胡麗芳(西北工業大學生命學院副教授)

胡麗芳(西北工業大學生命學院副教授)

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胡麗芳,女,博士,西北工業大學生命學院副教授。

基本介紹

  • 中文名:胡麗芳
  • 學位/學歷:博士
  • 職業:教師
  • 專業方向:生物學
  • 任職院校:西北工業大學
個人經歷,主講課程,榮譽獎項,研究方向,學術成果,

個人經歷

工作經歷 Work Experience
2013/12~2015/12,西北工業大學生命學院,博士後
2016/01~今,西北工業大學生命學院,助您棕鍵理教授,碩士研究生導師
教育經歷 Education Experience
2009/4~2013/12:西北工業大學,人機與環境工程,工學博士
2006/9~2009/3:西北工業大學,生物醫學工程,工學碩士
2002/9~2006/6:陝西師範大學,生物學(基地班),理學學士
社會兼職 Social Appointments
擔任Frontiers in Physiology期刊Review Editor.
擔任Seminars in Cell and Developmental Biology期刊2017年第69期Guest Editor.
擔任Experimental Biology and Medicine期刊Guest Reviewer.
擔任Astrobiology,Journal of Cellular Biochemistry等期刊審稿人.
美國漿茅骨礦鹽學會(American Society of Bone and Mineral Research)會員
國際華人骨研學會(International Chinese Musculoskeletal Research Society)會員
中國生物力學學會會員
陝西省細胞生物學學會會員

主講課程

本科生課程:
幹細胞生物學(英),分酷應悼局子生物學,生命科學導論
研究生課程:
細胞工程,細胞培養技術

榮譽獎項

2018年:西北工業大學“優秀青年教師獎”
2018年:陝西省細胞生物學學會“青年優秀論文獎”
2016年:陝西省細胞生物學學會“優秀青年論文墊跨婚鼓勵獎”
2014年:陝西省細胞生物學學會“優秀青年論文三等獎”
2014年:國際空間研究委員會(COSPAR)“青年科學家傑出論文獎(Outstanding Paper Award for Young Scientists)”局龍項

