趙英永

趙英永

男、醫學博士、藥理學博士後、教授、博士研究生導師。 曾獲全國百篇優秀博士學位論文提名獎、入選教育部新世紀優秀人才支持計畫、中國藥理學會第十五屆施維雅青年藥理學家獎、中國藥學會-賽諾菲青年生物藥物獎、第九屆陝西省青年科技獎；教育部學科（中藥學）評估專家；Scientific Reports和American Journal of Nephrology編委；Pharmacognosy Magazine 編輯；主要從事慢性腎臟病的發病機制及中藥抗腎間質纖維化研究。研究內容涉及中藥利尿藥化學成分的系統研究、利尿和腎保護活藥理學和系統生物學等方面。

基本介紹

  • 中文名：趙英永
  • 外文名：Ying-Yong Zhao
  • 國籍：中國
  • 民族：漢
  • 職業：教授
  • 畢業院校：西北大學
  • 代表作品：Trends in Pharmacological Sciences、British Journal of Pharmacology
個人說明,研究概況,招生方向,研究領域,研究方向,社會兼職,獲獎,主持科研項目,發表SCI論文,

個人說明

研究概況

男、醫學博士、藥理學博士後、教授、博士研究生導師。教育部學科（中藥學）評估專家、Scientific Reports和American Journal of Nephrology編委、世界中醫藥學會聯合會-臨床用藥安全研究專業委員會常務理事、中國藥理學會腎臟藥理專業委員會委員，西北大學從事科研工作。
2010年西北大學獲醫學博士學位，同年留校從事科研和教學工作，講師職稱；2012年破格晉升副教授職稱；2015年特別評審晉升教授職稱；2010年和2014年分別獲得碩士研究生和博士研究生指導資格；2012年-2014年，第四軍醫大學藥學院從事藥理學博士後工作。2014-2015年與University of California Irvine的腎臟病專家Nosratola D. Vaziri教授進行合作研究慢性腎臟病的病理機制及其中藥抗腎間質纖維化。
2009年-2018年，在Trends in Pharmacological Sciences、Nature Communications、British Journal of Pharmacology、Nephrology Dialysis Transplantation、Redox Biology、Phytomedicine等國際雜誌發表SCI源期刊論文130篇，其中第1作者和通訊作者論文96篇，H-index為34，全部論文被SCI資料庫引用超過3000次和Google scholar引用超過4500次；以第一發明人獲授權國家專利6項；主編專著兩部。

招生方向

博士後、博士研究生、碩士研究生招生專業：1、中藥化學與藥理學研究；2、藥物代謝與代謝組學研究。

研究領域

天然產物化學；中藥藥理學；系統生物學

研究方向

利水滲濕類中藥的化學成分研究；中藥利尿藥及治療慢性腎臟病的藥理學研究；慢性腎臟病及其中藥防治慢性腎臟病的系統生物學研究

社會兼職

1. 教育部學科（中藥學）評估專家
2. 陝西省綜合評標評審專家（陝西省發展與改革委員會）
3. 世界中醫藥學會聯合會臨床用藥安全研究專業委員會 常務理事
4. 中國藥理學會腎臟藥理專業委員會 委員
American Society of Nephrology Member
5. 期刊任職
Scientific Reports 編委 (影響因子：5.228)
American Journal of Nephrology 編委 (影響因子：2.740)
Pharmacognosy Magazine 編輯 (影響因子：1.069)
Frontiers in Medicine 副主編
Current Metabolomics 編委
藥物分析雜誌 編委

獲獎

1）2013年，入選教育部“新世紀優秀 人才支持計畫”（教育部）
2）2012年，獲全國百篇優秀博士學位論文提名獎（教育部）
3）2012年，獲第九屆陝西省青年科技獎（中共陝西省委組織部、陝西省科學技術協會）
4）2012年，獲中國藥學會-賽諾菲青年生物藥物獎（中國藥學會）
5）2011年，獲中國藥理學會第十五屆施維雅青年藥理學家獎（ 中國藥理學會）

