國家973項目首席科學家，中華醫學會眼科學分會名譽主任委員，中國醫師協會眼科學分會副主任委員，中華眼科學會青光眼學組前任組長，廣東省眼科醫師學會主任委員，世界青光眼協會常務理事，《中華眼科雜誌》及《中華實驗眼科雜誌》副總編。《Clinical and Experimental Optometry》、《Journal of Glaucoma》編委。
基本介紹
中文名：葛堅
外文名：Ge Jian
國籍：中國
民族：漢族
職業：中心主任
主要成就：973首席科學家
性別：男
個人簡介,科研項目,發表論文,
個人簡介
葛堅教授從事眼科臨床及研究工作30餘年，在青光眼診治、白內障超聲乳化與眼內窺鏡雷射治療疑難青光眼、幹細胞研究、近視眼防治等方面有較高的造詣。所領導的團隊相繼獲得了973計畫、863重大專項、衛生部臨床重點學科項目、教育部科學技術研究重大項目、國家自然科學基金重點項目等多項基金的資助，獲得國家科技進步二等獎、教育部及廣東省科技進步一等獎等獎項十餘次。截至目前，單獨或與他人合作發表論文330篇，其中SCI收錄論文140篇。主編衛生部統編七年制以及八年制《眼科學》教材、教育部五年制《眼科學》教材和《現代青光眼研究進展》。已培養博士研究生71名，已出站博士後8名，其中17人次獲得國家自然科學基金，1人獲得全國百篇優秀博士論文獎。分別獲得“全國醫院優秀院長”、 “廣東省優秀院長”、 “中華眼科傑出成就獎”、“中國醫師獎”、亞太眼科學會“傑出服務獎”、中美眼科學會“金鑰匙獎”、世界青光眼協會“高級研究科學家獎”（“Senior Research Scientist”獎）和“突出貢獻獎（The World Glaucoma Association Recognition Award）”，澳大利亞政府“傑出創新獎”（“Excellence in Innovation”獎)，亞太眼科學會“最高學術獎”(“De Ocampo”獎)等榮譽。
1. Wei Chi, Fei Li...Ge J*，Robert N. Weinre，Kang Zhang, and Yehong Zhuo, Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma，PNAS，Jun 11,2014
2. He Y, Leung KW, Ren Y, Pei JZ, Ge J*, Tombran-Tink J. PEDF Improves Mitochondrial Function in RPE cells During Oxidative Stress. Invest Ophthalmol Vis Sci. 2014 Sep 11.
3. Xi L, Wang T, Zhao F, Zheng Q, Li X, Luo J, Liu J, Quan D, Ge J*. Evaluation of an injectable thermosensitive hydrogel as drug delivery implant for ocular glaucoma surgery. PLoS One. 2014 Jun 20;9(6)
4. Chen P, Hu H, Chen Z, Cai X, Zhang Z, Yang Y, Yu N, Zhang J, Xia L, Ge J*, Yu K, Zhuang J. BRCA1 silencing is associated with failure of DNA repairing In retinal neurocytes. PLoS One. 2014 Jun 11;9(6).
5. Huang R,Ge J*, Chen G, Gao X, Laties AM, Zhang X. Four Measures of Intraocular Pressure Fluctuation: Which Correlates Most Optimally With Actual Office-hour Readings? J Glaucoma. 2014 Apr 25.
6. Liu B, Zhu Y, Zhou J, Wei Y, Long C, Chen M, Ling Y, Ge J*, Zhuo Y. ndoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells. Cell Stress Chaperones. 2014 Mar 19.
7. Huang J, Ling Y, Lin M, Wu Z, Cheng B, Ge J*. Ten-year follow-up of familial nanophthalmos in three siblings. Eye Sci. 2013 Sep;28(3):113-8.
8. Cai X, Chen Z, Pan X, Xia L, Chen P, Yang Y, Hu H, Zhang J, Li K, Ge J*, Yu K, Zhuang J. Inhibition of angiogenesis, fibrosis and thrombosis by tetramethylpyrazine: mechanisms contributing to the SDF-1/CXCR4 axis. PLoS One.2014 Feb 5;9(2).
