蔡時青，男，博士，1997年畢業於中國農業大學生物學院，獲理學學士學位。2009年回國擔任中國科學院上海生命科學研究院神經科學研究所離子通道調控研究組組長、研究員。
基本介紹
- 中文名：蔡時青
- 國籍：中國
- 畢業院校：中國農業大學
- 性別：男
人物簡介,研究方向,人物榮譽,代表性論文,
人物簡介
蔡時青博士1997年畢業於中國農業大學生物學院，獲理學學士學位。1997年至2002年就讀於中科院上海植物生理生態研究所，獲博士學位。2004至2009年在美國新澤西醫科牙科大學做博士後工作。2009年回國擔任中國科學院上海生命科學研究院神經科學研究所離子通道調控研究組組長。
研究方向
鉀離子通道是一類選擇性允許鉀離子順著電化學梯度通過細胞膜的跨膜蛋白, 它存在於幾乎所有的生物體包括細菌、植物和哺乳動物中；幾乎所有活體細胞，包括肌細胞，神經元，甚至免疫細胞中都存在鉀離子通道。因此鉀離子通道在生命過程中具有非常重要的作用：它參與了神經元和心肌動作電位的形成，腺體激素的分泌，甚至免疫細胞的免疫反應。鉀離子通道的功能通常是動態的，它受許多因子調控。在鉀離子通道的研究中，一個巨大的挑戰是鉀離子通道如何參與生命的各個生理過程，比如發育、衰老、學習和記憶的形成等等。回答這些基本問題，一個理想的生物體系十分重要，在這個體系里，我們能夠將離子通道調控和動物行為的變化聯繫起來。從這一點講線蟲提供了一個無法估量的價值：1 幾乎所有主要的鉀離子通道家族基因都線上蟲基因組中發現, 2 線蟲生活周期短，十分有利於遺傳學操作，3 最近發展起來的電生理技術使我們能夠在體內或體外, 甚至線蟲活體內測定單個神經元細胞的電生理特徵。這樣線蟲給我們提供了一個簡單的體系來回答鉀離子通道領域的基本問題，但又不失去普遍性。
我們課題組將結合生物化學、生物物理學、遺傳學、表現型分析、電生理學等方法來研究鉀離子通道在生長發育、衰老等過程中的調控機制。我們將致力於研究以下幾個問題：1 鉀離子通道α亞基和β亞基之間的相互作用機制及其生理意義；2 鉀離子通道的表達和運輸分子機制；3 鉀離子通道在肌肉細胞衰老過程中的調控及其生理作用。另外我們也將進行有關氯離子通道調控機制方面的研究。
我們課題組將結合生物化學、生物物理學、遺傳學、表現型分析、電生理學等方法來研究鉀離子通道在生長發育、衰老等過程中的調控機制。我們將致力於研究以下幾個問題：1 鉀離子通道α亞基和β亞基之間的相互作用機制及其生理意義；2 鉀離子通道的表達和運輸分子機制；3 鉀離子通道在肌肉細胞衰老過程中的調控及其生理作用。另外我們也將進行有關氯離子通道調控機制方面的研究。
人物榮譽
2019年8月2日，入選2019年度國家傑出青年科學基金建議資助項目申請人名單。
代表性論文
1. W. Tutak, Ki-Ho Park, G. Fanchini, A. Vasilov, Cai SQ, N.partridge, F. Sesti , M. Chhowalla (2009). Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single walled carbon nanotube networks. Nanotechnology, 20 (25): 255101.
2. Shi-qingCai*, Wang Yi*, Ki Ho Park*, Xin Tong, Zui Pan and Federico Sesti (2009) Auto-phosphorylation of a voltage-gated K + channel controls non-associative learning. EMBO J. 28 (11):1601-10. (* co-first author)
3. Shi-Qing Cai and F. Sesti (2009) Oxidation of a K+ Channel causes progressive decline in sensory function during ageing. Nature Neuroscience, 12 (5): 611-7.
4. L. Hernandez, K.H. Park, Shi-Qing Cai, L. Qin, N. Partridge, F. Sesti (2007) The antiproliferative role ofergK+ channels in rat osteoblastic cells. Cell Biochemstrybiophysics47: 199-208.
5. Shi-Qing Cai and F. Sesti (2007). A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel. The Journal of Biological Chemistry 282(25): 18597-601.
6. Shi-Qing Cai, W. Li, F. Sesti (2007) Multiple modes of A-type Potassium current regulation. Invited review. Current Pharmaceutical Design 13(31): 3178-84.
7. Shi-Qing Cai, Ki Ho Park, Federico Sesti (2006) An evolutionarily conserved family of accessory subunits of K+ channels. Invited review. Cell Biochemstry Biophysics 46(1): 91-100.
8. Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park, Federico Sesti (2005) MPS-1 is a K+ channel b-subunit and a serine/threonine kinase. Nature Neuroscience 8(11): 1503-9.
9. Ki Ho Park, Leonardo Hernandez, Shi-Qing Cai, Yi Wang, Federico Sesti (2005) A family of K+ Channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans. The Journal of Biological Chemistry 280: 21893-21899.