主持科研項目

1）RAS抑制劑茯苓皮三萜酸利尿及抗腎間質纖維化物質基礎及作用機制研究，國家自然科學基金
2）基於NF-κB/Nrf2信號通路和脂質組學技術探討豬苓的利尿物質基礎抗腎纖維化的機制，國家自然科學基金
3）豬苓及麥角甾酮對馬兜鈴酸腎病的保護作用及其機制研究，國家自然科學基金
4）貴細類中藥材摻偽造假等檢測技術平台，科技部十二五重大新藥創製科技重大專項子課題
5）豬苓甾酮研究，科技部十二五重大新藥創製科技重大專項子課題
6）茯苓皮的利尿活性成分分離及其防治慢性腎衰竭研究，中國博士後科學基金第七批特別資助基金
7）茯苓皮防治慢性腎病的物質基礎及基於代謝組學作用機制，中國博士後科學基金第52批面上資助基金
8）麥角甾酮的合成工藝最佳化及其治療慢性腎衰竭的藥理學研究，陝西省國際科技合作項目
9）治療慢性腎功能衰竭藥物的臨床前研究，陝西省科技廳社會發展攻關計畫項目

發表SCI論文

  1. Dan-Qian Chen, Gang Cao, Hua Chen, Christos P. Argyopoulos, Hui Yu, Wei Su, Lin Chen, David C. Samuels, Shougang Zhuang, George P. Bayliss, Shilin Zhao, Xiao-Yong Yu, Nosratola D. Vaziri, Ming Wang, Dan Liu, Jia-Rong Mao, Shi-Xing Ma, Jin Zhao, Yuan Zhang, You-Quan Shang, Huining Kang, Fei Ye, Xiao-Hong Cheng, Xiang-Ri Li, Li Zhang, Mei-Xia Meng, Yan Guo, Ying-Yong Zhao*. Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. Nature Communications2019;10:1476[IF=12.353]
  2. Dan-Qian Chen, Ya-Long Feng, Gang Cao, Ying-Yong Zhao*.Natural products as a source for antifibrosis therapy. Trends in Pharmacological Sciences 2018; 39(11):937-952. [IF=12.108] (Cell子刊，Top期刊)
  3. Ming Wang, Dan-Qian Chen, Lin Chen, Gang Cao, Hui Zhao, Dan Liu, Nosratola D. Vaziri, Yan Guo, Ying-Yong Zhao* Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. British Journal of Pharmacology 2018;175(13):2689-2708. [IF=6.810] (Top期刊)
  4. Dan-Qian Chen, Gang Cao, Hua Chen, Dan Liu, Wei Su, Xiao-Yong Yu, Nosratola D. Vaziri, Xiu-Hua Liu, Xu Bai, Li Zhang, Ying-Yong Zhao*. Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease. Redox Biology 2017; 12: 505-521. [IF=7.126](同時入選ESI 0.1%熱點論文和ESI 1%高倍引用論文)
  5. Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D. Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao*. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biology 2016;10:168–178. [IF=7.126](入選ESI 0.1%熱點論文)
  6. Dan-Qian Chen, Ya-Long Feng, Lin Chen, Jing-Ru Liu, Ming Wang, Nosratola D. Vaziri, Ying-Yong Zhao*. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl-NF-κB/Nrf2 axis. Free Radical Biology and Medicine 2019;134:484-497. [IF=6.020] (Top期刊)
  7. Lin Chen, Dan-Qian Chen, Jing-Ru Liu, Jun Zhang, Nosratola D. Vaziri, Shougang Zhuang, Hua Chen, Ya-Long Feng, Yan Guo, Ying-Yong Zhao*. Unilateral ureteral obstruction causes gut microbial dysbiosis and metabolome disorders contributing to interstitial fibrosis. Experimental & Molecular Medicine 2019;51:38. [IF=5.583]
  8. Lin Chen, Gang Cao, Ming Wang, Ya-Long Feng, Dan-Qian Chen, Nosratola D. Vaziri, Shougang Zhuang, Ying-Yong Zhao*. The matrix metalloproteinase-13 inhibitor poricoic acid ZI ameliorates renal fibrosis by mitigating epithelial-mesenchymal transition. Molecular Nutrition & Food Research 2019; DOI: 10.1002/mnfr.201900132. [IF=5.151] (Top期刊)
  9. Ming Wang, Dan-Qian Chen, Lin Chen, Hui Zhao, Dan Liu, Zhi-Hao Zhang, Nosratola D. Vaziri, Yan Guo, Ying-Yong Zhao*, Gang Cao. Novel RAS inhibitors poricoic acid ZG and poricoic acid ZH attenuate renal fibrosis via Wnt/β-catenin pathway and targeted phosphorylation smad3 signaling. Journal of Agricultural and Food Chemistry 2018;66(8):1828-1842. [IF=3.412] (Top期刊，同時入選ESI 0.1%熱點論文和ESI 1%高倍引用論文)
  10. Ming Wang, Dan-Qian Chen, Min-Chang Wang, Hua Chen, Lin Chen, Dan Liu, Hui Zhao, Ying-Yong Zhao*. Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway. Phytomedicine 2017; 36:243-253. [IF=3.610] (Top期刊)
  11. Dan-Qian Chen, Hua Chen, Lin Chen, Nosratola D. Vaziri, Ming Wang, Xiang-Ri Li, Ying-Yong Zhao*. The Link between phenotype and fatty acid metabolism in advanced chronic kidney disease. Nephrology Dialysis Transplantation 2017;32(7):1154–1166. [IF=4.600](同時入選ESI 0.1%熱點論文和ESI 1%高倍引用論文)
