譚斌博士。 2005年碩士畢業於廈門大學化學系。同年去新加坡留學，在新加坡南洋理工大學化學與生物化學系鐘國富教授的指導下從事新型手性有機催化劑的設計合成及不對稱domino反應的研究並於2010 年3月取得博士學位。2010年3月至2012 年9月，有幸在有機小分子催化領域的發源地之一美國The Scripps Research Institute，師從Barbas教授繼續在此領域從事博士後研究。與此同時得到碳氫鍵活化大師Yu Jin-Quan教授的指點。 2012年9月，以準聘（Tenure-Track）副教授身份加入南方科技大學化學系。2018年1月晉升為終身正教授。
基本介紹
- 中文名：譚斌
- 國籍：中國
- 民族：漢族
- 性別：男
人物經歷,工作經歷,學習經歷,研究方向,主要貢獻,代表文章,美國專利,獲獎記錄,
人物經歷
工作經歷
◆ 2010.3年至2012.9年，博士後, 美國斯克普斯研究所（The Scripps Research Institute）。
◆ 2012年9月至今， 副教授， 南方科技大學化學系。
學習經歷
◆ 2010年，獲得新加坡南洋理工大學哲學博士學位 (有機化學)。
◆ 2005年，獲得廈門大學理學碩士學位 (有機化學)。
◆ 2001年，獲得湖南科技大學理學學士學位 (化學教育)。
研究方向
◆ 核心骨架結構導向的有機催化不對稱合成。
◆ 現代催化體系和綠色合成全新方法的開發。
◆ 金屬與有機催化組成的協同催化體系拓展。
◆ 手性藥物的開發和天然產物的策略全合成。
主要貢獻
代表文章
代表性研究成果：（獨立工作以後從2013年7月至今）
24. Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones.Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu & Bin Tan.Nat.Commun. 2017, 8, 15489.
23. Organocatalytic atropselective synthesis of axially chiral styrenes. Sheng-Cai Zheng, San Wu, Qinghai Zhou, Lung Wa Chung, Liu Ye & Bin Tan.Nat.Commun. 2017, 8, 15238.
22. Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal–Knorr Reaction. Lei Zhang, Jian Zhang, Ji Ma, Dao-Juan Cheng, and Bin Tan*. J. Am. Chem. Soc., 2017, 139 (5), 1714–1717.
21. Phosphoric Acid-Catalyzed Asymmetric Synthesis of SPINOL Derivatives. Shaoyu Li, Ji-Wei Zhang, Xian-Lin Li, Dao-Juan Cheng, and Bin Tan*.J. Am. Chem. Soc., 2016, 138 (50), 16561–16566.
20.Construction of Tropane Derivatives by the Organocatalytic Asymmetric Dearomatization of Isoquinolines.Jin-Hui Xu, Sheng-Cai Zheng, Ji-Wei Zhang, Xin-Yuan Liu, and Bin Tan*.Angew. Chem. Int. Ed. 2016, 55, 11834–11839.
19. Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction.Ji-Wei Zhang,Jin-Hui Xu,Dao-Juan Cheng,Chuan Shi,Xin-Yuan Liu* &Bin Tan*.Nature Communications.,2016, 7, 10677.
18. Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2-Naphthols. Ye-Hui Chen,Dao-Juan Cheng,Jian Zhang,Yong Wang,Xin-Yuan Liu*, andBin Tan*. J. Am. Chem. Soc.,2015,137(48), 15062–15065.
17.Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. Jian Zhang,Shao-Xia Lin,Dao-Juan Cheng,Xin-Yuan Liu*, andBin Tan*.J. Am. Chem. Soc.,2015,137(44),14039–14042.
16. Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Ming-Yue Wu,Wei-Wei He, Xin-Yuan Liu*, Bin Tan*.Angew.chem. Int. Ed.2015,54,9409–9413.
15. Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid. Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan*.Angew. Chem. Int. Ed.2014,53, 3684–3687.
14. Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*, Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201503207.
13. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.
12. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*，Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.
11. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*,and Xin-Yuan Liu* “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene” Angew. Chem. Int. Ed. 2014, 53, 11890.
10. Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.
9. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589-1592.
13. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.
12. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*，Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.
11. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*,and Xin-Yuan Liu* “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene” Angew. Chem. Int. Ed. 2014, 53, 11890.
10. Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.
9. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589-1592.
8. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds. Chem. Eur. J. 2015, 21, 6718.