10. Shi-Qing Cai, Gen-Yun Chen, Hai-Bo Zhang, Da-Quan Xu (2002). No monomerisation of PSII dimer occurs during reversible inacivation of some photosystem II reaciton centers in soybean leavs. Photosynthetica 40 (2) 215-220.
11. Shi-Qing Cai, Da-Quan Xu (2002). Light intensity-dependent reversible down-regulation andirreversibledamage of photosystem II in soybean leaves. Plant Science Vol 163/4 pp 847-853.
12. Hai-Bo Zhang, Shi-Qing Cai, Da-Quan Xu (2002). D1 protein phosphorylation/ dephosphorylation alone has no effect on the electron transport activity of photosystem II in soybean leaves. Plant Science 162, 507-511.
13. Yue Chen, Xue-Hua Wang, Yi Liao, Shi-Qing Cai, Hai-Bo Zhang, Da-Quan Xu (2002) Effect of Flag Leaf Orientation on its Photosynthetic Capacity in Rice. Acta Phytophysiologia sinica 28 (5) 396-398.
14. Gen-Yun Chen, Yi Liao, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu (2002) Photosynthetic acclimation of Echinochloa crusgalli grown in rice field to free-air CO2 enrichment (FACE). Chinese Journal of Applied Ecology 13 (10): 1205-1209.
15. Yi Liao, Gen-Yun Chen, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu (2002) Responses and acclimation of photosynthesis to free-air carbon dioxide enrichment (FACE) in rice leaves. Chinese Journal of Applied Ecology 13(10): 1201-1204.
16. Shi-Qing Cai, Da-Quan Xu (2000) Relationship between the CO2 compensation point and photorespiration in soybean leaves. Acta Phytophysiologia sinica, 26 (6): 545-550.
2. Shi-qingCai*, Wang Yi*, Ki Ho Park*, Xin Tong, Zui Pan and Federico Sesti (2009) Auto-phosphorylation of a voltage-gated K + channel controls non-associative learning. EMBO J. 28 (11):1601-10. (* co-first author)
3. Shi-Qing Cai and F. Sesti (2009) Oxidation of a K+ Channel causes progressive decline in sensory function during ageing. Nature Neuroscience, 12 (5): 611-7.
4. L. Hernandez, K.H. Park, Shi-Qing Cai, L. Qin, N. Partridge, F. Sesti (2007) The antiproliferative role ofergK+ channels in rat osteoblastic cells. Cell Biochemstrybiophysics47: 199-208.
5. Shi-Qing Cai and F. Sesti (2007). A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel. The Journal of Biological Chemistry 282(25): 18597-601.
6. Shi-Qing Cai, W. Li, F. Sesti (2007) Multiple modes of A-type Potassium current regulation. Invited review. Current Pharmaceutical Design 13(31): 3178-84.
7. Shi-Qing Cai, Ki Ho Park, Federico Sesti (2006) An evolutionarily conserved family of accessory subunits of K+ channels. Invited review. Cell Biochemstry Biophysics 46(1): 91-100.
8. Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park, Federico Sesti (2005) MPS-1 is a K+ channel b-subunit and a serine/threonine kinase. Nature Neuroscience 8(11): 1503-9.
9. Ki Ho Park, Leonardo Hernandez, Shi-Qing Cai, Yi Wang, Federico Sesti (2005) A family of K+ Channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans. The Journal of Biological Chemistry 280: 21893-21899.
10. Shi-Qing Cai, Gen-Yun Chen, Hai-Bo Zhang, Da-Quan Xu (2002). No monomerisation of PSII dimer occurs during reversible inacivation of some photosystem II reaciton centers in soybean leavs. Photosynthetica 40 (2) 215-220.
11. Shi-Qing Cai, Da-Quan Xu (2002). Light intensity-dependent reversible down-regulation andirreversibledamage of photosystem II in soybean leaves. Plant Science Vol 163/4 pp 847-853.
12. Hai-Bo Zhang, Shi-Qing Cai, Da-Quan Xu (2002). D1 protein phosphorylation/ dephosphorylation alone has no effect on the electron transport activity of photosystem II in soybean leaves. Plant Science 162, 507-511.
13. Yue Chen, Xue-Hua Wang, Yi Liao, Shi-Qing Cai, Hai-Bo Zhang, Da-Quan Xu (2002) Effect of Flag Leaf Orientation on its Photosynthetic Capacity in Rice. Acta Phytophysiologia sinica 28 (5) 396-398.
14. Gen-Yun Chen, Yi Liao, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu (2002) Photosynthetic acclimation of Echinochloa crusgalli grown in rice field to free-air CO2 enrichment (FACE). Chinese Journal of Applied Ecology 13 (10): 1205-1209.
15. Yi Liao, Gen-Yun Chen, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu (2002) Responses and acclimation of photosynthesis to free-air carbon dioxide enrichment (FACE) in rice leaves. Chinese Journal of Applied Ecology 13(10): 1201-1204.
16. Shi-Qing Cai, Da-Quan Xu (2000) Relationship between the CO2 compensation point and photorespiration in soybean leaves. Acta Phytophysiologia sinica, 26 (6): 545-550.
