趙春順

趙春順

趙春順 博士，中山大學藥劑學教授，博士生導師。

基本介紹

  • 中文名：趙春順
  • 國籍：中國
  • 民族：漢族
  • 職業：教師
  • 畢業院校：瀋陽藥科大學
  • 性別：男
  • ：
個人簡介,講授課程,研究成果,主要研究方向,主持科研課題,部分發表論文,

個人簡介

趙春順 男，博士，教授，博士生導師。2003畢業於瀋陽藥科大學藥劑學專業，獲理學博士學位；1995年7月至1997年8月於河北製藥集團從事新藥研發工作；1999年9月至2000年8月於石藥集團從事新藥研發工作；2009年11月至2010年11月在北卡羅來納大學教堂山分校（UNC）藥學院從事靶向給藥系統研究；2003年9月入職中山大學藥學院。近幾年來負責國家“十一五”科技重大專項“新藥研究開發關鍵技術研究”專項、“大品種技術改造”專項、國家自然科學基金、廣東省科技計畫重點項目、平台項目、廣州市科技計畫重大項目等多項課題。同時，負責並完成企業合作項目30餘項；申請專利9項，授權7項；國際PCT 2項，目前已獲10個國家授權；發表研究論文50餘篇。
趙春順

講授課程

本科生：藥劑學，藥物製劑設計策略與實例
研究生：藥物吸收與劑型設計

研究成果

主要研究方向

新型給藥系統的設計與評價、藥物晶型的製備與篩選

主持科研課題

  1. 國家自然科學基金項目，“原位腫瘤疫苗的光激活協同IDO阻斷和抗骨重吸收用於乳腺癌骨轉移治療的研究” （81973256，2020-2023）
  2. 國家自然基金項目，“基於光觸發同步釋放ROS與藥物的眼內長效植入系統的構建及其用於後囊渾濁防治的評價” （81673369，2017-2020）
  3. 國家自然基金項目，“雙功能晶狀體囊袋植入系統的構建與性能評價” （81173003，2012-2015）
  4. 廣東省科技計畫重點項目，“抗缺血性腦卒中候選藥物--異吲哚酮類化合物的篩選及臨床前研究”，（2015，2015B020211005）
  5. “十一五”國家科技重大專項“重大新藥創製”項目“新藥研究開發關鍵技術研究”專項，“高生物利用度及穩定性藥物晶型的製備與分析技術及產業化套用”,（2009，2009ZX09501-022，分題負責人）；
  6. “十一五”國家科技重大專項“重大新藥創製”項目“大品種技術改造”專項，“丁苯酞高端製劑及其作用靶點、機理研究”，（2008，2008ZX09201-007，分題負責人）；
  7. 企業合作項目30餘項。

部分發表論文

  1. Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Yifeng Shen, Yali Jiang, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao*. A light-triggered self-reinforced nanoagent for targeted chemophotodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways. J. Control Release, 2020;319:119-134.
  2. Yanjuan Huang, Yali Jiang, Zhanghong Xiao, Yifeng Shen, Liangfeng Huang, Xiaoyu Xu, Gaofei Wei, Congjun Xu, Chunshun Zhao*. Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion. Chemical Engineering Journal, 2020;380:122369.
  3. Xiaoyu Xu, Zishan Zeng, Zeqian Huang, Yangwen Sun, Yanjuan Huang, Jie Chen, Junxian Ye, Haolan Yang, Chanzhen Yang, Chunshun Zhao*. Near-infrared light-triggered degradable hyaluronic acid hydrogel for ondemand drug release and combined chemo-photodynamic therapy. Carbohydrate Polymers, 2020; 229:115394.
  4. Zeqian Huang, Gaofei Wei, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao*. Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor. Theranostics, 2019; 9(19):5542-5557.
  5. Yuanfeng He, Yanjuan Huang, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao*. Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. J Control Release. 2017; 264:76-88.
  6. Ming Lei, Zihang Peng, Qian Dong, Yuanfeng He, Zhaoguo Zhang, Xuefei Zhang, Mina Yan, Chunshun Zhao*. A Novel Capsular Tension Ring as Local Sustained-Release Carrier for Preventing Posterior Capsule Opacification. Biomaterials, 2016; 89:148-156.
  7. Xiaoyu Xu, Ziyuan Huang, Zeqian Huang, Xuefei Zhang, Siyu He, Xiaoqi Sun, Yifeng Shen, Mina Yan, Chunshun Zhao*. Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemo-Photothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017;9(24):20361-20375
  8. Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao*. Coordination self-assembly of platinum-bisphosphonate polymer-metal complex nanoparticles for cisplatin delivery and effective cancer therapy. Nanoscale. 2017,9:10002-10019
  9. Ziyuan Huang, Liangfeng Huang, Yanjuan Huang, Yuanfeng He, Xiaoqi Sun, Xiang Fu, Xiaoyu Xu, Gaofei Wei, Dawei Chen and Chunshun Zhao*. Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy. Nanoscale.2017, 9, 15883–15894.
  10. Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui*, Chunshun Zhao*. Calcium phosphate nanoparticles functionalized with alendronate- conjugated polyethylene glycol (PEG) for the treatment of bone metastasis.Int J Pharm., 2017; 516(1-2):352–363
  11. Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao. Systemic toxicity induced by aggregated layered double hydroxide nanoparticles. Int J Nanomed. 2017; 12: 7183–7195.
  12. Yunhui Liao, Xuefei Zhang, Chenglin Li, Yanjuan Huang, Ming Lei, Mina Yan,Yuefang Zhou, Chunshun Zhao*. Inclusion complexes of HP-β-cyclodextrin with agomelatine:Preparation, characterization, mechanism study and in vivo evaluation. Carbohydrate Polymers, 2016;147: 415–425
  13. Zhaoguo Zhang, Wenyong Huang, Ming Lei, Yuanfeng He, Mina Yan, Xuefei Zhang, Chunshun Zhao*. Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention.Int J Pharm., 2016;498:1-11
  14. Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao*. Lipid-coated ZnO nanoparticles as lymphatictargeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo. J. Mater. Chem. B, 2015,3(26):5249-5260

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