  12. Hua Miao, Yu-Hui Zhao, Nosratola D. Vaziri, Dan-Dan Tang, Hua Chen, Han Chen, Mahyar Khazaeli, Mehrdokht Tarbiat-Boldaji, LeiliHatami, Ying-Yong Zhao*. Lipidomics biomarkers of diet-induced hyperlipidemia and its treatment with Poria cocos. Journal of Agricultural and Food Chemistry 2016;64(4):969-979. [IF=3.154](Top期刊)
  13. Hua Chen, Tian Yang, Min-Chang Wang, Dan-Qian Chen, Yang Yang*, Ying-Yong Zhao*. Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation. Phytomedicine 2018;42:207-218. [IF=3.610] (Top期刊)
  14. Hua Chen, Lin Chen, Dan Liu, Dan-Qian Chen, Nosratola D. Vaziri, Xiao-Yong Yu, Li Zhang, Wei Su, Xu Bai, Ying-Yong Zhao*.Combined clinical phenotype and lipidomic analysis reveals the impact of chronic kidney disease on lipid metabolism. Journal of Proteome Research 2017;16(4):1566-1578. [IF=4.268](入選ESI 1%高倍引用論文)
  15. Yuan‑Yuan Chen, Dan‑Qian Chen, Lin Chen, Jing‑Ru Liu, Nosratola D. Vaziri, Yan Guo, Ying‑Yong Zhao*. Microbiome–metabolome reveals thecontribution ofgut–kidney axis onkidney disease. Journal of Translational Medicine 2019;17:5 [IF=4.197]
  16. Fang Dou, Hua Miao, Jing-Wen Wang, Lin Chen, Ming Wang, Hua Chen, Ai-Dong Wen, Ying-Yong Zhao*.An integrated lipidomics and phenotype study reveals protective effect and biochemical mechanism of traditionally used Alisma orientale Juzepzuk in chronic kidney disease. Frontier in Pharmacology 2018; 9: 53. [IF=4.400]
  17. Yang Sun,Yingyong Zhao*.Enhanced pharmacokinetics and anti-tumor efficacy of PEGylated liposomal rhaponticin and plasma protein binding ability of rhaponticin.Journal of Controlled Release2013;172(1): e82-e83. [IF=8.078]
  18. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS.Journal of Proteome Research 2013;12(2):692–703 [IF=5.413]
  19. Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Miao, Li Zhang, Xu Bai, Ying-Yong Zhao*. Metabolomic signatures of chronic kidney disease of diverse etiologies in the rats and humans. Journal of Proteome Research 2016;15(10):3802-3812. [IF=4.268]
  20. Ying-Yong Zhao*,Nosratola D. Vaziri, Rui-Chao Lin. Lipidomics: new insight into kidney disease. Advances in Clinical Chemistry 2015;68:1-21. [IF=4.302]
  21. Ying-Yong Zhao, Xuefeng Shen, Xu Chao, Charlene C. Ho, Xian-Long Cheng, Yongmin Zhang, Rui-Chao Lin, Ke-Jun Du, Wen-Jing Luo, Jing-Yuan Chen. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.BBA-General Subjects2011;1810(4):384–390 [IF=5.000]
  22. Ying-Yong Zhao, Xiang-Yang Qin, Xian-Long Cheng, Xue-Ying Liu, Rui-Chao Lin. Rapid resolution liquid chromatography-mass spectrometry and high performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one.Analytica Chimica Acta2010;675(2):199–206 [IF=4.310]
  23. Ying-Yong Zhao*, Hui-Ling Wang, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin, Nosratola D Vaziri. Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy. Scientific Reports 2015;5:12936 [IF=5.228]
  24. Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao*.Anintegrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. Scientific Reports 2016; 6: 22151 [IF=5.578]
  25. Ting Tian, Hua Chen, Ying-Yong Zhao*. Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review. Journal of Ethnopharmacology 2014, 2014; 158: 373–387. [IF=3.284]
  26. Zhi-Hao Zhang, Feng Wei, Nosratola D. Vaziri, Xian-Long Cheng, Xu Bai, Rui-Chao Lin, Ying-Yong Zhao*. Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis. Scientific Reports 2015;5:14472 [IF=5.228]
