胡家銘，男，博士，華南師範大學生物光子學研究院研究員，主要圍繞當前社會急需的疾病早期檢測領域開展研究工作，從化學、生物、材料和物理多學科交叉角度，圍繞基於光信號和電信號的核酸/蛋白檢測來實現對疾病的體外診斷，尤其對癌症的早期診斷。主要研究方向包括高特異性分子診斷方法的研究、生物晶片、電化學生物感測及電化學發光技術。代表性論文有Nat. Commun., Chem, J. Am. Chem. Soc., Biomaterials, Nanoscale等。
基本介紹
- 中文名：胡家銘
- 畢業院校：美國俄亥俄州立大學
- 學位/學歷：博士
- 專業方向：生物分析與生物感測
- 職務：華南師範大學博士生導師
人物經歷,學術任職,主要論文,發明專利,
人物經歷
2002-2006 同濟大學，化學系，套用化學，學士
2006-2008 同濟大學，化學系，分子科學實驗室，研究助理
2008-2013 美國奧本大學，化學系，分析化學，博士
2013-2014 美國BioLegend, Inc.，生物標誌物開發部，產品開發首席科學家
2015-2018 美國俄亥俄州立大學，化學與生物分子工程學院，博士後
2018-至今 華南師範大學，生物光子學研究院，研究員
學術任職
《Developmental Biology》編委
《CPQ Cancer》編委
《European Journal of Biomedical Research》編委
《Analytica Chimica Acta》、《RSC Advances》、《Journal of Electrochemical Chemistry》、《Journal of Fluorescence》、《Analytical Methods》特邀審稿人
主要論文
1. Hu, J.*; Kwak, K. J.; Shi, J.; Yu, B.; Sheng, Y.; Lee, L. J. Overhang molecular beacons encapsulated in tethered cationic lipoplex nanoparticles for detection of single-point mutation in extracellular vesicle-associated RNAs. Biomaterials 2018, 183, 20-29. (IF: 8.402)
2. Hu, J.*; Kuang, T. DNA-Coded Fluorescence for Color Painting RNAs. Chem 2018, 4, 1194-1196. (IF: 14.104)
3. Hu, J.*; Sheng, Y.; Kwak, K. J.; Shi, J.; Yu, B.; Lee, L. J. A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection. Nature Communications 2017, 8, 1683. (IF: 12.353)
4. Hu, J.; Yu, Y.; Brooks, J. C.; Godwin, L. A.; Somasundaram, S.; Torabinejad, F.; Kim, J.; Shannon, C.; Easley, C. J. A Reusable Electrochemical Proximity Assay for Highly Selective, Real-Time Protein Quantitation in Biological Matrices. J. Am. Chem. Soc. 2014, 136, 8467-8474. (IF: 14.357)
5. Hu, J.; Wang, T.; Kim, J.; Shannon, C.; Easley, C. J. Quantitation of Femtomolar Protein Levels via Direct Readout with the Electrochemical Proximity Assay. J. Am. Chem. Soc. 2012, 134, 7066-7072. (IF: 14.357)
6 Chang, L.; Hu, J.†（共同第一）; Chen, F.; Chen, Z.; Shi, J.; Yang, Z.; Li, Y.; Lee, L. J. Nanoscale Bio-Platforms for Living Cell Interrogation: Current Status and Future Perspectives. Nanoscale 2015. (IF: 7.367)
7. Hu, J.; Sheng, Y.; Shi, J.; Yu, B.; Yu, Z.; Liao, G. Long Circulating Polymeric Nanoparticles for Gene/Drug Delivery. Current Drug Metabolism 2017.
8. Sheng, Y.; Hu, J.†（共同第一）; Shi, J.; Lee, L. J. Stimuli-responsive carriers for controlled intracellular drug release. Curr Med Chem 2017.
9. Hu, J.; Easley, C. J. A simple and rapid approach for measurement of dissociation constants of DNA aptamers against proteins and small molecules via automated microchip electrophoresis. Analyst 2011, 136, 3461-3468.
10. Kim, J.; Hu, J.; Sollie, R. S.; Easley, C. J. Improvement of Sensitivity and Dynamic Range in Proximity Ligation Assays by Asymmetric Connector Hybridization. Anal. Chem. 2010, 82, 6976-6982.
11. Sheng, Y.; Chang, L.; Kuang, T.; Hu, J. PEG/heparin-decorated lipid-polymer hybrid nanoparticles for long-circulating drug delivery. RSC Advances 2016, 6, 23279-23287.
12. Sun, B.; Hu, J.; Yao, J.; Ji, S. a new multiplex solution for cytokine and chemokine quantification in biological samples. Cytokine 2014, 70, 49.
13. Sun, B.; Hu, J.; Yao, J.; Ji, S. New multiplex assay panels for simultaneous quantification of major proinflammatory chemokines in human and mouse samples (TECH1P.866). The Journal of Immunology 2014, 192, 69.34.
14. Yang, J.; Hu, J.* Aptamer-functionalized nanoparticles for targeted drug delivery in cancer therapy. European Journal Of BioMedical Research 2015, 1, 17-24.
15. Chen, Z.; Wu, C.; Yang, Y.; Shi, J.; Hu, J.*; Yang, Z.; Chen, Z. Synthesis and drug delivery of mesoporous silica nanoparticles for cancer therapy. European Journal Of BioMedical Research 2015, 1, 30-36.
16. Chang, L.; Chen, F.; Zhang, X.; Kuang, T.; Li, M.; Hu, J.; Shi, J.; Lee, L. J.; Cheng, H.; Li, Y. Synthetic Melanin E-Ink. ACS Applied Materials & Interfaces 2017, 9, 16553-16560.
17. Chen, Z.; Chen, Z.; Yang, Z.; Hu, J.; Yang, Y.; Chang, L.; Lee, L. J.; Xu, T. Preparation and characterization of vacuum insulation panels with super-stratified glass fiber core material. Energy 2015, 93, Part 1, 945-954.
18. Chen, Z.; Chen, Z.; Zhang, A.; Hu, J.; Wang, X.; Yang, Z. Electrospun nanofibers for cancer diagnosis and therapy. Biomaterials Science 2016, 4, 922-932.
19. Chen, Z.; Cong, M.; Hu, J.; Yang, Z.; Chen, Z. Preparation of Functionalized TiO2 Nanotube Arrays and Their Applications. Science of Advanced Materials 2016, 8, 1231-1241.
發明專利
1. J Hu, T Wang, CJ Easley, CG Shannon. Electrochemical proximity assay, US Patent 9,335,292, 2016.
2. J Hu, Y Sheng, LJ Lee. Lipid-polymer Hybrid Nanoparticle Biochip and Application Thereof, US Patent App. 15/831,998, 2018.
3. LJ Lee, J Hu, Y Sheng. Highly Stable and Specific Molecular Beacons Encapsulated in Cationic Lipoplex Nanoparticles and Application Thereof, US Patent App. 15/880,309, 2018.
