肖玉秀，理學博士、武漢大學藥學院教授、博士生導師，國家自然科學基金項目通訊評審專家。兼任湖北省藥學會藥物分析專業委員會副主任委員，武漢市藥學會藥物分析與藥物化學專業委員會副主任委員，國家雙語教學示範課程建設項目通訊評審專家，國家自然科學基金項目通訊評審專家，全國優秀博士學位論文通訊評審專家，中國博士後科學基金評審，學術期刊Analytica Chimica Acta, Electrophoresis, Journal of Chromatography A, Phytochemical analysis, Asian Chemistry Letters、Current Pharmaceutical Analysis、醫藥導報、分析科學學報等審稿人。
研究興趣與方向：單細胞水平生物醫藥分析；藥物篩選與給藥系統；樣品預處理；藥物質量控制。
基本介紹
- 中文名：肖玉秀
- 國籍：中國
- 民族：漢
- 職業：教授、博士生導師
- 畢業院校：武漢大學
- 主要成就：一種混合表面活性劑雙水相萃取體系
基本情況,主要研究領域與項目,主要學術論文與專利、學術會議,代表性論文：,國際學術會議：,
基本情況
學習簡歷：
1994年 中國藥科大學藥學院藥物分析專業，理學碩士。
1991年 武漢大學化學系，理學學士。
工作簡歷：
2002-現在 武漢大學藥學院，副教授，教授
2001-2002 美國Iowa State University，訪問學者
1994-2001 武漢大學生命科學學院，講師
1995 同濟醫科大學藥學院，訪問學者
1987-1989 湖北中醫學院附屬醫院藥劑科
教學情況：
主講本科生課程《藥物分析》、《藥物分析實驗》，研究生課程 《藥物代謝與體內藥物分析》。
社會兼職：
湖北省藥學會藥物分析專業委員會副主任委員
武漢市藥學會藥物分析與藥船說雄物化學專業委員會副主任委員
國家繼續醫學教育學科專家組成員
國家留學基金委評審專家
國家雙語教學示範課程建設項目通訊評審專家
國家自然科學基金項目通訊評審專家
全國優秀博士學位論文通訊評審專家
學術期刊Analytica Chimica Acta, Journal of Chromatography A, Electrophoresis, Analytical and Bioanalytical Chemistry, Phytochemical analysis, Biomedical Chromatography, Analytical Method, International Journal of Environmental Analytical Chemistry等審稿人。
主要研究領域與項目
研究領域：
研究興趣與方向：
樣品預處理；生物醫藥分析新方法；藥物篩選與給藥系統；藥物質量控制。
主持學術研究課題：
1. 國家自然科學基金面上項目，基於六氟異丙醇-長鏈烷酸/烷醇體系的新型雙模式液相微萃頸棗乃拘取技術及其藥物分析套用 （項目批准號：81673394），2017-2020
2. 湖北省自然科學基金重點項目“以新型凝聚層為萃取介質的水體有機污染物快速現場萃取技術及HPLC/MS聯用研究”（No. 2015CFA139）2015-2017
4. 國家自然科學基金面上項目“抗腫瘤藥物單細胞水平藥物動力學的毛細管電泳研究”（No. 20575050）, 2006-2008
5. “中藥質量標準研究” 等橫向科研項目多項, 2016-2018
6. 湖北省自然科學基金項目“固定化P-糖蛋白脂質體毛細管電泳的研製及套用研究”(No. 131137)
7. 湖北省婚戒提端自然科學基金項目“脂質體整體柱毛細管電色譜及套用研究”(No. 131763)
8. 湖北省自然科學基金項目“連錢碑婆促草花學成分及抗腹瀉藥效學研究”（No. 130423）
9. 中央高校基本科研業務費專項資金項目“高通量單細胞CE-LIF分析儀器的研製” （No. 2081006）
教學及教學研究課題：
1. 主講本科生課程《藥物分析學》、《藥物分析學實驗》，研究生課程《藥物代謝與體內藥物分析》
2. 主持湖北省精品課程《藥物分析》建設項目，2010-
3. 主持武漢大學實驗技術項目(實驗技術和測試方法研究與創新類)“抹台狼藥物分析學實驗技術與測試方法的改革與創新”（WHU-2014-SYJS-07），2014-2016
4. 主持武漢大學教學改革建設項目“藥物分析學理論與實驗教學的改革研究”（JG201469），2014-2017
5. 主持武漢大學研究生精品課程建設項目《藥物代謝與體內藥物分析》，2015-2016
主要學術論文與專利、學術會議
代表性論文：
1. Yu Tian, Ran Wei, Bo Cai, Jinfeng Dong, Bin Deng, Yuxiu Xiao*. Cationic gemini pyrrolidinium surfactants based sweeping-micellar electrokinetic chromatography for simultaneous detection of nine organic pollutants in environmental water. Journal of Chromatography A, 1475 (2016, December) 95–101.