  27. Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in nephrotoxicity. Advances in Clinical Chemistry 2014;65:69-89. [IF=4.302]
  28. Hua Chen, Hua Miao, Ya-Long Feng, Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in Dyslipidemia. Advances in Clinical Chemistry 2014; 66:101-119. [IF=4.302]
  29. Lin Chen, Wei Su, Hua Chen, Dan-Qian Chen, Ming Wang, Yan Guo, Ying-Yong Zhao*. Proteomics for biomarker identification and clinical application in kidney disease. Advances in Clinical Chemistry 2018; 85: 91–113. [IF=4.722]
  30. Ying-Yong Zhao*. Metabolomics in chronic kidney disease.Clinica Chimica Acta 2013; 422:59-69. [IF=2.850]
  31. Ying-Yong Zhao*, Xian-Long Cheng, Nosratola D. Vaziri, Shuman Liu, Rui-Chao Lin. UPLC-based metabonomics applications for discovering biomarkers of diseases in clinical chemistry. Clinical Biochemistry2014; 47(15):16-26.[IF=2.450]
  32. Ying-Yong Zhao*, Hua Chen, Ting Tian, Dan-Qian Chen, Xu Bai, Feng Wei.A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS. Plos One 2014; 9(12): e115467. [IF=3.499]
  33. Ying-Yong Zhao*, Xian-long Cheng, Rui-Chao Lin, Feng Wei. Lipidomics applications for diseases biomarker discovery in mammal’s models. Biomarkers in Medicine 2015;9(2):153-168. [IF=3.217]
  34. Ying-Yong Zhao*, Shao-Ping Wu, Shuman Liu, Yongmin Zhang, Rui-Chao Lin. Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications. Chemico-Biological Interactions 2014; 220:181-192. [IF=3.060]
  35. Ming Wang, Lin Chen, Dan Liu, Hua Chen, Dan-Dan Tang, Ying-Yong Zhao*. Metabolomics highlights pharmacological bioactivity and biochemical mechanism of traditional Chinese medicine. Chemico-Biological Interactions 2017; 273:133–141. [IF=3.143]
  36. Ying-Yong Zhao*,Ya-Long Feng, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Ultra performanceliquid chromatography-based metabonomic study of therapeutic effect of thesurface layer ofPoria cocoson adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism.Plos One2013; 8(3): e59617. [IF=4.092]
  37. Lin Chen, Dan-Qian Chen, Ming Wang, Dan Liu, Hua Chen, Fang Dou, Nosratola D. Vaziri, Ying-Yong Zhao*. Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. Chemico-Biological Interactions 2017;273:56–72. [IF=3.143]
  38. Hua Miao, Ming-Hua Li, Xu Zhang, Sheng-Jun Yuan, Charlene C. Ho, Ying-Yong Zhao*. The antihyperlipidemic effect of Fu-Ling-Pi is associated with abnormal fatty acid metabolism as assessed by UPLC-HDMS-based lipidomics. RSC Advances 2015 5 (79), 64208–64219. [IF=3.289]
  39. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei. Lipidomics: novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease. Chemico-Biological Interactions 2015; 245: 220-238. [IF=2.577]
  40. Zhi-Hao Zhang, Jia-Rong Mao, Hua Chen, Wei Su, Yuan Zhang, Li Zhang, Dan-Qian Chen, Ying-Yong Zhao*, Nosratola D. Vaziri. Removal of uremic retention products by hemodialysis is coupled with indiscriminate loss of vital metabolites. Clinical Biochemistry 2017; 50(18):1078-1086. [IF=2.434]
  41. Dan-Qian Chen, Hua Chen, Lin Chen, Dan-Dan Tang, Hua Miao, Ying-Yong Zhao*. Metabolomic application in toxicity evaluation and toxicological biomarker identification of natural product. Chemico-Biological Interactions 2016; 252: 114–130 [IF=3.143]
  42. Ying-Yong Zhao*, Ya-Long Feng, Xiao Du, Zhi-Hui Xi, Xian-LongCheng, Feng Wei. Diuretic activity the ethanol and aqueous extracts of thesurface layer ofporia cocosin rat.Journal of Ethnopharmacology2012;144(3):775–778. [IF=3.728]
