教育經歷
2014.12~2019.01, 西北農林科技大學,博士後。
2008.09~2012.12, 就讀於西北農林科技大學基礎獸醫學專業,獲博灑阿海士學位。
2005.09~2008.07, 就讀於西北農林科技大學生理學專業,獲碩士學位。1996.09~2000.07, 就讀於西北農林科技大學獸醫專業,獲學士學位。
工作經歷
2000.07~至今,在西北農林科技大學動物醫學院從事教學、科研工作。
2011.01~2012.02,在美國密嬸棕放歇根理工大學理學院生物系從事科研。
2009.10~2010.12,在美國肯塔基大學醫學院分子與細胞生物化學系從事科婆境套研。2006.09~2007.09,在中國疾病預防控制中心病毒病預防控制所病毒基因工程國家重點實驗室從事科研。
主講課程
為本科生和研究生講授《動物病理解剖學》、《細胞與分子病理學》、《動物病理學專題》等課程,
研究方向
主要從事動物分子與細胞病理學和動物病毒性腹瀉的致病機制及防控技術研究。
科研項目
1.
國家自然基金(面上項目),獲批經費:59萬元,起止年月:2020.01~2023.12。
2.陝西省重點研發計畫項目,獲批經費:35萬元,起止年月:2018.01~2019.12。
3.楊凌示範區科技計畫項目,獲批經費:5萬元,起止年月:2018.07~2020.07。
4.
國家自然基金(面上項目),獲批經費:80萬元,起止年月:2015.01~2018.12。
5.中國博士後基金(一等資辯挨旋探助),獲批經費:8萬元,起止年月:2015.06~2017.06。
6.國際科技合作種子基金,獲批經茅碑費:4萬元,起止年月:2015.06~2017.06。
7.高校基本科研業務費專項,獲批經定戀捆費:10萬元,起止年月:2014.01~2017.01。
8.主持博士科研啟臘遷汗腿動基金,獲批經費:5萬元,起止年月:2013.01~2015.12。
主要論著
1. Lingling Chang, Yanping Qi,Dan Liu, Qian Du, Xiaomin Zhao* and Dewen Tong*. Molecular detection and genotyping of bovine viral diarrhea virus in WesternChina.BMC Veterinary Research, 2021, 17: 66.
2. Xuelian Ma, Xiaomin Zhao, Kaili Wang,Xiaoyi Tang, Jianxiong Guo, Mi Mi, Yanping Qi, Lingling Chang,Yong Huang andDewen Tong*. Identification and analysis of long non-coding RNAs that areinvolved in inflammatory process in response to transmissible gastroenteritisvirus infection. BMC genomics, 2019, 20: 806.
3. XiaominZhao, Xuelian Ma, Jianxiong Guo, Mi Mi, Kaili Wang, Chuyi Zhang, XiaoyiTang, Lingling Chang, Yong Huang, Dewen Tong*. Circular RNA CircEZH2 SuppressesTransmissible Gastroenteritis Coronavirus-induced Opening of MitochondrialPermeability Transition Pore via Targeting MiR-22 in IPEC-J2. InternationalJournal of Biological Sciences, 2019, 15(10): p. 2051-2064.
4. XiaominZhao, Xiangjun Song, Xiaoyuan Bai, Zhanhang Tan, Xuelian Ma, JianxiongGuo,Zhichao Zhang, Qian Du, Yong Huang, and Dewen Tong*. microRNA-222Attenuates Mitochondrial Dysfunction during Transmissible Gastroenteritis VirusInfection,Molecular & Cellular Proteomics,2019,18(1): p. 51-64.
5. Xuelian Ma, Xiaomin Zhao, ZhichaoZhang, Jianxiong Guo, Lijuan Guan,Juejun Li, Mi Mi, Yong Huang, Dewen Tong*.Differentially expressed non-coding RNAs induced by transmissiblegastroenteritis virus potentially regulate inflammation and NF-κB pathway inporcine intestinal epithelial cell line, BMC Genomics, 2018, 19(1): p. 747.
6. XiaominZhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma,Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang*, and Dewen Tong*.microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-inducedMitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 ReceptorAccessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro. Molecular& Cellular Proteomics, 2018, 17(2): p. 190-204.
7. XiaominZhao, Xiangjun Song, Xiaoyun Bai, Naijiao Fei, Yong Huang, Zhimin Zhao,Qian Du, Hongling Zhang, Liang Zhang, Dewen Tong*. miR-27b attenuates apoptosisinduced by transmissible gastroenteritis virus (TGEV) infection via targetingrunt-related transcription factor 1 (RUNX1). Peer J, 2016, 4: p. e1635.
8. XiaominZhao, Hailing Xiang, Xiaoyun Bai, Naijiao Fei, Yong Huang, Xiangjun Song,Hongling Zhang, Liang Zhang, Dewen Tong*. Porcine parvovirus infectionactivates mitochondria-mediated apoptotic signaling pathway by inducing ROSaccumulation. Virology Journal, 2016, 13(1): p. 26-34.
9. Xiangjun Song, Xiaomin Zhao, Yong Huang,Hailing Xiang, Wenlong Zhang, Dewen Tong*. Transmissible Gastroenteritis Virus(TGEV) Infection Alters the Expression of Cellular MicroRNA Species That AffectTranscription of TGEV Gene 7. International Journal of Biological Sciences,2015, 11(8): p. 913-922.
10. XiaominZhao, Ramkumar Mohan, Sabire Özcan*, and Xiaoqing Tang*. MicroRNA-30dInduces Insulin Transcription Factor MafA and Insulin Production by TargetingMitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic beta-Cells. Journalof Biological Chemistry, 2012, 287(37): p. 31155-31164.
11. Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, HonglingZhang, Xiangjun Song,Wenlong Zhang, Dewen Tong*. Regulation of ROS intransmissible gastroenteritis virus-activated apoptotic signaling. BiochemistryBiophysical Research Communications, 2013, 442(1-2): p. 33-37.
#為共同第一作者,*為通訊作者。
其他科研成果
1. 國家發明專利:牛病毒性腹瀉病毒、牛冠狀病毒和牛輪狀病毒的三重RPA檢測試劑盒(CN2021101563263.3)
2. 國家發明專利:牛副流感病毒和牛呼吸道合胞體病毒雙重RPA檢測試劑盒(CN202011602492.3)
3. 國家發明專利:口蹄疫病毒和水泡性口炎病毒雙重RPA檢測試劑盒(CN2021101774777.7)
4. 國家計算機軟體著作權:豬腹瀉病監測預警防控系統(軟著登字第5144284號)
5. 國家計算機軟體著作權:豬圓環病毒病監測大數據平台(軟著登字第6147017號)
6. 國家計算機軟體著作權:西農動物病理形態學雲課堂平台(軟著登字第6140279號)
7. 為企業制定了仔豬腹瀉防控標準、豬流行性腹瀉淨化標準、豬流行性腹瀉防控標準等。
主要論著
1. Lingling Chang, Yanping Qi,Dan Liu, Qian Du, Xiaomin Zhao* and Dewen Tong*. Molecular detection and genotyping of bovine viral diarrhea virus in WesternChina.BMC Veterinary Research, 2021, 17: 66.
2. Xuelian Ma, Xiaomin Zhao, Kaili Wang,Xiaoyi Tang, Jianxiong Guo, Mi Mi, Yanping Qi, Lingling Chang,Yong Huang andDewen Tong*. Identification and analysis of long non-coding RNAs that areinvolved in inflammatory process in response to transmissible gastroenteritisvirus infection. BMC genomics, 2019, 20: 806.
3. XiaominZhao, Xuelian Ma, Jianxiong Guo, Mi Mi, Kaili Wang, Chuyi Zhang, XiaoyiTang, Lingling Chang, Yong Huang, Dewen Tong*. Circular RNA CircEZH2 SuppressesTransmissible Gastroenteritis Coronavirus-induced Opening of MitochondrialPermeability Transition Pore via Targeting MiR-22 in IPEC-J2. InternationalJournal of Biological Sciences, 2019, 15(10): p. 2051-2064.