2. Cao Li,Jia Xu,Dan Chen,Yuxiu Xiao*. Detection of phthalates migration from disposable tablewares to drinking water using hexafluoroisopropanol-induced catanionic surfactant coacervate extraction. Journal of Pharmaceutical Analysis, 6 (2016, October): 292-299.
3. Jia Xu, Manli Niu, Yuxiu Xiao*. Hexafluoroisopropanol-induced catanionic surfactants based coacervate extraction for analysis of lysozyme. Anal Bioanal Chem, 2016, doi:10.1007/s00216-016-0054-3.
4. Yunfang Li, Jia Xu, Yu Chen, Zhinan Mei, Yuxiu Xiao*. Screening of inhibitors of glycogen synthase kinase-3β from traditional Chinese medicines using enzyme-immobilized magneticbeads combined with high-performance liquid chromatography. Journal of Chromatography A, 1425 (2015, December) 8–16.
5. Yu Tian, Yunfang Li, Jie Mei, Bo Cai, Jinfeng Dong, Zhiguo Shi, Yuxiu Xiao*. Simultaneous separation of acidic and basic proteins using geminipyrrolidinium surfactants and hexafluoroisopropanol as dynamic coating additives in capillary electrophoresis. Journal of Chromatography A, 1412 (2015, September) 151–158.
6. Yu Tian, Yunfang Li, Jie Mei, Bin Deng, Yuxiu Xiao. Hexafluoroisopropanol-modified cetyltrimethylammoniumbromide/sodium dodecyl sulfate vesicles as a pseudostationary phase in electrokinetic chromatography. Journal of Chromatography A, 1404 (2015, July) 131–140.
7. Yao Xiao, Yunfang Li, Jinjin Ying, Yu Tian, Yuxiu Xiao*, Zhinan Mei**. Determination of alditols by capillary electrophoresis with indirect laser-induced fluorescence detection. Food Chemistry 2015 174: 233–239.
8. Bin Deng, Yu Tian, Xu Yu, Jian Song, Feng Guo, Yuxiu Xiao*, Zhiling Zhang**. Laminar flow mediated continuous single-cell analysis on a novel poly(dimethylsiloxane) microfluidic chip. Analytica Chimica Acta, 2014, 820: 104-111.
9. Yunfang Li, Yu Chen, Chuying Xiao, Dan Chen, Yuxiu Xiao*, Zhinan Mei**. Rapid screening and identification of alpha-amylase inhibitors fromGarcinia xanthochymus using enzyme-immobilized magneticnanoparticles coupled with HPLC and MS. Journal of Chromatography B, 2014, 960 166–173.
10. Bin Deng, Zhi-Ming Wang, Zi-Hao Zhou, Yi-Meng Liu, Jian Song, Yu-Xiu Xiao*. Quantitative study of cellular heterogeneity in doxorubicin uptake and its pharmacological effect on cancer cells. Biomedical Chemistry 2014, 2014, 28: 1393–1401.
11. Dan Chen, Pei Zhang, Yunfang Li, Zhinan Mei, Yuxiu Xiao*. Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples. Anal Bioanal Chem 2014, 406(24) : 6051-6060.
12. Bin Deng, Yuxiu Xiao*. Heterogeneous cellular drug uptake in chemotherapy. Cancer Cell & Microenvironment 2014, 1: e272.