研究方向

骨生物學,骨代謝疾病,生物力學

學術成果

主持科研項目:
1. 國家自然科學基金面上項目,MACF1結合CDK12參與模擬失重抑制骨形成的作用及機制,81772017,2018.1-2021.12
2. 國家自然科學基金青年項目,MACF1通過Wnt/β-catenin信號通路參與模擬失重抑制成骨細胞分化的機制研究,31400725, 2015.1-2017.12
3. 陝西省自然科學基金面上項目,MACF1調節細胞骨架重排在成骨細胞感知與回響失重環境的作用,2018JM3040, 2018.1-2019.12
4. 陝西省高校科協青年人才托舉計畫項目,MACF1結合CDK12參與老年性骨質疏鬆症發生的作用及機制,20170401,2018.1-2019.12
5. 陝西省博士後基金,MACF1調節細胞骨架重排參與老年性骨質疏鬆症發生的作用研究,2017.1-2018.12
6. 中國博士後科學基金特別資助項目,miR-138-5p在模擬失重抑制骨形成中的作用及機制,2015T81051, 2015.9-2017.9
7. 中國博士後科學基金面上項目,MACF1分子參與員民嫌翻模擬失重條件抑制骨形成的作用研究,2014M562450, 2014.7-2015.12
8. 陝西省自然科學基金青年人才項目,MACF1參與模擬失重條件影響前成骨細胞遷移的作用及機制研究,2015JQ3076, 2015.1-2016.12
9. 中央高校基本科研業務費資助項目,一種新的非編碼RNA調控MACF1參與骨形成的分子機制研究,3102016ZY037,2016.1-2017.12
10. 中央高校基本科研業務費資助項目,前成骨細胞向煮悼酷骨形成表面遷移的分子機制研究,3102014JKY15007, 2014.5-2016.5
11. 西北工業大學基本科研費,非編碼RNA通過調節MACF1參與成骨細胞分化與骨形成的機制研究,3102016QD015,2016.1-2017.12代表性論文:
(1) Zhihao Chen#, Yan Zhang#, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu*, Yu Li, Airong Qian*. Recombinant irisin prevents the reduction of osteoblast differentiation induced by simulated microgravity through increasing β-catenin expression. International Journal of Molecular Science, 2020, 21(4), 1259.
(2) Abdul Qadir, Shujing Liang, Zixiang Wu, Zhihao Chen, Lifang Hu*, Airong Qian*. Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells. International Journal of Molecular Science, 2020, 21(1): 349.
(3) Zixiang Wu, Shujing Liang, Wenyu Kuai, Lifang Hu*, Airong Qian*. MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells. RSC Advances, 2019, 9, 37300–37311.
(4) Lifang Hu, Zizhan Huang, Zixiang Wu, Arshad Ali, Airong Qian*. Mammalian plakins, giant cytolinkers: versatile biological functions and roles in cancer. International Journal of Molecular Science. 2018, 19(4): 974
(5) Lifang Hu, Chong Yin, Fan Zhao, Arshad Ali, Jianhua Ma, Airong Qian*. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. International Journal of Molecular Science. 2018, 19(2): 360.
(6) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Zhiping Miao*, Airong Qian*, Cory J. Xian. Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis. Journal of Cellular Physiology. 2018, 233(2): 1574-1584.
(7) Lifang Hu, Yunyun Xiao, Zhipeng Xiong, Fan Zhao, Chong Yin, Yan Zhang, Peihong Su, Dijie Li, Zhihao Chen, Xiaoli Ma, Ge Zhang, Airong Qian*. MACF1, versatility in tissue-specific function and in human disease. Seminars in Cell & Developmental Biology. 2017, 69: 3-8.
(8) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian*. Isoforms, structures, and functions of versatile spectraplakin MACF1. BMB Reports. 2016, 49(1): 37-44.
(9) Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang, Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Reports. 2015, 48(10): 583-588.
(10) Lifang Hu, Jingbao Li, Airong Qian, Fei Wang, Peng Shang*. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biology International. 2015, 39(4): 364-372.
(11) Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian*. Response and adaptation of bone cells to simulated microgravity. Acta Astronautica, 2014, 104(1): 396-408.
(12) Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang*. Inhibitory effect of simulated microgravity on differentiating preosteoblasts. Advances in Space Research, 2013, 51(1), 107-114.
