藺梟

藺梟

藺梟，女，漢族。2011年畢業於中國農業大學食品科學與營養工程學院，獲工學學士學位；2016年畢業於清華大學生命科學學院，獲生物學理學博士學位。現任西北工業大學生命學院副教授，碩士生導師。

基本介紹

  • 中文名：藺梟
  • 國籍：中國
  • 民族：漢族
  • 出生日期：1989年11月 
  • 畢業院校：清華大學 
  • 職業：教師 
  • 職稱：副教授 
工作經歷,教育經歷,教育教學,科學研究,學術成果,學術論文,申請發明專利,會議報告,

工作經歷

2016/07—2022/06，西北工業大學，生命學院，助理教授
2022/06-今，西北工業大學，生命學院，副教授

教育經歷

  1. 2007/09-2011/07 中國農業大學食品科學與營養工程學院 工學學士
  2. 2011/09-2016/07 清華大學生命科學學院 理學博士

教育教學

  1. 本科生課程《Genetics》、《生命科學導論》
  2. 研究生課程《細胞培養技術》、《航天醫學工程》、《細胞工程》

科學研究

  1. 國家自然科學基金面上項目，第一參與人。
  2. 國家自然基金青年基金，項目負責人。
  3. 中國博士後科研基金， 項目負責人。
  4. 陝西省自然科學基金青年項目，項目負責人。
  5. 中央高校基本科研業務費“一帶一路”及校際重要合作夥伴科技合作種子基金，項目負責人。
  6. 中央高校基本科研業務費西北工業大學引進高層次人才科研啟動費資助項目，項目負責人。

