葉學松

葉學松

葉學松，男，1970年9月出生，浙江大學生物醫學工程與儀器科學學院教授，博導。浙江大學生物感測器國家專業實驗室副主任，浙江省腔鏡技術研究重點實驗室副主任。目前主要從事生物醫學感測檢測和環境監測領域新型感測檢測技術的科學研究工作。擔任"Chemical Sensors"和“Journal of Applied Mechanical Engineering”等國際期刊編委。研究領域是：MEMS感測器和CMOS積體電路設計；微納生物醫學感測檢測技術；微流體神經晶片與神經信息學；現代醫學儀器和醫療器械。

基本介紹

  • 中文名：葉學松
  • 畢業院校：浙江大學
  • 學位/學歷：博士
  • 專業方向：生物醫學感測檢測技術、醫學儀器與醫療器械、微流體生物晶片
  • 職務：醫療健康信息工程技術研究所所長
發明專利,研究領域,工作成果,發布論文成果,

發明專利

1.CN200410015906.7，聲表面波液相陣列感測器
2.CN200410015907.1，聲表面波陣列感測器液相成分分析儀
3.CN200510085895.4，聲表面波液相陣列感測器敏感膜的製備方法
4.CN200710156513.1，植入式神經微刺激和採集遙控晶片
5.CN200910100983.5，聲表面波壓力感測器
6.CN200910100984.X，聲表面波壓力和溫度感測器
7.CN200910100987.3，檢測神經細胞電信號的裝置
8.CN200910101086.6，聲表面波壓力溫度感測器
9.CN200910101381.1，無線控制的微型植入式無線供能電源管理積體電路晶片
10.CN200910101954.0，神經細胞立體生長及其電信號檢測的裝置
11.CN201010166106.0，植入式無源無線聲表面波感測檢測裝置
12.CN201010595180.4，穿戴式人體四大生命體徵參數實時監護系統
13.CN201010594212.9，用於植入式無線遙測的無線供能裝置
14.CN201310235757.4，一種高時空解析度的神經晶片測量裝置
15.CN201310236196.X，一種基於表面肌電的診療系統
16.CN201310449213.8，一種3D腹腔鏡視頻處理方法
17.CN201410027915.1，神經細胞紫外光刺激陣列的產生裝置
18.CN201410383326.7，一種採用PCB連線的內窺鏡微型成像模組及其製作方法
19.CN201410781008.6，葡萄糖感測系統
20.CN201420104041.0，一種人體生理參數監測裝置
21.CN201420269087.8，穿戴式心電測量裝置

研究領域

MEMS感測器和CMOS積體電路設計；微納生物醫學感測檢測技術；微流體神經晶片與神經信息學；現代醫學儀器和醫療器械。
  • 提出並發展一種以分子動力學模擬仿真計算為指導的，以蛋白分子形貌結構表征和電化學等多參數原位檢測為實驗驗證的微納生物感測器設計方法，探索微納生物感測器設計和實驗的新理論和新方法。
  • 發展一種新型的以微流體細胞晶片製造為基礎，以多模式光刺激和陣列電採集技術為手段的高時空分辨的神經細胞信息獲取測技術。在國際上首次提出基於微電極陣列的嗅覺神經晶片技術，通過與嗅覺神經細胞網路電生理仿真建模相結合，在細胞和亞細胞層次上研究神經信息編碼和解碼的科學問題。
  • 以MEMS感測器、CMOS積體電路、新型微納生物材料為基礎，開展基於穿戴式、植入式等技術的小型化、微型化、低功耗人體感測網無線遙測感測檢測技術及系統的研發工作。
  • 以現代生物醫學感測檢測技術為技術優勢，以先進的康復醫療器械和微創醫療器械研發為目標，重點開展“表面肌電下腰痛集成診療系統”和“3D立體腔鏡成像系統”等先進醫療器械的研發。

