基本介紹
- 中文名：譚臣
- 學位/學歷：博士
- 職業：教師
- 專業方向：動物醫學
- 任職院校：華中農業大學動物科學技術學院動物醫學院
個人經歷,研究方向,學術成果,榮譽獎項,
個人經歷
教育經歷
2001.09 - 2005.06，華中農業大學，動物醫學專業畢業，農學學士
2005.09 - 2010.06， 華中農業大學，預防獸醫學專業畢業，農學博士
2008.11 - 2010.05，倫敦大學衛生與熱帶醫學院，聯合培養博士研究
工作經歷
2010.7-2012.12，華中農業大學講師，
2013.1-2018.11，華中農業大學副教授、碩士生導師。
2018.11-至今，華中農業大學教授，博士生導師。
研究方向
動物細菌病原微生物基因組學、致病機理、免疫機理、新型疫苗與藥物的研發
學術成果
A著作類
1.《獸醫手冊》參編。
B論文類
1.Fei Rui-Hua#, Tan Chen#, Huang Yue, Chen Huan-Chun, Guo Ai-Zhen, Wang Hai-Lin, Hu Yong-Gang*. Self-Assembled Ti4+@Biospore Microspheres for Sensitive DNA Analysis. ACS Appl. Mater. Interfaces. 2017,9:34696-34705.
2.Xia Miaomiao, Li Zheng, Chen Yingyu, Xiang Yuqiang, Yang Li, Zhao Xiangwei, Guo Aizhen, Chen Huanchun, Tan Chen*, Hu Yonggang*. Protein self-assembly via Zr4+ ions on spore-based microspheres for immunoassays. Sensors and Actuators B. 2018,254:166-176.
3.Li Pei, Wang Rui, Dong Wenqi, Hu Linlin, Zong Bingbing, Zhang Yanyan, Wang Xiangru, Guo Aizhen, Zhang Anding, Xiang Yaozu, Chen Huanchun, Tan Chen*. Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis. Frontiers in Cellular and Infection Microbiology, 2017, 00065.
4.Liu Feng, Fu Jiyang, Liu Canying, Chen Jing, Sun Minhua, Chen Huanchun, Tan Chen*, Wang Xiangru*. Characterization and distinction of two flagellar systems inextraintestinal pathogenic Escherichia coli PCN033. Microbiol Res, 2017, 196:69−79.
5.Peng Ying, Wang Xiangru, Shou Jin, Zong Bingbing, Zhang Yanya, Tan Jia, Chen Jing, Hu Linlin, Zhu Yongwei, Chen Huanchun, Tan Chen*. Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system. Sci Rep, 2016, 6:26816.
6.Chen Jing, Su Lijie, Wang Xiangru, Zhang Tao, Liu Feng, Chen Huanchun, Tan Chen*. Polyphosphate Kinase Mediates Antibiotic Tolerance in Extraintestinal Pathogenic Escherichia coli PCN033. Front Microbiol, 2016, 7:724.
7.Gao Rongsui#, Li Yue#, Lin Jingxia, Tan Chen*,Youjun Feng*. Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli. Sci China Life Sci, 2016, 59(7):732-734.
8.Li Zhencui#, Tan Chen#, Lin Jingxia, Youjun Feng*. Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota. Sci China Life Sci, 2016, 59(9):91-97.
9.Zhang Yanyan, Ding Dandan, Liu Manli, Yang Xiaopei, Zong Bingbing, Wang Xiangru, Chen Huanchun, Bei Weicheng, Tan Chen*. Effect of the glycosyltransferases on the capsular polysaccharidesynthesis of Streptococcus suis serotype 2. Microbiol Res, 2016, 185:45−54.
10.Ding Yi, Zhu Dongmei, Zhang Jianmin, Yang Longsheng, Wang Xiangru, Chen Huanchun, Tan Chen*. Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae isolated from China. Emerg Microbes Infec, 2015,4(11):e69.
11.Liu Canying, Zheng Huajun, Yang Minjun, Xu Zhuofei, Wang Xiangru, Wei Liuya, Tang Biao, Liu Feng, Zhang Yanyan, Ding Yi, Tang Xibiao, Wu Bin, Timothy J. Johnson, Chen Huanchun, Tan Chen*. Genome analysis and in vivo virulence of porcine extraintestinal pathogenic Escherichia coli strain PCN033. BMC Genomics, 2015, 16: 717.