13. Han-Peng Jiang, Jiu-Xia Zhu, Chunyan Peng, Jiajia Gao, Fang Zheng, Yu-Xiu Xiao, Yu-Qi Feng* and Bi-Feng Yuan*. Facile one-pot synthesis of a aptamer-based organic–silica hybrid monolithic capillary column by “thiol–ene” click chemistry for detection of enantiomers of chemotherapeutic anthracyclines. Analyst, 2014,139: 4940-4946.
14. Bin Deng, Zhiming Wang, Jian Song, Yuxiu Xiao*, Dan Chen, Jun Huang. Analysis of doxorubicin uptake in single human leukemia K562 cells using capillary electrophoresis coupled with laser-induced fluorescence detection. Anal Bioanal Chem 2011, 401: 2143–2152.
15. Zhi-Guo Shi*, Qing-Zhong Guo, Yi-Ting Liu, Yu-Xiu Xiao*, Li Xu. Drug delivery devices based on macroporous silica spheres. Materials Chemistry and Physics 2011, 126: 826–831 (co-corresponding author).
16. Jie Mei, Yan-Ping Tian, Wen He, Yu-Xiu Xiao*, Juan Wei, Yu-Qi Feng. Preparation approaches of the coated capillaries with liposomes in capillary electrophoresis.J Chromatogr A 2010, 44: 6979-6986.
17. Deng Bin, Xu Jianrong, Wang Zhiming, Xiao Yuxiu*. Single-cell analysis using capillary electrophoresis. Progress in Chemistry, 2010, 22（11）: 2215-2223.
18. Jie Mei, Jian-Rong Xu, Yu-Xiu Xiao*, Xiao-Yan Liao, Guo-Fu Qiu, Yu-Qi Feng. A novel covalent coupling method for coating of capillaries with liposomes in capillary electrophoresis. Electrophoresis, 2008, 29: 3825-3833
19. Jie Mei, Jian-Rong Xu, Yu-Xiu Xiao*, Qian-Rui Zhang, Yu-Qi Feng. Immobilized phospholipid capillary electrophoresis for study of drug-membrane interactions and prediction of drug activity. Talanta, 2008，75: 104-110
專 利：
1. 肖玉秀，鄧彬. 一種兩用雷射誘導螢光檢測系統. 專利號：ZL 201310012461.6, 證書號：第1650205號，授權公告日：2015年4月29日
2. 肖玉秀，吳喆，梅潔. 一種混合表面活性劑雙水相萃取體系. 專利號 201110287840.7，授權公告日：2014年4月15日
3. 肖玉秀, 徐見容. 一種用於正交式雷射誘導螢光檢測器的四維可調毛細管夾持器. 專利號 ZL 200820230546.6, 授權公告日2009年10月9日
4. 肖玉秀，徐見容，倪峙旭. 一種毛細管視窗製作器. 專利號 ZL 200920084847.7，授權公告日2010年5月12日
5. 肖玉秀，汪志明，徐見容，倪峙旭. 一種毛細管沖洗及進樣兩用器. 專利號 ZL 200920228727.X，授權公告日2010年6月9日
6. 肖玉秀，廖曉燕，蔣永光. 奧沙普秦固體分散體、製備方法及套用. 申請號 201110202153.0，申請日期：2011年7月19日
國際學術會議：
1. Yu-Xiu Xiao, Edward S Yeung. “On-column monitoring of natural release of epirubicin from single breast cancer cells by capillary electrophoresis”. The Seventh Asian Conference on Analytical Sciences, Hong Kong 2004 July, p152
2. Xiao Yu Xiu, Mei Jie, Xu Jian Rong. Immobilization of liposomes in fused_silica capillary by covalent bonding. The 9th Asian Conference on Analytical Sciences & the 39th Convention of The Korean Society of Analytical Sciences, Ramada Plaza Jeju, Jeju Island, Korea. November 4-8, 2007