(13) Airong Qian, Lifang Hu. Spectraplakins, versatile roles in physiology and pathology. Seminars in Cell & Developmental Biology. 2017, 69: 1-2.
(14) Yan Zhang#, Chong Yin#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 overexpression by transfecting the 21-kbp large plasmid PEGFP-C1A-ACF7 promotes osteoblast differentiation and bone formation. Human Gene Therapy. 2018, 29(2):259-270.
(15) Chong Yin#, Yan Zhang#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian. Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation. Journal of Cellular Physiology. 2018, 233(7):5405-5419.
(16) 胡麗芳,騫愛榮,李迪傑,李京寶,商澎*. 不同分化階段的成骨細胞對強磁重力環境的回響. 中國細胞生物學學報. 2013, 35(7): 950-957.
(17) 胡麗芳,騫愛榮,商澎*. 骨硬化蛋白與骨代謝. 生命的化學. 2011, 31(5): 613-618.
(18) 胡麗芳,騫愛榮,商澎*. Vinculin在細胞回響力學刺激中的作用. 中國生物化學與分子生物學報. 2009, 25(9): 805-810.
(19) 胡麗芳,騫愛榮,楊鵬飛,張維,謝麗,商澎*. 中等強度靜磁場對白血病細胞增殖和細胞周期的影響. 第四軍醫大學學報. 2009, 30(5): 397-400.
專利:
(1) 騫愛榮,商澎,胡麗芳,李潤芝,蘇佩紅,印崇,閆琨,陳志浩,戚依朵,孫瑜隆. 抑制小鼠MACF1基因表達的shRNA序列及其套用。專利號:ZL 201410631379.6
(2) 騫愛榮,胡麗芳,印崇,趙帆,陳志浩,張琰,馬劍華,蘇佩紅,李迪傑,仇伍霞,馬小莉,王牌。MACF1基因及其表達產物在製備診斷和治療骨質疏鬆症藥物中的套用。公開號:CN106148520A
(3) 騫愛榮,胡麗芳,印崇,張琰,馬劍華,趙帆,陳志浩,李迪傑,李思宇,馬小莉,仇伍霞,楊超飛,王牌,蘇佩紅。miR-489-3p在製備診斷和治療人骨質疏鬆症藥物中的套用。公開號:CN106011264A
(4) 騫愛榮,胡麗芳,馬劍華,李思宇,趙帆,陳志浩,李迪傑,陳楚,楊團民,印崇,蘇佩紅,馬小莉,張琰,仇伍霞,張茹,王牌,楊超飛。老年骨質疏鬆性骨折的血清microRNA診斷標誌物及其診斷試劑盒。公開號:CN106591487A
(5) 騫愛榮,胡麗芳,王牌,馬小莉,趙帆,仇伍霞,張茹,陳蕾,印崇,李迪傑,蘇佩紅,陳志浩,張琰,楊超飛,李思宇。MACF1定點轉基因小鼠模型構建方法,發明專利,公開號:CN107446950A
(6) 騫愛榮,胡麗芳,仇伍霞,馬小莉,趙帆,張茹,王牌,陳蕾,印崇,陳志浩,蘇佩紅,李迪傑,張琰,李思宇,楊超飛。MACF1基因在成骨細胞中條件性敲除的小鼠模型的構建及套用。發明專利,公開號:CN107114311A
(7) 騫愛榮,馬小莉,胡麗芳,趙帆,張茹,仇伍霞,王牌,蘇佩紅,陳志浩,李迪傑,印崇,苗治平,陳蕾。間充質幹細胞中MACF1基因條件性敲除小鼠模型的建立及其套用,發明專利,公開號:CN107047452A
(8) 騫愛榮,印崇,苗治平,張琰,胡麗芳,陳志浩,趙帆,李迪傑,馬劍華,蘇佩紅,馬小莉,仇伍霞,楊超飛,李思宇,王牌。長鏈非編碼RNA Lnc-DIF的套用。公開號:CN106676177A
(9) 騫愛榮,陳志浩,Yasir Arfat,印崇,胡麗芳,趙帆,李迪傑,張琰,李潤芝,蘇佩紅,馬小莉,仇伍霞。力學敏感的miR-138-5p 作為藥物靶點在骨骼肌肉系統疾病中套用。公開號:CN105169411A
(10) 騫愛榮,馬劍華,趙帆,陳志浩,胡麗芳,李迪傑,印崇,馬小莉,蘇佩紅。與老年性骨質疏鬆相關微小RNA的寡核苷酸化合物的套用。公開號:CN106167824
3. 陝西省自然科學基金面上項目,MACF1調節細胞骨架重排在成骨細胞感知與回響失重環境的作用,2018JM3040, 2018.1-2019.12
4. 陝西省高校科協青年人才托舉計畫項目,MACF1結合CDK12參與老年性骨質疏鬆症發生的作用及機制,20170401,2018.1-2019.12
5. 陝西省博士後基金,MACF1調節細胞骨架重排參與老年性骨質疏鬆症發生的作用研究,2017.1-2018.12
6. 中國博士後科學基金特別資助項目,miR-138-5p在模擬失重抑制骨形成中的作用及機制,2015T81051, 2015.9-2017.9
7. 中國博士後科學基金面上項目,MACF1分子參與模擬失重條件抑制骨形成的作用研究,2014M562450, 2014.7-2015.12
8. 陝西省自然科學基金青年人才項目,MACF1參與模擬失重條件影響前成骨細胞遷移的作用及機制研究,2015JQ3076, 2015.1-2016.12
9. 中央高校基本科研業務費資助項目,一種新的非編碼RNA調控MACF1參與骨形成的分子機制研究,3102016ZY037,2016.1-2017.12
10. 中央高校基本科研業務費資助項目,前成骨細胞向骨形成表面遷移的分子機制研究,3102014JKY15007, 2014.5-2016.5
11. 西北工業大學基本科研費,非編碼RNA通過調節MACF1參與成骨細胞分化與骨形成的機制研究,3102016QD015,2016.1-2017.12代表性論文:
(1) Zhihao Chen#, Yan Zhang#, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Lifang Hu*, Yu Li, Airong Qian*. Recombinant irisin prevents the reduction of osteoblast differentiation induced by simulated microgravity through increasing β-catenin expression. International Journal of Molecular Science, 2020, 21(4), 1259.
(2) Abdul Qadir, Shujing Liang, Zixiang Wu, Zhihao Chen, Lifang Hu*, Airong Qian*. Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells. International Journal of Molecular Science, 2020, 21(1): 349.
(3) Zixiang Wu, Shujing Liang, Wenyu Kuai, Lifang Hu*, Airong Qian*. MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells. RSC Advances, 2019, 9, 37300–37311.