9. Lai K、Jin C、Tu S、Xiong Y、Huang R、Ge J*, Intravitreal injection of99Tc-MDP inhibits the development of laser-induced choroidal neovascularization in rhesus monkeys, Graefes Arch Clin Exp Ophthalmol, Jan 5, 2014
10. Wang Z、Huang J、Lin J、Liang X、Cai X、Ge J*，Quantitative Measurements of the Ciliary Body in Eyes with Malignant Glaucoma after Trabeculectomy Using Ultrasound Biomicroscopy，Ophthalmology，Dec 6，2013
11. Yang X、Su W、Wang M、Bai Y、Li Y、Ge J*, Zhuo Y Effect of anterior chamber paracentesis on initial treatment of acute angle closure，Can J Ophthalmol，(6)48553-8，2013
12. Yang XJ、Ge J*、Zhuo YH，Role of mitochondria in the pathogenesis and treatment of glaucoma. Chin Med J (Engl)，126(22)，4358-65，Nov 2013
13. Huang J、Wang Z、Wu Z、Li Z、Lai K、Ge J*，Comparison of Ocular Biometry Between Eyes With Chronic Primary Angle-Closure Glaucoma and their Fellow Eyes With Primary Angle-Closure or Primary Angle-Closure Suspect，J Glaucoma，Jun 25 2013
14. Yang Y、Tian S、Brown B、Chen P、Hu H、Xia L、Zhang J、Cai X、Chen Z、Pan X、Ge J、Yu K、Zhuang J，The Rb1 gene inhibits the viability of retinoblastoma cells by regulating homologous recombination，Int J Mol Med， 32(1)，137-43，Jul 2013
15. Yu D、Chen M、Sun X、Ge J*，Differentiation of mouse induced pluripotent stem cells into corneal epithelial-like cells，Cell Biol Int， 37(1)，87-94，Jan 2013
16. Deng F、Hu H、Chen M、Sun X、Liu X、Dong Z、Liu Y、Xi L、Zhuang J、Ge J*，Generation of induced pluripotent stem cells from human Tenon's capsule fibroblasts，Mol Vis，18，2871-81，2012
18. Lu R、Qu Y、Ge J*、Zhang L、Su Z、Pflugfelder SC、Li DQ，Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells，Stem Cells， 30(4)，753-61，Apr 2012
19. Lu R、Zhang X、Huang D、Huang B、Gao N、Wang Z、Ge J*，Conjunctival reconstruction with progenitor cell-derived autologous epidermal sheets in rhesus monkey，PLoS One，6(11)，e25713，2011
20. Li Y、Zhang Q、Yin X、Yang W、Du Y、Hou P、Ge J*、Liu C、Zhang W、Zhang X、Wu Y、Li H、Liu K、Wu C、Song Z、Zhao Y、Shi Y、Deng H，Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules，Cell Res，21(1):196-204，Jan 2011
21. Ma J、Kabiel M、Tucker BA、Ge J*、Young MJ，Combining chondroitinase ABC and growth factors promotes the integration of murine retinal progenitor cells transplanted into Rho(-/-) mice，Mol Vis， 17，1759-70，2011
22. Sun X、Chen M、Li J、Zhuang J、Gao Q、Zhong X、Huang B、Zhang W、Huang L、Ge J*，E13.5 retinal progenitors induce mouse bone marrow mesenchymal stromal cells to differentiate into retinal progenitor-like cells， Cytotherapy，13(3)，294-303，Mar 2011
23. Cui D、Trier K、Zeng J、Wu K、Yu M、Hu J、Chen X、Ge J*，Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs，Acta Ophthalmol，89(4)，328-34，Jun，2011
24. Wan P、Wang X、Ma P、Gao N、Ge J*、Mou Y、Wang Z，Cell delivery with fixed amniotic membrane reconstructs corneal epithelium in rabbits with limbal stem cell deficiency，Invest Ophthalmol Vis Sci，52(2)，724-30， 2011
25. Qi Y、Zhang F、Song G、Sun X、Jiang R、Chen M、Ge J*，Cholinergic neuronal differentiation of bone marrow mesenchymal stem cells in rhesus monkeys，Sci China Life Sci，53(5)，573-80，2010
26. Chen M、Chen Q、Sun X、Shen W、Liu B、Zhong X、Leng Y、Li C、Zhang W、Chai F、Huang B、Gao Q、Xiang AP、Zhuo Y、Ge J*，Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts，Invest Ophthalmol Vis Sci，51(11)，5970-8，2010
27. Cui D、Trier K、Zeng J、Wu K、Yu M、Ge J*，Adenosine receptor protein changes in guinea pigs with form deprivation myopia，Acta Ophthalmol， 88(7)，759-65，Nov 2010
28. Guan L、Yu J、Zhong L、Huang B、Luo T、Zhang M、Lin S、Li W、Ge J*、Chen X、Liu Q、Zeng MZ、Song X，Biological safety of human skin-derived stem cells after long-term in vitro culture，J Tissue Eng Regen Med，2010
29. Ke Q、Wang X、Gao Q、Wu Z、Wan P、Zhan W、Ge J*、Wang Z，Carrier-free epithelial cell sheets prepared by enzymatic degradation of collagen gel，J Tissue Eng Regen Med，5(2)，138-45，2010
30. Zhuo YH、He Y、Leung KW、Hou F、Li YQ、Chai F、Ge J*，Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells，Mol Vis，16，61-71，2010
31. Liu Y、Ding Y、Ma P、Wu Z、Duan H、Liu Z、Wan P、Lu X、Xiang P、Ge J*、Wang Z，Enhancement of long-term proliferative capacity of rabbit corneal epithelial cells by embryonic stem cell conditioned medium，Tissue Eng Part C Methods，16(4)，793-802，2010
