董岸傑，女，天津大學化工學院高分子科學與工程系教授，博士研究生導師。招生專業： 材料學，材料化學工程。2005年入選教育部新世紀優秀人才。作為負責人，承擔並完成了863、國家十五攻關、5項國家自然科學基金以及天津市科技攻關和重點項目，參與了“十一五”國家傳染病重大專項等項目。目前在研國家自然科學基金1項。所帶領的課題組獲得了多種具有自主智慧財產權的新型功能性藥用材料，包括親水性壓敏膠、納米材料、納米藥物遞送系統及多種藥物納米化製備技術。近年來，帶領課題組率先在納米粒溫敏自凝膠腫瘤定位給藥系統方面開展了大量研究工作，取得了多項創新性研究成果。此外，在DNA、siRNA納米遞送系統及藥物與核酸共輸送載體方面也進行了相應的研究工作。與復旦大學、國家納米科學中心、北京大學核酸技術研究室、天津醫科大學等單位深入合作，加強學科交叉。多篇文章發表在Biomaterials、Soft Matter 等期刊上。共發表論文160多篇。SCI收錄論文140多篇；獲得專利16項，申報並在審理中的專利10項。
基本介紹
- 中文名：董岸傑
- 國籍：中國
- 民族：漢族
- 出生日期： 1964年10月
- 職業：博導
- 主要成就：國家863項目：用於腫瘤介入治療的納米材料及其原位凝膠給藥系統
- 性別：女
人物經歷,主講課程,研究方向,主要貢獻,論著專利,合作交流:,
人物經歷
2004年到澳大利亞南澳大學進行訪問研究。
主講課程
高分子物理。
研究方向
從事功能高分子材料，高分子自組裝與生物膜，納米材料及技術，藥用高分子材料及給藥系統。目前研究領域：（1）可注射溫敏原位凝膠材料及其給藥系統，以及在抗腫瘤和抗愛滋病黏膜防護中的套用研究；（2）多功能性核酸傳遞載體及核酸遞送系統；（3）經皮給藥壓敏膠、膜材料和材料對藥物經皮滲透的調控作用研究；（4）口服、靜脈注射納米藥物的研究
主要貢獻
1）國家自然科學基金（青年基金）（物理化學學科）項目：兩親性聚氨酯水分散體系超分子自組裝及特性的研究。2）國家自然科學基金（生命科學部）項目：基於高分子自組裝體系研究生物膜的分子自組裝與功能性。3）國家十五科技攻關項目：中藥咳喘膏納米透皮吸收新製劑的研究開發。4）國家科技部中澳合作特別基金項目：基於分子設計和組裝開發新型藥用高分子材料及納米藥物傳遞體，中澳合作，2003.6～2005.6。5）天津市科委重點攻關項目：中藥納米透皮吸收製劑高分子輔料的研製。6）新世紀優秀人才資助項目。7）國家自然科學基金（藥劑學）：高分子多層次結構對經皮給藥功能性調控作用。
1）國家自然科學基金：高分子載體結構設計及其對愛滋病疫苗的黏膜免疫促進作用; 2）天津市重點項目：促進軟骨再生修復功能的可注射支架材料及套用技術研究; 3）國家863項目：用於腫瘤介入治療的納米材料及其原位凝膠給藥系統。
生物醫學材料科研成果 獲得發明專利8項。
論著專利
近兩年論文
1. Xu, S.,Wang, W.,Li, X., (...),Dong, A.,Deng, L, .DocumentSustained release of PTX-incorporated nanoparticles synergized by burst release of DOX·HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency, European Journal of Pharmaceutical Sciences,2014, 62:267-273
2. Huang, P.,Song, H.,Wang, W., (...),Kong, D.,Dong, A, .tIntegrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation and release in tumor,Biomacromolecules,2014, 15(8):3128-3138
3. Lv, Z.,Chang, L.,Long, X., (...),Deng, L.,Dong, A.,Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer, 2014, Carbohydrate Polymers, 108(1), pp. 26-33
4. Xiang, Y.,Xiao, M.,Han, S., (...),Deng, L.,Dong, A. Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method, Journal of Biomaterials Science, Polymer Edition,2014, 25(11), pp. 1144-1158
5. Wang, W.,Liu, J.,Li, C., (...),Dong, A.,Kong, D.,Real-time and non-invasive fluorescence tracking of in vivo degradation of the thermosensitive PEGlyated polyester hydrogel,2014, Journal of Materials Chemistry B, 2(26):4185-4192
6. Huang, P.,Yang, C.,Liiu, J., (...),Liu, J.,Dong, A.,Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles,Journal of Materials Chemistry B, 2014, 2(25), pp. 4021-4033
7. Shi, Y.,Li, Y.,Wu, J., (...),Dong, A.,Zhang, J., A novel transdermal drug delivery system based on self-adhesive Janus nanofibrous film with high breathability and monodirectional water-penetration，Journal of Biomaterials Science, Polymer Edition,2014, 25(7), pp. 713-728
8. Wang, W.,Li, C.,Zhang, J.,Dong, A.,Kong, D.Tailor-made gemcitabine prodrug nanoparticles from well-defined drug-polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy, Journal of Materials Chemistry B,2014, 2(13), pp. 1891-1901