工作成果

作為項目負責人主持國家自然科學基金、國家高技術研究發展計畫"863計畫”、國家科技支撐計畫和國家科技重大專項子課題、浙江省重大科技專項、浙江省自然科學基金重點以及其他省部級和地方合作項目30餘項。共發表學術論文80餘篇，其中SCI、EI學術論文50餘篇；獲國家發明專利10餘項，獲國防專利4項；獲浙江省科技進步二等獎一項。科研項目
1.醫療體域網中低功耗無線感測器節點產品的技術研發
國家工信部物聯網發展專項資金，2013-01-01~2014-12-31
2.無線體域網關鍵技術研究及套用驗證（無線低功耗CMOS積體電路收發晶片研製）
國家科技重大專項，2013-01-01~2014-12-31
3.三維腹腔鏡及成像系統研發(3D腔鏡圖像採集、處理及顯示系統）
國家科技支撐項目，2012-01-01~2014-12-31
4.高端低極化醫用電極關鍵技術及系列產品開發（植入式實時動態血糖監測系統）
國家科技支撐項目，2012-01-01~2014-12-31
5.老年人健康服務支撐平台研製與套用示範（穿戴式無線人體生理多參數監測系統）
國家科技支撐項目，2012-01-01~2013-12-31
6.基於神經細胞可控生長的陣列式光刺激電記錄晶片及其檢測系統的研製
國家自然科學基金，2012-01-01~2015-12-31
7.健康監護中新型人體感測網核心晶片的研發
中央高校基本科研業務費專項資金資助，2010-10-1~2012-10-1
8. GFJG-114103-E81001
總後衛生部科技重大專項，2009-11-20~2010-12-20
9. 植入式無線聲表面波感測陣列生理信號遙測系統的研製
浙江省重大科技專項，2008-12-29~2010-12-28
10.腦機互動中植入式無線微電極陣列神經晶片的研究
國家自然科學基金，2009-01-01~2011-12-31
11.基於分子模擬計算和AFM實驗驗證的納米免疫生物感測器的設計研究
浙江省自然科學基金重點項目，2009-01-01~2011-12-31
12.2006年教育部新世紀優秀人才支持計畫
教育部新世紀優秀人才基金，2007-01-01~2009-12-3
13.基於嗅覺神經晶片的嗅覺系統生理機理及其時空分辨的動力學模型的研究
國家自然科學基金，2004-01-01~2006-12-01
14.海水重金屬元素分離與富集自動化控制儀器
國家高技術研究發展計畫"863計畫"，2005-03-24~2005-05-24

