葉利明

葉利明，男，四川大學華西藥學院中心測試室主任，研究員，碩士生導師。

基本介紹

• 中文名：葉利明
• 國籍：中國
• 畢業院校：四川大學
• 學位/學歷：博士
• 職務：四川大學華西藥學院中心測試室主任
• 職稱：研究員

人物經歷

1984年畢業於華西醫科大學藥學院，藥物化學本科

1997年畢業於華西醫科大學藥學院，獲碩士學位

2008年畢業於四川大學華西藥學院，獲博士學位

1984年～至今四川大學華西藥學院中心測試室任助教、講師、副教授、研究員（教授）

1991年西藏自治區衛生學校自願援藏教師

研究方向

1.藥物“定量保留-活性關係”預測模型及細胞色譜研究

2.藥動學及藥物代謝產物研究

3. NIR&Raman線上測定系統方法學及套用研究

4.中藥、中藥材及化學藥質量標準研究

研究課題

1. 靶向釋藥系統與新製劑技術平台的建設。國家重大新藥創製科技重大專項課題（No.：2009ZX09310-002），2009—2010，參研

2. 中藥綿馬貫眾飲片炮製規範化研究中的質量標準研究（子課題）（“十五”國家科技攻關，No.20011701BA701A11），子課題負責人

3. 國家科技支撐計畫課題（多糖類功能食品有效成分檢測和鑒偽技術的研究-降壓類功能食品中違禁添加成分的HPLC和LC-MS檢測方法研究，No.2006BAD27B02）子課題負責人

4. 中藥成分受體的肝胞內靶向給藥系統的研究（國家自然科學基金，No.30271613），第一主研

5. 檳榔炒制過程中物質基礎與生物效應動態變化規律研究（國家自然科學基金No.30973942）。子課題負責人

6. 川產法定揮發性藥材指紋圖譜研究（四川省中醫藥管理局課題，No.H0020），負責人

7. 新型纖溶活性物質枯激酶的套用研究（四川省科技攻關項目，No.36001），第一主研

8. “十二五”國家科技支撐計畫子課題-三七三醇皂苷及三七通舒膠囊生產過程線上近紅外質量檢測與監控技術開發（13H0965）

9. 檳榔炒焦”長於消食導滯”的物質基礎與作用機理（國家自然科學基金No. 81373969）。子課題負責人

10.國家一類新藥KB藥學研究質量標準項目，負責人。

學術成果

完成和參與國家自然科學基金項目2項，國家“十一五”重大科技專項“重大新藥創製”單元平台項目項，國家“十二五”重大科技項目1項，國家科技支撐計畫課題項目2項，四川省重點項目2項，其他橫向課題約50項。發表論文90餘篇，其中SCI、EI收錄40餘篇。申請發明專利1項。

獲獎情況

獲四川省科技進步獎三等獎1項，獲得成都市科學技術獎勵二等獎2項。

社會任職

擔任以下學術期刊：《華西藥學雜誌》,《四川大學學報》,《JournalofPharmaceuticalAnalysis》,《Asian Journal of Chemistry》,《Biomedical Chromatography》,《Environmental Technology》,《Infrared Physics and Technology》and《Journal of Medicinal Plant Research》.審稿人。

教授課程

為博士、碩士研究生課堂講授《分析化學》，《現代儀器分析》（紅外，紫外，薄層掃描，質譜章節），《藥物研究新技術與新方法》（質譜新技術章節），《食品藥品分析儀器聯用技術選論》，《藥物分析學選論》和《藥物分析專業英語》課程。

代表論著

張志榮,胡清學,葉利明.《現代儀器聯用分析》成都科技大學出版社，1989，第一版

發表論文

（英文2007年以來）：

1．Shurong Wang, Yu Cheng, Zhaoxia Gao, Meijin Xiong, Zhirong Zhang, Liming Ye*. Gas chromatographic-mass spectrometric analysis of d-limonene in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 1095 - 1099

2．Qiang Zheng, Liming Ye, Rong Gao, Jing Han, Meijin Xiong, Dong Zhao, Tao Gong．Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney　study by liquid chromatography / mass spectrometry. Biomedical Chromatography. 2007, 21: 724–729.

3．Shu-Rong Wang, Yu Chen, Li-Ping Wu, Wen-Juan Miao, Mei-Jin Xiong, Cong Chen, Zhi-Rong Zhong and Li-Ming Ye*. Development of predictive quantitative retention-activity relationship models of HMG-CoA reductase inhibitors by biopartitioning micellar chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008, (2): 243-249

4．Li-Ping Wu, Yu Chen, Shu-Rong Wang, Cong Chen, Li-Ming Ye*. Quantitative retention-activity relationship models for quinolones using biopartitioning micellar chromatography. Biomedical Chromatography. 2008, 22(1):106-114

5．Li-ping Wu, Li-ming Ye, Cong Chen, Jia-qi Wu, Yu Chen. Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins. Biomedical Chromatography. 2008, 22: 606-615.

