譚嘉恆，男，1980年11月生，博士，中山大學藥學院教授、博士生導師。研究方向為核酸化學生物學與核酸藥物化學。
作為負責人先後主持3項國家自然科學基金，獲廣東省自然科學傑出青年基金及廣東特支計畫科技青年拔尖人才項目，共發表SCI論文100多篇，他引1600多次，獲授權專利20項。其中，作為通訊作者在J. Am. Chem. Soc.、Angew. Chem., Int. Ed.、Nucleic Acids Res.、J. Med. Chem.、Chem. Commun.、Biosens. Bioelectron.、Anal. Chem.等知名學術期刊發表論文20多篇，研究結果多次被Chem. Rev.、Chem. Soc. Rev.、J. Am. Chem. Soc.、Angew. Chem., Int. Ed.等期刊論文正面引用，部分探針被國際同行套用。在國內外重要學術會議上做學術報告10餘次，現任Sci. Rep.雜誌化學領域編委會成員，2017年獲第二十屆中國藥學會-施維雅青年藥物化學獎。
基本介紹
- 中文名：譚嘉恆
- 職業：教師
- 學位/學歷：博士
- 專業方向：核酸化學生物學與核酸藥物化學
- 職務：博士生導師
- 職稱：教授
人物經歷,教育經歷,工作經歷,教授課程,社會兼職,科研項目,獲獎記錄,代表性論著,
人物經歷
教育經歷
1999.09-2003.07 中山大學化學與化學工程學院，套用化學專業，獲學士學位
2003.09-2008.07 中山大學藥學院，藥物化學專業，獲博士學位
工作經歷
2008年7月-至今 中山大學藥學院。
教授課程
生物有機化學；藥物化學實驗；藥物發現中的關鍵技術
社會兼職
Scientific Reports雜誌化學領域編委會成員；廣東省藥學會第十屆藥物化學專業委員會委員。
科研項目
1.靶向G-四鏈體新型螢光原位雜交探針的設計合成及其在RNA結構與功能研究中的套用，21672268，國家自然科學基金—面上項目，65萬元
2.套用多芳基取代咪唑類螢光探針研究癌基因啟動子G-四鏈體作為轉錄調控元件的分子機制，21272291，國家自然科學基金—面上項目，80萬元
3. rDNA G-四鏈體螢光探針在靶向抗腫瘤藥物研發中的套用，2015A030306004，廣東省自然科學基金項目—傑出青年科學基金，100萬元
4.特異性靶向識別端粒G-四鏈體DNA的Isaidigotone衍生物：結構，結合模式與生物活性的關係，81001400,國家自然科學基金—青年基金項目, 20萬元
5. “廣東特支計畫”科技青年拔尖人才，2015TQ01R342，30萬元
獲獎記錄
第二十屆中國藥學會-施維雅青年藥物化學獎。
代表性論著
1. Chen, X.-C.; Chen, S.-B.; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.;Tan, J.-H.*Tracking the dynamic folding and unfolding of RNA G-quadruplexes in live cells.Angewandte Chemie, International Edition2018, 57, 4702-4706.
2. Hu, M.-H.; Wang, Y.-Q.; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.;Tan, J.-H.*Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex.Journal of Medicinal Chemistry2018, 61, 2447-2459.
3. Wang, Y.-Q.; Hu, M.-H.; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.;Tan, J.-H.*Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA.Sensors and Actuators, B: Chemical2018, 266, 187-194.
4. Che, T.; Chen, S.-B.; Tu, J.-L.; Wang, B.; Wang, Y.-Q.; Zhang, Y.; Wang, J.; Wang, Z.-Q.; Zhang, Z.-P.; Ou, T.-M.; Zhao, Y.;Tan, J.-H.*; Huang, Z.-S.* Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response.Journal of Medicinal Chemistry2018, 61, 3436-3453.
5. Chen, S.-B.; Liu, G.-C.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.*Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex.Journal of Molecular Structure2018, 1154, 1-7.
6. Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.;Tan, J.-H.*; Huang, Z.-S.* Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Nucleic Acids Research2017, 45, 1606-1618.
7. Wang, Y.-Q.; Huang, Z.-L.; Chen, S.-B.; Wang, C.-X.; Shan, C.; Yin, Q.-K.; Ou, T.-M.; Li, D.; Gu, L.-Q.;Tan, J.-H.*; Huang, Z.-S.* Design, synthesis, and evaluation of new selective NM23-H2 binders as c-MYC transcription inhibitors via disruption of the NM23-H2/G-quadruplex interaction.Journal of Medicinal Chemistry2017, 60, 6924-6941.