  43. Ying-Yong Zhao*, Qi Su, Xian-Long Cheng, Xiao-Jie Tan, Xu Bai,Rui-Chao Lin. Pharmacokinetics, bioavailability, and metabolism of rhaponticinin rat plasma by UHPLC–Q–TOF/MS and UHPLC–DAD–MSn.Bioanalysis2012;4(6):713–723. [IF=3.253]
  44. Ying-Yong Zhao*.Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control ofPolyporus umbellatus(Pers.) Fries: A review.Journal of Ethnopharmacology2013; 149(1): 35-48. [IF=3.728]
  45. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xin-Yue Xiao,Rui-Chao Lin. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Biomarkers2012;17(1):48–55. [IF=2.215]
  46. Ying-Yong Zhao*, Jing Liu, Xian-Long Cheng, Xu Bai, Rui-ChaoLin. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS.Clinica Chimica Acta2012;413(5–6):642–649. [IF=2.850]
  47. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-ChaoLin.Ultra performance liquid chromatography coupledwith electrospray and atmospheric pressure chemical (ESCi) ionization-quadrupole time-of-flight mass spectrometry with novel mass spectrometryElevated Energy (MSE) data collection technique: Determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat.Journal of Separation Science2012;35(13):1619–1629. [IF=2.733].
  48. Ying-Yong Zhao*,Xian-Long Cheng,Ji-Hong Cui, Xing-Rong Yan, Feng Wei, Xu Bai,Rui-Chao Lin. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) onadenine-induced chronic renal failure rat: A serum metabonomics study based onultra performance liquid chromatography/ high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm.Clinica Chimica Acta 2012;413(19–20): 1438–1445. [IF=2.850]
  49. Ying-Yong Zhao*,Xian-Long Cheng, Charlene C. Ho, Feng Wei,Rui-Chao Lin, Yongmin Zhang. Pharmacokinetics of ergosterol in rats using rapid resolution liquid chromatography–atmospheric pressure chemical ionization multi-stage tandem mass spectrometry and rapid resolution liquid chromatography/tandem mass spectrometry.Journal of Chromatography B2011;879(21):1945 –1953. [IF=3.057]
  50. Ying-Yong Zhao*, Rui-Chao Lin. UPLC–MSE application in disease biomarker discovery: the discoveries in proteomics to metabolomics. Chemico-Biological Interactions 2014; 215(1):7-16.[IF=3.060]
  51. Ying-Yong Zhao*, Li Zhang, Jia-Rong Mao, Xiao-Hong Cheng,Rui-Chao Lin. Ergosta-4,6,8(14),22-tetraen-3-one isolated fromPolyporus umbellatusprevents earlyrenal injury in aristolochic acid-induced nephropathy rats.Journal of Pharmacy and Pharmacology2011;63(12):1581–1561.[IF=2.175]
  52. Yingyong Zhao, Lili Wang, Hua Miao, Charlene C. Ho, Jing Li,Xianlong Cheng, Ruichao Lin. LC method for the determination of rhaponticin in rat plasma, faeces and urine for application to pharmacokinetic studies.Chromatographia2011;73(5–6):599–603. [IF=1.195]
  53. Ying-Yong Zhao, Xian-Long Cheng, Yongmin Zhang, Xu Chao,Rui-Chao Lin. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats.Journal of Chromatography B2010;878(1):29–33. [IF=2.971]
  54. Ying-Yong Zhao, Xu Chao, Yongmin Zhang, Rui-Chao Lin.Cytotoxic steroids fromPolyporus umbellatus.Planta Medica2010;76(15):1755–1758. [IF=2.369]
  55. Ying-Yong Zhao, Xian-long Cheng, Yongmin Zhang, Ye Zhao,Rui-chao Lin. Simultaneous determination of eight major steroids fromPolyporus umbellatusby high-performance liquid chromatography coupled with mass spectrometry detections.Biomedical Chromatograph2010; 24(2):222–230. [IF=1.545]
