基本介紹
- 中文名：邢少軍
- 學位/學歷：博士
- 職業：教師
- 專業方向：免疫與病原生物學
- 任職院校：深圳大學基礎醫學院
研究方向,學術成果,
研究方向
（1） 獲得性免疫細胞（T細胞）在病原感染、腫瘤發生等疾病狀態下的免疫應答及表觀修飾研究；（2）wnt信號通路轉錄因子（TCF1/LEF1）及其調控因子在免疫細胞發育及輔助性T細胞亞群（如調節性T細胞、濾泡調節性T細胞）免疫應答中的調控作用；（3）HDAC抑制劑在T細胞分化及功能中的作用機制。
學術成果
代表性成果
· Xing S#, Gai K#, Li X, Shao P, Zeng Z, Zhao X, Zhao X, Chen X, Paradee WJ, Meyerholz DK, Peng W*, Xue HH* Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med 2019 Mar 5. pii: jem.20182010. doi: 10.1084/jem.20182010.
· Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan et al Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018; 9: 5452. doi: 10.1038/s41467-018-07853-z PMCID: PMC6303346
· Shaojun Xing, Peng Shao, Fengyin Li et al. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 2018 July 25, 215(7) DOI: 10.1084/jem.20171514 IF=10.79
· Jiao Y-M#, Yang H-G#, Huang H-H, Tu B, Xing S-J, Mao L, Xia W, He R, Zhang J-Y, Xu R-N, Jin L, Shi M, Xu Z, Qin E-Q, Wang X-C, Wu H, Ye L and Wang F-S (2017) Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5− CD8+ T Cells during Chronic HIV Infection. Front. Immunol. 8:1786. doi: 10.3389/fimmu.2017.01786
· Shan Q#, Zeng Z#, Xing S, Li F, Hartwig SM,et al . The transcription factor Runx3 guards cytotoxic CD8(+)effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017 Jun 12. doi: 10.1038/ni.3773. PubMed PMID:28604718. IF=21.506
· Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng et al Differential requirements for Tcf1 long isoforms in CD8+ and CD4+ T cell responses to acute viral infection. J Immunol. 2017 Aug 1; 199(3): 911–919. doi: 10.4049/jimmunol.1700595 PMCID: PMC5531591
· Zhe Xu#, Shaojun Xing#, Qiang Shan et al Cutting Edge: beta-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017 Mar 27. pii: 1602139. doi: 10.4049/jimmunol.1602139. PMID: 28348272 IF=4.856 (co-first author).
· Bing He#, Shaojun Xing#, Changya chen et al CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. Immunity. 2016 Dec 20;45(6):1341-1354. PMID:27986453 IF=22.845 (co-first author).
· Shaojun Xing#, Fengyin Li#, Zhouhao Zeng#, Yunjie Zhao, Shuyang Yu, et al Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016 Jun;17(6):695-703. PMID: 27111144 IF=21.506 (F1000 prime recommended by Salvatore Spicuglia )
· Yu S#, Li F#, Xing S et al Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. J Biol Chem. 2016 May 20;291(21):11148-60. PMID: 27044748 IF=4.125
· Yang Q, Li F, Harly C, Xing S, Ye L, et al TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol. 2015 Oct;16(10):1044-50. doi: 10.1038/ni.3248. Epub 2015 Aug 17. PMID: 26280998 IF=21.506 (commentary by Kaye J.)
· Choi YS#, Gullicksrud JA#, Xing S et al LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 Nat Immunol. 2015 Sep;16(9):980-90. PMID:26214741 IF=21.506 (cited by Nature, commentary by Masato Kubo)
· Fu J, Zhang Z, Zhou L, Qi Z, Xing S, et al Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma. Hepatology. 2013 Jul;58(1):139-49. doi: 10.1002/hep.26054. Epub 2013 Feb 15. PMID: 22961630 IF=13.246 (commentary by Gyongyi Szabo)
· Xing S#, Fu J#, Zhang Z et al Increased turnover of FoxP3high regulatory T cells is associated with hyperactivation and disease progression of chronic HIV-1 infection. J Acquir Immune Defic Syndr. 2010 Aug;54(5):455-62. PMID: 20585263 IF=3.935
· Jiao Y#, Fu J#, Xing S, et al The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology. 2009 Sep;128(1 Suppl):e366-75. PMID:19016904 IF=3.701
