邵振(研究員)

簡歷：

1.2013年10月起:中國科學院上海生命科學研究院中科院-馬普學會夥伴計算生物學研究所;擔任研究員、課題組長。
2.2009年4月–2013年9月:美國達納法伯癌症研究所、波士頓兒童醫院與哈佛醫學院;擔任博士後研究學者。

研究方向：

1）針對以二代測序技術為基礎的生成的高通量生物數據為主，開發統計及計算模型的開發
2）結合生物實驗結果，解析轉錄因子和染色質結構調控蛋白的作用機制。以研究在待定生物過程中基因調控機制的動態性。

職稱：

研究員

職務：

計算生物所研究組長、博士生導師

獲獎及榮譽：

2015年入選“百人計畫”

代表論著：

1. Xu J*, Shao Z*, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH. Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions. Molecular Cell, 2015, 57 (2), 304–316.
2. Das PP*, Shao Z*, Beyaz S, Apostolou E, O’Brien K, Atsma JM, Ljuboja D, Guo G, Kerenyi M, Woo A, Yuan GC, Onder T, Hochedlinger K, Kim J, Orkin SH. Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity. Molecular Cell, 2014, 53 (1), 32-48.
3. Maroz A, Stachorski L, Emmrich S, Reinhardt K, Xu J,Shao Z, Käbler S, Dertmann T, Hitzler J, Roberts I, Vyas P, Juban G, Hennig C, Hansen G, Li Z, Orkin S, Reinhardt D, Klusmann JH. GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient. Leukemia, 2014, 28, 1259–1270.4. Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH. An erythroid enhancer of BCL11A determines fetal hemoglobin level. Science, 2013, 342 (6155), 253-257.
5. Kerenyi M, Shao Z, Hsu Y, Guo G, Luc S, O’Brien K, Fujiwara Y, Peng C, Nguyen M and Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. eLife, 2013, 2:e00633.
6. Baena E, Shao Z, Linn D, Glass K, Hamblen M, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho F, Bronson RT, Mucci L, Loda M, Yuan GC, Orkin SH and Li Z. ETV1 directs androgen metabolism and confers aggressive prostate cancer in
targeted mice and patients. Genes & Development, 2013, 27 (6), 683-698.
7. Xu J*, Shao Z*, Bauer DE, Glass K, Pinello L, Handel B, Hou S, Stamatoyannopoulos J, Mikkola H, Yuan GC and Orkin SH. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental Cell, 2012, 23 (4):796-811.
8. Shao Z*, Zhang Y*, Yuan GC, Orkin SH and Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biology, 2012, 13 R16 (Method Article).
9. Xu J, Peng C, Sankaran VJ, Shao Z, Esrick E, Chong B, Ippolito G, Fujiwara Y, Ebert B, Tucker P, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science, 2011, 334 993-996.
10. Rao, Shao Z, Roumiantsev S, McDonald L, Yuan GC and Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Molecular Cell Biology, 2010, 30 (22):5364-80.
11. Liu Y*, Shao Z* and Yuan GC. Prediction of Polycomb target genes in mouse embryonic stem cells. Genomics, 2010, 96: 17-26 (Cover Article).
12. Shao Z and Zhou H. Dynamics-driven evolution to structural heterogeneity in complex networks. Physica A, 2008, 388, 523-528.
13.Shao Z and Zhou H. Optimal transportation network with concave cost functions: Loop analysis and algorithms. Physics Review E, 2007, 75, 066112.

邵振(研究員)

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