蘭文智，畢業於美國加州大學，博士，南京大學生命科學學院教授。
基本介紹
- 中文名：蘭文智
- 畢業院校：美國加州大學
- 學位/學歷：博士
- 專業方向：營養分配和植物生長發育;植物營養穩態與逆境脅迫
- 職務：教師
- 任職院校：南京大學
人物經歷,研究方向,獲獎情況,科研成果,
人物經歷
2003-2006年：加拿大皇后大學(Queen’s University)，博士後。
2006-2011年：美國加州大學伯克利分校(University of California at Berkeley)，博士後、Associate Specialist。
2011年10月-今：南京大學生命科學學院教授。
2012年-今：南京大學博士生導師。
研究方向
營養分配和植物生長發育;植物營養穩態與逆境脅迫
研究內容：
生命活動依賴於物質的有效分配。植物利用各種膜(質膜和內膜)定位的轉運體蛋白將營養物質(養分)運送到特定的細胞空間，最佳化有限養分的利用，保障正常/逆境條件下生長發育的需要。本課題組主要利用分子生物學、生物物理學、組織化學、蛋白螢光標記和分子遺傳學等方法，探討植物協調物質分配的分子機理;側重於鑑定關鍵膜系統蛋白組分及其信號轉導過程，為分子培育優質作物提供新基因和新理論。
獲獎情況
1. 第二屆江蘇省特聘教授。
2. 2017年度“南京大學優秀博士論文”和2017年度“江蘇省優秀博士論文優秀博士論文”指導教師。
3. 湖北省2006年度科學技術三等獎(編號2006Z-033-3-015-012)。
科研成果
Selected：(*，第一作者;#，通訊作者)
Jing Y*, Zheng X*, Zhang D, Shen N, Wang Y, Yang L, Fu A, Shi J, Zhao F, Lan W#, Luan S#. Danger-Associated Peptides Interact with PIN-Dependent Local Auxin Distribution to Inhibit Root Growth in Arabidopsis. Plant Cell. 2019 Aug;31(8):1767-1787. doi: 10.1105/tpc.18.00757. (第一作者：荊彥平博士生/鄭小江博士後) 。
Luan M*, Lan W#. Escape routes for vacuolar phosphate. Nat Plants. 2019 Jan;5(1):9-10. doi: 10.1038/s41477-018-0343-2. (Invited Comment) (第一作者：欒明達博士生)。
Zhang F*, Yan X, Han X, Tang R, Chu M, Yang Y, Yang YH, Zhao F, Fu A, Luan S#, Lan W#. A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids. Plant Physiol. 2019 Oct;181(2):743-761. doi: 10.1104/pp.19.00626(第一作者：張豐博士生)。
Luan M*, Zhao F, Han X, Sun G, Yang Y, Liu J, Shi J, Fu A, Lan W#, Luan S#. Vacuolar phosphate transporters contribute to systemic phosphate homeostasis vital for reproductive development in Arabidopsis. Plant Physiol.2019 Feb;179(2):640-655. doi: 10.1104/pp.18.01424. (第一作者：欒明達博士生) 。
Zhang B*, Zhang C*, Liu C, Jing Y, Wang Y, Jin L, Yang L, Fu A, Shi J, Zhao F, Lan W#, Luan S#. Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis. Mol Plant. 2018 Jul 2;11(7):943-954. doi: 10.1016/j.molp.2018.04.007. Epub 2018 May 5. Mol Plant. (第一作者：張斌博士生/張弛博士生) 。
Zheng X*, Kang S*, Jing Y, Ren Z, Li L, Zhou JM, Berkowitz G, Shi J, Fu A, Lan W, Zhao F#, Luan S#. Danger-Associated Peptides Close Stomata by OST1-Independent Activation of Anion Channels in Guard Cells. Plant Cell. 2018 May;30(5):1132-1146. doi: 10.1105/tpc.17.00701. Epub 2018 Apr 30. (第一作者：鄭小江博士後/韓國KAIST Kang博士後) 。
Luan M*, Liu J*, Liu Y, Han X, Sun G, Lan W#, Luan S#. Vacuolar Phosphate Transporter 1 (VPT1) Affects Arsenate Tolerance by Regulating Phosphate Homeostasis in Arabidopsis. Plant Cell Physiol. 2018 Feb 6. doi: 10.1093/pcp/pcy025. (第一作者：欒明達博士生/劉金隆博士生)。
Wang Y*, Yang L*, Tang Y, Tang R, Jing Y, Zhang C, Zhang B, Li X, Cui Y, Zhang C, Shi J, Zhao F, Lan W#, Luan S#. Arabidopsis choline transporter-like 1 (CTL1) regulates secretory trafficking of auxin transporters to control seedling growth. PLoS Biol. 2017 Dec 28;15(12):e2004310. (第一作者：王願博士生/楊磊副研究員)。
Luan M*, Tang RJ, Tang Y, Tian W, Hou C, Zhao F, Lan W#, Luan S#. Transport and homeostasis of potassium and phosphate: limiting factors for sustainable crop production. J Exp Bot. 2017 Jun 1;68(12):3091-3105. (第一作者：欒明達博士生)。
Chen J, Yu F#, Liu Y, Du C, Li X, Zhu S, Wang X, Lan W, Rodriguez PL, Liu X, Li D, Chen L#, Luan S#. FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5519-27. doi: 10.1073/pnas.1608449113.
