個人簡介
學術和工作簡歷
1992-1995,東北師範大學,理學碩士
2007-現在,北京工業大學,副研究員
主講課程
研究領域和興趣
1. 新型的具有抗HIV和抗腫瘤活性的天然產物類似物的設計和合成
2. 新型手性配體的設計和合成以及不對稱催化反應的研究
3. 主客體化學:手性識別的研究
參與的科研項目
1 北京市自然科學基金面上項目,新型雙功能小分子催化劑的設計、合成和不對稱催化反應的研究,2012/01—2014/12,11.00萬,已結題,主持
2 北京市自然科學基金面上項目,新型橋連聯苯化合物的設計、合成與抗腫瘤活性研究,2010/01—2012/12,11.00萬,已結題,主持
3 北京市教委面上項目,新型秋水仙鹼B環類似物的設計、合成和構效關係研究,2009-/01—2011/12, 14.00萬,已結題,主持
4 北京市人才強教計畫中青年骨幹人才,新型(-)-Rhazinilam橋連聯芳基化合物的設計、立體選擇性合成和構效關係研究,2010/01—2012/12,10.00萬,已結題,主持
5 北京工業大學校基礎基金,固相負載的手性小分子催化劑的設計、合成及手性抗HIV-1藥物的不對稱催化合成,2011/10—2013/10,8.00萬,已結題,主持
6 企事業委託項目,40015001201002,芳基二氫吡啶酮化合物的合成, 2009/12至2010/12—2011/12,10.00萬,在研,主持
7 科技部國家科技重大專項目,2012ZX10001007-008-002,愛滋病和病毒性肝炎等重大傳染病防治:病毒吸附抑制劑HPB研究,2012/01—2015/12,在研,參加
8 國家重點基礎研究發展計畫(973計畫),載藥納米顆粒的藥效學、生物利用度及機理研究,2011/01—2013/08,在研,參加
代表性論文
1.Hongwu Zhao, Rugang Zhong, Hong Yan, Wei Yang, Jin Cui and Wenting Hua,Synthesis of A Series of Novel Chiral Aromatic Heterocyclic Macrocycles Containing L-Amino acid and 2,5-Bisphenyl-1,3,4-Triazole Subunits, Synthetic Communications,2009,39(17)
2.Hongwu Zhao, Jin Cui, Shi Su, Xiuqing Song, Hong Yan, Rugang Zhong, Liming Hu,Synthesis and Structure of C2-Symmetrical Optically Active Macrocycles Consisting of Two Biaryl and Two Amino Acid Moieties, 2010
3.Hongwu Zhao, Jin Cui, Shi Su, Xiuqing Song, Hong Yan, Rugang Zhong, Asymmetric Synthesis of Novel Biaryl Analogs Containing Chiral 5,6-Fused Bicyclic Bridges,2010
4.Paul R. Carlier* and Hongwu Zhao. Enantioselective Synthesis of Diversely Substituted Quaternary 1,4-Benzodiazepin-2-ones and 1,4-Benzodiazepin-2,5-diones. J. Am. Chem. Soc., 2006
5.Paul R. Carlier*, Polo C.-H. Lam, Joseph C. DeGuzman and Hongwu Zhao. Memory of Chirality Trapping of Low Inversion Barrier 1,4-Benzodiazepin-2-one enolates, Tetrahedron: Asymmetry, 2005
6.Hongwu Zhao, Danny C. Hsu and Paul R. Carlier. Memory of Chirality: An Emerging Strategy for Asymmetric Synthesis. Synthesis (invited review),2005
7.Paul R. Carlier, Hongwu Zhao, Joe DeGuzman and Polo C.-H. Lam. Enantioselective Synthesis of Quaternary 1,4-Benzodiazepin-2-onesvia Memory of Chirality, J. Am. Chem. Soc., 2003
8.Dan Yang, Shen Gu, Yi-Long Yan,Hongwu Zhao and Nian-Yong Zhu. Atom-Transfer Tandem Radical Cyclization Reactions Promoted by Lewis Acids, Angew. Chem. Int. Ed., 2002
9.Hongwu Zhaoand Wenting Hua. The Synthesis of Chiral Macrocyclic Ligands Containing a 2, 5-Bisphenyl-1, 3, 4-Oxadiazole Unit. Synthetic communications, 2000
10.Hongwu Zhaoand Wenting Hua. Synthesis and Characterization of PyridineBased Polyamido-polyester Optically Active Macrocycles and EnantiomericRecognition for D- and L- Amino acid Methyl Ester Hydrochloride. J. Org. Chem.,2000
11.Hongwu Zhao, Yongge Wei and Wenting Hua. The Synthesis, Crystal Structure and Self-Organization of Molecules Containing 2,5-Bis(o-aminophenyl)-1,3,4-Oxadiazoles Unit and N-Tos-L-Amino Acid Residues. J. Mol. Struct., 2000
12.Qun Liu, Hongwu Zhao, Zhiyun Yang and Bailing Xu. The Chemistry of a-Oxoketene Cyclic Dithioacetals (XXV ) - Studies on the Substitution Cycloaromatization Reaction of Adducts from β, β -1, 3-Propylenedithio α-, β- Unsaturated Ketones and Methallyl Grignard Reagent by Bifunctional Group Nucleophiles. Chemical Joural of Chinese Universitie, 1996