6．Li-ping Wu, Yan Cui, Mei-jin Xiong, Shu-rong Wang, Cong Chen and Li-ming Ye *. Mixed micellar chromatography methods: modelling quantitative retention–activity relationships of angiotensin converting enzyme inhibitors. Biomedical Chromatography. 2008, 22(11):1243-1251

7．Ke Lan, Xuehua Jiang, Yunxia Li, Ling Wang, Jing Zhou, Qian Jiang and Limin Ye. Quantitative determination of rosuvastatin in human plasma by ion pair liquid–liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 540-546.

8. Shu-Rong Wang, Cong Chen, Mei-Jin Xiong, Li-Ping Wu, Li-Ming Ye*, Cong Chen. Quantitative retention-activity relationship models of angiotensin enzyme inhibitors using biopartitioning micellar chromatography. Journal of Chromatographic Science. 2010, 48 (2): 134-138

9. Yu Chen, Li-Ping Wu, Li-Ming Ye* Cong Chen. Development of predictive quantitative retention-activity relationship models of alkaloids by mixed micellar liquid chromatography. Biomedical Chromatography. 2010, 24(2):195-201

10.Yan Cui , HaiLinYin , Xu Bao , MeiJin Xiong , Cong Chen and LiMing
Ye *. Determination of penehyclidine hydrochloride in beagle dog plasma by liquid chromatography electro spray ionization mass spectrometry and the pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. 2008, 17：32-38

11.Jian Zhong Wang*, Li Ming Ye, Xiao Bing Chen. A new C27-steroidal glycoside from Ophiogon japonicus. Chinese Chemical Letters. 2008, 19 (1): 82-84

12. Zhang Z, Sun W, Luo P, Wu L, Ye L, Zhang H. Simultaneous determination of five main active constituents of Erigeron multiradiatus by HPLC-DAD-MS. Journal of Pharmaceutical and Biomedical Analysis. 2008, 48 (3): 980-985.

13.Xiao-Juan Ren , Shu-Rong Wang, Yu-Jie Liu, Li-Ping Wu, Cong Chen,Li-Ming Ye*.
Effect of acidity of drugs on the prediction for human oral absorption by biopartitioning micellar chromatography. AJXJU(Academic Journal of Xi’an Jiaotong University).2010.229(4):233～240

14.Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Dynamic prediction models for alkaloid content using NIR technology for the
4 study and online analysis of parching in Areca Seed. Food Chemistry.2011 (126): 725～730

15.Si-Lan Wen*, Yu-Jie Liu*, Hai-Lin Yin , Liu Zhang*, Jin Xiao, Hong-Yuan Zhu , Jin-Tao Xue* and Li-Ming Ye*.Effect of Acupuncture on Rats with Acute Gouty Arthritis Inflammation: A Metabonomic Method for Profiling of both Urine and Plasma Metabolic Perturbation. AJCM(The American Journal of Chinese Medicine). 2011.39 (2) : 287～300

16. Intra-herb pharmacokinetics interaction between quercetin and isorhamentinLan, K., He, J.-L., ian, Y., Tan, F., Jiang, X.-H., Wang, L., Ye, L.-M. Acta Pharmacologica Sinica，2008（29）11：1376 - 1382

17. Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Rapid and Automated Analytical Method for Identification of the

Types of Parched Areca Seed by Near Infrared Spectroscopy. Asian Journal of Chemistry; 2011 (22) 12:6543

18. Yan Liang, Xiao Juan Ren, Jin Tao Xue,Si Lan Wen ,Cong Chen ,Li Ming Ye* Development of QSAR/QRAR methods by biopartioning micellar chromatography and application in prediction of oral absorption of bioactive ingredients in Traditional Chinese Medicines. Asian Journal of Chemistry. 2013 (25) 3: 1525-1530

19. Yan Liang,Zong-Ling Yin, Jing-Jing Zhang, Qi-Bing Zhang, Zhong-Xia Wang, Xiao –Juan Ren, Jian Chen, Li –Ming Ye*Release test of alliin /alliinase double-layer tablet by HPLC. JournalofPharmaceuticalAnalysis 2012 ( 4 ) 4 : 1234

20. Han Chen, Yan Liang, Xiao Juan Ren, Dong Mei Xiong, Shu Rong Wang, Li Ping Wu, Cong Chen, Li Ming Ye*. Studies effect of acid-base property in conjunction with molecular descriptors for chemical drugs and bioactive ingredients of Traditional Chinese Medicine on prediction of oral absorption by biopartioning micellar chromatography. Asian Journal of Chemistry; 2013 (25)15:8431-8443

21. Xue Jintao, Chen Han, Xiong Dongmei, Huang Guo, Ai Hong, Liang Yan, Yan Xinyu, Gan Yuan, Chen Cong, Chao Ruobing. Ye Liming *. Noninvasive Measurement of Glucose in Artificial Plasma with Near-Infrared (NIR) and Raman Spectroscopy Applied.Spectroscopy.2014 (68)04:08

22．D.M.XIONG,Z. LIU, H. CHEN, J.T. XUE, Y. YANG, C. CHEN, L.M.YE,* . Profiling the dynamics of Abscisic acid and ABA-glucose ester after using the glucosyltransferaseUGT71C5 to mediate abscisic acid homeostasis in Arabidopsis thaliana by HPLC-ESI-MS/MS .JournalofPharmaceuticalAnalysis. 2014 4（3）：190-196