3. Bin Deng，Zhi-Ming Wang，Yu-Xiu Xiao*. Analysis of doxorubicin uptake by single K562 human leukemia cells at clinical relevant concentration using CE-LIF. 2010 China-Japan-Korea Syposium on Analytical Chemistry, Oct 31-Nov 2, 2010, Wuhan, China, p103
4. Zhe Wu, Jie Mei, Yu-Xiu Xiao*. Catanionic Surfactant-Mediated Coacervate Extraction. 2010 China-Japan-Korea Syposium on Analytical Chemistry, Oct 31-Nov 2, 2010, Wuhan, China, p106
5. Bin Deng, Zhiming Wang, Zihao Zhou and Yuxiu Xiao*. Analysis of DOX uptake and its heterogeneity in single cancer cells using capillary electrophoresis coupled with laser-induced fluorescence detection. 37 International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Oct 8-11, 2011, Dalian, China, O-S23-5 (p153)
6. Bin Deng, Zhiming Wang, Zihao Zhou, Dan Chen, Yuxiu Xiao*. Analysis of heterogeneity in doxorubicin uptake by human leukemia K562 cells treated with different dosage schedules. 37 International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Oct 8-11, 2011, Dalian, China, P-486-B (p694)
7. Bin Deng, Zhiming Wang, Yuxiu Xiao*. Quanitative study of cellular heterogeneity in doxorubicin uptake and its phrmacological effects on cancer cells. Frontiers of Single Cell Analysis, Stanford University, Stanford, CA, USA, September 5-7, 2013，71#.
2. 湖北省自然科學基金重點項目“以新型凝聚層為萃取介質的水體有機污染物快速現場萃取技術及HPLC/MS聯用研究”（No. 2015CFA139）2015-2017
4. 國家自然科學基金面上項目“抗腫瘤藥物單細胞水平藥物動力學的毛細管電泳研究”（No. 20575050）, 2006-2008
5. “中藥質量標準研究” 等橫向科研項目多項, 2016-2018
6. 湖北省自然科學基金項目“固定化P-糖蛋白脂質體毛細管電泳的研製及套用研究”(No. 131137)
7. 湖北省自然科學基金項目“脂質體整體柱毛細管電色譜及套用研究”(No. 131763)
8. 湖北省自然科學基金項目“連錢草花學成分及抗腹瀉藥效學研究”（No. 130423）
9. 中央高校基本科研業務費專項資金項目“高通量單細胞CE-LIF分析儀器的研製” （No. 2081006）
教學及教學研究課題：
1. 主講本科生課程《藥物分析學》、《藥物分析學實驗》，研究生課程《藥物代謝與體內藥物分析》
2. 主持湖北省精品課程《藥物分析》建設項目，2010-
3. 主持武漢大學實驗技術項目(實驗技術和測試方法研究與創新類)“藥物分析學實驗技術與測試方法的改革與創新”（WHU-2014-SYJS-07），2014-2016
4. 主持武漢大學教學改革建設項目“藥物分析學理論與實驗教學的改革研究”（JG201469），2014-2017
5. 主持武漢大學研究生精品課程建設項目《藥物代謝與體內藥物分析》，2015-2016
主要學術論文與專利、學術會議
代表性論文：
1. Yu Tian, Ran Wei, Bo Cai, Jinfeng Dong, Bin Deng, Yuxiu Xiao*. Cationic gemini pyrrolidinium surfactants based sweeping-micellar electrokinetic chromatography for simultaneous detection of nine organic pollutants in environmental water. Journal of Chromatography A, 1475 (2016, December) 95–101.
2. Cao Li,Jia Xu,Dan Chen,Yuxiu Xiao*. Detection of phthalates migration from disposable tablewares to drinking water using hexafluoroisopropanol-induced catanionic surfactant coacervate extraction. Journal of Pharmaceutical Analysis, 6 (2016, October): 292-299.
3. Jia Xu, Manli Niu, Yuxiu Xiao*. Hexafluoroisopropanol-induced catanionic surfactants based coacervate extraction for analysis of lysozyme. Anal Bioanal Chem, 2016, doi:10.1007/s00216-016-0054-3.