12.Zhang Yun#, Tan Chen#, Fei Ruihua, Liu Xiaoxiao, Zhou Yuan, Chen Jing, Chen Huanchun, Zhou Rui, and Hu Yonggang*.Sensitive Chemiluminescence Immunoassay for E. coli O157:H7 Detection with Signal Dual-Amplification Using Glucose Oxidase and Laccase. Anal Chem, 2014, 86: 115−1122.
13.Xu Juan, Fu Shulin, Liu Manli, Xu Qiaoxia, Bei,Weicheng, Chen,Huanchun, Tan Chen*. The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2. Microbiol Res, 2014, 169: 541–546.
14.Wang Xiangru, Wei Liuya, Wang Bin, Zhang Ruixuan, Liu Canying, Bi Dingren, Chen Huanchun, Tan Chen*. Complete genome sequencing and characterization of an vian pathogenic Escherichia coli field isolate ACN001. Standards in Genomic Sciences, 2016, 11:13.
15.Wang xiangru, Hao Haihong, Xu Zhuofei, Zheng Huajun, Liu Canying, Wei Liuya, Zhang Ruixuan, Bi Dingren, Chen Huanchun, Tan Chen*. Plasmid-mediated multidrug resistance and virulence in an avian pathogenic Escherichia coli strain isolated in China. Journal of Global Antimicrobial Resistance, 2014,57–58.
16.Zong Bingbing, Liu Wugang, Zhang Yanyan, Wang Xiangru, Chen Huanchun, Tan Chen*. Effect of kpsM on the virulence of porcine extraintestinal pathogenic Escherichia coli. FEMS Microbiology Letters, 2016, Vol. 363, No. 21.
17.Tan Chen#, Tang Xibiao#, Zhang Xuan, Ding Yi , Zhao Zhanqin, Wu Bin*, Cai Xuwang , Liu Zhengfei, He Qigai , Chen Huanchun. Serotypes and virulence genes of extraintestinal pathogenic Escherichia coli isolates from diseased pigs in China. Vet J, 2012, 192:483–488.
18.Ding Yi, Tang Xibiao, Lu Ping, Wu Bin, Xu Zhuofei, Liu Wugang, Zhang Ruixuan, Bei Weicheng, Chen Huanchun, Tan Chen*. Clonal analysis and virulent traits of pathogenic extraintestinal Escherichia coli isolates from swine in China. BMC Vet Res, 2012, 8:140.
19.Tan Chen#, Xu Zhuofei#, Zheng Huajun, Liu Wugang, Tang Xibiao, Shou Jin, Wu Bin, Wang Shengyue, Zhao Guo-Ping, Chen Huanchun. Genome Sequence of Porcine Extraintestinal Pathogenic Escherichia coli. J Bacteriol, 2011, 193:5038.
20.Tan Chen, Liu Manli, Li Jinquan, Jin Meilin, Bei Weicheng, Chen Huanchun. SsPep contributes to the virulence of Streptococcus suis. Microb Pathogenesis, 2011, 51:319–324.
21.Li Jinquan#, Tan Chen#, Zhou Yang, Fu Shulin, Hu Linlin, Hu Jin, Chen Huanchun, Bei Weicheng. The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2. Vet Microbiol, 2011, 148:99–104.
22.Tang Xibiao#, Tan Chen#, Zhang Xuan, Zhao Zhanqin, Xia Xin, WuBin, Guo Aizhen, Zhou Rui, Chen Huanchun. Antimicrobial resistances of extraintestinal pathogenic Escherichia coli isolates from swine in China. Microb Pathogenesis, 2011, 50:207−212.
23.Tan Chen Liu Manli, Liu Jinlin, Yuan Fangyan , Fu Shulin, Liu Yuan, Jin Meilin, Bei Weicheng, Chen Huanchun. Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine. FEMS Microbiol Lett, 2009, 296:78–83.
24.Tan Chen, Liu Manli, Jin Meilin, Liu Jinlin, Chen Yan, Wu Tao, Fu Ting, Bei Weicheng, Chen Huanchun. The key virulence-associated genes of Streptococcus suis ktype 2 are upregulated and differentially expressed in vivo. FEMS Microbiol Lett, 2008, 278:108–114.
25.Tan Chen, Fu Shulin, Liu Manli, Jin Meilin, Liu Jinlin, Bei Weicheng, Chen Huanchun. Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2. Vet Microbiol, 2008, 130:363–370.
26.Liu Jinlin, Hu Linlin, Xu Zhuofei, Tan Chen, Yuan Fangyan, Fu Shulin, Cheng Hui, Chen Huanchun, Bei Weicheng. Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence. Vet Microbiol, 2015, 177:184–192.