7. Lei Li, Jing-Yao Guo, Su Chen, Tao Wang, Bin Tan* and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett., 2014, 16, 6032.
6. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.
5. Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles” Org. Lett. 2014, 16, 2192.
4. Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 2014, 16, 1000.
3. Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu.* “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles” Org. Lett. 2014, 16, 504.
2. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 2014, 20, 1332.
1. Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan* and Carlos F. Barbas, III* “Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies”.ACS Catal. 2014, 4, 743
代表性研究成果：（獨立工作以前，只列第一作者，所有文章的影響因子都大於5.5）
1.Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538-12541.
2.Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rational Design Enables Amide Nucleophiles for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381-5385.
3.Tan, B.; Zeng, X.; Leong, W. W. Y.; Shi, Z.; Barbas III, C.F.; Zhong, G. Core Structure-Based Design of a Novel Organocatalytic [3+2] Cycloaddition: Highly efficient and Stereocontrolled Synthesis of Spirocyclic Oxindoles. Chem. Eur. J. 2012, 18, 63-67.
4.Tan, B.; Candeias, N.; Barbas III, C.R. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nature Chem. 2011, 3, 473-477.
5.Tan B.; Hernández-Torres, G.; Barbas III, C.F. J. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. Am. Chem. Soc. 2011, 131, 12354-12358.
6.Tan, B.; Candeias, N.; Barbas III, C.F. J. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. Am. Chem. Soc. 2011, 131, 4672-4675.
7.Tan, B.; Zeng, X.; Chua, P. J.; Zhong, G. Rational Design of Domino Michael-Henry Reaction: Direct Construction of Bicyclo[3.2.1]octane Skeletons with Four Stereogeric Centers. Org. Lett. 2010, 12, 2682-2685.
8.Tan, B.; Zhu, D.; Zhang, L.; Dai, L.; Chua, P. J.; Shi, Z.; Zeng, X; Zhong, G. Water More than Just a Green Solvent: A Stereoselective One-Pot Access to All Chiral Tetrahydronaphthalenes in Aqueous Media. Chem. Eur. J. 2010, 16, 3842-3848.
9.Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758-761.
10.Tan, B.; Zhang, X.; Chua, P. J.; Zhong, G. Recyclable organocatalysis: highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins (Cover Article). Chem. Commun. 2009, 779-781
11.Tan, B.; Zeng, X.; Lu, Y.; Chua, P. J.; Zhong, G. Rational Design of Organocatalyst: Highly Stereoselective Michael Addition of Cyclic Ketones to Nitroolefins. Org. Lett. 2009, 11, 1931-1933.
12.Tan, B.; Chua, P. J.; Zeng, X.; Lu, M.; Zhong, G. A Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Cyclopentanes with Four Chiral Carbons by the Organocatalytic Domino Michael-Henry Reaction. Org. Lett. 2008, 10, 3489-3492.
13.Tan, B.; Shi, Z.; Chua, P. J.; Zhong, G. Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes. Org. Lett. 2008, 10, 3425-3428.
14.Tan, B.; Chua, P. J.; Li, Y.; Zhong, G. Organocatalytic Asymmetric Tandem Michael-Henry Reactions: A Highly Stereoselective Synthesis of Multifunctionalized Cyclohexanes with Two Quaternary Stereocenters. Org. Lett. 2008, 10, 2437-2440.
美國專利
1.Zhong, G.; Tan, B.; Zhang, X.; Chua, P. J. Process for highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins using using cinchona alkaloids as recyclable organocatalysts. U.S. Pat. Appl. Publ. (2012), US 20120004424 A1 20120105.
2.Zhong, G,; Tan, B.; Shi, Z. Chua, P. J. Process of forming pyrrole compounds. U.S. Pat. Appl. Publ. (2011), US 20110124881 A1 20110526.
3.Zhong, G,;Tan, B.; Chua, P. J.; Shi, Z. Process for preparation of chiral cycloalkane derivatives by asymmetric cyclization. U.S. Pat. Appl. Publ. (2010), US 20100298576 A1 20101125.
4.Zhong, G.; Lu, M.; Zhu, D.; Lu, Y.; Hou, Y.; Tan, B. Processes for enantioselective preparation of an aminoxy compound and an 1,2-oxazine compound. U.S. Pat. Appl. Publ. (2011), US 20110224429 A1 20110915.
獲獎記錄
◆ 2013年，深圳市海外高層次人才“孔雀計畫”入選者。
◆ 2009年，國家優秀自費留學生獎學金。