4. Yunfang Li, Jia Xu, Yu Chen, Zhinan Mei, Yuxiu Xiao*. Screening of inhibitors of glycogen synthase kinase-3β from traditional Chinese medicines using enzyme-immobilized magneticbeads combined with high-performance liquid chromatography. Journal of Chromatography A, 1425 (2015, December) 8–16.
5. Yu Tian, Yunfang Li, Jie Mei, Bo Cai, Jinfeng Dong, Zhiguo Shi, Yuxiu Xiao*. Simultaneous separation of acidic and basic proteins using geminipyrrolidinium surfactants and hexafluoroisopropanol as dynamic coating additives in capillary electrophoresis. Journal of Chromatography A, 1412 (2015, September) 151–158.
6. Yu Tian, Yunfang Li, Jie Mei, Bin Deng, Yuxiu Xiao. Hexafluoroisopropanol-modified cetyltrimethylammoniumbromide/sodium dodecyl sulfate vesicles as a pseudostationary phase in electrokinetic chromatography. Journal of Chromatography A, 1404 (2015, July) 131–140.
7. Yao Xiao, Yunfang Li, Jinjin Ying, Yu Tian, Yuxiu Xiao*, Zhinan Mei**. Determination of alditols by capillary electrophoresis with indirect laser-induced fluorescence detection. Food Chemistry 2015 174: 233–239.
8. Bin Deng, Yu Tian, Xu Yu, Jian Song, Feng Guo, Yuxiu Xiao*, Zhiling Zhang**. Laminar flow mediated continuous single-cell analysis on a novel poly(dimethylsiloxane) microfluidic chip. Analytica Chimica Acta, 2014, 820: 104-111.
9. Yunfang Li, Yu Chen, Chuying Xiao, Dan Chen, Yuxiu Xiao*, Zhinan Mei**. Rapid screening and identification of alpha-amylase inhibitors fromGarcinia xanthochymus using enzyme-immobilized magneticnanoparticles coupled with HPLC and MS. Journal of Chromatography B, 2014, 960 166–173.
10. Bin Deng, Zhi-Ming Wang, Zi-Hao Zhou, Yi-Meng Liu, Jian Song, Yu-Xiu Xiao*. Quantitative study of cellular heterogeneity in doxorubicin uptake and its pharmacological effect on cancer cells. Biomedical Chemistry 2014, 2014, 28: 1393–1401.
11. Dan Chen, Pei Zhang, Yunfang Li, Zhinan Mei, Yuxiu Xiao*. Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples. Anal Bioanal Chem 2014, 406(24) : 6051-6060.
12. Bin Deng, Yuxiu Xiao*. Heterogeneous cellular drug uptake in chemotherapy. Cancer Cell & Microenvironment 2014, 1: e272.
13. Han-Peng Jiang, Jiu-Xia Zhu, Chunyan Peng, Jiajia Gao, Fang Zheng, Yu-Xiu Xiao, Yu-Qi Feng* and Bi-Feng Yuan*. Facile one-pot synthesis of a aptamer-based organic–silica hybrid monolithic capillary column by “thiol–ene” click chemistry for detection of enantiomers of chemotherapeutic anthracyclines. Analyst, 2014,139: 4940-4946.
14. Bin Deng, Zhiming Wang, Jian Song, Yuxiu Xiao*, Dan Chen, Jun Huang. Analysis of doxorubicin uptake in single human leukemia K562 cells using capillary electrophoresis coupled with laser-induced fluorescence detection. Anal Bioanal Chem 2011, 401: 2143–2152.
15. Zhi-Guo Shi*, Qing-Zhong Guo, Yi-Ting Liu, Yu-Xiu Xiao*, Li Xu. Drug delivery devices based on macroporous silica spheres. Materials Chemistry and Physics 2011, 126: 826–831 (co-corresponding author).
16. Jie Mei, Yan-Ping Tian, Wen He, Yu-Xiu Xiao*, Juan Wei, Yu-Qi Feng. Preparation approaches of the coated capillaries with liposomes in capillary electrophoresis.J Chromatogr A 2010, 44: 6979-6986.
