虞沂

虞沂，男，2002年6月畢業於華中農業大學生物技術基地班。2010年7月先後任武漢大學藥學院副教授、教授。

基本介紹

• 中文名：虞沂
• 國籍：中國
• 職業：教授
• 畢業院校：華中農業大學

人物經歷

學習簡歷

1996.9 – 2002.6 華中農業大學生物技術基地班，本碩連讀

2003.9 – 2007.3 中科院微生物研究所，博士

工作簡歷

2007.7 - 2009. 6 上海交通大學生命科學技術學院生物工程系，講師

2009.7 - 2010. 6 華中農業大學生命科學技術學院，講師

2010.7 – 2016.11武漢大學藥學院，副教授

2012.8 – 2013.8美國Washington University in Saint Louis,訪問學者

2016.11武漢大學藥學院，教授

研究方向

微生物來源天然產物的組合生物合成。

研究興趣與方向:以天然產物為基礎研製和開發新藥一直是國際化學界和醫藥界共同關注的重點領域。天然產物的生物合成就是由小分子的簡單化合物作為底物，經過一系列順序催化反應，最終形成複雜化學結構的過程。本人的研究興趣在於通過代謝工程和組合生物合成研究複雜天然產物的生物合成，即利用基因工程技術，有目的地對細胞代謝途徑進行精確的修飾或改造，以提高目的天然產物活性或產量、或合成新的代謝產物；或是通過操縱天然產物生物合成途徑中的基因來產生非天然的天然產物類似物庫，並從中發現和發展更具套用價值的藥物。

主要貢獻

承擔課題與經費：

2010年度武漢市青年科技晨光計畫，6萬
2010年度教育部新教師基金，3萬

2011年國家自然科學基金，25萬

2011年973子課題，26萬

2014年973子課題，28.8萬
2015年國家自然科學基金，78萬

2017年武漢大學自主科研-拔尖創新人才，15萬

科研成果:

1. Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H* andYu Y*. Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution.Organic & Biomolecular Chemistry, 2017, 15(18): 3843-3848

2. Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai andYu Yi *.Organic & Biomolecular Chemistry, 2016 (14): 8679-8684

3. Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z,Yu Yi*and Zhang Q*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic.J AM CHEM SOC,2016, 138(20):6427-35

4. Huang S., Elsayed S., Lv M., Tabudravu J., Rateb M., Gyampoh R., Kyeremyh K., Ebel R., Jaspars M., Deng Z.,Yu Yi* and Deng H.* Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps.Chemistry & Biology, 2015, 22(12):1633-42

5. Lv Meinan, Zhao Junfeng, Deng Zixin andYu Yi*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic.Chemistry & Biology, 2015, 22(10):1313-1324.

6. Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M,Yu Yi*and Deng H*. Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins.Angew Chem Int Ed Engl.2015, 54(43):12697-12701

7. Huang S, Tong MH, Qin Z, Deng Z, Deng H,Yu Y.*. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, inSaccharothrix algeriensisNRRL B-24137.Anticancer Agents Med Chem, 2015, 15(3):277-84.

8. Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin,Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng* and David OHagan*. Identification of a fluorometabolite fromStreptomycessp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri

hydroxypentanoic acid.Chemical Science, 2015, 6(2):1414-1419

9. Hao C.L., Huang S., Deng Z.X., Zhao C.M.,Yu Y.*Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization.PLOS ONE,2014, 9(6):e99077.

10. Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Assad Lina, Jaspars Marcel, Deng Zixin,Yu Yi, Deng Hai*. Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin.FEMS Microbiology Letters,2014, 352(1): 62-8

11. Sheng Huang, Long Ma, Ming Him Tong,Yi Yu*, David OHagan and Hai Deng* Fluoroacetate biosynthesis from the marine-derived bacteriumStreptomyces xinghaiensisNRRL B-24674.Org Biomol Chem, 2014, 12(27): 4828-4831

12. Varman, A.M.*,Yu, Y.*, You L., Tang, Y.J. Photoautotrophic production of D-lactate in an engineered cyanobacterium.Microbial Cell Factories,2013, 12: 117 (*Contributed equally)

13. Qin, Z., Huang, S.,Yu, Y.*, Deng, H*.Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis.Marine Drugs,2013, 11(10):3970-97

14.Yu, Y., You, L., Liu, D.Y., Hollinshead, W., Tang, Y.J., Zhang, F.Z. Development ofSynechocystissp. PCC 6803 as a Phototrophic Cell Factory.Marine Drugs,2013, 11(8):2894-916

15. Wang, X., Tabudravu, J., Rateb, M.E., Annand, K.J., Qin, Z., Jaspars, M., Deng, Z.,Yu, Y.*, Deng, H*. Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus.Molecular Biosystems,2013, 9(6):1286-9

16. Wu XM,Yu Y., Han LB, Li CL, Wang HY, Zhong NQ, Yao Y, Xia GX*.The tobacco BLADE-ON-PETIOLE2 gene mediates differentiation of the corolla abscission zone by controlling longitudinal cell expansion.Plant Physiology,2012, 159(2):835-50

