董世輝

董世輝

董世輝，理學博士，蘭州大學化學化工學院教授。

基本介紹

學歷,研究與工作經歷,研究方向,代表論文,

學歷

2006年6月畢業於武漢大學藥學院
2011年畢業於中國科學院上海藥物研究所新藥研究國家重點實驗室，獲藥物化學博士學位，師從岳建民院士。

研究與工作經歷

2011年與2018年，分別在美國伊利諾伊大學芝加哥分校和厄巴納-香檳分校從事博士後研究工作，研究方向為具有重要活性和複雜結構天然產物的生物合成途徑解析及關鍵酶功能鑑定。
2018年11月，通過蘭州大學“萃英特聘教授”人才引進加入化學化工學院、功能有機分子化學國家重點實驗室從事教學科研工作。
近年來，以第一作者在PNAS、eLife、Chem. Sci.、Cell Chem. Biol.、J. Nat. Prod.等雜誌上發表論文十餘篇。

研究方向

  1. 新穎結構活性天然產物生物合成的酶學催化機制
  2. 新穎結構活性天然產物的生物合成途徑解析
  3. 新穎結構活性天然產物的基因組挖掘及發現

代表論文

(1) Shi-Hui Dong, Alexey Kulikovsky, Svetlana Dubiley, Konstantin Severinov, and Satish K. Nair. Biosynthesis of the RiPP Trojan Horse Antibiotic Microcin C is Directed by the N-Formyl Peptide Substrate. Chem. Sci.2019, 10, 2391-2395.
(2) Silvia C Bobeica,* Shihui Dong,* Liujie Huo, Nuria Mazo, Martin Irving Harrison McLaughlin, Gonzalo Jiménez-Osés, Satish K Nair, Wilfred A van der Donk. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. 2019, 8, e42305.
(3) Wenjia Gu, Shi-Hui Dong, Snigdha Sarkar, Satish K Nair, Eric W Schmidt. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis. Methods in Enzymology 2018, 604, 113-163.
(4) Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K Nair, Douglas A Mitchell. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. PNAS 2018, 12, 3030-3035.
(5) Matthew C. O’Reilly,* Shihui Dong,* Francis M. Rossi, Kaleigh M. Karlen, Rohan S. Kumar, Satish K. Nair, and Helen E. Blackwell. Non- Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop 'Out' Conformation for LasR. Cell Chem. Biol. 2018, 20, 1128-1139
(6) Shi-Hui Dong, Nicole Frane, Quin H. Christensen, E. Peter Greenberg, Rajesh Nagarajan, and Satish K. Nair. Molecular basis for the substrate specificity of quorum signal synthases. PNAS 2017, 114, 9092-9097.
(7) Shi-Hui Dong,* Weixin Tang,* Tiit Lukk, Satish K Nair, and Wilfred A van der Donk. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. eLife 2015, DOI: 10.7554/eLife.07607.
(8) Weixin Tang,* Shi-Hui Dong,* Lindsay M. Repka, Chang He, Satish K Nair, and Wilfred A van der Donk. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chem. Sci. 2015, 6, 6270-6279.
(9) XiangMing Hu, Shi-Hui Dong, Jinjing Chen, Ruichuan Chen, Satish K Nair, Kun Ping Lu, and Lin-Feng Chen. Prolyl isomerase Pin1 regulates the stability, transcriptional activity and oncogenic potential of Brd4. Oncogene 2017 doi:10.1038/onc.2017.137.
(10) Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E. Cronan, and Satish K. Nair. The Pimeloyl-CoA Synthetase BioW Defines a New Fold for Adenylate-Forming Enzymes. Nat. Chem. Biol. 2017, 13, 668-674.

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