17. Deng Bin, Xu Jianrong, Wang Zhiming, Xiao Yuxiu*. Single-cell analysis using capillary electrophoresis. Progress in Chemistry, 2010, 22（11）: 2215-2223.
18. Jie Mei, Jian-Rong Xu, Yu-Xiu Xiao*, Xiao-Yan Liao, Guo-Fu Qiu, Yu-Qi Feng. A novel covalent coupling method for coating of capillaries with liposomes in capillary electrophoresis. Electrophoresis, 2008, 29: 3825-3833
19. Jie Mei, Jian-Rong Xu, Yu-Xiu Xiao*, Qian-Rui Zhang, Yu-Qi Feng. Immobilized phospholipid capillary electrophoresis for study of drug-membrane interactions and prediction of drug activity. Talanta, 2008，75: 104-110
專 利：
1. 肖玉秀，鄧彬. 一種兩用雷射誘導螢光檢測系統. 專利號：ZL 201310012461.6, 證書號：第1650205號，授權公告日：2015年4月29日
2. 肖玉秀，吳喆，梅潔. 一種混合表面活性劑雙水相萃取體系. 專利號 201110287840.7，授權公告日：2014年4月15日
3. 肖玉秀, 徐見容. 一種用於正交式雷射誘導螢光檢測器的四維可調毛細管夾持器. 專利號 ZL 200820230546.6, 授權公告日2009年10月9日
4. 肖玉秀，徐見容，倪峙旭. 一種毛細管視窗製作器. 專利號 ZL 200920084847.7，授權公告日2010年5月12日
5. 肖玉秀，汪志明，徐見容，倪峙旭. 一種毛細管沖洗及進樣兩用器. 專利號 ZL 200920228727.X，授權公告日2010年6月9日
6. 肖玉秀，廖曉燕，蔣永光. 奧沙普秦固體分散體、製備方法及套用. 申請號 201110202153.0，申請日期：2011年7月19日
國際學術會議：
1. Yu-Xiu Xiao, Edward S Yeung. “On-column monitoring of natural release of epirubicin from single breast cancer cells by capillary electrophoresis”. The Seventh Asian Conference on Analytical Sciences, Hong Kong 2004 July, p152
2. Xiao Yu Xiu, Mei Jie, Xu Jian Rong. Immobilization of liposomes in fused_silica capillary by covalent bonding. The 9th Asian Conference on Analytical Sciences & the 39th Convention of The Korean Society of Analytical Sciences, Ramada Plaza Jeju, Jeju Island, Korea. November 4-8, 2007
3. Bin Deng，Zhi-Ming Wang，Yu-Xiu Xiao*. Analysis of doxorubicin uptake by single K562 human leukemia cells at clinical relevant concentration using CE-LIF. 2010 China-Japan-Korea Syposium on Analytical Chemistry, Oct 31-Nov 2, 2010, Wuhan, China, p103
4. Zhe Wu, Jie Mei, Yu-Xiu Xiao*. Catanionic Surfactant-Mediated Coacervate Extraction. 2010 China-Japan-Korea Syposium on Analytical Chemistry, Oct 31-Nov 2, 2010, Wuhan, China, p106
5. Bin Deng, Zhiming Wang, Zihao Zhou and Yuxiu Xiao*. Analysis of DOX uptake and its heterogeneity in single cancer cells using capillary electrophoresis coupled with laser-induced fluorescence detection. 37 International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Oct 8-11, 2011, Dalian, China, O-S23-5 (p153)
6. Bin Deng, Zhiming Wang, Zihao Zhou, Dan Chen, Yuxiu Xiao*. Analysis of heterogeneity in doxorubicin uptake by human leukemia K562 cells treated with different dosage schedules. 37 International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Oct 8-11, 2011, Dalian, China, P-486-B (p694)
7. Bin Deng, Zhiming Wang, Yuxiu Xiao*. Quanitative study of cellular heterogeneity in doxorubicin uptake and its phrmacological effects on cancer cells. Frontiers of Single Cell Analysis, Stanford University, Stanford, CA, USA, September 5-7, 2013，71#.