  56. Ying-Yong Zhao, Xiang-Yang Qin, Yongmin Zhang, Rui-chao Lin,Xiao-Ye Li. Quantitative HPLC method and pharmacokinetic studies ofergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity fromPolyporus umbellatus.Biomedical Chromatography2010;24(10):1120–1124. [IF=1.545]
  57. Ying-Yong Zhao, Xian-long Cheng, Ren-ming Xie, Xu Chao,YongminZhang, Rui-chao Lin. Bioactivity-directed isolation, identification of diuretic compounds fromPolyporus umbellatus.Journal ofEthnopharmacology2009;126(1):184–187. [IF=3.728]
  58. Ying-Yong Zhao, Yong-min Zhang, Rui-chao Lin. An expeditious HPLC method to distinguishAconitum kusnezoffiifrom related species.Fitoterapia2009;80(6):333–338. [IF=2.139]
  59. Ying-Yong Zhao, Ye Zhao, Yong-min Zhang, Rui-chao Lin.Qualitative and quantitative analysis of diuretic component ergone inPolyporus umbellatusby HPLC with fluorescence detection and HPLC-APCI-MS/MS.Pharmazie2009;64(6):366–370. [IF=0.812]
  60. Ying-Yong Zhao, Libin Yang, Minchang Wang, Lili Wang ,Xian-long Cheng, Rui-chao Lin. 1β-hydroxylfriedelin, a new natural pentacylic triterpene from the sclerotia ofPolyporus umbellatus.Journal of Chemical Research2009;11:699–701. [IF=0.550]
  61. Ying-Yong Zhao, Xiang-Yang Qin, San-Ping Chen, Yongmin Zhang,Rui-Chao Lin. Crystal and molecular structure of rhaponticin fromRheum hotaoense.Journal of Chemical Crystallography2011;41(3):409–414. [IF=0.566]
  62. Ying-Yong Zhao*, Xuefeng Shen, Xian-Long Cheng, Feng Wei, XuBai, Rui-Chao Lin. Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSEdata collection technique.Process Biochemistry2012;47(12):1980–1987. [IF=3.225]
  63. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-ChaoLin.Application of faecal metabonomics on an experimentalmodel of tubulointerstitial fibrosis by ultra performance liquid chromatography/ high-sensitivity mass spectrometry with MSEdata collection technique.Biomarkers2012;17(8):721–729.[IF=2.215]
  64. Ying-Yong Zhao*, Li Zhang, Ya-Long Feng, Dan-Qian Chen, Zhi-HuiXi, Xiao Du, Xu Bai, Rui-Chao Lin. Pharmacokinetics of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside inrat using ultra-performance LC-quadrupole TOF-MS.Journal of Separation Science2013; 2013;36(5):863 –871. [IF=2.733]
  65. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xiao-Qiang Han,Xin-Yue Xiao, Rui-Chao Lin. Pharmacokinetics,bioavailability, and metabolismof 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucosidein rats by ultra performance liquid chromatography–quadrupole time-of-flightmass spectrometry and high performance liquid chromatography-ultraviolet detection.Journal of Liquid Chromatography & Related Technologies2013;36(6):717–730. [IF=0.706]
  66. Ying-Yong Zhao*, Li Zhang, Feng-Ya Long,Xian-Long Cheng, Xu Bai, Feng Wei, Rui-Chao Lin.UPLC-Q-TOF/HSMS/MS-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one.Chemico-Biological Interactions2013;301(1–3):31–38. [IF=3.060]
  67. Ying-Yong Zhao*, Ping Lei,Dan-Qian Chen, Ya-Long Feng, Xu Bai.Renal metabolic profiling of early renal injury and renoprotective effects ofporia cocosepidermis using UPLCQ-TOF/HSMS/MS.Journal of Pharmaceutical and Biomedical Analysis2013; 81–82(1):202–209. [IF=2.967]
  68. Ying-Yong Zhao*,Hai-Tao Li, Ya-Long Feng,Xu Bai, Rui-Chao Lin.Urinary metabonomic study of the surface layerofporia cocosas an effective treatment for chronic renal injury in rats.Journal of Ethnopharmacology 2013;148(2):403-410. [IF=3.728]
  69. Ying-Yong Zhao*, Ting Tian, Hua Chen, Jia-Rong Mao, Xu Bai, Xiao-Hong Cheng, Xin-Yue Xiao. Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS. Bioanalysis 2015; 7(6):685-700. [IF=3.027]