32. Yuan J、Yu JX、Ge J*，Sexual dimorphism on the neurogenic potential of rhesus monkeys mesenchymal stem cells，Biochem Biophys Res Commun，396(2)，394-400，2010
33. Chai F、Luo R、Li Y、Bai Y、He Y、Wei Y、Yan Z、Ge J*、Zhuo Y，Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells，Mol Vis，16，1122-31，2010
34. Liu Y、Jiang Z、Gao Q、Ge J*、 Chen J、Cao X、Shen Q、Ma P，Technical standards of a foldable capsular vitreous body in terms of mechanical, optical, and biocompatible properties，Artif Organs，34(10)，836-45， 2010
35. Song J、Li Y、Ge J*、Duan Y、Sze SC、Tong Y、Shaw PC、Ng TB、Tsui KC、Zhuo Y、Zhang KY，Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC)，Phytother Res，24(4)，520-4，2010
36.Ge J*、Sun XH,、Wang NL、Zhao JL、Wu LL、Chen XM、Wang ZX、Li B，Intraocular pressure lowering efficacy and safety of travoprost 0.004% as a replacement therapy in patients with open angle glaucoma or ocular hypertension，Chin Med J (Engl)，123(11)，1417-21，2010
37. Yang Z、Lan W、Ge J*、Liu W、Chen X、Chen L、Yu M，The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic Physiol Opt，29(1)，41-8，Jan，2009
38. Yin Q、Hu A、Liang Y、Zhang J、He M、Lam DS、Ge J*、Wang N、Friedman DS、Zhao J、Congdon N，A two-site, population-based study of barriers to cataract surgery in rural China，Invest Ophthalmol Vis Sci， 50(3)，1069-75，Mar 2009
39. Liu B、Rasool S、Yang Z、Glabe CG、Schreiber SS、Ge J*、Tan Z，Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice，Am J Pathol，175(5)，2099-110，2009
40. Shao T、Gao Q、Jiang R、Duan Y、Sun X、Ge J*，Dynamic alteration of low-density lipoprotein receptor after exposure to transforming growth factor-beta2 in human Tenon's capsule fibroblasts. J Ocul Pharmacol Ther，25(6)，499-506，2009
41. Sun X、Jiang R、Zhang Y、Chen M、Xiang P、Qi Y、Gao Q、Huang B、Ge J*， Gene expression and differentiation characteristics in mice E13.5 and E17.5 neural retinal progenitors，Mol Vis，15，2503-14，2009
42. Zhuang J、Li F、Liu X、Liu Z、Lin J、Ge Y、Kaminski JM、Summers JB、Wang Z、Ge J*、Yu K，Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining，Biochem Biophys Res Commun，380(3)，650-4，2009
43. Zhuo YH、Wang M、Li Y、Hao YT、Lin MK、Fang M、Ge J*，Phacoemulsification treatment of subjects with acute primary angle closure and chronic primary angle-closure glaucoma，J Glaucoma，18(9)，646-51，2009
44. Gao Q、Tan J、Ma P、Ge J*、Liu Y、Sun X、Zhou L，PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1，Mol Vis，15，2683-95，2009
45. He Y、Leung KW、Zhuo YH、Ge J*，Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells，Mol Vis， 15、815-25，2009
46.Yang Z、Lan W、Ge J*、Liu W、Chen X、Chen L、Yu M，The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic Physiol Opt，29(1)，41-8，2009
47. Gao Q、Chen X、Ge J*、Liu Y、Jiang Z、Lin Z、Liu Y，Refractive shifts in four selected artificial vitreous substitutes based on Gullstrand-Emsley and Liou-Brennan schematic eyes，Invest Ophthalmol Vis Sci，50(7)，3529-34，2009
48. Wang Y、Guo L、Ren L、Yin S、Ge J*、Gao Q、Luxbacher T、Luo S，A study on the performance of hyaluronic acid immobilized chitosan film，Biomed Mater，4(3)， 035009，2009
49. Liu Q、To CH、Ge J*、Chan CY、Lv L、Lam TC、Siu AW，Astigmatic shift and conjunctival epithelial ingrowths following late-onset iatrogenic LASIK flap dehiscence during scleral buckling surgery，Clin Exp Optom，92(6)，500-2，2009
50. Huang DP、Zhuo YH、Cai JH、Xu N、Zhong XF、Yu YY、Lai ZG、Gong D、Ge J*，Histological and ultrastructural study on the medial canthal ligament of blepharophimosis, ptosis and epicanthus inversus syndrome，Chin Med J (Engl)，122(22)，2700-4，2009
51. Zhang X、Du S、Fan Q、Peng S、Yu M、Ge J*，Long-term surgical outcomes of primary congenital glaucoma in China，Clinics (Sao Paulo)，64(6)， 543-51，2009
52. Lan YQ、Zhang C、Xiao JH、Zhuo YH、Guo H、Peng W、Ge J*，Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells，Mol Vis，15，1977-87，2009
53. Wu Z、Zhou Y、Li N、Huang M、Duan H、Ge J*、Xiang P、Wang Z，The use of phospholipase A(2) to prepare acellular porcine corneal stroma as a tissue engineering scaffold. Biomaterials，30(21)，3513-22，2009
54. Chen M、Sun X、Jiang R、Shen W、Zhong X、Liu B、Qi Y、Huang B、Xiang AP、Ge J*，Role of MEF feeder cells in direct reprogramming of mousetailtip fibroblasts，Cell Biol Int，33(12)，1268-73，2009
