060-2076.
8. Yan Yan, Yuanying Zhang, Yifeng Huaxia, XiulingWang, Pengbo Yao, Xingqi Guo*, Baohua Xu. Identification and characterisation of a novel 1-Cys thioredoxin peroxidase gene (AccTpx5) from Apis cerana cerana. Comparative Biochemistry and Physiology, Part B, 2014, 172-173: 39-48.
9. Weina Shi, Lili Hao, Jing Li, Dongdong Liu, Xingqi Guo*, Han Li. The Gossypium hirsutum WRKY gene GhWRKY39-1 promotes pathogen infection defense responses and mediates salt stress tolerance in transgenic Nicotiana benthamiana. Plant Cell Report, 2014, 33(3): 483-498.
10. Xiuling Wang, Yan Yan, Yuzhen Li, Xiaoqian Chu, Changai Wu, Xingqi Guo*. GhWRKY40, a multiple stress-responsive cotton WRKY gene, plays an important role in the wounding response and enhances susceptibility to ralstonia solanacearum infection in transgenic Nicotiana benthamiana. PLoS ONE, 2014, 9(4): e93577.
11. Yuzhen Li, Liang Zhang, Wenjing Lu, Xiuling Wang, Changai Wu,Xingqi Guo*. Overexpression of Cotton GhMKK4 enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic Nicotiana benthamiana. Molecular Plant Pathology, 2014, 15(1): 94-108.
12. Pengbo Yao, Xiaobo Chen, Yan Yan, Feng Liu, Yuanying Zhang, Xingqi Guo*, Baohua Xu. Glutaredoxin, glutaredoxin 2, thioredoxin 1 and thioredoxin peroxidase 3 play important roles in antioxidant defense in Apis cerana cerana. Free Radical Biology and Medicine, 2014, 68: 335-346.
13. Yuzhen Li, Liang Zhang, Xiuling Wang, Wei Zhang, Lili Hao, Xiaoqian Chu, Xingqi Guo*. Cotton GhMPK6a negatively regulates osmotic tolerance and bacterial infection in transgenic Nicotiana benthamiana, and plays a pivotal role in development. The FEBS Journal, 2013, 280: 5128-5144.
14. Wenjing Lu, Xiaoqian Chu, Yuzhen Li, Chen Wang, Xingqi Guo*. Cotton GhMKK1 induces the tolerance of salt and drought stress, and mediates defence responses to pathogen infection in transgenic Nicotiana benthamiana. PLoS ONE, 2013, 8(7): e68503.
15. Pengbo Yao, Lili Hao, Fang Wang, Xiaobo Chen, Yan Yan, Xingqi Guo*, Baohua Xu. Molecular cloning, expression and antioxidant characterisation of a typical thioredoxin gene (AccTrx2) in Apis cerana cerana. Gene, 2013, 527(1): 33-41.
16. Pengbo Yao, Wenjing Lu, Fei Meng, Xiuling Wang, Baohua Xu, Xingqi Guo*. Molecular cloning, expression and oxidative stress response of a mitochondrial thioredoxin peroxidase gene (AccTpx-3) from Apis cerana cerana. Journal of Insect Physiology, 2013, 59(3): 273-282.
17. Huiru Yan, Haihong Jia, Xiuling Wang, Hongru Gao, Xingqi Guo*, Baohua Xu. Identification and characterization of an Apisceranacerana Delta class glutathione S-transferase gene (AccGSTD) in response to thermal stress. Naturwissenschaften, 2013, 100(2): 153-163.
18. Yuanying Zhang, Huiru Yan, Wenjing Lu, Yuzhen Li, Xingqi Guo*, Baohua Xu. A novel Omega-class glutathione S-transferase gene in Apis cerana cerana: molecular characterisation of GSTO2 and its protective effects in oxidative stress. Cell Stress and Chaperones, 2013, 18(4): 503-516.
19. Huiru Yan, Haihong Jia, Hongru Gao, Xingqi Guo*, Baohua Xu. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana. Cell Stress and Chaperones, 2013, 18(4): 415-426.