17. Zhang, Q.;Yu, Y.*, Thioether Crosslinkages Created by a Radical SAM Enzyme.ChemBioChem,2012, 13(8), 1097-1099

18. Huang, S.; Zhao, Y.D.; Qin, Z.W.; Wang, X.L.; Onega, M.; Chen, L.; He, J.;Yu, Y.*; Deng, H.*, Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus.Process Biochemistry,2011, 46, 811-16（*Co-Corresponding Author）

19. Zhang, Q.; Li, Y.X.; Chen, D.D.;Yu, Y.; Duan, L.; Shen, B.; Liu, W. Radical-mediated enzymatic carbon chain fragmentation-recombination.Nature Chemical Biology,2011, 7, 154-60

20.Yu, Y.; Guo, H.; Zhang, Q.; Duan, L.; Ding, Y.; Liao, R.J.; Lei, C.; Shen, B.; Liu, W. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide.J AM CHEM SOC,2010, 132(46), 16324-26.

21. Wang, J.;Yu, Y.; Tang, K.; Liu, W.; He, X.; Huang, X.; Deng, Z. Thiopeptide antibiotic cyclothiazomycin: Identification and Analysis of its biosynthetic gene cluster in Streptomyces hygroscopicus 10-22.(2010)Appl Environ Microb, 76(7), 2335-44.

22.Ding, Y.; Yu, Y.; Pan, H.; Guo, H.; Li, Y.; Liu, W.Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. (2010)Molecular Biosystems, 6(7), 1180-85.

23.Yu, Y.; Duan, L.; Zhang, Q.; Liao, R. J.; Ding, Y.; Pan, H. X.; Wendt-Pienkowski, E.; Tang, G. L.; Shen, B.; Liu, W., Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. (2009)ACS Chem Biol, 4(10), 855-64.

24. Liao, R. J.; Duan, L.; Lei, C.; Pan, H. X.; Ding, Y.; Zhang, Q.; Chen, D. J.; Shen, B.;Yu, Y.*; Liu, W.* Thiopeptide Biosynthesis Featuring Ribosomally SynthesizedPrecursor Peptides and Conserved Posttranslational Modifications. (2009)Chem Biol, 16 (2), 141-47.（*Co-Corresponding Author）

25. Liu, W.;Yu, Y.Combinatorial Biosynthesis of Pharmaceutical Natural Products. Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing (Chapter 11)Wiley Press, ISBN: 978-0-470-82314-9, Oct. 2008, 229-246

26.Yu, Y.; Wang, H.Y.; Liu, L.N.; Chen, Z.L.; Xia, G.X. Functional identification of cytokinesis-related genes from tobacco BY-2 cells. (2007)Plant Cell Rep, 26(7), 889-94

27. Chen, Z.L.#;Yu, Y.#; Liu, L.N.; Xia, G.X. Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells. (2007)Progress in Nature Science17, 156-62. (*Co-First Author)

28.Yu, Y.; Bai, L. Q.; Minagawa, K.; Jian, X. H.; Li, L.; Li, J. L.; Chen, S. Y.; Cao, E. H.; Mahmud, T.; Floss, H. G.; Zhou, X. F.; Deng, Z. X., Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp jinggangensis 5008. (2005)Appl Environ Microb, 71 (9), 5066-76.

29. Wang, H.Y.*;Yu, Y.*, Chen, Z.L.; Xia, G.X. Functional characterization of Gossypium hirsutum profilin 1 gene (GhPFN1) in tobacco suspension cells. Characterization of in vivo functions of a cotton profilin gene. (2005)Planta222, 594-603. (*Co-First Author)

30.王岩；虞沂；趙群飛；孔毅；劉文，天然產物的生物合成和組合生物合成研究進展。國外醫藥（抗生素分冊）2008，29（6），275-282

31.張華；趙群飛；虞沂；陸大年；劉文，特異性克隆編碼多肽合成酶還原結構域基因的PCR方法。中國抗生素雜誌2009，34（3），189-192

32. 呂美男；虞沂，2-脫氧鏈霉胺類抗生素的生物合成研究進展。中國科技論文線上, 2014

33. 張玉；虞沂，吡咯醯胺類化合物合成途徑中醛基轉移酶Pya26的功能研究。武漢大學學報（理學版），2016，62（1）：078-084

34. 黃勝；虞沂，二硫吡咯酮類抗生素的生物合成研究與代謝工程套用。微生物學報（微生物藥物創新專刊），2016，3

　　

專利

諾絲七肽的生物合成基因簇(專利號：ZL 2009 1 0053427.7授權公告日：2011年6月22日)

劉文；虞沂；段煉；雷春；丁瑩；廖日晶

國際合作：

Dr. Hai Deng, Lecturer

University of Aberdeen, Department of Chemistry, Marine Biodiscovery Center

獲獎記錄

教育部2007年度高等學校科學技術獎自然科學獎二等獎

2015-2016年度武漢大學醫學部突出貢獻獎

2016-2017年度武漢大學醫學部朱裕璧獎

武漢大學十佳教師（第十屆）