9. Zhao, J.,Liu, J.,Han, S., (...),Dong, A.,Zhang, J. Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization, Polymer Chemistry,2014,5(6), pp. 1852-1856
10. Peng, M.,Xu, S.,Zhang, Y., (...), Dong, A., Zhang, R.,Meng, W.Thermosensitive injectable hydrogel enhances the antitumor effect of embelin in mouse hepatocellular carcinoma, Journal of Pharmaceutical Sciences,2014, 3(3), pp. 965-973
11. Wang, W.,Zhang, J.,Li, C., (...),Dong, A.,Kong, D.,Facile access to cytocompatible multicompartment micelles with adjustable Janus-cores from A-block-B-graft-C terpolymers prepared by combination of ROP and ATRP, Colloids and Surfaces B: Biointerfaces,2014, 115, pp. 302-309
12. Wang, W.,Deng, L.,Huang, P., (...),Zhang, J.,Dong, A.Toxicity and in vivo biological effect of the nanoparticular self-supported hydrogel of a thermosensitive copolymer for non-invasive drug delivery, Journal of Biomedical Materials Research - Part A,2014, 102(1), pp. 17-29
13. Han, S.,Wan, H.,Lin, D., (...),Tang, H.,Dong, A. Contribution of hydrophobic/hydrophilic modification on cationic chains of poly(ε-caprolactone)-graft-poly(dimethylamino ethylmethacrylate) amphiphilic co-polymer in gene delivery, Acta Biomaterialia,2014,10(2), pp. 670-679
14. Zwitterionic nanoparticles constructed with well-defined reduction-responsive shell and pH-sensitive core for "spatiotemporally Pinpointed" drug delivery,ACS Applied Materials and Interfaces,2014,6(16), pp. 14631-14643
15. Zhao, J., Liu, J., Xu, S., (...), Meng, A., Dong*, Graft copolymer nanoparticles with ph and reduction dual-induced disassemblable property for enhanced intracellular curcumin release，ACS Applied Materials and Interfaces, 2013
16 WD Zhang, Q Cheng, ST Guo, DS Lin, PS Huang, (...),AJ Dong*, Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid, Biomaterials, 34 (27)：6495-6503，2013.
17. DS Lin, Q Jiang, Q Cheng, YY Huang, (...),AJ Dong*,Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery, Acta Biomaterialia, 9(8): 7746-7757,2013.
18. DS Lin, Q Cheng, Q Jiang, YY Huang, Z Yang, (...),AJ Dong* Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo, Nanoscale, 5 (10) :4291-4301, 2013.
19. WW Wang, LD Deng, SX Xu, X Zhao,N Lv, (...),AJ Dong*, A reconstituted "two into one" thermosensitive hydrogel system assembled by drug-loaded amphiphilic copolymer nanoparticles for the local delivery of paclitaxel, Journal of Materials Chemistry, B 1 (4): 552-563, 2013.
20. JH Zhang, XN Lin, JF Liu, JQ Zhao, HX Dong, LD Deng,JF Liu, AJ Dong*, Sequential thermo-induced self-gelation and acid-triggered self-release process of drug-conjugated nanoparticles: A strategy for the sustained and controlled drug delivery to tumors, Journal of Materials Chemistry , B 1 (36): 4667-4677 , 2013.
合作交流:
Victor C. Yang, Ph.D., College of Pharmacy, University of Michigan
Jørgen Kjems, Professor, Interdisciplinary Nanoscience Center, Aarhus University
國內，與北京大學梁子才教授，國家納米科學中心梁興傑教授，天津醫科大學湯華教授等課題組緊密合作。
Jørgen Kjems, Professor, Interdisciplinary Nanoscience Center, Aarhus University
國內，與北京大學梁子才教授，國家納米科學中心梁興傑教授，天津醫科大學湯華教授等課題組緊密合作。