  70. Ying-Yong Zhao*, Ya-Long Feng, Ren-Ming Xie, Rui-Chao Lin.Polyporus umbellatus(Pers.) Fries:Traditional uses, phytochemistry, pharmacology, pharmacokinetics and qualitycontrol: A review.Acta Pharmacologia Sinica2013; 34:35. [IF=2.083]
  71. Yang Sun,Yingyong Zhao (co-first author),Guobo Li, Shengyong Yang, Xiaoyun Hu, Jun Fan. Studies of Interaction between Ergosta-4,6,8(14),22-tetraen-3-one (Ergone) and human serum albumin bymolecular spectroscopy and modeling.Journal of the Chinese Chemical Society-Taipei2011;58(5):602–610. [IF=0.678]
  72. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Xiang-Yang Qin,Ying-Yong Zhao*. Cloud-point extraction combined with liquid chromatography for determination of ergosterol, a natural product with diuretic activity, in rat plasma, urine and faeces.Journal of Analytical Methods in Chemistry2013; 2013: 479056. [IF=0.565]
  73. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Hua Chen, Lu Yin, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of fractions of Alismatis Rhizoma. Journal of Ethnopharmacology 2014;157:114–118. [IF=3.728]
  74. Yang Sun, Chun-Mei Hu, Guo-Bo Li, Sheng-Yong Yang, Lu-Sha Liu, Chun-Lei Tan, SongWei, Xaio-Yun Hu,Ying-Yong Zhao*,Jun Fan. Studies on the binding of iosalantolactone to human serum albumin by molecular spectroscopy and modeling.Indian Journal of Chemistry2011;50A:1477–1484. [IF=0.891]
  75. Lushu Liu, Yang Sun, Song Wei, Xiaoyun Hu,YingyongZhao*, Jun Fan. Solvent effect on the absorption and fluorescence of ergone:Determination of ground and excited state dipole moments.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012;86:120–123. [IF=2.098]
  76. Yang Sun,Yingyong Zhao*. Enhanced pharmacokinetics and anti-Tumor efficacy of PEGylated liposomal rhaponticin andplasma protein binding ability of rhaponticin.Journal of Nanoscience and Nanotechnology2012;12(10):7677–7684. [IF=1.563]
  77. Yang Sun, Zhen Ji,Yingyong Zhao*, XuhuaLiang, Xiaoyun Hu, Jun Fan. Enhanced distribution and anti-tumor activity ofergosta-4,6,8(14),22-tetraen-3-one by PEG liposomalization.Journal ofNanoscience and Nanotechnology2013;13(2):1435–1439. [IF=1.563]
  78. Xuhua Liang, Yang Sun, Wenyuan Zeng, Lusha Liu, Xuan Ma,Yingyong Zhao*, Jun Fan. Synthesis and biological evaluation of afolate-targeted rhaponticin conjugate.Bioorganic & Medicinal Chemistry2013;21(1):178–185. [IF=2.554]
  79. Xuhua Liang, Yang Sun, Lusha Liu, Xuan Ma, Xiaoyun Hu, Jun Fan,Yingyong Zhao*. Folate-functionalized nanoparticles for controlled ergosta-4,6,8(14),22-tetraen-3-one delivery.International Journal of Pharmaceutics2013;441(1–2):1–8. [IF=3.785]
  80. Chang Wang, Mei-Xia Meng, Xu-Lei Tang, Ke-Ming Chen, Li Zhang, Wei-Ning Liu,Ying-Yong Zhao*The proliferation, differentiation and mineralization effects of puerarin on osteoblastsin vitro.Chinese Journal of Natural Medicines 2014;12(6):444-450.
  81. Ya-Long Feng, Ping Lei, Hua Chen, Ting Tian, Lu Yin, Dan-Qian Chen, Qibing Mei,Ying-Yong Zhao*, Rui-Chao Lin. Diuretic activity of some fractions of the epidermis ofPoria cocos.Journal of Ethnopharmacology 2013, 150(3):1114-1118. [IF=3.728]
  82. Ya-Long Feng, Hua Chen, Ting Tian, Dan-Qian Chen, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis Rhizoma. Journal of Ethnopharmacology 2014, 154(2):386-390. [IF=3.728]
  83. Hua Chen, Lin Chen, Dan-Dan Tang, Dan-Qian Chen, Hua Miao, Ying-Yong Zhao*, Shuang-Cheng Ma*.Metabolomics reveals hyperlipidemic biomarkers and antihyperlipidemic effect of Poria cocos. Current Metabolomics 2016;4(2):104-115.