20. Liang Zhang, Yuzhen Li , Wenjing Lu, Fei Meng, Changai Wu, Xingqi Guo*. Cotton GhMKK5 affects disease resistance, induces HR-like cell death, and reduces the tolerance to salt and drought stress in transgenic Nicotiana benthamiana. Journal of Experimental Botany, 2012, 63(10): 3935-3952.
21. Feifei Yu, Yifeng Huaxia, Wenjing Lu, Changai Wu, Xuecheng Cao, Xingqi Guo*. GhWRKY15, a member of the WRKY transcription factor family identified from cotton (Gossypium hirsutum L.), is involved in disease resistance and plant development. BMC Plant Biology, 2012, 12(1): 144.
22. Wang Mian, Li Shanwei, Yang Haifang, Gao Zheng, Wu Changai, Xingqi Guo*. Characterization and functional analysis of GhRDR6, a novel RDR6 gene from cotton (Gossypium hirsutum L.). Bioscience Reports, 2012, 22: 139-151.
23. Huiru Yan, Fei Meng, Haihong Jia, Xingqi Guo*, Baohua Xu. The identification and oxidative stress response of a zeta class glutathione S-transferase (GSTZ1) gene from Apis cerana cerana. Journal of Insect Physilology, 2012, 58(6): 782-791.
24. Fei Meng, Wenjing Lu, Feifei Yu, Minjiang Kang, Xingqi Guo*, Baohua Xu. Ribosomal protein L11 is related to brain maturation during the adult phase in Apis cerana cerana (Hymenoptera, Apidae). Naturwissenschaften, 2012, 99(2): 343-352.
25. Xiaoli Yu, Wenjing Lu, Rujiang Sun, Xingqi Guo*, Baohua Xu. Identification and characterization of a novel calcyclin binding protein (CacyBP) gene from Apis cerana cerana. Molecular Biology Reports, 2012, 39(8): 8053-8063.
26. Liang Zhang, Dongmei Xi, Shanwei Li, Zheng Gao, SL Zhao, Jing Shi, Changai Wu, Xingqi Guo*. A cotton group C MAP kinase gene, GhMPK2, positively regulates salt and drought tolerance in tobacco. Plant Molecular Biology, 2011, 77: 17-31.
27. Jing Shi, Liang Zhang, Hailong An, Changai Wu, Xingqi Guo*. GhMPK16, a novel stress-responsive group D MAPK gene from cotton, is involved in disease resistance and drought sensitivity. BMC Molecular Biology, 2011, 12: 22
28. Liang Zhang, Dongmei Xi, Lu Luo, Fei Meng, Yuzhen Li, Changai Wu, Xingqi Guo*. Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress. The FEBS Journal, 2011, 278(8): 1367-1378.
29. Xiaoli Yu, Mian Wang, Minjiang Kang, Li Liu, Xingqi Guo*, Baohua Xu. Molecular cloning and characterization of two nicotinic acetylcholine receptor β subunit genes from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2011, 77(4): 163-178.
30. Feifei Yu, Mingjiang Kang, Fei Meng, Xingqi Guo*, Baohua Xu. Molecular cloning and characterization of a thioredoxin peroxidase gene from Apis cerana cerana. Insect Molecular Biology, 2011, 20(3): 367-378.
31. Fei Meng, Mingjiang Kang, Li Liu, Lu Luo, Baohua Xu, Xingqi Guo*. Characterization of the TAK1 gene in Apis cerana cerana (AccTAK1) and its involvement in the regulation of tissue-specific development. BMB reports, 2011, 44(3): 187-192.
32. Haifang Yang, Mian Wang, Zheng Gao, Changxiang Zhu, Xingqi Guo*. Isolation of a novel RNA-dependent RNA polymerase 6 from Nicotiana glutinosa, NgRDR6, and analysis of its response to biotic and abiotic stresses. Molecular Biology Reports, 2011, 38: 929-937.
33. Ruoyu Guo, Feifei Yu, Zheng Gao, Hailong An, Xuecheng Cao, Xingqi Guo*. GhWRKY3, a novel cotton (Gossypium hirsutum L.) WRKY gene, is involved in diverse stress responses. Molecular Biology Reports, 2011, 38: 49-58.