4. XiaominZhao, Xiangjun Song, Xiaoyuan Bai, Zhanhang Tan, Xuelian Ma, JianxiongGuo,Zhichao Zhang, Qian Du, Yong Huang, and Dewen Tong*. microRNA-222Attenuates Mitochondrial Dysfunction during Transmissible Gastroenteritis VirusInfection,Molecular & Cellular Proteomics,2019,18(1): p. 51-64.
5. Xuelian Ma, Xiaomin Zhao, ZhichaoZhang, Jianxiong Guo, Lijuan Guan,Juejun Li, Mi Mi, Yong Huang, Dewen Tong*.Differentially expressed non-coding RNAs induced by transmissiblegastroenteritis virus potentially regulate inflammation and NF-κB pathway inporcine intestinal epithelial cell line, BMC Genomics, 2018, 19(1): p. 747.
6. XiaominZhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma,Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang*, and Dewen Tong*.microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-inducedMitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 ReceptorAccessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro. Molecular& Cellular Proteomics, 2018, 17(2): p. 190-204.
7. XiaominZhao, Xiangjun Song, Xiaoyun Bai, Naijiao Fei, Yong Huang, Zhimin Zhao,Qian Du, Hongling Zhang, Liang Zhang, Dewen Tong*. miR-27b attenuates apoptosisinduced by transmissible gastroenteritis virus (TGEV) infection via targetingrunt-related transcription factor 1 (RUNX1). Peer J, 2016, 4: p. e1635.
8. XiaominZhao, Hailing Xiang, Xiaoyun Bai, Naijiao Fei, Yong Huang, Xiangjun Song,Hongling Zhang, Liang Zhang, Dewen Tong*. Porcine parvovirus infectionactivates mitochondria-mediated apoptotic signaling pathway by inducing ROSaccumulation. Virology Journal, 2016, 13(1): p. 26-34.
9. Xiangjun Song, Xiaomin Zhao, Yong Huang,Hailing Xiang, Wenlong Zhang, Dewen Tong*. Transmissible Gastroenteritis Virus(TGEV) Infection Alters the Expression of Cellular MicroRNA Species That AffectTranscription of TGEV Gene 7. International Journal of Biological Sciences,2015, 11(8): p. 913-922.
10. XiaominZhao, Ramkumar Mohan, Sabire Özcan*, and Xiaoqing Tang*. MicroRNA-30dInduces Insulin Transcription Factor MafA and Insulin Production by TargetingMitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic beta-Cells. Journalof Biological Chemistry, 2012, 287(37): p. 31155-31164.
11. Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, HonglingZhang, Xiangjun Song,Wenlong Zhang, Dewen Tong*. Regulation of ROS intransmissible gastroenteritis virus-activated apoptotic signaling. BiochemistryBiophysical Research Communications, 2013, 442(1-2): p. 33-37.
#為共同第一作者,*為通訊作者。
其他科研成果
1. 國家發明專利:牛病毒性腹瀉病毒、牛冠狀病毒和牛輪狀病毒的三重RPA檢測試劑盒(CN2021101563263.3)
2. 國家發明專利:牛副流感病毒和牛呼吸道合胞體病毒雙重RPA檢測試劑盒(CN202011602492.3)
3. 國家發明專利:口蹄疫病毒和水泡性口炎病毒雙重RPA檢測試劑盒(CN2021101774777.7)
4. 國家計算機軟體著作權:豬腹瀉病監測預警防控系統(軟著登字第5144284號)
5. 國家計算機軟體著作權:豬圓環病毒病監測大數據平台(軟著登字第6147017號)
6. 國家計算機軟體著作權:西農動物病理形態學雲課堂平台(軟著登字第6140279號)
7. 為企業制定了仔豬腹瀉防控標準、豬流行性腹瀉淨化標準、豬流行性腹瀉防控標準等。