  84. Hua Miao, Li Zhang, Dan-Qian Chen, Hua Chen, Ying-Yong Zhao*, Shuang-Cheng Ma. Urinary biomarker and treatment mechanism of Rhizoma Alismatis on hyperlipidemia. Biomedical Chromatography 2017;31(4):e3829. [IF=1.729]
  85. Ying-Yong Zhao*, Xian-Long Cheng, Rui-Chao Lin. Lipidomics applications for discovering biomarkers of diseases in clinical chemistry.International review of cell and molecular biology 2014; 313: 1-26. [IF=4.970]
  86. Chung-I Li, David C Samuels, Ying-Yong Zhao, Yan Guo. Power and sample size calculations for high throughput sequencing based experiments. Briefings in Bioinformatics 2017; doi: 10.1093/bib/bbx061. [IF=8.399]
  87. Pan Zhang, Brian D. Lehmann, David C. Samuels, Shilin Zhao, Ying-Yong Zhao, Yu Shyr, Yan Guo. Estimating relative mitochondrial DNA copy number using high throughput sequencing data. Genomics 2017;109(5-6):457–462. [IF=2.801]
  88. Nosratola D. Vaziri, Shuman Liu, Seyed HFarzane, SohrabNazertehrani, MahyarKhazaeli, Ying-Yong Zhao. Dose-dependent deleterious and salutary actions of Nrf2 inducer, dh404, in chronic kidney disease. Free Radical Biology and Medicine 2015; 86: 374–381. [IF=5.710]
  89. Zhi-Hao Zhang,Ying-Yong Zhao, Xian-long Cheng, Zhong Dai, Chao Zhou, Xu Bai, Rui-Chao Lin. General toxicity ofPinellia ternate(Thunb.) Berit. in rat: A metabonomic method for profiling of serum metabolic changes.Journal of Ethnopharmacology 2013;149(1):303–310. [IF=3.728]
  90. Zhi-Hao Zhang,Ying-Yong Zhao, Xian-longCheng, Rui-Chao Lin, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced byPinelliaternata(Thunb.) Berit.Journal of Pharmaceutical and Biomedical Analysis2013;85(1):186–193. [IF=2.967]
  91. Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-yan He, Zhang Di, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao*, Si-wang Wang.Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition.Biomedicine & Pharmacotherapy 2018; 102: 765-771. [IF=3.457]
  92. Lin Chen, Tian Yang, De-Wen Lu, Hui Zhao, Ya-Long Feng, Hua Chen, Dan-Qian Chen, Nosratola D Vaziri, Ying-Yong Zhao*. Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment. Biomedicine & Pharmacotherapy 2018; 101: 670–681. [IF=2.759]
  93. Lusha Liu, Jun Fan, Chunmei Hu, Yang Sun, Xiaoyun Hu,Yingyong Zhao, Song Wei, Xuhua Liang. Studies on the Interaction between tubeimoside II and human serum albumin by spectroscopic methods.Acta Chimica Sinica2011;69(21):2589–2596. [IF=0.533]
  94. He-He Hu, Dan-Qian Chen, Yan-Ni Wang, Ya-Long Feng, Gang Cao, Nosratola D. Vaziri, Ying-Yong Zhao*. Newinsights into TGF-β/Smad signaling in tissue fibrosis. Chemico-Biological Interactions 2018; 292: 76–83. [IF=3.143]
  95. Xu Chao, Feng Shi,Ying-Yong Zhao, Ke Li, Ming-Li Peng, Chao Chen, Ya-Li Cui. Cytotoxicity of Fe3O4/Au composite nanoparticles loaded with doxorubicin combined with magnetic field.Pharmazie2010;65(7):500–504. [IF=0.869]
  96. Sui-Hong Yan,Ying-Yong Zhao, Hai-Song Zeng,Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun. Chemical composition and antioxidant activities of extracts fromApocyni Veneti Folium.Natural Products Research2012;26(7):600–608. [IF=0.906]
  97. Ying-Yong Zhao, Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements 2014.Journal of Analytical Methods in Chemistry2013;2014:109068. [IF=0.948]
  98. Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun,Ying-Yong Zhao*, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements.Journal of Analytical Methods in Chemistry2013;2013:182573. [IF=0.948]

相關詞條

熱門詞條

聯絡我們