發布論文成果

  1. Liang B, Ye X*. Towards high-density recording of brain-wide neural activity[J]. Science China Materials, 2018, 61(3): 432-434.
  2. Zhou J, Tu CL, Liang YT, Huang BB, Fang YF, Liang X,Papautsky I,Ye X*.Isolation of cells from whole blood using shear-induced diffusion[J].SCIENTIFIC REPORTS, 2018,8: 1-13.
  3. Zhu Q, Liang B, Cai Y, Cao Q, Tu T, Huang B, Fang L,Ye X*. Layer-by-layer chitosan-decorated pristine graphene on screen-printed electrodes by one-step electrodeposition for non-enzymatic hydrogen peroxide sensor[J]. Talanta, 2018, 190: 70-77.
  4. Feng J, Huang Z, Zhou C,Ye X*. Study of continuous blood pressure estimation based on pulse transit time, heart rate and photoplethysmography-derived hemodynamic covariates[J]. Australasian physical & engineering sciences in medicine, 2018, 41(2): 403-413.
  5. Ji Q, Wang F, Zhou R, Li J, Wang J,Ye X*. Assessment of ankle muscle activation by muscle synergies in healthy and post-stroke gait[J]. Physiological measurement, 2018, 39(4): 045003.
  6. Fang L, Liang B, Yang G, Hu Y, Zhu Q,Ye X*. A needle-type glucose biosensor based on PANI nanofibers and PU/E-PU membrane for long-term invasive continuous monitoring[J]. Biosensors and Bioelectronics, 2017, 97: 196-202.
  7. Feng J, Zhou C, He C, Li Y,Ye X*. Development of an improved wearable device for core body temperature monitoring based on the dual heat flux principle[J]. Physiological measurement, 2017, 38(4): 652. SCI, 2.068
  8. Tu C, Zhou J, Liang Y, Huang B, Fang Y, Liang X,Ye X*. A flexible cell concentrator using inertial focusing[J]. Biomedical microdevices, 2017, 19(4): 83.
  9. Liang B, Zhu Q, Fang L, Cao Q, Liang X,Ye X*. An origami paper device for complete elimination of interferents in enzymatic electrochemical biosensors[J]. Electrochemistry Communications, 2017, 82: 43-46.
  10. Wei J, Liang B, Cao Q, Mo C, Zheng Y,Ye X*. Vertically aligned PANI nanorod arrays grown on graphene oxide nanosheets for a high-performance NH 3 gas sensor[J]. RSC Advances, 2017, 7(53): 33510-33520.
  11. Tian J, Tu C, Huang B,Liang Y, Zhou J,Ye X*. Study of the union method of microelectrode array and AFM for the recording of electromechanical activities in living cardiomyocytes[J]. European Biophysics Journal, 2017, 46(5): 495-507.
  12. Hu Y, Liang B, Fang L, Ma G, Yang G, Zhu Q, Chen S,Ye X*. Antifouling zwitterionic coating via electrochemically mediated atom transfer radical polymerization on enzyme-based glucose sensors for long-time stability in 37 C serum[J]. Langmuir, 2016, 32(45): 11763-11770.
  13. Zhou C, Feng J, Hu J,Ye X*. Study of artifact-resistive technology based on a novel dual photoplethysmography method for wearable pulse rate monitors[J]. Journal of medical systems, 2016, 40(3): 56.
  14. Yang G, Liang B, Zhu Q, Hu Y,Ye X*. Comprehensive study of the effects of nanopore structures on enzyme activity for the enzyme based electrochemical biosensors based on molecular simulation[J]. The Journal of Physical Chemistry A, 2016, 120(50): 10043-10056.
  15. Tu C, Huang B, Zhou J, Liang Y, Tian J, Ji L, Liang X,Ye X*. A microfluidic chip for cell patterning utilizing paired microwells and protein patterns[J]. Micromachines, 2016, 8(1): 1.
  16. Huang B, Yin M, Zhang A P,Ye X*. On-chip microfabrication of thermally controllable PNIPAAm microvalves by using optical maskless stereolithography[J]. Sensors and Actuators A: Physical, 2016, 247: 397-402.
  17. Zheng Q, Chen L, Lu L,Ye X*. A review of olfactory cell-based sensors: coupling microelectronics to olfactory cells[J]. Sensor Review, 2016, 36(4): 446-455.
  18. Liang B, Guo X, Fang L, Hu Y, Yang G, Zhu Q, Wei J,Ye X*. Study of direct electron transfer and enzyme activity of glucose oxidase on graphene surface[J]. Electrochemistry Communications, 2015, 50: 1-5.
  19. Hu Y, Yang G, Liang B, Fang L, Ma G, Zhu Q, Chen S,Ye X*. The fabrication of superlow protein absorption zwitterionic coating by electrochemically mediated atom transfer radical polymerization and its application[J]. Acta biomaterialia, 2015, 13: 142-149.
  20. Tian J, Tu C, Liang Y, Zhou J,Ye X*. Study of laser uncaging induced morphological alteration of rat cortical neurites using atomic force microscopy[J]. Journal of neuroscience methods, 2015, 253: 151-160.
  21. Zhou C, Tu C, Tian J,Feng J, Gao Y,Ye X*. A low power miniaturized monitoring system of six human physiological parameters based on wearable body sensor network[J]. Sensor Review, 2015, 35(2): 210-218.
