基本介紹
- 中文名：蔣曉燕
- 國籍：中國
- 民族：漢族
- 畢業院校：上海交通大學
- 職業：教學科研工作者
研究方向,獲獎情況,代表性成果,
研究方向
為如皋衰老縱向佇列的核心建設者（Rugao Longevity and Ageing Study, RuLAS）Co-PI，建立佇列資料庫，建立多學科（各器官、系統、社會心理）表型、基因組、代謝組、宏基因組等多組學資料庫。研究方向：心血管與代謝性疾病分子和遺傳流行病學。長期從事心血管代謝性疾病及衰弱的分子和遺傳流行病學研究，並有多年的多基因病與藥物遺傳學諮詢、心血管藥理學及病理生理學研究教學經歷。
獲獎情況
主持國家自然科學基金面上項目、國家自然科學基金青年基金、國家教育部博士點新教師基金、上海市自然科學基金、中央高校基本科研業務費專項基金等項目。為國家重點研發計畫“主動健康和老齡化科技應對”專項“老年衰弱快速篩查評估量表的研發與建立”任務責任人。發表SCI論文50多篇，其中以通訊或第一作者（含並列）名義發表SCI論文26篇。獲濟南市科技進步二等獎（2015，排名第二）。是國家自然科學基金及教育部博士學位論文評審專家以及J Nutr Health Aging、Frontiers in Public Health、Molecular Biology Reports、Psychiatry Research等國際SCI期刊的審稿人。
代表性成果
近5年發表文章（Publication）：*通訊作者（corresponding author），#並列第一（co-first author）
1.H Zhang#, M Sun#, Z Hu, Y Cao, M Hao, Y Li, L Jin, X Sun, X Wang, X Jiang*. Association of Arterial Stiffness with Functional Disability and Mobility Limitation: The Rugao Longitudinal Ageing Study. J Nutr Health Aging. 2022; Online ahead of print.（corresponding author）
2.Yuan JL#, Zhao RX#, Ma YJ, Li XD, Zhou XM, Wang XF, Jiang XY*, Li SJ*. Prevalence/potential risk factors for motoric cognitive risk and its relationship to falls in Chinese elderly people: A cross-sectional study. Eur J Neurol. 2021 Aug;28（8）:2680-2687. doi: 10.1111/ene.14884. （co-corresponding author）
3.Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*.Cognitive frailty and falls in Chinese older people：a population-based longitudinal study. Eur J Neurol. 2021 Feb; 28（2）:381-388. doi: 10.1111/ene.14572.（co-corresponding author）
4.Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*. Cognitive frailty predicting death and disability in Chinese elderly. Neurol Res. 2021 Oct;43（10）:815-822. doi: 10.1080/01616412.2021.1939235. （co-corresponding author）
5.Guo JH#, Shi JM#, Shi GP, Wang Y, Chu XF, Wang ZD, Yao S, Sun XH, Wang XF, Zhu YS*, Jiang XY*. Association Study of Mitochondrial DNA Haplogroup D and C5178A Polymorphisms with Chronic Kidney Disease. Genet Test Mol Biomarkers. 2021 Aug;25（8）:546-550. doi: 10.1089/gtmb.2020.0306. （co-corresponding author）
6.Chen Z#, Jiang X#, Shi G, Wang Y, Chu X, Wang Z, Guo J, Zhu Y, Chen J, Wang X, Bao Z*. Social frailty and longitudinal risk of depressive symptoms in a Chinese population: the Rugao Longevity and Aging Study. Psychogeriatrics. 2021 Jul;21（4）:483-490. doi: 10.1111/psyg.12696. Epub 2021 May 6. （co-first author）
7.Sun XH#, Ma T#, Yao S, Chen ZK, Xu WD, Jiang XY*, Wang XF*. Associations of sleep quality and sleep duration with frailty and pre-frailty in an elderly population Rugao longevity and ageing study. BMC Geriatr. 2020 Jan 6;20（1）:9. doi: 10.1186/s12877-019-1407-5. （co-corresponding author）
8.Ma T#, Sun XH#, Yao S, Chen ZK, Zhang JF, Xu WD, Jiang XY*, Wang XF*. Genetic Variants of Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity and Ageing Study.J Nutr Health Aging. 2020;24（2）:198-204. doi: 10.1007/s12603-019-1304-9. （co-corresponding author）
9.Li YX#, Jiang XY#, Stone C, Ma YJ, Liu Q, Hu ZH, Li XD, Wang XF, Li SJ. A new physical-cognitive scale for assessment of frailty in Chinese Han elderly. Neurol Res. 2019 Aug;41（8）:728-733. doi: 10.1080/01616412.2019.1609164. Epub 2019 Apr 28. （co-first author）
10. Shi GP#, Ma T#, Zhu YS, Wang ZD, Chu XF, Wang Y, Chen ZK, Xu WD, Wang XF, Guo JH, Jiang XY*. Frailty phenotype, frailty index and risk of mortality in Chinese elderly population- Rugao longevity and ageing study. Arch Gerontol Geriatr. 2019 Jan - Feb;80:115-119. doi: 10.1016/j.archger.2018.11.001. Epub 2018 Nov 6.（co-corresponding author）
11. Ma T #, Cai J#, Zhu Y, Chu X, Wang Y, Shi G, Wang Z, Yao S, Wang X*, Jiang X*. Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the rugao longevity and Ageing study. Clin Interv Aging. 2018;13:797-804. eCollection 2018. （co-corresponding author）