23. D.M.XIONG, S.L.WEN,? H.CHEN, X.BAO*, and L.M.YE*. Determination of Leuprolide in Beagle Dogs’ serum by High Performance Liquid Chromatography-mass Spectrometry and Study on Bioequivalence. Asian Journal of Chemistry;2013 (25)18:15826-15831

24. Yuan Gan, Yan Liang, Han Chen,Jin Tao Xue,Yu Xin Yan,Mei Dong Xiong,

Cong Chen, Ming Li Ye*,, Ting Xu, Yu Chen. Prediction and Screening of Biologically Active Compounds In Honeysuckle (Lonicera japonica) by Biopartitioning Micellar Chromatography. Asian Journal of Chemistry; 2015 (27)

25.Jia –Yu Ding, Xiu-Xiu Liu, Dong-Mei Xiong, Li-Ming Ye, Rou-Bing Chao. Simultaneous Determination of Thirteen Aminoalcohl-Diterpenoid Alkaloid in the Lateral Roots of Aconitum carmichaeli by Solid-Phase Extraction-Chromatography-Tandem Mass Spectrometry. Planta Med 2014,80:723-731 DOI 10.1055/s-0034-1368550

26. Liu Z,Yan JP,Li DK,Luo Q,Yan Q,Liu ZB,Ye LM,Wang JM,Li XF,Yang Y.

UDP-glucosyltransferase71c5, a major glucosyltransferase, mediates abscisic acid homeostasis in Arabidopsis. Plant Physiol.2015 Apr;167(4):1659-70. doi: 10.1104/pp.15.00053. Epub 2015 Feb 20.

27．Shuping Shuai, Shanlan Yue, Junyi Yang, Liming Ye et al. Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability. European journal of drug metabolism and pharmacokinetics. Fist online: 11 February 2015, pp 1-10.

28. L. WANG, H.R. YANG, J.T. XUE, L.M. YE, D.S. LIN and X.P. XU. Simultaneous Determination of Ginsenosides, Ginsenosides, Notoginsenosides and Panaxtrol Saponin of Panax notoginseng by Near Infrared Spectroscopy. Asian Journal of Chemistry; Vol. 27, No. 2 (2015), 555-557

29. Xue Jintao, Ye Liming *. Noninvasive and Fast Measurement of Blood Glucose in vivo by Near Infrared (NIR) Spectroscopy .Spectrochimica Acta Part A: Molecular and Biomolecular SpectroscopySaa, doi: 10.1016/j.saa.2017.02.032

29. Kaiyue Li, Weiying Wang, Yanping Liu, Su Jiang, Guo Huang, Liming Ye*. NIR Spectroscopy as a Process Analytical Technology Tool for Monitoring the Parching Process of Traditional Chinese Medicine based on Two Kinds of Representative Chemical Values. Pharmacognosy Magazine.2017(printing)

30. Dan Hu, Tian Cai, Wei-Ying Wang, Li-Ming Ye,* and Zhi-Jun Wu,* .Unexpected hydrated ions in the detection of sodium adduct coumarins using electrospray tandem mass spectrometry. European Journal of Mass Spectrometry.2017(printing)

31. Yanping LIU, Min LIANG, Jintao XUE, Jianzhong WANG1, Kaiyue LI & Liming YE*. Simultaneous determination of five isosteroidalalkaloidsinSiberian Fritillary Bulbin rat plasma anditsapplication in pharmacokinetic studyby HPLC-MS/MS.Latin American Journal of Pharmacy(Lat. Am. J. Pharm). (2017) (printing)

32. Weiying Wang, Jintao Xue, *Kaiyue Li, Dan Hu, Guo Huang, Liming Ye*. Dynamic Predictive Models ofFive Alkaloids during theProcess of Stir-frying with Wine inCoptisUsing Near-infrared Spectroscopy. International Journal of Food Properties. (2017) (printing)

33. J. LIU, S. Y. DAI, L. M. YE AND C. M. FU. Study on the Chemical Profiling of Fangfeng Tongsheng Pills by HPLC. Indian Journal of Pharmaceutical Sciences. May - June 2016

34. D. Hu, X. Xu, T. Cai, W.-y. Wang, C.-j. Wu and L.-m. Ye*. Simultaneous determination of isopyrazam and azoxystrobin in cucumbers by Liquid Chromatography-Tandem Mass Spectrometry". Journal of Food Protection Decision for Manuscript # JFP-17-228 (printing)

35. Hongqian Wang, Man Wang, Yajun Mei, Yongping Qin, Jin Xiang, Liming Ye*. Determination of vernakalant hydrochloride in human plasma by LC-MS/MS and its pharmacokinetic study in healthy Chinese volunteers. Biomedical Chromatography.2017. (revised)

36. Binge Deng,Yuan Gan,Kaiyue Li,MengZhang,Liming Ye,* Study on chromatographic behavior of different water-soluble drugs via dynamic cell membrane chromatography online coupled with HPLC. Analytical Letters. 2017. (printing)