(4) Lifang Hu, Zizhan Huang, Zixiang Wu, Arshad Ali, Airong Qian*. Mammalian plakins, giant cytolinkers: versatile biological functions and roles in cancer. International Journal of Molecular Science. 2018, 19(4): 974
(5) Lifang Hu, Chong Yin, Fan Zhao, Arshad Ali, Jianhua Ma, Airong Qian*. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. International Journal of Molecular Science. 2018, 19(2): 360.
(6) Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Zhiping Miao*, Airong Qian*, Cory J. Xian. Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis. Journal of Cellular Physiology. 2018, 233(2): 1574-1584.
(7) Lifang Hu, Yunyun Xiao, Zhipeng Xiong, Fan Zhao, Chong Yin, Yan Zhang, Peihong Su, Dijie Li, Zhihao Chen, Xiaoli Ma, Ge Zhang, Airong Qian*. MACF1, versatility in tissue-specific function and in human disease. Seminars in Cell & Developmental Biology. 2017, 69: 3-8.
(8) Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian*. Isoforms, structures, and functions of versatile spectraplakin MACF1. BMB Reports. 2016, 49(1): 37-44.
(9) Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang, Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Reports. 2015, 48(10): 583-588.
(10) Lifang Hu, Jingbao Li, Airong Qian, Fei Wang, Peng Shang*. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biology International. 2015, 39(4): 364-372.
(11) Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian*. Response and adaptation of bone cells to simulated microgravity. Acta Astronautica, 2014, 104(1): 396-408.
(12) Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang*. Inhibitory effect of simulated microgravity on differentiating preosteoblasts. Advances in Space Research, 2013, 51(1), 107-114.
(13) Airong Qian, Lifang Hu. Spectraplakins, versatile roles in physiology and pathology. Seminars in Cell & Developmental Biology. 2017, 69: 1-2.
(14) Yan Zhang#, Chong Yin#, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang*, Airong Qian*, Cory J. Xian. MACF1 overexpression by transfecting the 21-kbp large plasmid PEGFP-C1A-ACF7 promotes osteoblast differentiation and bone formation. Human Gene Therapy. 2018, 29(2):259-270.
(15) Chong Yin#, Yan Zhang#, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang*, Airong Qian*, Cory J. Xian. Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation. Journal of Cellular Physiology. 2018, 233(7):5405-5419.
(16) 胡麗芳,騫愛榮,李迪傑,李京寶,商澎*. 不同分化階段的成骨細胞對強磁重力環境的回響. 中國細胞生物學學報. 2013, 35(7): 950-957.
(17) 胡麗芳,騫愛榮,商澎*. 骨硬化蛋白與骨代謝. 生命的化學. 2011, 31(5): 613-618.
(18) 胡麗芳,騫愛榮,商澎*. Vinculin在細胞回響力學刺激中的作用. 中國生物化學與分子生物學報. 2009, 25(9): 805-810.
(19) 胡麗芳,騫愛榮,楊鵬飛,張維,謝麗,商澎*. 中等強度靜磁場對白血病細胞增殖和細胞周期的影響. 第四軍醫大學學報. 2009, 30(5): 397-400.
專利:
(1) 騫愛榮,商澎,胡麗芳,李潤芝,蘇佩紅,印崇,閆琨,陳志浩,戚依朵,孫瑜隆. 抑制小鼠MACF1基因表達的shRNA序列及其套用。專利號:ZL 201410631379.6
(2) 騫愛榮,胡麗芳,印崇,趙帆,陳志浩,張琰,馬劍華,蘇佩紅,李迪傑,仇伍霞,馬小莉,王牌。MACF1基因及其表達產物在製備診斷和治療骨質疏鬆症藥物中的套用。公開號:CN106148520A
(3) 騫愛榮,胡麗芳,印崇,張琰,馬劍華,趙帆,陳志浩,李迪傑,李思宇,馬小莉,仇伍霞,楊超飛,王牌,蘇佩紅。miR-489-3p在製備診斷和治療人骨質疏鬆症藥物中的套用。公開號:CN106011264A
(4) 騫愛榮,胡麗芳,馬劍華,李思宇,趙帆,陳志浩,李迪傑,陳楚,楊團民,印崇,蘇佩紅,馬小莉,張琰,仇伍霞,張茹,王牌,楊超飛。老年骨質疏鬆性骨折的血清microRNA診斷標誌物及其診斷試劑盒。公開號:CN106591487A
(5) 騫愛榮,胡麗芳,王牌,馬小莉,趙帆,仇伍霞,張茹,陳蕾,印崇,李迪傑,蘇佩紅,陳志浩,張琰,楊超飛,李思宇。MACF1定點轉基因小鼠模型構建方法,發明專利,公開號:CN107446950A
(6) 騫愛榮,胡麗芳,仇伍霞,馬小莉,趙帆,張茹,王牌,陳蕾,印崇,陳志浩,蘇佩紅,李迪傑,張琰,李思宇,楊超飛。MACF1基因在成骨細胞中條件性敲除的小鼠模型的構建及套用。發明專利,公開號:CN107114311A
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