8. Hu, M.-H.; Guo, R.-J.; Chen, S.-B.; Huang, Z.-S.;Tan, J.-H.*Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes.Dyes and Pigments2017, 137, 191-199.
9. Chen, S.-B.; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*;Tan, J.-H.*Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe.Journal of the American Chemical Society2016, 138, 10382-10385.
10. Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.*Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.Biosensors & Bioelectronics2016, 83, 77-84.
11. Guo, R.-J.; Yan, J.-W.; Chen, S.-B.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.*A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes.Dyes and Pigments2016, 126, 76-85.
12. Xiong, Y.-X.; Huang, Z.-S.;Tan, J.-H.*Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives.European Journal of Medicinal Chemistry2015, 97, 538-551.
13. Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.*A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology.Scientific Reports2015, 5, 17202.
14. Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.;Tan, J.-H.*Development of a highly sensitive fluorescent light-up probe for G-quadruplexes.Analyst2015, 140, 4616-4625.
15. Hou, J.-Q.; Chen, S.-B.; Zan, L.-P.; Ou, T.-M.;Tan, J.-H.*; Luyt, L. G.; Huang, Z.-S.* Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach.Chemical Communications2015, 51, 198-201.
16. Yan, J.-W.; Chen, S.-B.; Liu, H.-Y.; Ye, W.-J.; Ou, T.-M.;Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.Chemical Communications2014, 50, 6927-6930.
17. Chen, S.-B.; Wu, W.-B.; Hu, M.-H.; Ou, T.-M.; Gu, L.-Q.;Tan, J.-H.*; Huang, Z.-S.* Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes.Chemical Communications2014, 50, 12173-12176.
18. Wang, X.; Zhou, C.-X.; Yan, J.-W.; Hou, J.-Q.; Chen, S.-B.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.*Synthesis and evaluation of quinazolone derivatives as a new class of c-KIT G-quadruplex binding ligands.ACS Medicinal Chemistry Letters2013, 4, 909-914.
19. Chen, S.-B.; Shi, Q.-X.; Peng, D.; Huang, S.-Y.; Ou, T.-M.; Li, D.;Tan, J.-H.*; Gu, L.-Q.; Huang, Z.-S. The role of positive charges on G-quadruplex binding small molecules: Learning from bisaryldiketene derivatives.Biochimica et Biophysica Acta, General Subjects2013, 1830, 5006-5013.
20. Yan, J.-W.; Ye, W.-J.; Chen, S.-B.; Wu, W.-B.; Hou, J.-Q.; Ou, T.-M.;Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.Analytical Chemistry2012, 84, 6288-6292.
21. Yan, J.-W.; Li, Y.-P.; Ye, W.-J.; Chen, S.-B.; Hou, J.-Q.; Tan, J.-H.*; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.Bioorganic & Medicinal Chemistry2012, 20, 2527-2534.
22. Chen, S.-Y.; Chen, Y.; Li, Y.-P.; Chen, S.-H.;Tan, J.-H.*; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & Medicinal Chemistry2011, 19, 5596-5604.
23. Chen, S.-B.;Tan, J.-H.*; Ou, T.-M.; Huang, S.-L.; An, L.-K.; Luo, H.-B.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.Bioorganic & Medicinal Chemistry Letters2011, 21, 1004-1009.
24. An, Z.-Y.; Yan, Y.-Y.; Peng, D.; Ou, T.-M.;Tan, J.-H.*; Huang, S.-L.; An, L.-K.; Gu, L.-Q.; Huang, Z.-S.* Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.European Journal of Medicinal Chemistry2010, 45, 3895-3903.
25. Tan, J.-H.; Ou, T.-M.; Hou, J.-Q.; Lu, Y.-J.; Huang, S.-L.; Luo, H.-B.; Wu, J.-Y.; Huang, Z.-S.*; Wong, K.-Y.; Gu, L.-Q.* Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA.Journal of Medicinal Chemistry2009, 52, 2825-2835.
26. Tan, J.-H.; Gu, L.-Q.; Wu, J.-Y.* Design of selective G-quadruplex ligands as potential anticancer agents.Mini-Reviews in Medicinal Chemistry2008, 8, 1163-1178.
27. Tan, J.-H.; Lu, Y.-j.; Huang, Z.-S.; Gu, L.-Q.*; Wu, J.-Y.* Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.European Journal of Medicinal Chemistry2007, 42, 1169-1175.
28. Tan, J. H.; Zhang, Q. X.; Huang, Z. S.; Chen, Y.; Wang, X. D.; Gu, L. Q.*; Wu, J. Y.* Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives.European Journal of Medicinal Chemistry2006, 41, 1041-1047.
