《螺環哌嗪類銨鹽類新型鎮痛藥物研究》是李潤濤為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：螺環哌嗪類銨鹽類新型鎮痛藥物研究
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：李潤濤
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Unique Spirocyclopiperazinium Salt. Part 2: Synthesis and Structure–Activity Relationship of Dispirocyclopiperazinium Salts as Analgesics | 期刊論文 | Xin Wang|Feng-Li Gao|Hong-Bin Piao|Tie-Ming Cheng and Run-Tao Li*| |
2 | Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594 | 期刊論文 | Chuan-Xin Zhang|Ze-Mei Ge|Tie-Ming Cheng and Run-Tao Li*| |
3 | Unique Spirocyclopiperazinium Salt I: Synthesis and Structure–Activity Relationship of Spirocyclopiperazinium Salts as Analgesics | 期刊論文 | Feng-Li Gao|Xin Wang|Hong-Mei Zhang|Tie-Ming Cheng and Run-Tao Li*| |
4 | Synthesis and Structure-Activity Relationship of Di-(3,8-diazabicyclo[3.2.1]octane) Diquaternary Ammonium Salts as Unique Analgesics | 期刊論文 | Hong Liu|Tie-Ming Cheng|Hong-Mei Zhang|Run-Tao Li| |
5 | Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions | 期刊論文 | Xin Wang|Yaowu Sha and Runtao Li| |
6 | Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions | 期刊論文 | Xin Wang|Yaowu Sha|Runtao Li| |
7 | Synthesis and Analgesic Activity of Hydrochlorides and Quaternary Ammoniums of Epibatidine Incorporated with Amino Acid Ester | 期刊論文 | Jing-Chao Dong|Xin Wang|Run-Tao Li|* Hong-Mei Zhang|Tie-Ming Cheng and Chang-Ling Li| |
項目摘要
螺環哌嗪季銨鹽是我們發現的一類結構全新的鎮痛化合物，其中有兩個化合物活性很好。據最近專利報導，橋環哌嗪類化合物既具有鎮痛活性，又具有非成癮性，與螺環哌嗪季銨鹽的結構很相似。本研究以發現的兩個活性很好的化合物為先導，結合橋環哌嗪的結構特徵對其進行結構改造，可望發現鎮痛活性更強，非成癮性的化合物。然後，再開發出一類新藥