Liu J*, Yang L, Luan M, Wang Y, Zhang C, Zhang B, Shi J, Zhao FG#, Lan W#, Luan S# (2015) A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6571-8. (第一作者：劉金隆博士生)。
Zhou L*, Lan W*, Chen B, Fang W, Luan S#. A calcium sensor-regulated protein kinase, CALCINEURIN B-LIKE PROTEIN-INTERACTING PROTEIN KINASE19, is required for pollen tube growth and polarity. Plant Physiol 2015 Apr;167(4):1351-60.
Zhou L*, Lan W*, Jiang Y, Fang W, Luan S#(2014) A calcium-dependent protein kinase interacts with and activates a calcium channel to regulate pollen tube growth. Mol Plant 7(2):369-76.
Lee SC*, Lim CW*, Lan W*, He K, Luan S#, (2013). ABA Signaling in Guard Cells Entails a Dynamic Protein-Protein Interaction Relay from the PYL-RCAR Family Receptors to Ion Channels. Mol Plant, 6(2):528-538.
Lan WZ *, Lee SC*, She YF, Jiang YX, Luan S#. (2011) Mechanistic analysis of AKT1 regulation by the CBL-CIPK- PP2CA network. Mol Plant, 4:527-536.
Lan WZ *, Wang W, Wang SM, Li LG, Buchanan BB, Lin HX, Gao JP, Luan S# (2010) A rice high-affinity potassium transporter (HKT) conceals a calcium-permeable cation channel. Proc Natl Acad Sci U S A,107:7089-7094.
Lee SC*, Lan WZ*, Buchanan BB#, Luan S#. (2009) A protein kinase- phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A, 106:21419-21424.
Lee SC*, Lan WZ*, Kim BG*, Li LG*, Cheong YH, Pandey GK, Lu G, Buchanan BB#, Luan S# (2007) A protein phosphorylation/dephosphorylation network regulates a plant potassium channel. Proc Natl Acad Sci U S A, 104:15959-15964.
Others：
Yang Y*, Tang RJ, Mu B, Ferjani A, Shi J, Zhang H, Zhao F, Lan WZ #, Luan S#. Vacuolar Proton Pyrophosphatase Is Required for High Magnesium Tolerance in Arabidopsis . Int J Mol Sci. 2018 Nov 16;19(11). pii: E3617. doi: 10.3390/ijms19113617.
Yu J, Ge H, Wang X, Tang R, Wang Y, Zhao F, Lan W#, Luan S#, Yang L#. Overexpression of Pyrabactin Resistance-Like Abscisic Acid Receptors Enhances Drought, Osmotic, and Cold Tolerance in Transgenic Poplars. Front Plant Sci. 2017 Oct 13;8:1752.
Zhang C*, Li H*, Wang J, Zhang B, Wang W, Lin H, Luan S, Gao J#, Lan W #. The Rice High-Affinity K+ Transporter OsHKT2;4 Mediates Mg2+ Homeostasis under High-Mg2+ Conditions in Transgenic Arabidopsis. Front Plant Sci. 2017, 24;8:1823.
Ji R, Zhou L, Liu J, Wang Y, Yang L, Zheng Q#, Zhang C, Zhang B, Ge H, Yang Y, Zhao F, Luan S, Lan W#. Calcium-dependent protein kinase CPK31 interacts with arsenic transporter AtNIP1;1 and regulates arsenite uptake in Arabidopsis thaliana. PLoS One. 2017 Mar 15;12(3):e0173681.
Yu J, Li H, Peng Y, Yang L, Zhao F, Luan S#, Lan W#. A survey of the pyrabactin resistance-like abscisic acid receptor gene family in poplar. Plant Signal Behav. 2017 Aug 3;12(8):e1356966.
Liu J, Fu S, Yang L, Luan M, Zhao F, Luan S#, Lan W#. Vacuolar SPX-MFS transporters are essential for phosphate adaptation in plants. Plant Signal Behav. 2016;11(8):e1213474.
Yu J, Yang L#, Liu X, Tang R, Wang Y, Ge H, Wu M, Zhang J, Zhao F, Luan S#, Lan W#. Overexpression of Poplar Pyrabactin Resistance-Like Abscisic Acid Receptors Promotes Abscisic Acid Sensitivity and Drought Resistance in Transgenic Arabidopsis. PLoS One. 2016;11(12):e0168040.
Luan S#, Lan WZ, Lee SC. (2009) Potassium nutrition, sodium toxicity, and calcium signaling: connections through the CBL-CIPK network. Current Opinion in Plant Biology, 12:339-346.
Lan WZ, Wang PYT, Hill CE. (2006) Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C. American Journal of Physiology-Cell Physiology, 291:93-103.
Lan WZ, Abbas H, Lam HD, Lemay AM, Hill CE. (2005) Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 288:G221-G229.
Lan WZ, Abbas H, Lemay AM, Briggs MM, Hill CE. (2005) Electrophysiological and molecular identification of hepatocellular volume-activated K+ channels. Biochimica Et Biophysica Acta-Biomembranes, 1668:223-233.
專著：
Wu W, Wang Y, Lee S, Lan WZ, Luan S. Regulation of Ion Channels by the Calcium Signaling Network in Plant Cells. Demidchik V and Maathuis F (eds.) Ion channels and plant stress responses. Signaling and communication in plants. 2010, Springer-Verlag Berlin Heidelberg.