12. Zheng HX#, Li L#, Jiang XY#, Yan S, Qin Z, Wang X, Jin L. MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Hum Genet （2017） 136:1353–1362. （co-first author）
13. Wang Y#, Ma T#, Zhu YS, Chu XF, Yao S, Wang HF, Cai J, Wang XF*, Jiang XY*. The KSR2-rs7973260 Polymorphism is Associated with Metabolic Phenotypes, but Not Psychological Phenotypes, in Chinese Elders. Genet Test Mol Biomarkers. 2017 Jul;21（7）:416-421. （co-corresponding author）
14. Zhi T#, Wang Q#, Liu Z#, Zhu Y, Wang Y, Shi R, Wang Z, Chu X, Wang X, Jiang X*. Body mass index, waist circumference and waist-hip ratio are associated with depressive symptoms in older Chinese women: results from the Rugao Longevity and Ageing Study （RuLAS）. Aging Ment Health. 2017 May;21（5）:518-523. doi: 10.1080/13607863.2015.1124837. Epub 2015 Dec 21. （corresponding author）
15. Hao M#, Zhang H#, Hu Z, Jiang X, Song Q, Wang X, Wang J, Liu Z*, Wang X*, Li Y*, Jin L*. Phenotype correlations reveal the relationships of physiological systems underlying human ageing. Aging Cell. 2021 Dec;20（12）:e13519.
16. Zhang H#, Zhu Y#, Hao M, Wang J, Wang Z, Chu X, Bao Z, Jiang X, Shi G*, Wang X*. The modified Healthy Aging Index is Associated with Mortality and Disability: The Rugao Longevity and Ageing Study. Gerontology. 2021;67（5）:572-580.
17. Zhang H#, Zhu Y#, Gong W, Sun X, Jiang X, Wang J, Jin L, Xu X, Luo D*, Wang X*. Plasma Homocysteine and Macular Thickness in Older Adults-the Rugao Longevity and Aging Study. Eye （Lond）. 2021. Online ahead of print.
18. Zhang H#, Li Y#, Hao M, Jiang X, Wang J, Jin L, Bao Z*, Wang X*. Kidney function decline is associated with an accelerated increase in plasma homocysteine in older adults: a longitudinal study. Br J Nutr. 2021, 24:1-7.
19. Chu X#, Zhang N#, Shi G, Wang Y, Wang Z, Guo J, Jiang X, Jin L, Wang X*, Zhu Y*. Frailty and Incident Depressive Symptoms in a Chinese Sample: The Rugao Longevity and Ageing Study. Psychogeriatrics. 2020;20（5）:691-698.
20. Wang Z#, Yao S#, Shi G, Wang Y, Shi J, Guo J, Zhu Y, Jiang X, Chu X*, Wang X*.Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32（2）:305-311.
21. Yao S, Zhu Y , Shi G, Guo J, Wang Z, Chu X, Jiang X, Jin L*, Wang X*. Associations of TNF-α -308 G＞A and TNF-β 252 A＞G with Physical Function and BNP-Rugao Longevity and Ageing Study. J Nutr Health Aging. 2020;24（3）:358-363.
22. Zhang N#, Shi GP#, Wang Y, Chu XF, Wang ZD, Shi JM, Guo JH, Wang YC, Yao S, Jiang XY, Zhu YS*, Wang XF*. Depressive symptoms are associated with incident frailty in a Chinese population- the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32（11）:2297-2302.
23. Yao S#, Guo J#, Shi G, Zhu Y, Wang Y, Chu X, Jiang X, Jin L, Wang Z*, Wang X*. Association Of BNP with frailty in elderly population: Rugao Longevity and Ageing Study. J Nutr Health Aging. 2019;23（1）:73-78.
24. Ma T, Lu D, Zhu Y, Chu X, Wang Y, Shi G, Wang Z, Yu L, Jiang X, Wang X*.ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. Age Ageing. 2018;47（3）:416-422.
25. Liu Q#, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Comparing associations of different metabolic syndrome definitions with ischemic stroke in Chinese elderly population. Eur J Intern Med. 2018,47:75-81.
26. Liu Q, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Reduced estimated glomerular filtration rate is associated with depressive symptoms in elder Chinese: A population-based cross-sectional study. Neurosci Lett. 2018;666:127-132.
27. Ma T#, Shi G#, Zhu Y, Wang Y, Chu X, Jiang X, Liu Z, Cai J, Wang H, Jin L, Wang Z*, Wang X*. Sleep disturbances and risk of falls in an old Chinese population-Rugao Longevity and Ageing Study. Arch Gerontol Geriatr. 2017,12;73:8-14.Liu Q#, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Reduced estimated glomerular filtration rate is associated with depressive symptoms in elder Chinese: a population-based cross-sectional study. Neurosci Lett. 2017;666:127-132.