學術成果

學術論文

Lin X, Xu F, Zhang KW, Qiu WX, Zhang H, Hao Q, Li M, Deng XN, Tian Y, Chen ZH, Qian AR，Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis, Front Cell Dev Biol, 2022, 10, 796227. doi: 10.3389/fcell.2022.796227
Lin X, Xiao YY, Zhang KW, Yang D, Miao ZP, Deng XN, Qian AR, Knockdown of MACF1 inhibits the migration and cytoskeletal arrangement of pre-osteoclasts induced by simulated microgravity, Acta Astronaut, 2022, 190:149-159. doi: 10.1016/j.actaastro.2021.10.010
Ma JH, Lin X, Chen C, Li SY, Zhang SS, Chen ZH, Li DJ, Zhao F, Yang CF, Yin C, Qiu WX, Xiao YY, Zhang KW, Miao ZP, Yang TM, Qian AR, Circulating miR-181c-5p and miR-497-5p are potential biomarkers for prognosis and diagnosis of osteoporosis, J Clin Endocrinol Metab, 2020, 105(5). doi: 10.1210/clinem/dgz300
Cao FJ, Wang L, Feng CL, Lin X, Feng H, Synthesis of polyurethane-derived nitrogen-doped carbon dots for a high-performance fluorescence bioimaging probe, Rsc Advances, 2021, 11(54). doi: 10.1039/d1ra06334k
Qiu WX, Ma XL, Lin X, Zhao F, Li DJ, Chen ZH, Zhang KW, Zhang R, Wang P, Xiao YY, Miao ZP, Dang K, Wu XY, Qian AR, Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway, J Cell Mol Med, 2020, 24(1):317-327. doi: 10.1111/jcmm.14729
Lin X, Chen Q, Xiao YY, Gao YG, Ifty Ahmed, Li M, Li H, Zhang KW, Qiu WX, Liu XH, Aldo R. Boccaccini, Qian AR, Phosphate glass fibers facilitate proliferation and osteogenesis through Runx2 transcription in murine osteoblastic cells, J Biomed Mater Res A, 2020, 108(2): 316-326. doi: 10.1002/jbm.a.36818
Lin X, Suryaji Patil, Gao YG, Qian AR, The bone extracellular matrix in bone formation and regeneration, Front Pharmacol, 2020, 11: 757. doi: 10.3389/fphar.2020.00757（ESI高被引論文）
Lin X, Zhang KW, Wei DX, Tian Y, Gao YG, Chen ZH, Qian AR, The impact of spaceflight and simulated microgravity on cell adhesion. Int J Mol Sci, 2020, 21(9). doi: 10.3390/ijms21093031
Lin X, Xiao YY, Chen ZH, Ma JH, Qiu WX, Zhang KW, Xu F, Dang K, Qian AR, Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway, Mol Cell Endocrinol, 2019, 494:110494. doi: 10.1016/j.mce.2019.110494
Suryaji Patil, Gao YG, Lin X, Li Y, Dang K, Tian Y, Zhang WJ, Jiang SF, Abdul Qadir, Qian AR. The development of functional non-viral vectors for gene delivery. Int J Mol Sci, 2019, 20(21), pii:E5491. doi: 10.3390/ijms20215491
Chen ZH, Zhao F, Liang C, Hu LF, Li DJ, Zhang Y, Yin C, Chen L, Wang LY, Lin X, Su PH, Ma JH, Yang CF, Tian Y, Zhang WJ, Li Y, Peng SL, Chen WY, Zhang G, Qian AR. Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli. Theranostics, 2020, 10(26):12263–12278. doi: 10.7150/thno.53009
Ma XL, Su PH, Yin C, Lin X, Wang X, Gao YG, Suryaji Patil, Abdul Rouf War, Abdul Qadir, Tian Y, Qian AR, The roles of FoxO transcription factors in regulation of bone cells function, Int J Mol Sci, 2020, 21(3): 692. doi: 10.3390/ijms21030692
Chen ZH, Zhang Y, Zhao F, Yin C, Yang CF, Wang X, Wu ZX, Liang SJ, Li DJ, Lin X, Tian Y, Hu LF, Li Y, Qian AR. Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression. Int J Mol Sci, 2020, 21(4):1259. doi: 10.3390/ijms21041259
Dang K, Zhang WJ, Jiang SF, Lin X, Qian AR, Application of lectin microarrays for biomarker discovery. ChemistryOpen, 2020, 9(3):285-300. doi: 10.1002/open.201900326
Gao YG, Liu FL, Suryaji Patil, Li DJ, Abdul Qadir, Lin X, Tian Y, Li Y, Qian AR, 1,8-Naphthalimide-based multifunctional compounds as Cu probes, lysosome staining agents, and non-viral vectors, Front Chem, 2019, 7:616. doi: 10.3389/fchem.2019.00616
Abdul Qadir, Gao YG, Patil Suryaji, Tian Y, Lin X, Dang K, Jiang SF, Li Y, Miao ZP, Qian AR. Non-Viral Delivery System and Targeted Bone Disease Therapy. Int J Mol Sci, 2019, 20(3), pii:E565. doi: 10.3390/ijms20030565
Gao YG, Lin X, Dang K, Jiang SF, Tian Y, Liu FL, Li DJ, Li Y, Miao ZP, Qian AR. Structure-activity relationship of novel low-generation dendrimers for gene delivery. Org Biomol Chem, 2018, 16(42):7833-7842. doi: 10.1039/c8ob01767k
Lin X, He Y, Hou X, Zhang ZM, Wang R, Wu Q, Endothelial cells can regulate smooth muscle cells in contractile phenotype through the miR-206/ARF6&NCX1/exosome axis, PLoS One, 2016, 11(3):e0152959. doi: 10.1371/journal.pone.0152959
Lin X, Wu L, Zhang ZM, Yang RH, Guan Q, Hou XF, Wu Q, MiR-335-5p promotes chondrogenesis in mouse mesenchymal stem cells and is regulated through two positive feedback loops, J Bone Miner Res, 2014, 29(7):1575-1585. doi: 10.1002/jbmr.2163
Wang Y, Jiang XL, Yang SC, Lin X, He Y, Yan C, Wu L, Chen GQ, Wang ZY, Wu Q, MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern, Biomaterials, 2011, 32(35):9207-9217. doi: 10.1016/j.biomaterials.2011.08.058
Wang Y, Gao R, Wang PP, Jian J, Jiang XL, Yan C, Lin X, Wu L, Chen GQ, Wu Q, The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARgamma signaling, Biomaterials, 2012, 32(2):485-493. doi: 10.1016/j.biomaterials.2011.09.089

申請發明專利

  1. 騫愛榮，高永光，藺梟，胡麗芳，張文娟，羅曉慶，趙欣，李迪傑，骨靶向肽與萘醯亞胺修飾的樹形高分子轉基因載體、其製備方法及套用，申請號：201810620827.0
  2. 騫愛榮，田野，王雪，藺梟，裴佳偉，蘇佩紅，印崇，譚慎行，趙欣，一種治療骨質疏鬆的組合物，申請號：201910855234.7

會議報告

  1. Xiao Lin, Chao Yan, Yang Wang, Qiong Wu*. MicroRNA Regulating Cell Differentiation on PHA materials, The 13th International Symposium on Biopolymers, Cairns, Australia, 7-10 October 2012
  2. Xiao Lin, et al.Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis by regulating cell migration and fusion, 第九屆國際骨質疏鬆和骨礦鹽疾病學術會議（IOCBR 2018），優秀論文獎，2018.10
  3. Xiao Lin, et al.Microtubule actin crosslinking factor 1 (MACF1) positively controls osteoclastogenesis and bone resorption activity，陝西省細胞生物學學會2018年年會，優秀牆報獎，2018.11
  4. Xiao Lin, et al.Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3β/NFATc1 signalling pathway. 2019 ASBMR Annual meeting.Olando, USA, 19-23 September 2019 (poster)
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