基本介紹
- 中文名：趙健元
- 出生日期：1980年
- 畢業院校：安徽大學生命科學學院
- 學位/學歷：博士學位
- 主要成就：國家優秀青年基金
個人簡介,研究方向,獲獎情況,主要成果,
個人簡介
1999-2006年就讀安徽大學生命科學學院。
2003-2006分別獲得擊騙愚生物技術專業學士學位和生化分子生物學專業碩士學位。
2008-2011年臘台朽就讀復旦大學遺傳學專業並獲博士學位。
2011-2013在美國約翰霍普金斯大學從事博士後研究。
2013年9月復旦大學工作，先後被聘為青年副研究員、副研究員、研究員。
研究方向
從遺傳和代謝的角度研究人類重大出生缺陷（先天性心臟病、神經管畸形）和腫瘤的發病機制，碑謎凳發展新型的干預策略。主持863青年科學家專題和多項國家自然基奔糊海危金面上項目，作為骨幹參與基金委創新群體基金和國家973項目。
獲獎情況
國家優秀青年基金（2017）、教育部自然科學一等獎（2015，排名第三）、國家婦幼健康雅煉灑戰科學技術一等獎（2015，排名第四）、上海市優秀博士論文（2014）、復星獎教金特等獎（2018）、羅氏診斷危多研究獎（2013）。榜府府
主要成果
1.Wang D, Wang F, Shi KH, Tao H, Li Y, Zhao R, Lu H, Duan W, Qiao B, Zhao SM*, Wang H*,Zhao JY*. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.Circulation. 2017 May 2; 135(18): 1733-1748.
2. Xu S, Liu CX, Xu W, Huang L,Zhao JY*, Zhao SM*. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation.Signal Transduction & Target Therapy. 2017 Feb 10; 2, e16035. doi: 10.1038/sigtrans.2016.35.
3. Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX*. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.Nature Communications. 2017 Mar 8; 8:14712.
4. Zhao JY, Qiao B, Duan WY, Gong XH, Peng QQ, Jiang SS, Lu CQ, Chen YJ, Shen HB, Huang GY*, Jin L*, Wang HY*. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations.European Heart Journal. 2014 Mar; 35(11): 733-42.
5. Xu JT,Zhao JY, Zhao X, Ligons D, Tiwari V, Atianjoh FE, Lee CY, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.The Journal of Clinical Investigation. 2014 Feb; 124(2): 592-603.
6. Zhao X, Tang Z, Zhang H, Atianjoh FE,Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX*. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.Nature Neuroscience. 2013 Aug; 16(8): 1024-31.
7. Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao B, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY*. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population.Cell Research. 2013, 23:242-53.
8. Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B*, Wang HY*. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population.Circulation. 2012 Jan 24; 125(3): 482-90.
5. Xu JT,Zhao JY, Zhao X, Ligons D, Tiwari V, Atianjoh FE, Lee CY, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.The Journal of Clinical Investigation. 2014 Feb; 124(2): 592-603.
6. Zhao X, Tang Z, Zhang H, Atianjoh FE,Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX*. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.Nature Neuroscience. 2013 Aug; 16(8): 1024-31.
7. Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao B, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY*. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population.Cell Research. 2013, 23:242-53.
8. Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B*, Wang HY*. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population.Circulation. 2012 Jan 24; 125(3): 482-90.