27.Hou Bo, MengXian-Rong, Zhang Li-Yuan, Tan Chen, Jin Hui, Zhou Rui, Gao Jian-Feng, WuBin, Li Zi-Li, Liu Mei, Chen Huan-Chun, Bi Ding-Ren, and Li Shao-Wen. TolC Promotes ExPEC Biofilm Formation and Curli Production in Response to Medium Osmolarity. Biomed Research International, 2014,574274.
28.Liu Canying, Chen Zhaohui, Tan Chen, Liu Wugang, Xu Zhuofei, Zhou Rui, Chen Huanchun. Immunogenic characterization of outer membrane porins OmpC and OmpF of porcine extraintestinal pathogenic Escherichia coli. FEMS Microbiol Lett. 2012, 337(2):104−11.
29.Fu Shulin, Zhang Minmin, Ou Jiwen, Liu Huazhen, Tan Chen, Liu Jinlin, Chen Huanchun, Bei Weicheng. Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice. Vaccine. 2012, 30:6839−6844.
30.Fu Shulin, Yuan Fangyan, Zhang Minmin, Tan Chen, Chen Huanchun, Bei Weicheng. Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate dehydrogenase, of Haemophilus parasuis. Res Vet Sci, 2012, 93:57−62.
31.Yuan Fangyan, Liu Jinlin, Guo Yi, Tan Chen, Fu Shulin, Zhao Jin, Chen Huanchun, Bei Weicheng. Influences of ORF1 on the Virulence and Immunogenicity of Actinobacillus pleuropneumoniae. Curr Microbiol, 2011, 63:574−80.
32.Liu Manli, Fang Liurong, Tan Chen, Long Tiansi, Chen Huanchun, Xiao Shaobo. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011, 20:253.
33.Li Jinquan, Xia Jing, Tan Chen, Zhou Yang, Wang Yan, Zheng Chengkun, Chen Huanchun, Bei Weicheng. Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2. Vaccine. 2011, 29:6514−6519.
34.Liu Manli, Tan Chen, Fang Liurong, Xiao Shaobo, Chen Huanchun. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet Microbiol, 2011，150:126-31.
35.Wu Tao, Yuan Fangyan, Chang Haitao, Zhang Lin, Chen Guanping, Tan Chen, Chen Huanchun, Bei Weicheng. Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2. Microb Pathog, 2010, 49:32−37.
36.Liu Jinlin, Chen Xia, Tan Chen, Guo Yi, Chen Yan, Fu Shulin, Bei Weicheng, Chen Huanchun. In-vivo induced RTX toxin ApxIVA is essential for the full virulence of Actinobacillus pleuropneumoniae. Vet Microbiol, 2009, 137: 282−289.
37.Wu Tao, Chang Haitao, Tan Chen, Bei Weicheng, Chen Huanchun. The orphan response regulator RevSC21controls the attachment of Streptococcus suis serotype-2 to human laryngeal epithelial cells and the expression of virulence genes. FEMS Microbiol Lett, 2009, 292 :170–181.
38.Liu Jinlin, Tan Chen, Li Jingquan, Chen Huiwen, Xu Peng, He Qigai, Bei Weicheng, Chen Huanchun. Characterization of ISApl1, an insertion element identified from Actinobacillus pleuropneumoniae field isolate in China. Vet Microbiol, 2008, 132: 348−354.
39.Liu Jinlin, Chen Xia, Lin Liwen, Tan Chen, Chen Yan, Guo Yi, Jin Meilin, Guo Aizhen, Bei Weicheng*, Chen Huanchun. Potential use an Actinobacillus pleuropneumoniae double mutant strain DeltaapxIICDe
科研項目
1. 病原菌代謝調控機制研究 2017.07
2. 畜禽重要胞內菌基因調控及其與宿主互作的分子機制 2017.07
3. 綠色山豬肉產業化生產技術研究與開發 2015.01
4. 豬腸外致病性大腸桿菌六型分泌系統致病機制研究 2015.01
5. 豬鏈球菌2型雙組分信號轉導系統883hk/rr功能研究 2012.01
6. 病原菌表面多糖的結構與功能2012.01
7. 豬鏈球菌2型雙組分信號轉導系統1660rr/hk調控機制研究 2012.01
榮譽獎項
1. 2013年獲湖北省科技進步一等獎，豬鏈球菌病防控關鍵技術研究與套用,。
2. 2012湖北省優秀博士論文。