34. Taobo Ai, Liang Zhang, Zheng Gao, Changxiang Zhu, Xingqi Guo*. Highly efficient virus resistance mediated by artificial microRNAs that target the suppressor of PVX and PVY in plants. Plant Biology, 2011, 13: 304-316.
35. Jing Shi, Hailong An, Liang Zhang, Zheng Gao, Xingqi Guo*. GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development. Plant Molecular Biology, 2010, 74: 1-17.
36. Fei Meng, Liang Zhang, Mingjiang Kang, Xingqi Guo*, Baohua Xu. Molecular characterization immunohistochemical localization and expression of a ribosomal protein L17 gene from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2010, 75(2): 121-138.
37. Wang Mian, Kang Mingjiang, Xingqi Guo*, Baohua Xu. Identification and characterization of two phospholipid hydroperoxide glutathione peroxidase gene from Apis cerana cerana. Comparative Biochemistry and Physiology, Part C, 2010, 152: 75-83.
38. Ying Zhang, Jing Shi, Yan Liu, Yi Zhang, Jiedao Zhang, Xingqi Guo*. Identification of a novel NPR1-like gene from Nicotiana glutinosa and its role in resistance to fungal, bacterial and viral pathogens. Plant Biology, 2010, 12: 23-34.
39. Yan Liu, Qiouqiang Gao, B Wu, Taobo Ai, Xingqi Guo*. NgRDR1, an RNA-dependent RNA polymerase isolated from Nicotiana glutinosa, was involved in biotic and abiotic stresses. Plant Physiology and Biochemistry, 2009, 47(5): 359-368.
40. Yi Zhang, Dongmei Xi, Jian Wang, D Zhu, Xingqi Guo*. Functional analysis reveals effects of tobacco alternative oxidase gene (NtAOX1a) on regulation of defence responses against abiotic and biotic stress. Bioscience Reports, 2009, 29(6): 375-383.
41. Qiouqiang Gao, Yan Liu, Meimei Wang, Jiedao Zhang, Yingqi Gai, Changxiang Zhu, Xingqi Guo*. Molecular cloning and characterization of an inducible RNA- dependent RNA polymerase gene, GhRdRP, from cotton (Gossypium hirsutum L.). Molecular Biology Reports, 2009, 36(1): 47-56.
42. Fang Li, Yi Zhang, Meimei Wang, Ying Zhang, Xiaoliang Wu, Xingqi Guo*. Molecular cloning and expression characteristics of alternative oxidase gene of cotton (Gossypium hirsutum). Molecular Biology Reports, 2008, 35: 97-105.
43. Xiaoliang Wu, Wencui Hou, Meimei Wang, Fang Li, Jiedao Zhang, Xingqi Guo*. RNA silencing-mediated resistance is related to biotic/abiotic stresses and cellular RdRP expression in transgenic tobacco plants. BMB Reports, 2008, 41(5): 376-381.
44. Jian Wang, Xia Wang, Cheng Liu, Jiedao Zhang, Changxiang Zhu, Xingqi Guo*. The NgAOX1a gene cloned from Nicotiana glutinosa is implicated in response to abiotic and biotic stresses. Bioscience Reports, 2008, 28(5): 259-266.
45. Ying Zhang, Xia Wang, Cheng Cheng, Qiuqiang Gao, Jingyun Liu, Xingqi Guo*. Molecular cloning and characterization of GhNPR1, a gene implicated in pathogen responses from cotton (Gossypium hirsutum L.). Bioscience Reports, 2008, 28(1): 7-14.
46. Meimei Wang, Yi Zhang, Jian Wang, Xiaoliang Wu, Xingqi Guo*. A novel cotton (Gossypium hirsutum L.) MAP kinase gene, GhMAPK1, involved in encountering diverse environmental stresses. Journal of Biochemistry and Molecular Biology, 2007, 3: 325-332.
47. Xia Wang, Yi Zhang, Jiedao Zhang, Cheng Cheng, Xingqi Guo*. Molecular characterization of a transient expression gene encoding 1-aminocyclopropane -1-carboxylate synthase in cotton (Gossypium hirsutum L.). Journal of Biochemistry and Molecular Biology, 2007, 5: 791-800.
