研究方向
植物低氧感知與信號轉導
植物細胞自噬發生的調控機理
個人經歷
2011-現在:中山大學生命科學學院
2008-2011:香港大學生物科學學院(Post-Doctoral Fellow)
2005-2008:香港大學生物科學學院(Ph.D.)
2001-2005:新加坡分子與細胞生物研究院(Assistant Research Officer)
講授課程
新生研討課、代謝組學、
蛋白質組學、現代生命科學進展
學術成就
近年來在脂分子參與低氧信號轉導的分子機理、自噬調控低氧應答的功能及發生機制、以及植物低氧後復氧保護機制等方面取得了許多重要發現。在Autophagy、Plant Cell、PLoS Genetics、Molecular Plant、Plant Physiology和Plant Journal等國際權威期刊上發表SCI論文50餘篇,發表著作章節和評述8篇,獲美國和中國授權專利4項,論文被引用3000餘次。
承擔課題
2017年,國家傑出青年科學基金項目(在研,主持);
2014年,國家自然科學基金國際合作研究項目(已結題,主持);
2013年,國家自然科學基金面上項目(已結題,主持);
2012年,廣東省科技創新重點項目(已結題,主持);
2011年,中山大學“百人計畫”引進人才科研啟動費(已結題,主持)。
論文專著
代表性論文
1.Qi H, Li J., Xia FN, Chen JY, Lei X, Han MQ, Xie LJ, Zhou QM, andXiao S*. (2019) Arabidopsis SINAT proteins control autophagy by mediating ubiquitylation and degradation of ATG13.Plant Cellin press.(通訊作者)
2.Liao K, Peng YJ, Yuan LB, Dai YS, Chen QF, Yu LJ, Bai MY, Zhang WQ, Xie LJ*, andXiao S*. (2019) Brassinosteroids antagonize plant defense responses through BES1-mediated suppression of defensin and glucosinolate biosynthesis.Plant Physiologyin press.(通訊作者)
3.Zhou Y, Tan WJ, Xie LJ, Qi H, Yang YC, Huang LP, Lai YX, Tan YF, Zhou DM, Yu LJ, Chen QF, Chye ML, andXiao S*. (2019) Polyunsaturated linolenoyl-CoA modulates ERF-VII-mediated hypoxia signaling in Arabidopsis.Journal of Integrative Plant Biologydoi: 10.1111/jipb.12875.(通訊作者)
4. Huang L, Yu LJ, Zhang X, Fan B, Wang FZ, Dai YS, Qi H, Zhou Y, Xie LJ, andXiao S*. (2019)Autophagy regulates glucose-mediated root meristem activity by modulating ROS production inArabidopsis.Autophagy15: 407-422.(通訊作者)
5.Tan WJ, Yang YC, Zhou Y, Huang LP, Xu L, Chen QF,Yu LJ*, andXiao S*.(2018) Diacylglycerol acyltransferase and diacylglycerol kinase modulate triacylglycerol and phosphatidic acid production in the plant response to freezing stress.Plant Physiology177: 1303-1318. (通訊作者;重點推薦論文)
6. Qi H, Xia FN, Xie LJ, Yu LJ, Chen QF, Zhuang XH, Wang Q, Li F, Jiang L, Xie Q, andXiao S*. (2017) TRAF-family proteins regulate autophagy dynamics by modulating AUTOPHAGY PROTEIN6 stability in Arabidopsis.Plant Cell29: 890-911. (通訊作者;重點推薦論文)
7. Yuan LB, Dai YS, Xie LJ, Yu LJ, Zhou Y, Lai YX, Yang YC, Xu L, Chen QF, andXiao S*. (2017) Jasmonate regulates plant responses to postsubmergence reoxygenation through transcriptional activation of antioxidant synthesis.Plant Physiology173: 1864-1880. (通訊作者;ESI擴展版高引論文)
8. Chen L, Su ZZ, Huang L, Xia FN, Qi H, Xie LJ,Xiao S*, and Chen QF*. (2017) The AMP-activated protein kinase KIN10 is involved in the regulation of autophagy in Arabidopsis.Frontiers in Plant Science8:1201. (通訊作者)
9. Chen L, Liao B, Qi H, Xie LJ, Huang L, Tan WJ, Zhai N, Yuan LB, Zhou Y, Yu LJ, Chen QF, Shu W, andXiao S*. (2015) Autophagy contributes to regulation of the hypoxia response during submergence inArabidopsis thaliana.Autophagy11: 2233-2246. (通訊作者)
10. Chen QF, Xu L, Tan WJ, Chen L, Qi H, Xie LJ, Chen MX, Liu BY, Yu LJ, Yao N, Zhang JH, Shu W, andXiao S*. (2015) Disruption of theArabidopsisdefense regulator genesSAG101,EDS1, andPAD4confers enhanced freezing tolerance.Molecular Plant8(10): 1536-1549. (通訊作者)
11.Xie LJ, Chen QF, Chen MX, Yu LJ, Huang L, Chen L, Wang FZ, Xia FN, Zhu TR, Wu JX, Yin J, Liao B, Shi JX, Zhang JH, Aharoni A, Yao N, Shu W, andXiao S*. (2015) Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis.PLoS Genetics11(3): e1005143. (通訊作者;封面推薦論文)
12.Xie LJ, Yu LJ, Chen QF, Wang FZ, Huang L, Xia FN, Zhu TR, Wu JX, Yin J, Liao B, Yao N, Shu W, andXiao S*. (2015) Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism.Plant Journal81: 53-67. (通訊作者;ESI擴展版高引論文)
所獲榮譽
2022年1月,肖仕主要完成的植物逆境回響的膜脂重塑與分子調控機理入選2021 年度廣東省科學技術獎自然科學獎擬獎項目,二等獎。