趙子建，教授，博士導師，廣東工業大學百人計畫特聘教授，國家特聘專家，科技部“973”重大研究計畫首席科學家，江蘇省特聘教授第一批人選，廣東省珠江人才計畫創新創業團隊帶頭人。於美國南加州大學獲得生物化學及分子生物學博士學位後在美國華盛頓州大學西雅圖醫學院藥理學系從事藥物開發研究。2000年任職匹茲堡大學醫學院細胞生物和生理學系tenure-track教授直至終身教授（tenured）。
基本介紹
- 中文名：趙子建
- 職業：教師
- 畢業院校：北京大學
- 學位/學歷：博士
研究領域,主要論文,
研究領域
1.基因工程改造的微生物在腫瘤治療中的套用；
2.多不飽和脂肪酸代謝對糖尿病和肥胖的影響機制及藥物研發；
3.脫細胞異種生物材料在臨床中的套用；
4.腫瘤分子病理和個性化病理診斷以及代謝性相關婦科疾病研究；
5.不孕不育的分子機理和防治。
主要論文
1. Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X,Zhao AZ*.(2017) ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017 May 1;127(5):1757-1771.
2. Cheng, Lixian，Shi, Hui，Jin, Yan，Li, Xiaoxi，Pan, Jinshun，Lai, Yimei，Lin, Yan，Jin, Ya，Roy, Gaurab，Zhao, Allan*，Li, Fanghong*. (2016) Adiponect in Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice.，Endocrinology，157(12)：4875~4887.
3. Li, Jie，Wei, Dong，McCrory, Mark A，Szalai, Alexander J，Yang, Gangyi，Li, Ling，Li, Fanghong(*)，Zhao, Allan Z *.(2016) Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.，Biochem J，473(9): 1215~1224.
4. Zhou S, Zhao Z, Lin Y, Gong S, Li F, Pan J, Li X, Gao Z,Zhao AZ*.(2016) Suppression of pancreatic ductal adenocarcinoma growth by intratumoral delivery of attenuated Salmonella typhimurium using a dual fluorescent live tracking system. Cancer Biol Ther, 17(7):732-40.
5. Pan J, Cheng L, Bi X, Zhang X, Liu S, Bai X, Li F,Zhao AZ*.(2015) Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. Sci Rep. 5:14958.
6. Wei, D., Li, J., Shen, MD, Jia,W, Tian,H., Dai,Y., andZhao, AZ*. (2010) Cellular Production of n-3 PUFAs and Reduciton of n-6/n-3 ratios in the Pancreatic b-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes. 59: 471-478.
7. Cong L, Gasser J, Zhao J, Yang B, Li F,Zhao AZ*.(2007) Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95- Endocr Relat Cancer. 14(3): 713-20.
8. Cong L, Chen K, Li J, Gao P, Li Q, Mi S, Wu X,Zhao AZ *.(2007) Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. Biochem J. 403(3): 519-25.
9. Chen, K., Li, FH, Li, J., Cai, H., Strom, S., Bisello, A., Friedman-Einat, M., Kelley, DE, McCroy, M., Szalai, A.,Zhao, AZ *.(2006) Induction of Leptin Resistance through Direct Interaction ofC-Reactive Protein with Leptin. Nature Medicine 12: 425-432.
10.Li, J, Li, F, andZhao, AZ *.(2006) Inflammation and Leptin，Drug Discovery Today: Disease Mechanisms 3 (3): 387-393.
11.Huan, J.N., Li, J., Han, Y.P., Chen, K., Wu, N., andZhao, A.Z*. (2003) Adipocyte-Selective Reduction of the Leptin Receptors Induced by Antisense-RNA Leads to Increased Adiposity, Dyslipidemia and Insulin Resistance. J. Biol. Chem. 278: 45638-45650.
12.Zhao, A.Z.,Huan, J.N. and Sahu, A. (2002) Requirement of a PI3K-PDE3B-cAMP Pathway for the Satiety Function of Leptin in the Hypothalamus. Nature Neuroscience 5:727-728.
13.Zhao, A.Z.,Shinohara, M., Huang, D., Eldar-Finkelman, H., Krebs, E.G., Beavo, J.A. and Bornfeldt, K.E. (2000) Leptin Antagonizes the Action of Glucagon by Activating Phosphodiesterase 3B in Primary Hepatocytes. J. Biol. Chem. 275:11348-11354.
14.Zhao, A.Z.,Bornfeldt, K.E., and Beavo, JA. (1998) Leptin Inhibition of Insulin Secretion through Activation of Phosphodiesterase 3B.J. Clinc. Inves. 102: 869-873.
15.Zhao, A.Z.,Zhao, H., Teague, J., Fujimoto, W., and Beavo, J.A. (1997) Attenuation of Insulin Secretion by Insulin-like Growth Factor 1 Is Mediated through Activation of Phosphodiesterase 3B. Proc. Natl. Acad. U.S.A. 94: 3223-3228.