  22. Liang B, Fang L, Hu Y, Yang G, Zhu Q,Ye X*. Fabrication and application of flexible graphene silk composite film electrodes decorated with spiky Pt nanospheres. Nanoscale, 2014, 6(8): 4264-4274.
  23. Fang L, Liang B, Yang G, Hu Y, Zhu Q,Ye X*.Study of glucose biosensor lifetime improvement in 37 C serum based on PANI enzyme immobilization and PLGA biodegradable membrane[J]. Biosensors and Bioelectronics, 2014, 56: 91-96.
  24. Guo X, Liang B, Jian J, Zhang Y,Ye X*. Glucose biosensor based on a platinum electrode modified with rhodium nanoparticles and with glucose oxidase immobilized on gold nanoparticles[J]. Microchimica Acta, 2014, 181(5-6): 519-525.
  25. Liang B, Fang L, Yang G, Hu Y, Guo X,Ye X*. Direct electron transfer glucose biosensor based on glucose oxidase self-assembled on electrochemically reduced carboxyl graphene[J]. Biosensors and Bioelectronics, 2013, 43: 131-136.
  26. Yang G, Kang Z, Ye X*, Wu T, Zhu Q. Molecular simulation of flavin adenine dinucleotide immobilized on charged single-walled carbon nanotubes for biosensor applications[J]. Biomaterials, 2012, 33(34): 8757-8770.
  27. Ying N, Tian J, Yu S N, Zhou J, Ling S, Xia L, Ye X*. Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb[J]. Science China Life Sciences, 2012, 55(7): 567-575.
  28. Ye X, Zeng Y, Zhou T, Liu F, Liu J, Sha J, Xu X, Xia L. In Situ Comparative Studies of Self-Assembly Adsorption of Bovine Serum Albumin on Nano Films by Atomic Force Microscopy[J]. Journal of nanoscience and nanotechnology, 2011, 11(12): 10765-10769.
  29. Ye X*, Wang X, Liang B, Wang Q, He L, Bei W. Implantable passive and wireless telemetering system based on SAW temperature sensor[J]. Journal of Zhejiang University. Engineering Science, 2011, 45(11): 2068-2072.
  30. Ye X*, Fang L, Liang B, Wang Q, Wang X, He L, Bei W, Ko W. H. Studies of a high-sensitive surface acoustic wave sensor for passive wireless blood pressure measurement[J]. Sensors and Actuators A: Physical, 2011, 169(1): 74-82.
  31. Ling S, Gao T, Liu J, Li Y, Zhou J, Li J, Zhou C, Tu C, Han F,Ye X*. The fabrication of an olfactory receptor neuron chip based on planar multi-electrode array and its odor-response analysis[J]. Biosensors and Bioelectronics, 2010, 26(3): 1124-1128.
  32. Lu L, Xia L, Ye X*. Cheng H. Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure[J]. Physical biology, 2010, 7(2): 026005.
  33. Ko W H, Zhang R, Huang P, Guo J, Ye X, Young D J, Megerian C. A. Studies of MEMS acoustic sensors as implantable microphones for totally implantable hearing-aid systems[J]. IEEE transactions on biomedical circuits and systems, 2009, 3(5): 277-285.
  34. Liu F, Ye X*， Wu T, Wang C, Shen J, Kang Y. Conformational mobility of gox coenzyme complex on single-wall carbon nanotubes[J]. Sensors, 2008, 8(12): 8453-8462.
  35. Ye X, Wang P, Liu J, Zhang S, Jiang J, Wang Q, Zheng X*. A portable telemetry system for brain stimulation and neuronal activity recording in freely behaving small animals[J]. Journal of Neuroscience Methods, 2008, 174(2): 186-193.
  36. Feng Z, Chen W, Ye X, Zhang S, Zheng X, Wang P, Jiang J, Jin L, Xu Z, Liu C, Liu F, Luo J, Zhuang Y, Zheng X.A remote control training system for rat navigation in complicated environment, Source:Journal of Zhejiang University: Science A, v 8, n 2, p 323-330, February 2007.
  37. Men H, Zou S, Li Y, Wang Y, Ye X, Wang P.A novel electronic tongue combined MLAPS with stripping voltammetry for environmental detection. Source:SensorsAnd Actuators, B: Chemical, v 110, n 2, p 350-357, October 14, 2005
  38. Xu G,Ye X, Qin L, Xu Y, Li Y, Li R, Wang P.Cell-based biosensors based on light-addressable potentiometric sensors for single cell monitoring. Source:Biosensors& Bioelectronics, v 20, n 9, p 1757-1763, March 15, 2005
  39. He H,Xu G,Ye X,Wang P.A novel chemical image sensor consisting of integrated microsensor array chips and pattern recognition. Source:Measurement Science and Technology, v 14, n 7, p 1040-1046, July 2003
  40. Wu Y, Wang P, Ye X,Zhang Q; Li R, Yan W, Zheng X.A novel microphysiometer based on MLAPS for drugs screening. Source:Biosensors & Bioelectronics, v 16, n 4-5, p 277-286, 2001
  41. Wu Y, Wang P, Ye X,Zhang G, He H, Yan W, Zheng X, Han J,Cui D.Drug evaluations using a novel microphysiometer based on cell-based biosensors. Source:Sensors And Actuators, B: Chemical, v 80, n 3, p 215-221, December 1, 2001

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